CN103371188B - A kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class - Google Patents
A kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class Download PDFInfo
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- CN103371188B CN103371188B CN201210108920.6A CN201210108920A CN103371188B CN 103371188 B CN103371188 B CN 103371188B CN 201210108920 A CN201210108920 A CN 201210108920A CN 103371188 B CN103371188 B CN 103371188B
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- antibiotic
- pyrimidine nucleoside
- nucleoside class
- prochloraz
- cyazofamid
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Abstract
The invention discloses a kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, the bactericidal composition containing active components A Yu active component B, active components A are selected from following any one compound selected from antibiotic in pyrimidine nucleoside class, active component B：Fluorine bacterium azoles, cyazofamid, Prochloraz and prochloraz-manganese chloride complex, ethirimol and bupirimate, and active components A and the weight ratio of active component B are 1: 70～70: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious potentiation, expands fungicidal spectrum.And there is the characteristics of dosage is little, resistance of rainwater washing against, and potentiation is obvious.
Description
Technical field
The invention belongs to technical field of pesticide, is related to a kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class and is making
Application in thing disease.
Technical background
Antibiotic in pyrimidine nucleoside class (agricultural antiobiotic 120) is called：Pesticide corrosion 120, antimycoin
120th, 120 agricultural antibiotic.Antibiotic in pyrimidine nucleoside class is a kind of broad-spectrum antibiotic, and it has strong to many phytopathogens
Inhibitory action, it is preferable to cucurbits powdery mildew, flowers powdery mildew and wheat rust preventive effect.
The content of the invention
Antibiotic in pyrimidine nucleoside class, fluorine bacterium azoles, cyazofamid, Prochloraz and prochloraz-manganese chloride complex, ethirimol and ethirimol sulfonic acid
The problems such as ester single dose life-time service may bring resistance to occur, drug effect declines, bactericidal composition proposed by the present invention is containing active
Composition A and active component B, and appropriate surfactant and carrier.
A kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, containing active components A and active component B, which is special
Levy and be：Active components A is 1: 70～70: 1 with active component B weight ratio, and described active components A is anti-selected from pyridimine nucleosides
Rhzomorph, active component B is selected from one of fluorine bacterium azoles, cyazofamid, Prochloraz and prochloraz-manganese chloride complex, ethirimol and bupirimate
Kind.Active components A is 1: 40～40: 1 with active component B preferably weight ratios；Active components A is preferably weighed with active component B
Amount is than being 1: 30～30: 1；More preferably antibiotic in pyrimidine nucleoside class and the weight ratio of fluorine bacterium azoles are 1: 10～10: 1, pyrimidine core
The weight ratio of glycoside antibiotics and cyazofamid is 1: 10～10: 1, antibiotic in pyrimidine nucleoside class and Prochloraz and prochloraz-manganese chloride complex
Weight ratio is 1: 30～10: 1, and antibiotic in pyrimidine nucleoside class is 1: 20～10 with the weight ratio of ethirimol and bupirimate:
1。
The manganese salt of Prochloraz, mantoquita, zinc salt also have good bactericidal activity simultaneously, are agriculturally being widely used；Second is phonetic
Sulfocarbolate is ethirimol salt, it may have good bactericidal activity, is widely used in agricultural.
The described Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, it is characterised in that：Compositionss make wettability
Powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
The described Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class is used for the disease for preventing and treating crop, described crop
Including fruit tree, vegetable, cereal crops, Camellia sinensis, ornamental plant.
Described disease includes powdery mildew, anthrax, banded sclerotial blight, droop, rust, melasma, epidemic disease, downy mildew, black
Star disease, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mould, penicilliosiss, crown rot, damping off.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on a kind of chemical combination
The mixed ratio and potentiation degree of thing and another kind of compound, while also relevant with target disease.Generally in compositionss
The weight percentage of active component for gross weight 1%～90%, preferably 5%～80%.According to different preparation classes
Type, active component content scope are different.Generally, liquid preparation contains by weight 1%～60% active substance, preferably
Ground is 5%～50%；Solid preparation contains by weight 5%～80% active substance, and preferably 10%～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, active component is in water when being beneficial to administration
Dispersion.Surface-active contents for total formulation weight 2%～30%, balance of solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art：Can be selected from
One or more in dispersant, wetting agent, thickening agent or defoamer.According to different dosage form, this area in preparation, can also be contained
Stabilizer, antifreeze well known to technical staff etc..
