CN103393865A - Medicament for treating gout and preparation method thereof - Google Patents
Medicament for treating gout and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating gout and a preparation method thereof. The medicament is mainly prepared from amur cork tree bark, rhizoma rhizoma atractylodis, gentian, tetrandra root, bile arisaema, ligusticum wallichii, peach kernel, safflower and notopterygium root according to a certain weight ratio. The medicament disclosed by the invention has the effects of promoting the circulation of qi to expel stagnation, dispelling pathogenic wind to remove dampness, activating blood to stimulate meridians and removing blood stasis to stop pain, and is quick in response, good in curative effect and high in cure rate when used for treating gout.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of gout and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Gout is by the crystal dependency arthrosis due to the monosodium urate mineralization, with purine metabolic disturbance and (or) hyperuricemia due to underexcretion is directly related, refer in particular to acute characteristic arthritis and chronic gout disease, mainly comprise acute attack arthritis and chronic arthritis, urate nephropathy and uric acid lithangiuria, joint deformity and renal insufficiency can appear in severe one.Gout is often accompanied the performances such as abdominal obesity, hyperlipemia, hypertension, type 2 diabetes mellitus and cardiovascular diseases.Gout can be divided into constitutional and the large class of Secondary cases two according to cause of disease difference.Primary gout refers to getting rid of on the basis of other diseases, due to congenital purine metabolic disturbance and (or) uric acid excretion disorder causes; Secondary gout refers to be secondary to uricopoiesis due to underexcretion due to kidney disease or some drugs, myeloproliferative disease and chemotherapy of tumors to be increased etc.At present, because Western medicine can't the rapid, effective treatment gout, and certain side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of rapid, effective treatment gout.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the medicine of effective treatment gout, thereby has completed the present invention.
Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat gout.
Another object of the present invention just has been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Cortex Phellodendri, Rhizoma Atractylodis, Radix Gentianae, Radix Stephaniae Tetrandrae, Arisaema Cum Bile, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Radix Clematidis, Radix Achyranthis Bidentatae, Caulis Akebiae, Massa Medicata Fermentata, Radix Glycyrrhizae medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can the fast treating gout.Wherein select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enter spleen, stomach warp, and spleen invigorating is arranged, dampness, and resolving depression, ward off dirty function, control the wet tired spleen of containing, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, have loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, the eliminating pathogen in the liver excess-fire is arranged, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the carbuncle skin infection, scrotum swells and ache, the pudendum pruritus due to damp pathogen.Select Radix Stephaniae Tetrandrae to be because its nature and flavor are bitter, cold, enter wing thorax, spleen, kidney channel, capable water is arranged, rush down the function of damp-heat in lower-JIAO, the swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, the tinea scabies is swollen.Select Arisaema Cum Bile to be because its nature and flavor are bitter, cool in nature, enter the heart, liver, lung three warps, clearing away fire and eliminating phlegm is arranged, the relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature, enter liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Flos Carthami to be because its nature and flavor are hot, temperature, enter the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Rhizoma Et Radix Notopterygii to be because its nature and flavor are arduous, temperature, enter bladder, kidney channel, and loose exterior cold is arranged, wind-damp dispelling, and the function in sharp joint, the wind and cold that cures cold, have a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.Select the Radix Angelicae Dahuricae to be because its nature and flavor are hot, temperature, enter lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Selecting Ramulus Cinnamomi is that temperature, enter bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Radix Clematidis to be because its nature and flavor suffering is salty, temperature, poisonous, enter urinary bladder channel, wind-damp dispelling is arranged, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, control gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, give birth to and use dissipating blood stasis blood, subduing inflammation, control gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripely use invigorating the liver and kidney, and bone and muscle strengthening, control waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Select Caulis Akebiae to be because its nature and flavor are bitter, cool, enter the heart, small intestinal, urinary bladder channel, pathogenic fire purging row water is arranged, the function of promoting blood circulation, control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm enters upright stone tablet, stomach warp, invigorating the spleen and regulating the stomach is arranged, the function in the accent that helps digestion, control retention of food and drink, feeling of stuffiness in chest abdominal distention, and vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription are arranged and middle emergency; Process use, control the taste lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Give birth to use, control laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separate poison of drug and alimentary toxicosis.
