CN104107370A - Traditional Chinese medicament for treating ulcerative colitis - Google Patents
Traditional Chinese medicament for treating ulcerative colitis Download PDFInfo
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- CN104107370A CN104107370A CN201410325281.8A CN201410325281A CN104107370A CN 104107370 A CN104107370 A CN 104107370A CN 201410325281 A CN201410325281 A CN 201410325281A CN 104107370 A CN104107370 A CN 104107370A
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Abstract
The invention relates to a traditional Chinese medicament for treating ulcerative colitis. The traditional Chinese medicament is prepared from the following medicinal materials in parts by weight: 12 parts of verbenaceae callicarpa longissima, 5 parts of chicory root, 10 parts of sparganium stoloniferum, 8 parts of carrageenan, 8 parts of litsea sericea, 12 parts of phymatopteris conjuncta, 8 parts of thinleaf buckthorn fruit, 6 parts of phenylpropanoid, 14 parts of rectanglesickle medick, 15 parts of Japanese raspberry root, 10 parts of bidens biternata, 12 parts of jagged-leaved oak seed, 10 parts of fallopia convolvulus, 5 parts of delphinium tatsienense franch. Clinical experiments prove that the traditional Chinese medicament can be used for safely and effectively treating ulcerative colitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis (ulcerative colitis, UC) be a kind of chronic nonspecific enteritis, clinical taking mucopurulent bloody stool, stomachache, diarrhoea, tenesmus as main manifestations, outbreak repeatedly, protracted course of disease, is classified as one of modern difficult treatment by World Health Organization (WHO).In recent years, pathogenesis of ulcerative colitis rate has the trend rising gradually, and causes the probability of canceration to increase along with the course of disease extends.Its cause of disease and pathogenesis are not yet completely clear and definite, think relevant with infective agent with immunity, heredity more.Still lack clinically at present targetedly, the specific treatment medicine of good effect and few side effects.Doctor trained in Western medicine is many from antiinflammatory, immunomodulating reaction, inhibition radical damage, and change the aspect such as gene expression and treat, show in the early stage good therapeutic effect, but along with the prolongation of the course of disease and corresponding treatment, still have a large portion patient because side effect or drug resistance can not get sufficient treatment, be clinically still badly in need of developing new medicine safely and effectively.Chinese medicine ulcerative colitis has the feature of multipath, multi-level, many target spots and few side effects, can long term maintenance medication treatment.Therefore explore effectively treatment side's medicine and there is profound significance for clinical prevention and treatment ulcerative colitis.
The present Research of the related medical material of Chinese medicine of the present invention is as follows:
Caulis te Folium Callicarpae Longissimae [source] medical material Ji Yuan: be stem, the leaf of Verbenaceae Folium Callicarpae Longissimae.Latin plant animal mineral name: Callicarpa longissima (Hemsl.) Merr. gathers and stores: summer, autumn gather, and dry or using fresh herb.[nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[function cures mainly] expelling wind and cold; Dissipating blood stasis hemostasis; Removing toxic substances and promoting subsidence of swelling.Main cough due to wind and cold; Abdominal pain due to accumulation of cold; Rheumatic arthralgia; Traumatic injury; Interior traumatic hemorrhage; Innominate toxic swelling.[usage and dosage] is for oral administration: decoct soup, and 10-15g, fresh goods adds position; Or smash juice and drink.External: appropriate, smash deposited: or grind into powder and spread.
Root of Herba Cichorii [source] medical material Ji Yuan: be the root of feverfew Herba Cichorii.Latin plant animal mineral name: Cichorium intybus L. gathers and stores: summer, autumn gather, and section is dried.[nature and flavor] mildly bitter flavor; Cool in nature.[function cures mainly] heat clearing away; Stomach invigorating.Main dyspepsia; Born of the same parents' abdominal distention is vexed.[usage and dosage] is for oral administration: grind 3-6g into powder.