The bactericidal composition of the present invention can be being diluted using front Jing or directly used by user.Its preparation can be by ability
Prepared by processing method well known to field technique personnel, will add after active component mixed with liquid flux or solid carrier
One or more in surfactant such as dispersant, stabilizer, wetting agent, binding agent, defoamer etc..
The bactericidal composition of the present invention, can be processed into acceptable dosage form on any pesticide on demand.Wherein preferably agent
Type is wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-outstanding
Floating agent.
Compositionss include following component and content when making wettable powder：Active components A 1%～70%, active component B
1%～70%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
Compositionss include following component and content when making water dispersible granules：Active components A 1%～70%, active component B
1%～70%, dispersant 1%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0%～8%, filler
Surplus.
Compositionss include following component and content when making suspending agent：Active components A 1%～50%, active component B
1%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.1%～2%, thickening agent 0.05%～2%,
Antifreeze 0%～8%, deionized water adds to 100%.
Compositionss include following component and content when making suspension emulsion：Active components A 0.5%～50%, active component B
0.5%～50%, emulsifying agent 1%～10%, dispersant 1%～10%, solvent 0～20%, defoamer 0.1%～2%, thickening
Agent 0.05%～2%, antifreeze 0%～8%, stabilizer 0%～3%, deionized water add to 100%.
Compositionss include following component and content when making aqueous emulsion：Active components A 1%～50%, active component B
1%～50%, solvent 1%～20%, emulsifying agent 1%～12%, antifreeze 0%～8%, defoamer 0.1%～2%, thickening
Agent 0.05%～2%, deionized water adds to 100%.
Compositionss include following component and content when making microemulsion：Active components A 1%～50%, active component B 1%
～50%, emulsifying agent 1%～15%, solvent 1%～10%, antifreeze 0%～8%, stabilizer 0%～3%, defoamer
0.1%～2%, deionized water adds to 100%.
Compositionss include following component and content when making microcapsule suspending agent：Active components A 1%～50%, active component B
1%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifying agent 1%～
7%th, pH adjusting agent 0.1%～5%, defoamer 0.1%～2%, deionized water add to 100%.
Compositionss include following component and content when making microcapsule suspension-suspendinagent agent：Active components A 0.5%～50%, work
Property composition B 0.5%～50%, macromolecule cyst material 1%～12%, surfactant 2%～15%, solvent 1%～
15%th, emulsifying agent 1%～8%, defoamer 0.1%～2%, thickening agent 0.05%～2%, pH adjusting agent 0.1%～5%, go
Ionized water adds to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
It is an advantage of the current invention that：
(1) present composition has good potentiation and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) agriculture
Medicinal dose is reduced, and reduces residual quantity of the pesticide on crop, mitigates environmental pollution；(3) fungicidal spectrum is expanded, to multiple diseases
Powdery mildew, anthrax, banded sclerotial blight, droop, rust, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, evil
Seedling diseases, blossom-end rot, green mould, penicilliosiss, crown rot, damping off have greater activity.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage ratio in embodiment is weight percentage, but
The invention is not limited in this.
Application Example one
1 80% antibiotic in pyrimidine nucleoside class triflumizole wettable powder of example
Antibiotic in pyrimidine nucleoside class 40%, fluorine bacterium azoles 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3.5%, tea seed cake 2.5%,
Starch adds to 100%, and mixture carries out comminution by gas stream, and 80% antibiotic in pyrimidine nucleoside class triflumizole wettable powder is obtained.
2 71% antibiotic in pyrimidine nucleoside class triflumizole wettable powder of example
Antibiotic in pyrimidine nucleoside class 70%, fluorine bacterium azoles 1%, ester Polyethylene oxide are phonetic 4.2%, wetting and penetrating agent F 2.8%, silicon
Diatomaceous earth adds to 100%, and mixture carries out comminution by gas stream, and 71% antibiotic in pyrimidine nucleoside class triflumizole wettable powder is obtained.
