CN103393837A - External medicine for curing radial nerve palsies - Google Patents
External medicine for curing radial nerve palsies Download PDFInfo
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- CN103393837A CN103393837A CN2013103613953A CN201310361395A CN103393837A CN 103393837 A CN103393837 A CN 103393837A CN 2013103613953 A CN2013103613953 A CN 2013103613953A CN 201310361395 A CN201310361395 A CN 201310361395A CN 103393837 A CN103393837 A CN 103393837A
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Abstract
The invention discloses an external medicine for curing radial nerve palsies, and aims to solve the problem of curing radial nerve palsies. The medicine is characterized by being composed of following raw materials: solanum lyratum, immature fruit of cassiabarktree, ipomoea pes-caprae, herbofpaniculatespotflower, securinega suffruticosa, mulberry, dipsacus root, dried orange peel, leaf of ringworm senna, viburnum foetidrm wall, amblystegium serpens and climbing fig. The characteristics of good curative effect on radial nerve palsies and high safety have been testified by clinical tests, and the external medicine is worthy for being promoted and applied to the clinic.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of medicine for external use for musculospiral paralyses.
Background technology
Radial nerve is comprised of C5 ~ 8, causes after it is impaired to stretch elbow, stretch wrist, stretch and refer to obstacle and the back of the hand thumb and first and second intermetacarpal spaces district sensory disturbance, i.e. musculospiral paralyses.
The many employings of present Drug therapy give vitamin B group and carry out neurotrophy, apply in case of necessity analgesics.But this kind therapeutic scheme is for the impaired more serious musculospiral paralyses of radial nerve, and effect is bad.In recent years, there is clinical report to use exogenous neurotrophic factor, adenylic acid Cycloxygenase activator and cyclic adenosine monophosphate, Protein kinase C, inflammatory factor etc. to treat from the angle of neuranagenesis.(the nerve growth factor of the nerve growth factor in exogenous neurotrophic factor wherein, NGF) curative effect is the most reliable, but also there is side effect in application NGF: sprouting of int normal neural axon can cause the untoward reaction such as chronic pain and abnormal neural reflex to occur.Explore the cheap medicine that a class can promote neural Fast Growth, can guarantee again the nerve fiber function therefore still need at present.
The Chinese medicine of musculospiral paralyses is circulation of qi promoting promoting blood circulation to remove obstruction in the collateral on the bases that are heat-clearing and toxic substances removing more, but actual clinical effect and not obvious.Acupuncture effect obviously is better than Chinese medicine, but the patient is difficult to adhere to.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine for external use that is used for musculospiral paralyses that a kind of curative effect is sure and side effect is little is provided.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for external use for musculospiral paralyses is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Solani Lyratis, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Herba Ipomoeae Pes-Capraes, 6 ~ 12 parts of Herba Spilanthis Acmellae, 3 ~ 10 parts of Cacumen Securinegae Suffruticosaes, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Radix Dipsaci, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Folium Cassiae Alataes, 1 ~ 5 part, Fructus Viburni Foetidi leaf, 3 ~ 10 parts of Folium Salicis Babylonicae moss, 10 ~ 25 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Herba Solani Lyratis, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Radix Dipsaci, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Folium Cassiae Alataes, 2 parts, Fructus Viburni Foetidi leaf, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Wherein said: Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.But merit clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Fructus cinnamomi immaturus, be the young tender fruit of canella Cortex Cinnamomi.Gas fragrance, distinguish the flavor of little sweet.Nature and flavor Wen Xingan, return the stomach warp.But merit warming spleen and stomach for dispelling cold.
Herba Ipomoeae Pes-Capraes, be the herb of Convolvulaceae morning glory two leaf Radix Ipomoeae Ipomoea pescarpae (L.) Sweet.Nature and flavor are hot, little hardship, and are wet.But the merit expelling wind and removing dampness, the detumescence of drawing out pus by applying a plaster to the affected part.
Herba Spilanthis Acmellae, be the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.But merit relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.
Cacumen Securinegae Suffruticosae, be euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse or the root of Rehd..Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.But merit expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Fructus Mori, be the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, and are cold.GUIXIN, liver, kidney channel.The merit YIN nourishing of can enriching blood, promote the production of body fluid and moisturize.
