CN103381271A - 治疗生物膜形成的三唑化合物 - Google Patents

治疗生物膜形成的三唑化合物 Download PDF

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Publication number
CN103381271A
CN103381271A CN2013103034363A CN201310303436A CN103381271A CN 103381271 A CN103381271 A CN 103381271A CN 2013103034363 A CN2013103034363 A CN 2013103034363A CN 201310303436 A CN201310303436 A CN 201310303436A CN 103381271 A CN103381271 A CN 103381271A
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China
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compound
combination product
purposes
low
alkyl group
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CN2013103034363A
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English (en)
Chinese (zh)
Inventor
D·里德
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38534753&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103381271(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN103381271A publication Critical patent/CN103381271A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2013103034363A 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物 Pending CN103381271A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP071086508 2007-05-22
EP07108650A EP1994930A1 (en) 2007-05-22 2007-05-22 Triazol compounds for treating biofilm formation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880015539A Division CN101678004A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Publications (1)

Publication Number Publication Date
CN103381271A true CN103381271A (zh) 2013-11-06

Family

ID=38534753

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2013103034363A Pending CN103381271A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物
CN200880015539A Pending CN101678004A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880015539A Pending CN101678004A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Country Status (18)

Country Link
US (2) US8309590B2 (enExample)
EP (3) EP1994930A1 (enExample)
JP (1) JP5470245B2 (enExample)
KR (1) KR101519675B1 (enExample)
CN (2) CN103381271A (enExample)
AU (1) AU2008252964B2 (enExample)
BR (1) BRPI0811103A2 (enExample)
CA (1) CA2685112A1 (enExample)
CL (1) CL2008001469A1 (enExample)
IL (1) IL201832A (enExample)
MA (1) MA31388B1 (enExample)
MX (1) MX2009012628A (enExample)
NZ (1) NZ580735A (enExample)
RU (1) RU2478385C2 (enExample)
TN (1) TN2009000487A1 (enExample)
TW (1) TWI419690B (enExample)
WO (1) WO2008142094A1 (enExample)
ZA (1) ZA200907415B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110448693A (zh) * 2019-07-30 2019-11-15 华东理工大学 氟喹诺酮类药物作为多粘菌素类抗生素增敏剂的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829198B2 (en) 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
GB2463181B (en) 2007-05-14 2013-03-27 Univ New York State Res Found Induction of a physiological dispersion response in bacterial cells in a biofilm
EP1994930A1 (en) * 2007-05-22 2008-11-26 Novartis AG Triazol compounds for treating biofilm formation
WO2009111611A2 (en) 2008-03-05 2009-09-11 Proteotech Inc. Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes
GB201021186D0 (en) * 2010-12-14 2011-01-26 Novabiotics Ltd Composition
TWI415572B (zh) 2011-06-17 2013-11-21 Univ Chang Gung 利用1,2,3,4,6-五-o-沒食子醯基-d-葡哌喃糖來抑制生物膜形成
US10028933B2 (en) * 2015-07-22 2018-07-24 Ohio State Innovation Foundation Compositions and methods for inhibiting the growth of multi-drug resistant microbes
RU2646488C2 (ru) * 2016-04-25 2018-03-05 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ОрГМУ Минздрава России) Средство для селективного влияния на биопленкообразование микроорганизмами
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004438A (en) * 1991-12-31 1999-12-21 3M Innovative Properties Company Biofilm reduction sterilizer
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
TW533205B (en) * 1996-06-25 2003-05-21 Novartis Ag Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition
WO1997049397A1 (en) * 1996-06-26 1997-12-31 Sankyo Company, Limited Novel medicinal compositions of hydropyridines
US6759040B1 (en) * 1997-09-12 2004-07-06 University Of Maryland, College Park Preparation and use of biofilm-degrading, multiple-specificity, hydrolytic enzyme mixtures
WO2001070213A2 (en) 2000-03-23 2001-09-27 Influx, Inc. Bactericidal antimicrobial methods and compositions for use in treating gram positive infections comprising an antibiotic potentiator having acyl hydrazide oxy amide or 8-hydroxy quinoline structure
WO2002076439A2 (en) * 2001-03-23 2002-10-03 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
GB0126618D0 (en) * 2001-11-06 2002-01-02 Novartis Ag Organic compounds
GB0205593D0 (en) * 2002-03-09 2002-04-24 Univ Nottingham Treatment of surfaces populated by bacteria
US20040043052A1 (en) * 2002-05-24 2004-03-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for coating medical implants
US7498292B2 (en) 2002-08-15 2009-03-03 The Research Foundation Of State University Of New York Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
GB0223978D0 (en) 2002-10-15 2002-11-20 Novartis Ag Organic compound
EP1994930A1 (en) * 2007-05-22 2008-11-26 Novartis AG Triazol compounds for treating biofilm formation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
E. D. WEINBERG: "Suppression of bacterial biofilm formation by iron limitation", 《MEDICAL HYPOTHESES》 *
PRADEEP K. SINGH ET AL: "A component of innate immunity prevents bacterial biofilm development", 《NATURE》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110448693A (zh) * 2019-07-30 2019-11-15 华东理工大学 氟喹诺酮类药物作为多粘菌素类抗生素增敏剂的应用

Also Published As

Publication number Publication date
TN2009000487A1 (en) 2011-03-31
RU2009147297A (ru) 2011-06-27
MX2009012628A (es) 2009-12-07
JP5470245B2 (ja) 2014-04-16
US20100152101A1 (en) 2010-06-17
EP2253317A2 (en) 2010-11-24
AU2008252964A1 (en) 2008-11-27
KR101519675B1 (ko) 2015-05-12
BRPI0811103A2 (pt) 2014-12-09
NZ580735A (en) 2012-02-24
US8309590B2 (en) 2012-11-13
KR20100017153A (ko) 2010-02-16
JP2010527960A (ja) 2010-08-19
CN101678004A (zh) 2010-03-24
ZA200907415B (en) 2010-07-28
US8592473B2 (en) 2013-11-26
MA31388B1 (fr) 2010-05-03
EP1994930A1 (en) 2008-11-26
IL201832A0 (en) 2010-06-16
RU2478385C2 (ru) 2013-04-10
AU2008252964B2 (en) 2011-12-01
CL2008001469A1 (es) 2010-10-29
IL201832A (en) 2015-11-30
WO2008142094A1 (en) 2008-11-27
TWI419690B (zh) 2013-12-21
TW200913996A (en) 2009-04-01
EP2162130A1 (en) 2010-03-17
EP2253317A3 (en) 2011-03-16
WO2008142094A4 (en) 2009-01-29
CA2685112A1 (en) 2008-11-27
US20120329746A1 (en) 2012-12-27

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Application publication date: 20131106