3 70% antibiotic in pyrimidine nucleoside class triflumizole water dispersant of example
Antibiotic in pyrimidine nucleoside class 10%, fluorine bacterium azoles 60%, arylphenol polyoxyethylene succinate sulfonate 2.5%, drawing
Open powder BX 1.5%, aluminum chloride 3%, attapulgite and add to 100%, be mixed to prepare 70% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles
Water dispersible granules.
4 25% antibiotic in pyrimidine nucleoside class triflumizole water dispersant of example
Antibiotic in pyrimidine nucleoside class 10%, fluorine bacterium azoles 15%, polycarboxylate 5%, spaonin powder 3%, ammonium sulfate 2.5%,
Kaolin adds to 100%, is mixed to prepare 25% antibiotic in pyrimidine nucleoside class triflumizole water dispersant.
5 30% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles suspending agent of example
Antibiotic in pyrimidine nucleoside class 15%, fluorine bacterium azoles 15%, alkylnaphthalene sulfonate 3.5%, sodium lauryl sulphate
2.5%th, C8～10Aliphatic alcohols 0.15%, Magnesiumaluminumsilicate 0.07%, ethylene glycol 2.6%, deionized water add to 100%, mixing system
Obtain 30% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles suspending agent.
6 20% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles suspending agent of example
Antibiotic in pyrimidine nucleoside class 5%, fluorine bacterium azoles 15%, octylphenol polyethylene oxyethylene group ether sulfate 5%, Bombyx mori L. 4%, silicon
Ketone 0.05%, xanthan gum 0.14%, glycerol 2.8%, deionized water add to 100%, are mixed to prepare 20% pyridimine nucleosides
Antibiotics fluorine bacterium azoles suspending agent.
7 22% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles suspension emulsion of example
Antibiotic in pyrimidine nucleoside class 20%, fluorine bacterium azoles 2%, polyoxyethylene carboxylate 4.5%, Nekal BX 2%, plant
Thing oil 5%, alkyl biphenyl ether disulfonic acid magnesium salt 6%, silicone oil 0.13%, polyvinylpyrrolidone 0.09%, 2,2'-ethylenedioxybis(ethanol). 2%, go
Ionized water adds to 100%, is mixed to prepare 22% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles suspension emulsion.
8 30% antibiotic in pyrimidine nucleoside class triflumizole microemulsion of example
Antibiotic in pyrimidine nucleoside class 5%, fluorine bacterium azoles 25%, Ketohexamethylene 2.6%, vegetable oil 5%, Polyethylene Glycol 2%,
C10～20Saturated fat acids 0.08%, sorbitan monostearate 8%, deionized water supply 100%, are mixed to prepare 30%
Antibiotic in pyrimidine nucleoside class triflumizole microemulsion.
9 31% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles aqueous emulsion of example
Antibiotic in pyrimidine nucleoside class 1%, fluorine bacterium azoles 30%, phenethyl phenol polyoxyethanyl polypropylene-base ether 3.5%, toluene
1%th, solvent naphtha 8%, C8～10Aliphatic alcohols 0.15%, phenolic resin 0.06%, deionized water supply 100%, are obtained 31% phonetic
Pyridine nucleoside antibiotics fluorine bacterium azoles aqueous emulsion.
10 20% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles microcapsule suspending agent of example
Antibiotic in pyrimidine nucleoside class 10%, fluorine bacterium azoles 10%, polyfunctional group acyl halide dihydroxylic alcohols 4.5%, octyl phenol polyoxy
Vinyl ethers sulfate 3%, ethyl acetate 4%, alkylaryl polyoxyethylene poly-oxygen propylene aether 3%, PH regulators citric acid with
Sodium hydroxide amounts to 2.5%, silicone 0.08%, deionized water and adds to 100%, is mixed to prepare 20% pyridimine nucleosides antibacterial
Plain fluorine bacterium azoles microcapsule suspending agent.