The specific embodiment
The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Cortex Phellodendri 25-35 gram Rhizoma Atractylodis 25-35 cron gallbladder 15-25 grams
Radix Stephaniae Tetrandrae 15-25 gram Arisaema Cum Bile 25-35 gram Rhizoma Chuanxiong 10-20 grams
Semen Persicae 10-20 gram Flos Carthami 8-15 gram Rhizoma Et Radix Notopterygii 20-30 grams
The Radix Angelicae Dahuricae 20-30 gram Ramulus Cinnamomi 10-20 gram Radix Clematidis 10-20 grams
Radix Achyranthis Bidentatae 15-25 gram Caulis Akebiae 20-30 gram Massa Medicata Fermentata 20-30 grams
Radix Glycyrrhizae 10-20 grams
Preferable amount is
Cortex Phellodendri 30 gram Rhizoma Atractylodis 30 cron gallbladder 20 grams
Radix Stephaniae Tetrandrae 20 gram Arisaema Cum Bile 30 gram Rhizoma Chuanxiong 15 grams
Semen Persicae 15 gram Flos Carthami 10 gram Rhizoma Et Radix Notopterygii 25 grams
The Radix Angelicae Dahuricae 25 gram Ramulus Cinnamomi 15 gram Radix Clematidis 15 grams
Radix Achyranthis Bidentatae 20 gram Caulis Akebiae 25 gram Massa Medicata Fermentata 25 grams
Radix Glycyrrhizae 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
2, Rhizoma Atractylodis: choose decontamination,, with blister to seven, most probably saturating, pull out, run through rear section, dry;
3, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
4, Radix Stephaniae Tetrandrae: former medicine washes, and pulls out and runs through, and section, dry;
5, Arisaema Cum Bile: get crude drug, choose decontamination;
6, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, cuts into slices after moistening, and drying;
7, Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the little wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
8, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
9, Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;
10, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
11, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
12, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dry;
13, Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting, dry;
14, Caulis Akebiae: water slightly soaks, and moistening, to thoroughly, is cut into slices, and dries;
15, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in the heat pot, the cigarette of having waited, pour Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
16, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, dry.
Two, preparation
1, the Cortex Phellodendri of described weight, Rhizoma Atractylodis, Radix Gentianae, Radix Stephaniae Tetrandrae, Arisaema Cum Bile, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Radix Clematidis, Radix Achyranthis Bidentatae, Caulis Akebiae, Massa Medicata Fermentata, Radix Glycyrrhizae medicine are decocted with water, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, used again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues after filtering for the first time add 4 times of amounts of water, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time.
3, twice decoction liquor merged, then boil with high heat, slow fire boiled 10 minutes, obtained medicinal liquid, medicinal liquid is divided into 6 doses takes.
Medicine of the present invention has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, and promoting blood circulation to restore menstrual flow, the blood stasis removing pain relieving, invigorating the liver and kidney, the effect of bone and muscle strengthening, treatment gout instant effect, short treating period, do not recur.
Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 20 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, and every day, secondary, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 140 examples for medical treatment, male patient's 105 examples wherein, female patient 35 examples.
2, diagnostic criteria
Gout is more common in middle-aged male, and the women only accounts for 5%, is mainly postmenopausal women, and gout has rejuvenation trend.
Acute attack stage:, without obvious sign, or tired, general malaise and joint sting etc. are only arranged before most of patients outbreak.Typical case outbreak is often waken up with a start because of arthralgia the late into the night, and the aggravation of carrying out property of pain, reach peak about 12 hours, be tear sample, sample or sting and bite sample, endurable lancinates.Joint and the surrounding tissue of getting involved be red, swollen, hot, pain and function limitation.More than spontaneous remission in a couple of days or 2 weeks.First-episode is invaded simple joint more, occurs in the first metatarsophalangeal joints more than 50%, and in the course of disease afterwards, 90% patient involves this position.Secondly be the joints such as instep, heel, ankle, knee joint, wrist and elbow, getting involved less in the joints such as shoulder, hip, spinal column and temporo jaw, can involve simultaneously a plurality of joints, shows as polyarthritis.Some patients were can have heating, shiver with cold, headache, cardiopalmus and the General Symptoms such as feel sick, and can accompany leucocytosis, erythrocyte sedimentation rate to speed with C reactive protein and increase etc.
The stage of attack at intermittence: but spontaneous remission after the gout outbreak continues a couple of days to several weeks, general without obvious sequela shape, or leave over localised skin pigmentation, desquamation and scratchy etc., enter the asymptomatic intermission later, last the several months, recur after several years or more than ten years, most of patients recurred in 1 year, all the more more frequently, the joint of getting involved is more and more, and duration of symptoms is more and more longer.Get involved joint generally from lower limb to upper limb, from the little joint of far-end, to large joint, develop, occur referring to, the joint involvement such as wrist and elbow, small number of patients can have influence on shoulder, hip, sacrum ilium, breast lock or joint of vertebral column, also can involve the positions such as periarticular synovial bursa, tendon and stndon sheath, and symptom is tending towards not being true to type.The small number of patients Non-intermittent phase, be the chronic arthritis performance after first attack.