Radix Dipsaci, be the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.Bitter in the mouth is hot; Slightly warm in nature.Return liver, kidney channel.But merit invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous folding wound; Only metrorrhagia.
Pericarpium Citri Reticulatae, be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Folium Cassiae Alatae,, for pulse family Folium Cassiae Alatae Cassia alata L., be used as medicine with leaf.Nature and flavor are hot, temperature.But the merit parasite killing is antipruritic.
The Fructus Viburni Foetidi leaf, be the leaf of Radix Ophiopogonis place's plant Caulis Viburni Dilatati Viburnum foetidrm Wall..Puckery; Property is put down.Merit can be detoxified; Symplectic bone.
The Folium Salicis Babylonicae moss, be Amblystegiaceae Folium Salicis Babylonicae moss Amblystegium serpens(Hedw.) plant of B.S.G..Nature and flavor are puckery; Flat.But merit astringing to arrest bleeding.
Caulis fici pumilae (Fructus Fici Pumilae), be stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) Ficus pumila L..Sour in the mouth, cool in nature.But merit expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.
Composition principle: musculospiral paralyses shows as sensory disturbance, the dyskinesia in various degree, the present Chinese medicine of musculospiral paralyses circulation of qi promoting promoting blood circulation to remove obstruction in the collateral on the bases that are heat-clearing and toxic substances removing, but actual clinical effect and not obvious more.Inventor's clinical research is for many years found, musculospiral paralyses is except stagnation of QI blood stasis, its limbs channels is obstructed, stay poly-loose relevantly to body fluid, surely belong to the traditional Chinese medical science and be referred to as " phlegm stagnating in meridian ", accumulation of phlegm blocks, in network, QI and blood is not all right, also can cause blood stasis, and " accumulation of blood is both of a specified duration, also can turn to expectorant water " (" treatise on blood trouble " volume five).So, because expectorant causes the stasis of blood, the long-pending stasis of blood is reduced phlegm, and phlegm and blood stasis, glue work are for suffering from, and be then obstructed till passages through which vital energy circulates, and four ends do not reach and produce the malnutrition in nerve distribution area territory.Therefore, the musculospiral paralyses main pathological basis is to be the accumulation of phlegm folder stasis of blood.Expectorant, the stasis of blood are pathological product, are again paathogenic factors; Being both the mark of disease, is also basis of disease, wherein especially take accumulation of phlegm as main pathological factor.Therefore its treatment, should invigorate blood circulation, eliminate the phlegm, eliminating stagnation, collateral dredging go forward side by side, and can promote musculospiral paralyses symptom local recovery.
Compared with prior art, the present invention has following characteristics.
1, Herba Solani Lyrati and Fructus cinnamomi immaturus coordinate for monarch drug, wherein: but Herba Solani Lyrati merit clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, inventor's cell culture experiments proves: Herba Solani Lyrati decocting liquid is used for radial nerve repair and has unique logical stagnant effect, its mechanism of action may be that Herba Solani Lyrati can promote local growth associated protein (Growth associated protein-43, synthesizing GAP-43), and specific proteins GAP-43 is in the growth of nerve fiber, grow, axon regeneration and synaptic function the important role such as keep, and the adjusting of participation neurotransmitter release, can determine and induce nervous process to grow along correct direction in neural growth again or regeneration, and there is no a side effect of sprouting of the sort of int normal neural axon of NGF, and Fructus cinnamomi immaturus is warm in nature, and dispersing strength is strong, can strengthen the logical stagnant effect of Herba Solani Lyrati, and the balance cold and heat reach the effect of eliminating the retardance of meridians accumulation of phlegm.We avoid using eliminating phlegm eliminating stagnation medicine, and its reason is that the meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, the nerve conduction irritability, easily cause the untoward reaction such as chronic pain and abnormal neural reflex.
2, Herba Ipomoeae Pes-Capraes expelling wind, removing dampness and detumescence, Herba Spilanthis Acmellae expelling wind and removing dampness, reducing swelling and alleviating pain, auxiliary Herba Solani Lyrati and Fructus cinnamomi immaturus are dispelled the phlegm-damp in meridians, remove long-pending this pathologic basis of wet retention of phlegm.