11 31% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles microcapsule suspension-suspendinagent agent of example
Antibiotic in pyrimidine nucleoside class 30%, fluorine bacterium azoles 1%, maltose 3.8%, polyfunctional group acyl halide polyamines 2.5%, fat
Fat amide groups are to methoxy benzenesulfonic acid sodium 6%, sodium tripolyphosphate 0.04%, vegetable oil 4%, styrene polyoxyethylene ether ammonium sulfate
Salt 5%, C10～20Saturated fat acids 0.07%, PH regulators hydrochloric acid and sodium hydroxide amount to 2%, deionized water and add to
100%, it is mixed to prepare 31% antibiotic in pyrimidine nucleoside class fluorine bacterium azoles microcapsule suspension-suspendinagent agent.
Fluorine bacterium azoles in example 1-11 are changed to into cyazofamid, Prochloraz and prochloraz-manganese chloride complex, ethirimol and bupirimate
Novel formulation can be equally obtained.
12 71% antibiotic in pyrimidine nucleoside class cyazofamid wettable powder of example
Antibiotic in pyrimidine nucleoside class 1%, cyazofamid 70%, alkyl benzene sulfonate calcium salt 6%, dodecylbenzene sodium sulfonate 4%,
White carbon adds to 100%, and mixture carries out comminution by gas stream, and 71% antibiotic in pyrimidine nucleoside class cyazofamid wettable powder is obtained
Agent.
13 60% antibiotic in pyrimidine nucleoside class cyazofamid wettable powder of example
Antibiotic in pyrimidine nucleoside class 30%, cyazofamid 30%, the arylphenol polyoxyethylene succinate sulfonate 4.5%, moon
Lauryl sulfate 2.5%, precipitated calcium carbonate adds to 100%, and mixture carries out comminution by gas stream, and 60% pyridimine nucleosides antibacterial is obtained
Plain cyazofamid wettable powder.
14 35% antibiotic in pyrimidine nucleoside class cyazofamid water dispersible granules of example
Antibiotic in pyrimidine nucleoside class 20%, cyazofamid 15%, double (alkyl) naphthalenesulfonate formaldehyde condensation compounds 3%, dodecane
Base sodium sulfate 2%, sodium bicarbonate 3%, starch add to 100%, are mixed to prepare 35% antibiotic in pyrimidine nucleoside class cyazofamid water
Dispersible granule.
15 60% antibiotic in pyrimidine nucleoside class cyazofamid water dispersible granules of example
The phonetic formaldehyde condensation products sulfate 4% of antibiotic in pyrimidine nucleoside class 10%, cyazofamid 50%, alkylphenol-polyethenoxy,
Spaonin powder 2.5%, carbamide 2%, bentonite add to 100%, are mixed to prepare 60% antibiotic in pyrimidine nucleoside class cyazofamid moisture
Shot agent.
16 30% antibiotic in pyrimidine nucleoside class cyazofamid suspending agent of example
Antibiotic in pyrimidine nucleoside class 20%, cyazofamid 10%, alkylphenol-polyethenoxy are phonetic 5%, Bombyx mori L. 4%, capric acid
0.2%th, sodium alginate 0.15%, deionized water adds to 100%, is mixed to prepare 30% antibiotic in pyrimidine nucleoside class cyazofamid and hangs
Floating agent.
17 25% antibiotic in pyrimidine nucleoside class cyazofamid suspending agent of example
Antibiotic in pyrimidine nucleoside class 5%, cyazofamid 20%, polycarboxylate 3.5%, spaonin powder 2.5%, silicone compound
0.04%th, methylcellulose 0.17%, deionized water adds to 100%, is mixed to prepare 25% antibiotic in pyrimidine nucleoside class cyanogen frost
Azole suspending agent.
18 20.5% antibiotic in pyrimidine nucleoside class cyazofamid suspension emulsion of example
Antibiotic in pyrimidine nucleoside class 20%, cyazofamid 0.5%, naphthalene sulfonic acid-formaldehyde condensation product 5%, sodium laurylsulfate 3%,
Vegetable oil 5%, castor oil polyoxyethylene ether 4%, silicone oil 0.2%, polyvinyl alcohol 0.15%, glycerol 2%, deionized water are added to
100%, it is mixed to prepare 20.5% antibiotic in pyrimidine nucleoside class cyazofamid suspension emulsion.