Rhizoma scirpi [source] medical material Ji Yuan: be the tuber of sedge cyperus iria L. rhizoma scirpi.Latin plant animal mineral name: Scirpus yagara Ohwi[Scirpus maritimus C.B.Clarke] to gather and store: excavate autumn, removes rhizome and fibrous root, clean, or the crust of pruning dries.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[return through] liver; Spleen channel.[function cures mainly] blood stasis dispelling stimulates the menstrual flow; Removing blood stasis eliminating mass; Circulation of qi promoting removing food stagnancy.Main amenorrhea due to stagnation of blood; Dysmenorrhea; Postpartum stagnation stomachache; Traumatic injury congestive edema; Enclosed mass in abdomen; Abdominal pain due to retention of food.[usage and dosage] is for oral administration: decoct soup, 4.5-9g.
Chondrus ocellatus Holmes [source] medical material Ji Yuan: be the frond of Shan Zao section plant chondrus ocellatus Holmes.Latin plant animal mineral name: Chondrus ocellatus Holm.[nature and flavor] sweet; Salty; Cold.[return through] large intestine; Stomach warp.[function cures mainly] heat-clearing and toxic substances removing; Stomach function regulating relieving constipation.Main laryngopharynx swelling and pain; Traumatic injury; Flu cold and heat; Mumps; Gastralgia; Dryness of the intestine constipation.[usage and dosage] is for oral administration: decoct soup 5-20g.External: smash in right amount deposited.
Litsea sericea (Nees) Hook. F [source] medical material Ji Yuan: be the fruit of canella Litsea sericea (Nees) Hook. F.Latin plant animal mineral name: Litsea sericea (Nees) Hook.f.[Tetranthera sericea Nees] to gather and store: pluck summer and autumn, dries.[nature and flavor] are pungent; Temperature.[return through] spleen; Lung; Urinary bladder channel.[function cures mainly] diuresis; Eliminate the phlegm; Dispelling-wind invigorating stomach; Anticorrosion.The cold pain of main gastral cavity abdomen; Abdominal distention vomiting.[usage and dosage] is for oral administration: decoct soup clothes, 3-6g.
Phymatopsis conjuneta Ching [source] medical material Ji Yuan: be the rhizome of Plants of Polypodiaceae Phymatopsis conjuneta Ching.Latin plant animal mineral name: Phymatopsis conjuneta Ching gathers and stores: all can take the whole year, removes fibrous root, cleans using fresh herb or dry.[nature and flavor] micro-hardship; Cool.[return through] spleen; Stomach warp.[function cures mainly] heat-clearing and toxic substances removing; Circulation of qi promoting dampness removing.Main urinary tract infection; Hematuria; Have loose bowels; Dysentery; Rheumatic arthralgia; Dyspepsia.[usage and dosage] is for oral administration: decoct soup, 9-15g.
Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) [source] medical material Ji Yuan: be the fruit of Rhamnaceae plant fineflower buckthorn.Latin plant animal mineral name: Rhamnus leptosphylla Schneid. gathers and stores: 8-9 gathers when month fruit maturation, using fresh herb or dry.[nature and flavor] hardship; Puckery; Flat.[return through] heart; Spleen; Kidney channel.[function cures mainly] relieving dyspepsia; Row water can be just.Main dyspeptic abdominal distention; Edema; Ascites; Constipation.[usage and dosage] is for oral administration: decoct soup, 5-15g; Or grind into powder; Or steep in wine.
Radix Euphorbiae [source] medical material Ji Yuan: be the root of the Radix Euphorbiae Pekinensis, euphorbia plant Hubei.Latin plant animal mineral name: Euphorbia hylonoma Hand.Mazz. gathers and stores: excavate autumn, cleans, and dries.[nature and flavor] sweet in the mouth; Bitter; Cool in nature; Poisonous.[return through] liver; Spleen channel.[function cures mainly] removing stagnancy of indigested food and relieving flatulence; Removing water retention by purgation; Removing blood stasis with potent drugs analgesic therapy.Staple food amasss tympanites; Constipation and anuresis; Traumatic injury.[usage and dosage] is for oral administration: decoct soup, 1.5-3g.External: appropriate, smash deposited.
