CN103006845A - Medicine for internally and externally treating ulcerative colitis by aid of decoction containing radix puerariae, radix scutellariae, rhizoma coptidis and five charred components - Google Patents
Medicine for internally and externally treating ulcerative colitis by aid of decoction containing radix puerariae, radix scutellariae, rhizoma coptidis and five charred components Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a medicine for internally and externally treating ulcerative colitis by the aid of decoction containing radix puerariae, radix scutellariae, rhizoma coptidis and five charred components. The medicine comprises 20g of the radix puerariae, 10g of the radix scutellariae, 10g of the rhizoma coptidis, 10g of charred angelica sinensis, 10g of charred hawthorn, 6g of charred schizonepeta, 20g of charred fructus mume, 20g of charred sanguisorba officinalis and 6g of raw licorice. Summary of years of clinical experience of an inventor are combined on the basis of an ancestral secrete recipe, so that the medicine is obtained after repeated experiments. The medicine has the advantages that various Chinese herbal medicines jointly act to internally and externally treat the ulcerative colitis comprehensively, effective ingredients of the medicine can be quickly permeated to a focus of a patient, the condition of a lesion portion of the patient is improved, patients suffering from the ulcerative colitis due to various reasons can be quickly cured, and the medicine becomes effective fast and is short in treatment course, high in curing rate and low in expense.
Description
Technical field
The present invention relates to a kind of Chinese medicine, relate to specifically a kind of medicine of Gegen Qinlian five charcoal soup Chinese medicine ulcerative colitiss.
Background technology
Ulcerative colitis (ulcerative colitis, UC) is that the not bright non-specific enteritis sexually transmitted disease (STD) of a kind of cause of disease becomes, course of disease length and easily repeatedly outbreak, and quite common in western countries, prevalence is annual 79/10 ten thousand～2,68/,100,000
[1]Be low at China's sickness rate than western countries.But the UC case of China had the trend that increases gradually in recent years.Add up nearly 15 years documents, accumulative total reaches 140,000 examples.
The UC main manifestations is stomachache, diarrhoea, mucus hemafecia, tenesmus, and a few patients is with heating, abdominal colic and lose weight etc.The clinical manifestation of current diagnosis Main Basis, colonoscope, biopsy and antibacterial culturing etc.Foreign literature report, the course of disease of UC is longer, and canceration rate is higher, and onset is canceration rate canceration rate 16.5% after 7.2%, 30 year after 20 years.Still lack at present satisfied Therapeutic Method.Its prevalence has the trend that obviously increases in recent years, and is considered to the precancerous lesion of colon cancer, is classified as one of modern difficult treatment by World Health Organization (WHO).
Modern medicine adopts the multiple therapy methods such as rest, diet, salicylic acid, corticosteroid, antibiotic, immunosuppressant and operation to the treatment of primary disease more, but effect is dissatisfied, and side effect is more, and the state of an illness easily recurs, and curative effect is unstable.
Therefore, seeking the cost-effective Therapeutic Method for UC patient, reach good curative effect, improve the UC Quality of Life, is numerous medical personnels' target.Chinese medicine has been brought into play certain advantage at the clinical treatment primary disease, and curative effect certainly, and few side effects has obvious advantage than all methods of western medical treatment.For this reason, the oral clinical research that adds coloclysis on ulcerative colitis of Gegen Qinlian five charcoal soup is carried out in this research, exploration can improve the clinical efficacy for the treatment of ulcerative colitis and treatment side's medicine of safety, for the good result of Ulcerative Colitis Treated with Chinese Drugs provides scientific basis, for clinical application provides objective basis.
Domestic and international progress and existing problems
At present, the UC cause of disease and pathogenesis are still not very clear, may be relevant with the interaction of a series of tumor susceptibility gene, environmental factors and immune system abnormality.Studies show that there is serious Cellular Immune Disturbances in patients with active ulcerative colitis, TNF-α, IL-6, IL-8, the cytokines such as sIL-2R play an important role in the generation of ulcerative colitis and PD, and can be used as one of biological indicator of observe the curative effect and judging prognosis.TNF-α has widely biologic activity, except antitumor, and to immunoreation, organism metabolism, inflammatory reaction all has important adjusting mediation, is acknowledged as the cytokine of mediation ulcerative colitis.IL-6 is a kind of widely pro-inflammatory cytokine, and a series of researchs find that patients of ulcerative colitis blood serum IL-6 concentration obviously raises, and become positive correlation with extent of disease with the pathological changes order of severity.IL-8 is a kind of powerful neutrophilic granulocyte chemotactic and activation factor, main biological action is chemotactic and activates neutrophilic granulocyte, promote lysosomal enzyme activities and the phagocytosis of neutrophilic granulocyte, basophilic granulocyte and T cell are also had certain chemotaxis.Think that at present TNF-α, the inflammatory reaction that IL-1, IL-6 bring out are by inducing the chemotactic factor take IL-8 as representative to be mediated to a great extent.UC patient IL-8 level significantly raises, and becomes positive correlation with the inflammatory reaction degree of focus, and its detection can be used as the index of judging clinically disease severity and curative effect.