19 21% antibiotic in pyrimidine nucleoside class cyazofamid microemulsion of example
Antibiotic in pyrimidine nucleoside class 20%, cyazofamid 1%, NPE 10%, ethylene glycol monomethyl ether 3%, second
Acetoacetic ester 4%, silicone oil 0.12%, deionized water supply 100%, and 21% antibiotic in pyrimidine nucleoside class cyazofamid microemulsion is obtained
Agent.
20 20.5% antibiotic in pyrimidine nucleoside class cyazofamid aqueous emulsion of example
Antibiotic in pyrimidine nucleoside class 0.5%, cyazofamid 20%, fatty alcohol-polyoxyethylene ether 5%, Ketohexamethylene 4%, aluminium silicate
Magnesium 0.08%, vegetable oil 8%, C8～10Aliphatic alcohols 0.13%, deionized water supply 100%, and 20.5% pyridimine nucleosides are obtained
Antibiotics cyazofamid aqueous emulsion.
21 40% antibiotic in pyrimidine nucleoside class cyazofamid microcapsule suspending agent of example
Antibiotic in pyrimidine nucleoside class 35%, cyazofamid 5%, modified starch 4.5%, wetting agent T 5%, di-2-ethylhexylphosphine oxide methyl
Naphthalene sulfonate 3%, Polyethylene Glycol 5%, phenethyl phenol formaldehyde resin polyoxyethyl ether 4.5%, PH regulators sodium hydroxide and salt
Acid amounts to 2.8%, C10～20Saturated fat acids 0.06%, deionized water add to 100%, are mixed to prepare 40% pyridimine nucleosides
Antibiotics cyazofamid microcapsule suspending agent.
22 10% antibiotic in pyrimidine nucleoside class cyazofamid microcapsule suspension-suspendinagent agent of example
Antibiotic in pyrimidine nucleoside class 5%, cyazofamid 5%, calcium chloride 4%, maltose 2%, polymeric polycarboxylic acid salt 3%,
Nekal BX 2%, Ketohexamethylene 4.5%, sorbitan fatty acid ester polyoxyethylene ether 3.5%, silicone compound
0.08%th, PH regulators sodium hydroxide and sorbic acid amount to 3%, deionized water and add to 100%, are mixed to prepare 10% pyrimidine nucleoside
Antibiotics cyazofamid microcapsule suspension-suspendinagent agent.
Cyazofamid in example 12-22 is changed to into fluorine bacterium azoles, Prochloraz and prochloraz-manganese chloride complex, ethirimol and bupirimate
Novel formulation can be equally obtained.
23 70% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder of example
Antibiotic in pyrimidine nucleoside class 5%, Prochloraz 65%, alkylphenol-polyethenoxy are phonetic 5.5%, Nekal BX 2.5%,
White carbon adds to 100%, is mixed to prepare 70% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder.
24 40% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder of example
Antibiotic in pyrimidine nucleoside class 20%, Prochloraz 20%, lignosulfonates 3.5%, spaonin powder 2%, Kaolin add
To 100%, 40% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder is mixed to prepare.
25 50% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder of example
Antibiotic in pyrimidine nucleoside class 10%, Prochloraz 40%, ester Polyethylene oxide are phonetic 4.5%, sodium lauryl sulphate 3%,
Attapulgite adds to 100%, is mixed to prepare 50% antibiotic in pyrimidine nucleoside class Prochloraz wettable powder.
26 75% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder of example
Antibiotic in pyrimidine nucleoside class 5%, prochloraz-manganese chloride complex 70%, octylphenol polyethylene oxyethylene group ether sulfate 3.5%, moistening
Penetrating agent F 2.5%, starch adds to 100%, is mixed to prepare 75% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder
Agent.
27 70% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder of example
Antibiotic in pyrimidine nucleoside class 10%, prochloraz-manganese chloride complex 60%, double (alkyl) naphthalenesulfonate formaldehyde condensation compounds 6%, moon
Lauryl sulfate 4%, kieselguhr adds to 100%, is mixed to prepare 70% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettability
Powder.