Herba Medicaginis archiducis-nicolai [source] medical material Ji Yuan: be the herb of the dark blue Semen Trigonellae of leguminous plant.Latin plant animal mineral name: Trigonella archiducisnicolai (Sirj.) Vassilcz.[Medicago archiducisnicolai Sirj.] to gather and store: gather summer, using fresh herb or dry.[nature and flavor] mildly bitter flavor; Cold nature.[return through] heart; Small intestine meridian.[function cures mainly] heat clearing away; Cough-relieving.Main pneumonia cough; Wound.[usage and dosage] is for oral administration: decoct soup, 6-12g.External: appropriate, smash wiping.
Radix Rubi parvifolii [source] medical material Ji Yuan: be the root of rosaceous plant Rubus Parvifolius L..Latin plant animal mineral name: Rubus parvifolius L. gathers and stores: autumn, winter uproot, cleans using fresh herb, or section is dried.[nature and flavor] sweetness and bitterness; Cool; Nontoxic.[return through] liver; Lung; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and removing dampness; Promoting blood circulation and cooling blood.Main cold, fever; Laryngopharynx swelling and pain; Rheumatic arthralgia; Hepatitis; Intestinal inflammation; Dysentery; Oedema due to nephritis; Urinary tract infection; Calculus; Traumatic injury; Hemoptysis; Spit blood; Metrorrhagia; Furuncle swelling toxin; Parotitis.[usage and dosage] is for oral administration; Decoct soup, 6-15g; Or infusing drugs in wine.External: appropriate, smash deposited; Or decoct soup fumigation and wash method; Or grind and do not dress.
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) [source] medical material Ji Yuan: be the herb of section of district plant Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae).Latin plant animal mineral name: Bidens biternata (Lour.) Merr.EtSherff[CoreopsisbiternataLour.; PBidenschinensisWilld.; B.robertianifo lia Levl.et Van] to gather and store: spring, summer gather, and using fresh herb or cutting are dried.[nature and flavor] sweet in the mouth; Micro-hardship; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main cold, fever; Jaundice; Have loose bowels; Dysentery; Heat in blood is spitted blood; Metrorrhagia; Traumatic injury; Carbuncle sore tumefacting virus; The arthroncus of knee; Mange.[usage and dosage] is for oral administration: decoct soup, 10-30g; Or infusing drugs in wine drink.External: appropriate, smash deposited; Or decoct washing.
Semen querci dentatae [source] medical material Ji Yuan: be the seed of Fagaceae live oak.Latin plant animal mineral name: Quercus dentata Thunb. gathers and stores: gather after fruit maturation winter, and Fructus Forsythiae bucket is taken, and dries, removes acorn-cup and plants shell, takes out seed and dries, and puts aeration-drying place.[nature and flavor] hardship; Puckery; Property is put down.[return through] spleen; Stomach; Large intestine channel.[function cures mainly] relieving diarrhea with astringents.Main diarrhoea; Dysentery.[usage and dosage] is for oral administration: decoct soup, 9-15g; Or levigation, each 0.5-1g.
Volume stem knotweed [source] medical material Ji Yuan: be the herb of polygonaceae plant volume stem knotweed.Latin plant animal mineral name: olygonum convolvulus L. gathers and stores: summer, autumn gather, cleans, and dries.[nature and flavor] are pungent; Warm in nature.[function cures mainly] strengthening the spleen to promote digestion.Main dyspepsia; Diarrhoea.[usage and dosage] is for oral administration: decoct soup, 6-12g.