Modern medicine adopts the multiple therapy methods such as rest, diet, salicylic acid, corticosteroid, antibiotic, immunosuppressant and operation to the treatment of primary disease more, but effect is dissatisfied, and side effect is more, and the state of an illness easily recurs, and curative effect is unstable.
Ulcerative colitis belongs to " having loose bowels " " dysentery " categories such as " stomachache " of " having blood in stool " in the traditional Chinese medical science.At present the traditional Chinese medical science is multiple to the Therapeutic Method of primary disease, and take oral administration and intestinal topical as main, and curative effect certainly on route of administration, and few side effects has obvious advantage than all methods of western medical treatment.Oral Chinese medicine is main mainly with the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the pattern of syndrome such as damp and hot, insufficiency of the spleen damp and hot, the insufficiency of the spleen leading to overabundance of dampness (coldheat complex) of intestinal, incoordination between the liver and spleen, the hot stasis of blood are tied mutually, deficiency of spleen-YANG and kidneyYANG are generally arranged,, cooling blood for hemostasis damp and hot take Qinghua at acute attack stage be as main, repeatedly outbreak or to continue outbreak be main mainly with strengthening vital QI to eliminate pathogenic factors then.Retention enema after intestinal local application is concentrated mainly with Chinese medicine decoction, or receive the anus treatment with Chinese medicine suppository.Local application is main mainly with the palliative of heat-clearing and toxic substances removing, cooling blood for hemostasis.Herbal retention enema have direct, evident in efficacy, simple and convenient and easy to study, the medicine source of effect sufficient, can be with advantages such as card plus-minuss, overcome that the course for the treatment of that many Chinese medicine and western medicine oral medications exist is long, side effect is large, the easy shortcoming such as recurrence, local damage and the untoward reaction of having avoided traditional oral, intramuscular injection or intravenously administrable to cause have demonstrated fully advantage and the characteristic of Chinese medicine.
Take a broad view of a large amount of Chinese medicines to the research of primary disease, highlighted certain advantage.Chinese medicine is owing to having treatment to UC in mind from Overall View, and curative effect is sure, few side effects, its drug development just is being subject to domestic and international attention, and Therapeutic Method and means for UC seeks determined curative effect provide direction and basis, can satisfy clinical requirement, the Chinese medicine gastrointestinal disease has wide prospect.
Summary of the invention
The objective of the invention is to overcome the prior art deficiency, and provide that a kind of curative effect is fast, expense is low, have no side effect, can thoroughly cure fast the medicine of ulcerative colitis.
For realizing purpose of the present invention, existing according to following technical scheme.This medicine is to be made by the raw material of following weight portion proportioning:
Radix Puerariae 20g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Radix Angelicae Sinensis carbon 10g, Fructus Crataegi charcoal 10g, Herba Schizonepetae charcoal 6g, carbonized Fructus Mume 20g, charred Radix Sanguisorbae 20g, Radix Glycyrrhizae 6g.
Preparation method of the present invention is: take by weighing in proportion two groups of above-mentioned each component medicines, then will be wherein one group add an amount of hydrology fire and decocted 30 minutes, must fry in shallow oil juice 400mL, be endo-medicine of the present invention; Another group is wherein added an amount of decocting boiled 50 minutes, must fry in shallow oil juice 100mL, be external used medicine of the present invention.
The instructions of taking of endo-medicine is: every day sooner or later each once, decoction being taken warmly after meal.External used medicine using method of the present invention is: in the retention enema that moves ahead of sleeping every night, about 36 ℃ of enema are taked to get left lateral position and poured into, and then get knee joint clinostatism 15min, and are flat sleeping again, keep more than the 4h.
The present invention is that the inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with oneself for many years summary of clinical experience, get through repeatedly testing, it adopts multiple Chinese herbal medicine synergy, inside and outside comprehensive measure makes the active ingredient rapid permeability focus of medicine, improves pathological changes section, can rapid healing the ulcerative colitis that causes of a variety of causes, and instant effect, short treating period, cure rate is high, expense is little.
The specific embodiment
Take by weighing raw material in following ratio:
Radix Puerariae 20g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Radix Angelicae Sinensis carbon 10g, Fructus Crataegi charcoal 10g, Herba Schizonepetae charcoal 6g, carbonized Fructus Mume 20g, charred Radix Sanguisorbae 20g, Radix Glycyrrhizae 6g.
