CN103385971A - 一种治疗痤疮的中药组合物 - Google Patents
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Abstract
一种治疗痤疮的中药组合物，该中药组合物是由金银花、桃仁、蛇床子、黄柏、牛膝、山茱萸、玄参、苍术、茯苓、川军、水牛角、天花粉、甘草制成。临床可用于治疗痤疮。
Description
一种治疗痤疮的中药组合物
技术领域
[0001] 本发明属于中药技术领域，尤其是涉及一种治疗痤疮的中药组合物。
背景技术
[0002] 痤疮是俗称“粉刺”、“青春痘”，是一种毛囊皮脂腺的慢性炎症性疾病，多发于青年人的颜面部及胸背部，由于发病率高，严重的形成结节、囊肿，色素沉着及瘢痕。现代医学认为其发病与内分泌、毛囊皮脂腺导管角化异常、微生物感染、免疫、遗传等因素有关，化妆品使用不当、精神因素、嗜烟酒及辛辣甜腻食物也可成为加重和促发因素。经过发明人的长期实践得出，中药治痤疮具有较好作用，取得不错效果。
发明内容
[0003] 本发明的目的在于提供一种治疗效果好、有效率高、对人体无毒副作用的治疗痤疮的中药组合物。
[0004] 本发明的目的是这样实现的，根据中医药理论，利用中药独特的药性，采用金银花、桃仁、蛇床子、黄柏、牛膝、山茱萸、玄参、苍术、茯苓、川军、水牛角、天花粉、甘草按照一定的配伍要求，经过加工制成。
[0005] 制备本发明中药组合物由下述原料药制成:金银花30-50份、桃仁30-50份、蛇床子30-50份、黄柏20-40份、牛膝20-40份、山茱萸20-40份、玄参20-40份、苍术10-30份、茯苓10-30份、川军10-30份、水牛角10-30份、天花粉10-30份、甘草10-30份。
[0006] 本发明中药组合物原料药的最佳重量份为:金银花40份、桃仁40份、蛇床子40份、黄柏30份、牛膝30份、山茱萸30份、玄参30份、苍术20份、茯苓20份、川军20份、水牛角20份、天花粉20份、甘草20份。
[0007] 本发明中药的药理作用如下:
[0008] 金银花:甘、寒，归肺、心、胃经。清热解毒，疏散风热。用于痈肿疔疮、热毒血痢。
[0009] 桃仁:苦、甘、平。归心、肝、大肠经。活血化瘀，润肠通便。用于多种瘀血证，肠燥便秘，肺痈，肠痈。
[0010] 蛇床子:辛、苦、温，归肾经。杀虫止痒，温肾壮阳。外用于湿疹、疥癣，除痹气，利关节,癫痫恶疮。
[0011] 黄柏:苦、寒。归肾、膀胱经。清热燥湿，泻火解毒。主治湿热痢疾、泄泻、黄疸；梦遗、淋浊、带下；骨蒸劳热；以及口舌生疮；目赤肿痛；痈疽疮毒；皮肤湿疹。
[0012] 牛膝:苦、甘、酸、平。归肝、肾经。活血通经，补肝肾，强筋骨，利水通淋，引火下行。用于瘀血阻滞的经闭、痤疮、月经不调，肾虚腰痛及久痹腰膝酸痛乏力，头痛，眩晕等火热上炎之证。
[0013] 山茱萸:酸、微温，归肝、肾经。补益肝肾、收敛固脱。主治头晕目眩，耳聋耳鸣等证。
[0014] 玄参:苦、甘、咸、寒，归肺、胃、肾经。清热凉血，滋阴解毒。用于温邪入营、内陷心包，温毒发斑，咽喉肿痛，瘰疬痰核等证。
[0015] 苍术:辛、苦、温，归脾、胃经。燥湿健脾，祛风湿。用于湿滞中焦证，风湿痹证，外感风寒挟湿之表证。
[0016] 茯苓:甘、淡、平。归心、脾、肺、肾经。渗湿利水，健脾和胃，宁心安神。用于小便不利，水肿胀满，痰饮咳逆，呕吐，脾虚食少，泄泻，心悸不安，失眠健忘，遗精白浊等。
[0017] 川军:苦、寒。归胃、大肠、肝、脾经。具有攻积滞，清湿热，泻火，凉血，祛瘀，解毒的功效。用于实热便秘，热结胸痞，湿热泻痢，黄疸，淋病，水肿腹满，小便不利，目赤等。
[0018] 水牛角:苦、咸、寒。归心、肝经。清热、解毒、凉血、定惊。用于热病头痛，商热神昏，发斑发疹，瘀热发黄，小儿^(风及咽喉肿痛，口舌生疮。
[0019] 天花粉:甘、微苦、微寒，归肺、胃经。清热生津、清肺润燥、解毒消痈。主治热病口渴，消渴多饮，痈肿疮疡。
[0020] 甘草:甘、平，归心、肺、脾、胃经。益气补中，清热解毒，祛痰止咳，缓急止痛，调和药性。用于心气不足的心动悸、脉结代，热毒疮疡，咽喉肿痛。
[0021] 本发明中药组合物于2008年至2012年临床观察痤疮100例患者，临床报告如下:
[0022] 1、一般资料
[0023] 120例患者中，年龄16-28岁，病程多在2个月到3年，平均年龄22岁。