28 50% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder of example
Antibiotic in pyrimidine nucleoside class 15%, prochloraz-manganese chloride complex 35%, double (alkyl) naphthalenesulfonate formaldehyde condensation compounds 4.5%,
Wetting and penetrating agent F 2.8%, starch adds to 100%, is mixed to prepare 50% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable
Property powder.
29 40% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder of example
Antibiotic in pyrimidine nucleoside class 10%, prochloraz-manganese chloride complex 30%, alkyl benzene sulfonate calcium salt 4%, DBSA
Sodium 2.5%, bentonite adds to 100%, is mixed to prepare 40% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex wettable powder.
30 60% antibiotic in pyrimidine nucleoside class Prochloraz water dispersible granules of example
Antibiotic in pyrimidine nucleoside class 50%, Prochloraz 10%, polyoxyethylene carboxylate 4.3%, Nekal BX 3.2%,
Sodium carbonate 3%, precipitated calcium carbonate adds to 100%, is mixed to prepare 60% antibiotic in pyrimidine nucleoside class Prochloraz water dispersible granules.
31 71% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex water dispersible granules of example
Antibiotic in pyrimidine nucleoside class 1%, prochloraz-manganese chloride complex 70%, polycarboxylate 4%, spaonin powder 2%, glucose
3.5%th, kieselguhr adds to 100%, is mixed to prepare 71% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex water dispersible granules.
32 40% antibiotic in pyrimidine nucleoside class Prochloraz suspending agent of example
Antibiotic in pyrimidine nucleoside class 10%, Prochloraz 30%, aliphatic alcohol polyethenoxy base ether 4.5%, lauryl sulphate acid
Sodium 2.5%, silicone oil 0.05%, sodium tripolyphosphate 0.13%, deionized water add to 100%, are mixed to prepare 40% pyridimine nucleosides
Antibiotics Prochloraz suspending agent.
33 25% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex suspending agent of example
Antibiotic in pyrimidine nucleoside class 5%, prochloraz-manganese chloride complex 20%, alkylphenol-polyethenoxy are phonetic 4.3%, sodium laurylsulfate
2%th, C10～20Saturated fat acids 0.05%, sodium acrylate 0.1%, deionized water add to 100%, are mixed to prepare 25% pyrimidine
Nucleoside antibiotics prochloraz-manganese chloride complex suspending agent.
34 20% antibiotic in pyrimidine nucleoside class Prochloraz suspension emulsion of example
Antibiotic in pyrimidine nucleoside class 5%, Prochloraz 15%, lignosulfonates 3.2%, spaonin powder 2.8%, Ketohexamethylene
4%th, styrene polyoxyethylene ether ammonium sulfate salt 5%, silicone 0.08%, arabic gum 0.13%, glycerol 2%, deionization
Water adds to 100%, is mixed to prepare 20% antibiotic in pyrimidine nucleoside class Prochloraz suspension emulsion.
35 21% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex suspension emulsion of example
Antibiotic in pyrimidine nucleoside class 1%, prochloraz-manganese chloride complex 20%, alkyl benzene sulfonate calcium salt 4%, spaonin powder 3%, plant
Oil 4%, phenyl phenol polyoxyethyl ether 3.5%, silicone compound 0.07%, phenolic resin 0.14%, 2,2'-ethylenedioxybis(ethanol). 3%, go from
Sub- water adds to 100%, is mixed to prepare 21% antibiotic in pyrimidine nucleoside class prochloraz-manganese chloride complex suspension emulsion.
36 35% antibiotic in pyrimidine nucleoside class Prochloraz microemulsion of example
Antibiotic in pyrimidine nucleoside class 5%, Prochloraz 30%, thermally coupled distillation columns 8%, Polyethylene Glycol 4%,
Butanol 7%, silicone 0.05%, deionized water supply 100%, and 35% antibiotic in pyrimidine nucleoside class Prochloraz microemulsion is obtained
Agent.