Preparation method of the present invention is: take by weighing in proportion two groups of above-mentioned each component medicines, then will be wherein one group add an amount of hydrology fire and decocted 30 minutes, must fry in shallow oil juice 400mL, be endo-medicine of the present invention; Another group is wherein added an amount of decocting boiled 50 minutes, must fry in shallow oil juice 100mL, be external used medicine of the present invention.
The instructions of taking of endo-medicine is: every day sooner or later each once, decoction being taken warmly after meal.External used medicine using method of the present invention is: in the retention enema that moves ahead of sleeping every night, about 36 ℃ of enema are taked to get left lateral position and poured into, and then get knee joint clinostatism 15min, and are flat sleeping again, keep more than the 4h.
The present invention is in the experimental result for the treatment of ulcerative colitis
(1) case choice criteria
1. diagnostic criteria
1.1 Western medicine diagnose standard
All can discuss the ulcerative colitis diagnostic criteria of formulation with reference to 2000 year's harvest:
Clinical symptoms diarrhoea, mucus hemafecia, stomachache;
Colonoscopy: mucosa hyperemia, edema, erosion, ulcer;
Barium coloclysis X-ray is seen haustra of colon hairiness thorn-like, and intestinal tube is stiff, and enteral has filling defect, and it is disorderly that mucosa resembles the pleat traveling;
Stool is cultivated twice without bacterial growth.
1.2 Standards of Chinese Medical Syndrome Differentiation
With reference to " new Chinese medicine guideline of clinical investigations ", " chronic non-specific ulcerative colitis Chinese and Western is in conjunction with diagnosis, dialectical and criterion of therapeutical effect ", meet the diagnostic criteria of traditional Chinese medical science retention of damp-heat in the interior card, primary symptom: diarrhoea, bloody purulent stool or hemafecia, tenesmus, stomachache.Inferior disease: burning sensation of the anus, fever of the body, urinate red, red tongue with yellowish and greasy fur, slippery and rapid pulse or moisten number.
2. inclusive criteria
All ulcerative colitiss that meets Western medicine diagnose standard and tcm diagnosis standard, light, middle degree meet Edwards and Fruelove compressive classification standard, at 18～65 years old age, all can include the test case in.
3. exclusion standard
Allly meet above any one person, namely get rid of.
(2) case is selected
Select the routine UC patient of active stages 200 of the 3rd Affiliated Hospital outpatient service of Luohe Medical college and lesion during in October, 2010～2012 year October, table of random number is divided into treatment group, matched group.Treatment group (Chinese medicine of the present invention) 100 examples, male's 55 examples, women's 45 examples; Matched group (sulfasalazine enteric coatel tablets) 100 examples, male's 60 examples, women's 40 examples.
(3) Therapeutic Method
The treatment group treatment group gives Gegen Qinlian five charcoal soup, and square medicine forms: Radix Puerariae 20g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Radix Angelicae Sinensis carbon 10g, Fructus Crataegi charcoal 10g, Herba Schizonepetae charcoal 6g, carbonized Fructus Mume 20g, charred Radix Sanguisorbae 20g, Radix Glycyrrhizae 6g.2 doses of every days, wherein fry in shallow oil juice 400mL for 1 dose, minute 2 decoction being taken warmly.In addition fry in shallow oil juice and be concentrated into 100mL for 1 dose, in the retention enema that moves ahead of sleeping every night, about 36 ℃ of enema are taked to get left lateral position and poured into, and then get knee joint clinostatism 15min, and are flat sleeping again, keep more than the 4h.
The oral sulfasalazine enteric coatel tablets of matched group (SASP, Xinyi, Shanghai Jia Hua pharmaceutcal corporation, Ltd produces, the 0.25g/ sheet) 3g ﹒ d
-1, each 1g, every day 3 times.
Above two groups all take 20d as a course for the treatment of, observe and pass judgment on curative effect 2 courses for the treatment of.Patient's greasy, pungent product of avoiding eating anything raw or cold during treating, ban on opium-smoking and the opium trade wine is withdrawn other drug.The normal healthy controls group will not medication and enteroscopy.
(4) observation index
1. symptom integral before and after treating
The integration of the symptoms such as diarrhoea or bloody purulent stool, stomachache, abdominal distention before and after treatment drafted calculating according to the quantification grade scale of syndrome effect index, see Table 1
Table 1 symptom scalar quantization score standard
2. clinical efficacy after treating
2.1 the curative effect of disease standard is alleviated fully: clinical symptom disappearance, the colonoscopy mucosa is roughly normal; Effectively: clinical symptom disappearance, intestinal mirror check mucosa mild inflammation or pseudopolyp form; Invalid: clinical symptoms, intestinal mirror and pathologic finding are without improvement.