[0024] 2、诊断标准:依据国家中医药管理局颁发的《中医病证诊断疗效标准》:
[0025] ①初期在毛囊口呈现 米粒大小的红色丘疹，亦可演变为脓疱，此后可形成硬结样的白头粉刺或黑头粉刺，严重病例可形成硬结性囊肿；②多发于男女青年青春期，分布于面部及胸背部，常伴有皮脂溢出多有饮食不节、过食肥甘厚腻或外邪等诱发；④妇女多伴有月经不调。
[0026] 2.2排除标准:
[0027] ①已知对维胺酯过敏者入试前2周曾外用皮质类固醇激素、抗生素等抗痤疮药物者入试前4周曾口服皮质类固醇激素、性激素、抗生素药物者；④妊娠或哺乳期妇女；⑤化学物质所致的职业性痤疮，药物引起的痤疮。
[0028] 3、治疗方法
[0029] 3.1处方:金银花40g、桃仁40g、蛇床子40g、黄柏30g、牛膝30g、山茱萸30g、玄参30g、苍术20g、茯苓20g、川军20g、水牛角20g、天花粉20g、甘草20g。
[0030] 3.2制备及使用方法:上述药物按常规工艺制成汤剂，口服每日I剂，每日2次，10天为I疗程。
[0031] 4、治疗结果:
[0032] 4.1参照《中医药新药临床研究指导原则》制定:
[0033] 痊愈:皮损消退率> 95%，或仅遗留少许色素沉着，症状消失；
[0034] 显效:皮损大部分消退，消退率70%〜95%，症状明显减轻；
[0035] 有效:皮损部分消退，消退率50%〜70%，症状改善；
[0036] 无效:皮损消退不明显或者加重，消退率< 50%，症状未见变化。
[0037] 4.2结果:100例患者中，临床治愈72例(72 % )，显效13例(13 % )，好转8例(8% ),无效7例(7% ),总有效率为93%。
[0038] 5、典型病例[0039] 5.1、陈某，女，16岁，面部油腻，毛孔粗大，面部除鼻及眼外，均可见黑头粉刺及米粒至豌豆大小结节隆起，肿胀紫黑。同时患有便秘，口鼻干燥、口臭等症状。服用本发明药物，每日I剂，3个疗程后，症状明显好转，继续服用2个疗程，痊愈，一年后随访无复发。
[0040] 5.2、王某，男，21岁，患有痤疮3年，面颊部痤疮融合成片，色红，尖部有脓包，面部皮肤出油较多，伴有便秘等症状。服用本发明药物，治疗3个疗程，症状明显减轻，继续服用2个疗程，痊愈，半年后随访无复发。
具体实施方式
[0041] 下面结合实施例对本发明作进一步的说明，下述该实施例仅用于说明本发明而对本发明没有限制。
[0042] 实施例1，一种治疗痤疮的中药组合物，是由金银花30g、桃仁30g、蛇床子30g、黄柏20g、牛膝20g、山茱萸20g、玄参20g、苍术10g、茯苓10g、川军10g、水牛角10g、天花粉10g、甘草IOg制成。
[0043] 实施例2，一种治疗痤疮的中药组合物，是由金银花40g、桃仁40g、蛇床子40g、黄柏30g、牛膝30g、山茱萸30g、玄参30g、苍术20g、茯苓20g、川军20g、水牛角20g、天花粉20g、甘草20g制成。
[0044] 实施例3，一种治疗痤疮的中药组合物，是由金银花50g、桃仁50g、蛇床子50g、黄柏40g、牛膝40g、山茱萸40g、玄参40g、苍术30g、茯苓30g、川军30g、水牛角30g、天花粉30g、甘草30g制成。
Claims (2)
1.一种治疗痤疮的中药组合物，其特征在于它是由下述原料药制成: 金银花30-50份、桃仁30-50份、蛇床子30-50份、黄柏20-40份、牛膝20-40份、山茱萸20-40份、玄参20-40份、苍术10-30份、茯苓10-30份、川军10-30份、水牛角10-30份、天花粉10-30份、甘草10-30份。
2.根据权利要求1所述的中药组合物，其特征在于它是由下述原料药制成: 金银花40份、桃仁40份、蛇床子40份、黄柏30份、牛膝30份、山茱萸30份、玄参30份、苍术20份、茯苓20份·、川军20份、水牛角20份、天花粉20份、甘草20份。
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| CN104547786B (zh) * | 2014-12-26 | 2017-10-31 | 浙江大学 | 治疗高雄激素性痤疮的外用中药组合物及应用 |
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