3, the Fructus Mori yin nourishing of enriching blood, the Radix Dipsaci nourishing the liver and kidney, Pericarpium Citri Reticulatae invigorating the spleen and benefiting QI diuretic, train benefit from the phlegm-damp upstream and downstream respectively, helps Herba Solani Lyrati processed, Fructus cinnamomi immaturus, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, and anti-its got rid of evils too and just hinders.
4, Caulis fici pumilae (Fructus Fici Pumilae) promoting blood circulation to remove obstruction in the collateral, Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, the strong muscle of kidney tonifying, two flavor blood system medicines, return liver, kidney channel, reinforcement and elimination in combination, and the motionless blood of invigorating blood circulation, and the strong muscle effect of collateral dredging is arranged.
5, inventor's experimentation shows: low dose of Fructus Viburni Foetidi leaf can increase the neurocyte liveness effectively.
6, Folium Cassiae Alatae can reduce we's local skin stimulation, is beneficial to the Drug Percutaneous Absorption rate.
7, add low dose of Folium Salicis Babylonicae moss in the loose collateral dredging medicine of one row, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Radix Dipsaci, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Folium Cassiae Alataes, 2 parts, Fructus Viburni Foetidi leaf, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
The preparation method of embodiment 1 is: Herba Solani Lyrati, Fructus cinnamomi immaturus, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Cacumen Securinegae Suffruticosae, Fructus Mori, Radix Dipsaci, Pericarpium Citri Reticulatae, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, Caulis fici pumilae (Fructus Fici Pumilae) mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and transfers and applies after concentrate drying is pulverized.
Embodiment 2, the crude drug weight proportion: 10 parts of Herba Solani Lyratis, 6 parts of Fructus cinnamomi immaturus, 3 parts of Herba Ipomoeae Pes-Capraes, 6 parts of Herba Spilanthis Acmellae, 3 parts of Cacumen Securinegae Suffruticosaes, 6 parts of Fructus Mori, 6 parts of Radix Dipsaci, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Folium Cassiae Alataes, 1 part, Fructus Viburni Foetidi leaf, 3 parts of Folium Salicis Babylonicae moss, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Embodiment 3, the crude drug weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Radix Dipsaci, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Folium Cassiae Alataes, 2 parts, Fructus Viburni Foetidi leaf, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Embodiment 4, the crude drug weight proportion: 30 parts of Herba Solani Lyratis, 12 parts of Fructus cinnamomi immaturus, 10 parts of Herba Ipomoeae Pes-Capraes, 12 parts of Herba Spilanthis Acmellae, 10 parts of Cacumen Securinegae Suffruticosaes, 12 parts of Fructus Mori, 12 parts of Radix Dipsaci, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Folium Cassiae Alataes, 5 parts, Fructus Viburni Foetidi leaf, 10 parts of Folium Salicis Babylonicae moss, 25 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Cacumen Securinegae Suffruticosae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss are pulverized 150 mesh sieves, and became fine powder standby;
(3) Herba Solani Lyrati, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Fructus Mori, Folium Cassiae Alatae, Pericarpium Citri Reticulatae, Caulis fici pumilae (Fructus Fici Pumilae) are decocted with water 2 times, filter, merging filtrate, be concentrated into relative density 1.1, obtains water extraction liquid;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the water extraction liquid of step 3 gained, stir, be concentrated into relative density 1.36.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Effective combination of said medicine, coordinate mutually, invigorates blood circulation, eliminates the phlegm, collateral dredging, effectively reach the purpose that promotes neural reparation after musculospiral paralyses, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: musculospiral paralyses patient 32 examples that accept for medical treatment year June in March, 2011 ~ 2013, male's 20 examples wherein, women's 12 examples, 16 ~ 41 years old age, average 22.4 years old.
1.1.2 grouping: be divided at random matched group 11 examples, transfer and apply group 11 examples, unguentum group 10 examples.Compare on sex, age, the state of an illness before three groups of patient treatments, and the difference not statistically significant (P〉0.05), have comparability.
1.2 method.