(5) index of correlation detects
Include case in before the treatment and after the treatment, and Normal group is all got Venous Blood 6ml, EDTA anticoagulant in fasting after 12 hours.TNF-α, IL-6 and IL-8 measure: adopt the ELISA double antibody sandwich method.Test kit is provided by Bang Ding biotech firm of Military Medical Science Institute, and the strict by specification of all operations carries out.
(6) statistical procedures
Adopt SPSS13.0 software to add up, measurement data with
± sExpression is relatively used between group
tCheck, enumeration data is used
x 2Check,
P＜0.05 for there being statistical significance.
(7) therapeutic outcome
Two groups of patient clinical symptoms are clearly better, and every biochemical indicator significantly improves, treatment group clinical cure rate 70%, effective percentage 98%, inefficiency 2%; Matched group clinical cure rate 40%, effective percentage 85%, inefficiency 15%.Treatment group be better than matched group (
P＜0.01).Curative effect relatively sees Table 7.1 before and after two groups of patient treatments, and all experimental datas all use the SPSS13.0 statistical software to carry out statistical procedures.
Table 7.1 liang group patient curative effect relatively
| Group | The example number | Clinical cure | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 100 | 70 | 98 | 2 | 98.0 |
| Matched group | 100 | 40 | 85 | 15 | 85.0 |
Annotate: two groups of curative effects relatively, difference have statistical significance (
P＜0.01)
1, by Gegen Qinlian five charcoal soup oral with coloclysis in clinical application, obtain the good efficacy to UC patient.
2, by oral to Gegen Qinlian five charcoal soup be the observation of main treatment UC patient's curative effect with coloclysis, and serum TNF-α, the content detection of IL-6 and IL-8 is inquired into its theoretical foundation, for effective treatment of UC provides referential experience to sum up.
3, by research and the clinical practice of this problem, obtain higher Social benefit and economic benefit, apply.
Claims (1)
1. the medicine of Gegen Qinlian five charcoal soup Chinese medicine ulcerative colitiss is characterized in that it is to be made by the raw material of following weight portion proportioning: Radix Puerariae 20g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Radix Angelicae Sinensis carbon 10g, Fructus Crataegi charcoal 10g, Herba Schizonepetae charcoal 6g, carbonized Fructus Mume 20g, charred Radix Sanguisorbae 20g, Radix Glycyrrhizae 6g.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655834A (en) * | 2013-12-10 | 2014-03-26 | 江西新世纪民星动物保健品有限公司 | Traditional Chinese medicine composition used for preventing and controlling porcine ileitis, and preparation method thereof |
| CN104107370A (en) * | 2014-07-09 | 2014-10-22 | 陈永泉 | Traditional Chinese medicament for treating ulcerative colitis |
| CN104491420A (en) * | 2014-11-25 | 2015-04-08 | 哈尔滨医科大学 | Enema traditional Chinese medicinal composition for treating ulcerative colitis, and preparation method thereof |
| CN105250830A (en) * | 2015-11-23 | 2016-01-20 | 李先强 | Medicine for treating Crohn's disease |
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| CN102716215A (en) * | 2012-07-11 | 2012-10-10 | 河南中医学院 | Collaterals dredging decoction for curing UC |
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2013
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716215A (en) * | 2012-07-11 | 2012-10-10 | 河南中医学院 | Collaterals dredging decoction for curing UC |
Non-Patent Citations (1)
| Title |
|---|
| 王雁梅: "葛根芩连五炭汤内外合治溃疡性结肠炎临床观察", 《中国医药指南》, vol. 9, no. 29, 31 October 2011 (2011-10-31), pages 5 - 6 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655834A (en) * | 2013-12-10 | 2014-03-26 | 江西新世纪民星动物保健品有限公司 | Traditional Chinese medicine composition used for preventing and controlling porcine ileitis, and preparation method thereof |
| CN104107370A (en) * | 2014-07-09 | 2014-10-22 | 陈永泉 | Traditional Chinese medicament for treating ulcerative colitis |
| CN104491420A (en) * | 2014-11-25 | 2015-04-08 | 哈尔滨医科大学 | Enema traditional Chinese medicinal composition for treating ulcerative colitis, and preparation method thereof |
| CN104491420B (en) * | 2014-11-25 | 2017-11-17 | 哈尔滨医科大学 | A kind of bowel lavage Chinese medicine composition for treating ulcerative colitis and preparation method thereof |
| CN105250830A (en) * | 2015-11-23 | 2016-01-20 | 李先强 | Medicine for treating Crohn's disease |
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