37 20% antibiotic in pyrimidine nucleoside class prochloraz aqueous emulsion of example
Antibiotic in pyrimidine nucleoside class 10%, Prochloraz 10%, phenyl phenol polyoxyethanyl ether phosphate 4.5%, toluene 6%,
Gelatin 0.12%, Propylene Glycol 3%, silicone oil 0.05%, deionized water supply 100%, and 20% antibiotic in pyrimidine nucleoside class is obtained
Prochloraz aqueous emulsion.
38 31% antibiotic in pyrimidine nucleoside class prochloraz aqueous emulsion of example
Antibiotic in pyrimidine nucleoside class 1%, Prochloraz 30%, sorbitan monostearate 5%, vegetable oil 6%, methylol
Cellulose 0.1%, diethylene glycol 3.5%, C10～20Saturated fat acids 0.06%, deionized water supply 100%, are obtained 31% phonetic
Pyridine nucleoside antibiotics prochloraz aqueous emulsion.
39 45% antibiotic in pyrimidine nucleoside class prochloraz aqueous emulsion of example
Antibiotic in pyrimidine nucleoside class 10%, Prochloraz 35%, NPE 3.2%, ethylene glycol monomethyl ether 6%,
White dextrin 0.12%, ethylene glycol 4%, silicone compound 0.07%, deionized water supply 100%, and 45% pyrimidine nucleoside is obtained
Antibiotics prochloraz aqueous emulsion.
40 30% antibiotic in pyrimidine nucleoside class Prochloraz microcapsule suspending agent of example
Antibiotic in pyrimidine nucleoside class 10%, Prochloraz 20%, polyisocyanate 5%, tristyryl phenol formaldehyde resin gather
Oxygen ethylene ether phosphate salt 3%, dimethylbenzene 4%, silicone compound 0.1%, fatty alcohol-polyoxyethylene ether 4%, PH regulators
Citric acid amounts to 2%, deionized water with sodium hydroxide and adds to 100%, is mixed to prepare 30% antibiotic in pyrimidine nucleoside class miaow fresh
Amine microcapsule suspending agent.
41 42% antibiotic in pyrimidine nucleoside class Prochloraz microcapsule suspension-suspendinagent agent of example
Antibiotic in pyrimidine nucleoside class 40%, Prochloraz 2%, polyvinyl alcohol 3.5%, beta-schardinger dextrin -4.2%, Propylene Glycol polyoxy
Ethylene oxypropylene block polyethers 3.5%, polyvinylpyrrolidone 0.13%, 2,4 toluene diisocyanate 4%, vinyl acetate
Ester 5%, silicone oil 0.07%, PH regulators sorbic acid and sodium hydroxide amount to 3.4%, deionized water and add to 100%, are mixed to prepare
42% antibiotic in pyrimidine nucleoside class Prochloraz microcapsule suspension-suspendinagent agent.
Prochloraz and prochloraz-manganese chloride complex in example 23-41 are changed to into cyazofamid, fluorine bacterium azoles, ethirimol and bupirimate
Novel formulation can be equally obtained.
42 70% antibiotic in pyrimidine nucleoside class ethirimol wettable powder of example
Antibiotic in pyrimidine nucleoside class 20%, ethirimol 50%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, Bombyx mori L. 4%, swelling
Soil adds to 100%, is mixed to prepare 70% antibiotic in pyrimidine nucleoside class ethirimol wettable powder.
43 60% antibiotic in pyrimidine nucleoside class bupirimate wettable powder of example
Antibiotic in pyrimidine nucleoside class 20%, bupirimate 40%, lignosulfonates 3.5%, sodium laurylsulfate
3%th, precipitated calcium carbonate adds to 100%, is mixed to prepare 60% antibiotic in pyrimidine nucleoside class bupirimate wettable powder.
44 45% antibiotic in pyrimidine nucleoside class bupirimate water dispersible granules of example
Antibiotic in pyrimidine nucleoside class 15%, bupirimate 30%, ester Polyethylene oxide are phonetic 5%, DBSA
Sodium 3%, carbamide 3.5%, kieselguhr add to 100%, are mixed to prepare 45% antibiotic in pyrimidine nucleoside class bupirimate water
Dispersible granule.