Chicken feet crow [source] medical material Ji Yuan: be the root of Zhi Gen section plant Kangding Herba delphinii grandiflori.Latin plant animal mineral name: Delphinium tatsienense Franch.[D.soonmingense Chen] to gather and store: all can excavate the whole year, digs stem and leaf, fibrous root, cleans, and dries.[nature and flavor] acrid in the mouth; Micro-hardship; Hot in nature; Poisonous.[function cures mainly] warming middle-JIAO to relieve pain.Cold type of pain in main abdomen; Impairment caused by overstrain bones and muscles pain.[usage and dosage] is for oral administration: grind into powder, and 0.3-0.6g, boiled water takes.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine for the treatment of ulcerative colitis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing ulcerative colitis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine for the treatment of ulcerative colitis, it is characterized in that, be prepared from by the medical material of following weight proportion: 12 parts of Caulis te Folium Callicarpae Longissimaes, 5 parts of root of Herba Cichorii, 10 parts of rhizoma scirpis, 8 parts of chondrus ocellatus Holmes, 8 parts of Litsea sericea (Nees) Hook. Fs, 12 parts of Phymatopsis conjuneta Chings, 8 parts of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), 6 parts of Radix Euphorbiae, 15 parts of 14 parts of Radix Rubi parvifolii of Herba Medicaginis archiducis-nicolai, 10 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 12 parts of Semen querci dentatae, 10 parts of volume stem knotweeds, 5 parts of chicken feet crows.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, physical data
Inventor in July, 2010-2012 collect between year May that 75 examples are light altogether, the ulcerative colitis outpatient service of moderately active phase or inpatient, wherein male 50 examples, female's 25 examples, age 20-55 year, course of disease 1-5.Be divided at random: treatment group 40 examples, matched group 35 examples.Difference that under two groups of patient ages, sex, the course of disease, the clinical manifestation order of severity and colonoscopes there are no significant degree of inflammation and scope aspect, has comparability.
2, test method
The capsule that the oral the present invention of 2.1 treatment group makes according to specific embodiment 1, sooner or later respectively once.4 weeks courses for the treatment of.
The oral sulfasalazine of 2.2 matched group (SASP) 0.5g, every day 4 times.4 weeks courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Effective: clinical symptom disappearance, times of defecation≤2 times/day, feces is without red, leukocyte, and scope check mucosa is roughly normal.Effective: clinical symptoms disappears substantially, times of defecation 2-4 times/day, stool is shaped, 10/high power lens of the equal < of feces erythrocyte and leukocyte, scope check, the reaction of mucosa mild inflammation and part pseudopolyp form.Invalid: after treatment, clinical symptoms, chemical examination and scope are without improvement.
3.2 treatment statistical results are in table 1.
Table 1 liang group curative effect comparison
| Group | n | Effective | Effectively | Invalid | Untoward reaction example | Total effective rate (%) |
| Treatment group | 40 | 13(32.5％) | 17(42.5％) | 10(25％) | 0 | 75％ |
| Matched group | 35 | 15(42.9％) | 11(31.4％) | 9(25.7％) | 3(8.6％) | 74.3％ |
Visible, the medicine that the present invention makes can safe and effective treatment ulcerative colitis.
Detailed description of the invention
In order to understand better and to implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: 12 grams of Caulis te Folium Callicarpae Longissimaes, 5 grams of root of Herba Cichorii, 10 grams of rhizoma scirpis, 8 grams of chondrus ocellatus Holmes, 8 grams of Litsea sericea (Nees) Hook. Fs, 12 grams of Phymatopsis conjuneta Chings, 8 grams of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), 6 grams of Radix Euphorbiae, 14 grams of Herba Medicaginis archiducis-nicolais, 15 grams of Radix Rubi parvifolii, 10 grams of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 12 grams of Semen querci dentatae, 10 grams of volume stem knotweeds, 5 grams of chicken feet crows, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.
Be used for the treatment of ulcerative colitis.Oral, every bu is taken for twice sooner or later.