3, Therapeutic Method
Select above-mentioned medicament, to the patient, take, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 20 days is a course for the treatment of, takes continuously 3 courses for the treatment of.
4, efficacy assessment standard
Produce effects: gout is eliminated, and physical recovery is normal, observes after half a year without recurrence;
Take a turn for the better: the gout symptom is clearly better, and body constitution obviously recovers;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy patient with gout 140 examples of the present invention, produce effects 135 examples as a result, obvious effective rate is 96.43%, 32 examples that take a turn for the better, improvement rate is 2.14%, invalid 2 examples, total effective rate is 98.57%.
Claims (3)
1. medicine for the treatment of gout, it is characterized in that: it is to be made by the crude drug in following weight range:
Cortex Phellodendri 25-35 gram Rhizoma Atractylodis 25-35 cron gallbladder 15-25 grams
Radix Stephaniae Tetrandrae 15-25 gram Arisaema Cum Bile 25-35 gram Rhizoma Chuanxiong 10-20 grams
Semen Persicae 10-20 gram Flos Carthami 8-15 gram Rhizoma Et Radix Notopterygii 20-30 grams
The Radix Angelicae Dahuricae 20-30 gram Ramulus Cinnamomi 10-20 gram Radix Clematidis 10-20 grams
Radix Achyranthis Bidentatae 15-25 gram Caulis Akebiae 20-30 gram Massa Medicata Fermentata 20-30 grams
Radix Glycyrrhizae 10-20 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Cortex Phellodendri 30 gram Rhizoma Atractylodis 30 cron gallbladder 20 grams
Radix Stephaniae Tetrandrae 20 gram Arisaema Cum Bile 30 gram Rhizoma Chuanxiong 15 grams
Semen Persicae 15 gram Flos Carthami 10 gram Rhizoma Et Radix Notopterygii 25 grams
The Radix Angelicae Dahuricae 25 gram Ramulus Cinnamomi 15 gram Radix Clematidis 15 grams
Radix Achyranthis Bidentatae 20 gram Caulis Akebiae 25 gram Massa Medicata Fermentata 25 grams
Radix Glycyrrhizae 15 grams.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) get the raw materials ready
(1) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
(2) Rhizoma Atractylodis: choose decontamination,, with blister to seven, most probably saturating, pull out, run through rear section, dry;
(3) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(4) Radix Stephaniae Tetrandrae: former medicine washes, and pulls out and runs through, and section, dry;
(5) Arisaema Cum Bile: get crude drug, choose decontamination;
(6) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, cuts into slices after moistening, and drying;
(7) Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the little wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
(8) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(9) Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;
(10) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
(11) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
(12) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dry;
(13) Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting, dry;
(14) Caulis Akebiae: water slightly soaks, and moistening, to thoroughly, is cut into slices, and dries;
(15) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in the heat pot, the cigarette of having waited, pour Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
(16) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, dry;
(2) preparation
(1) Cortex Phellodendri of described weight, Rhizoma Atractylodis, Radix Gentianae, Radix Stephaniae Tetrandrae, Arisaema Cum Bile, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Radix Clematidis, Radix Achyranthis Bidentatae, Caulis Akebiae, Massa Medicata Fermentata, Radix Glycyrrhizae medicine are decocted with water, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, used again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;
(2) medicinal residues after filtering for the first time add 4 times of amounts of water, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time;
(3) twice decoction liquor merged, then boil with high heat, slow fire boiled 10 minutes, obtained medicinal liquid, medicinal liquid is divided into 6 doses takes.
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| CN106729214A (en) * | 2017-01-19 | 2017-05-31 | 重庆同康骨科医院有限公司 | Medicine and preparation method thereof for treating gout |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940677A (en) * | 2010-08-25 | 2011-01-12 | 肖富洲 | Traditional Chinese medicinal powder for treating uarthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101940677A (en) * | 2010-08-25 | 2011-01-12 | 肖富洲 | Traditional Chinese medicinal powder for treating uarthritis |
Non-Patent Citations (1)
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| 黄建华，等: "秦蜂汤合消炎止痛膏治疗急性痛风性关节炎的临床研究", 《中医正骨》, vol. 19, no. 5, 2007053 * |
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| CN106729214A (en) * | 2017-01-19 | 2017-05-31 | 重庆同康骨科医院有限公司 | Medicine and preparation method thereof for treating gout |
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Application publication date: 20131120 |