1.2.1 administering mode: the oral mecobalamin of matched group, accent apply group and adopt the local accent of embodiment 1 gained medicament to apply, and the unguentum group adopts the local external applications of embodiment 3 gained unguentum, transfers deposited group and unguentum group all to change dressings once in every three days, and be 4 weeks total course for the treatment of.
1.2.2 criterion of therapeutical effect: cure: the Ipsilateral wristdrop disappears, and freely, thumb and other metacarpophalangeal joints stretch freely wrist joints moving; Take a turn for the better: wristdrop alleviates, slightly dorsiflex of carpal joint, and thumb and other metacarpophalangeal joints can slightly stretch; Invalid: wristdrop and other metacarpophalangeal joints are without improvement.
1.2.3 epicritic sensibility observation index: 2 patient's number and percents of differentiating feel＜10 mm measuring respectively skin in radial nerve domination zone, treatment front and back.
2 results.
2.1 clinical efficacy: three groups of clinical efficacies see the following form:
| Group | Number of cases | Cure (example) | Take a turn for the better (example) | Invalid (example) | Total effective rate (%) |
| Matched group | 11 | 5 | 4 | 2 | 81.82% |
| Transfer and apply group | 11 | 8 | 2 | 1 | 90.91% |
| The unguentum group | 10 | 8 | 2 | 0 | 100% |
Result shows: application the present invention transfers and applies total effective rate 90.91%, unguentum external application total effective rate 100%, and cure rate is apparently higher than mecobalamin matched group (P＜0.05).
2.2 before and after treatment, three groups 2 differentiate are felt〉patient of 10mm compares, and the results are shown in following table:
| Group | Number of cases | Before treatment | ? | After treatment | ? |
| Matched group | 11 | 2 | 18.18% | 5 | 45.45% |
| Transfer and apply group | 11 | 2 | 18.18% | 9 | 81.82% |
| The unguentum group | 10 | 2 | 20% | 9 | 90% |
Result shows: application the present invention transfers the recovery of patient aspect 2 resolution feels of deposited or unguentum external application apparently higher than mecobalamin matched group (P＜0.05).
2.3 three groups of adverse reactions of patients incidence rates relatively: three groups any obvious adverse reaction record all do not occur, transfer deposited group and unguentum group local skin obvious red and swollen pruritus not occur, the equal omnidistance completed treatment of all cases.
3. conclusion.
This result of study shows, the present invention transfers and applies or the unguentum external application can accelerate to repair the nervous tissue of damage, improves radial nerve transmission and dysbolismus.And follow up a case by regular visits to and do not find in the medication process to occur any untoward reaction, illustrate that this medicine for external use clinical practice is safe.
Claims (2)
1. a medicine for external use that is used for musculospiral paralyses, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Solani Lyratis, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Herba Ipomoeae Pes-Capraes, 6 ~ 12 parts of Herba Spilanthis Acmellae, 3 ~ 10 parts of Cacumen Securinegae Suffruticosaes, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Radix Dipsaci, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Folium Cassiae Alataes, 1 ~ 5 part, Fructus Viburni Foetidi leaf, 3 ~ 10 parts of Folium Salicis Babylonicae moss, 10 ~ 25 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
2. a kind of medicine for external use for musculospiral paralyses according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Radix Dipsaci, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Folium Cassiae Alataes, 2 parts, Fructus Viburni Foetidi leaf, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
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| CN201310361395.3A CN103393837B (en) | 2013-08-19 | 2013-08-19 | External medicine for curing radial nerve palsies |
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| CN201510113620.0A Division CN104688922A (en) | 2013-08-19 | 2013-08-19 | External mixing and applying agent for treating radial nerve palsies |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998814A (en) * | 2016-06-29 | 2016-10-12 | 田强元 | Traditional Chinese medicine composition for treating paralysis of radial nerve and preparation method thereof |
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| CN105998814A (en) * | 2016-06-29 | 2016-10-12 | 田强元 | Traditional Chinese medicine composition for treating paralysis of radial nerve and preparation method thereof |
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Inventor after: Zhou Jiandi Inventor after: Tang Junmei Inventor after: Lang Xiaoling Inventor before: Zhou Jiandi Inventor before: Teng Shaoling Inventor before: Tang Junling |
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