Specific embodiment 2
Take: 12 grams of Caulis te Folium Callicarpae Longissimaes, 5 grams of root of Herba Cichorii, 10 grams of rhizoma scirpis, 8 grams of chondrus ocellatus Holmes, 8 grams of Litsea sericea (Nees) Hook. Fs, 12 grams of Phymatopsis conjuneta Chings, 8 grams of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), 6 grams of Radix Euphorbiae, 14 grams of Herba Medicaginis archiducis-nicolais, 15 grams of Radix Rubi parvifolii, 10 grams of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 12 grams of Semen querci dentatae, 10 grams of volume stem knotweeds, 5 grams of chicken feet crows, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, pulverize, must meet the powder of 1 day consumption of normal adult.
Be used for the treatment of ulcerative colitis.Oral, every bu is taken for twice sooner or later.
Specific embodiment 3
Take: 12 grams of Caulis te Folium Callicarpae Longissimaes, 5 grams of root of Herba Cichorii, 10 grams of rhizoma scirpis, 8 grams of chondrus ocellatus Holmes, 8 grams of Litsea sericea (Nees) Hook. Fs, 12 grams of Phymatopsis conjuneta Chings, 8 grams of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), 6 grams of Radix Euphorbiae, 14 grams of Herba Medicaginis archiducis-nicolais, 15 grams of Radix Rubi parvifolii, 10 grams of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 12 grams of Semen querci dentatae, 10 grams of volume stem knotweeds, 5 grams of chicken feet crows, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, then add appropriate dextrin and correctives, and to granulate according to this area common process, packaging, can make the granule that meets 1 day consumption of normal adult.
Be used for the treatment of ulcerative colitis.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. treat the Chinese medicine of ulcerative colitis for one kind, it is characterized in that, be prepared from by the medical material of following weight proportion: 12 parts of Caulis te Folium Callicarpae Longissimaes, 5 parts of root of Herba Cichorii, 10 parts of rhizoma scirpis, 8 parts of chondrus ocellatus Holmes, 8 parts of Litsea sericea (Nees) Hook. Fs, 12 parts of Phymatopsis conjuneta Chings, 8 parts of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), 6 parts of Radix Euphorbiae, 14 parts of Herba Medicaginis archiducis-nicolais, 15 parts of Radix Rubi parvifolii, 10 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 12 parts of Semen querci dentatae, 10 parts of volume stem knotweeds, 5 parts of chicken feet crows.
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| CN201410325281.8A CN104107370A (en) | 2014-07-09 | 2014-07-09 | Traditional Chinese medicament for treating ulcerative colitis |
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| CN201410325281.8A CN104107370A (en) | 2014-07-09 | 2014-07-09 | Traditional Chinese medicament for treating ulcerative colitis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671096A (en) * | 2012-04-18 | 2012-09-19 | 王桂琴 | Traditional Chinese medicine for treating ulcer colonitis and preparation method thereof |
| CN103006845A (en) * | 2013-01-19 | 2013-04-03 | 王雁梅 | Medicine for internally and externally treating ulcerative colitis by aid of decoction containing radix puerariae, radix scutellariae, rhizoma coptidis and five charred components |
| CN103705660A (en) * | 2013-12-14 | 2014-04-09 | 黄根强 | Traditional Chinese medicine for treating ulcerative colitis (UC) |
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2014
- 2014-07-09 CN CN201410325281.8A patent/CN104107370A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671096A (en) * | 2012-04-18 | 2012-09-19 | 王桂琴 | Traditional Chinese medicine for treating ulcer colonitis and preparation method thereof |
| CN103006845A (en) * | 2013-01-19 | 2013-04-03 | 王雁梅 | Medicine for internally and externally treating ulcerative colitis by aid of decoction containing radix puerariae, radix scutellariae, rhizoma coptidis and five charred components |
| CN103705660A (en) * | 2013-12-14 | 2014-04-09 | 黄根强 | Traditional Chinese medicine for treating ulcerative colitis (UC) |
Non-Patent Citations (2)
| Title |
|---|
| 谢健元等: "半夏泻心汤合当归芍药散加味治疗溃疡性结肠炎76例", 《福建中医药》 * |
| 顾庆华: "健脾化滞丸治疗溃疡性结肠炎48例", 《实用中医内科杂志》 * |
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Application publication date: 20141022 |