45 80% antibiotic in pyrimidine nucleoside class ethirimol water dispersible granules of example
Antibiotic in pyrimidine nucleoside class 60%, ethirimol 20%, alkylphenol-polyethenoxy are phonetic 4.5%, wetting and penetrating agent F
3.5%th, sodium bicarbonate 2.5%, white carbon adds to 100%, is mixed to prepare 80% antibiotic in pyrimidine nucleoside class ethirimol moisture
Shot agent.
46 31% antibiotic in pyrimidine nucleoside class ethirimol suspending agent of example
Antibiotic in pyrimidine nucleoside class 1%, ethirimol 30%, double (alkyl) naphthalenesulfonate formaldehyde condensation compounds 4.5%, pull open powder
BX 3%, silicone 0.07%, crospolyvinylpyrrolidone 0.16%, deionized water add to 100%, are mixed to prepare 31% phonetic
Pyridine nucleoside antibiotics ethirimol suspending agent.
47 20% antibiotic in pyrimidine nucleoside class bupirimate suspending agent of example
Antibiotic in pyrimidine nucleoside class 5%, bupirimate 15%, arylphenol polyoxyethylene succinate sulfonate 4%,
Sodium lauryl sulphate 2%, silicone oil 0.2%, sodium acrylate 0.05%, deionized water add to 100%, are mixed to prepare 20% pyrimidine
Nucleoside antibiotics bupirimate suspending agent.
48 21% antibiotic in pyrimidine nucleoside class bupirimate suspension emulsion of example
Antibiotic in pyrimidine nucleoside class 1%, bupirimate 20%, polyoxyethylene carboxylate 6%, detergent alkylate sulphur
Sour sodium 2.5%, vegetable oil 5%, ethylene oxide-propylene oxide block copolymer 4%, silicone compound 0.08%, guar gum
0.17%th, Propylene Glycol 3%, deionized water adds to 100%, is mixed to prepare 21% antibiotic in pyrimidine nucleoside class bupirimate
Suspension emulsion.
49 30% antibiotic in pyrimidine nucleoside class ethirimol microemulsion of example
Antibiotic in pyrimidine nucleoside class 10%, ethirimol 20%, triethanolamine salt 9%, Ketohexamethylene 4%, toluene 5%, capric acid
0.08%th, deionized water supplies 100%, and 30% antibiotic in pyrimidine nucleoside class ethirimol microemulsion is obtained.
50 32% antibiotic in pyrimidine nucleoside class ethirimol emulsion in water of example
Antibiotic in pyrimidine nucleoside class 2%, ethirimol 30%, xanthan gum 0.12%, Polyethylene Glycol 4%, silicone oil 0.05%, castor
Oleum Sesami polyoxyethylene ether 4%, acetone 2%, vegetable oil 7%, deionized water supply 100%, and 32% pyridimine nucleosides antibacterial is obtained
Plain ethirimol emulsion in water.
51 20% antibiotic in pyrimidine nucleoside class ethirimol microcapsule suspending agent of example
Antibiotic in pyrimidine nucleoside class 2%, ethirimol 18%, deformation lactoprotein 5%, Nekal BX 3%, solvent naphtha 7%,
C8～10Aliphatic alcohols 0.14%, methacrylate 6%, PH regulators hydrochloric acid and sodium hydroxide amount to 2.7%, deionized water and add
To 100%, 20% antibiotic in pyrimidine nucleoside class ethirimol microcapsule suspending agent is mixed to prepare.
52 32% antibiotic in pyrimidine nucleoside class ethirimol microcapsule suspension-suspendinagent agent of example
Antibiotic in pyrimidine nucleoside class 30%, ethirimol 2%, sodium alginate 5%, polyfunctional group acyl halide dihydroxylic alcohols 4%, alkane
Base arylphenol polyoxyethylene succinate sulfonate 4.5%, sodium acrylate 0.11%, dichloromethane 4.5%, polymethylacrylic acid
Sodium 3%, organic silicon defoamer 0.08%, PH regulators citric acid and sodium hydroxide amount to 3.2%, deionized water and add to 100%,
It is mixed to prepare 32% antibiotic in pyrimidine nucleoside class ethirimol microcapsule suspension-suspendinagent agent.
Ethirimol and bupirimate in example 42-52 are changed to into cyazofamid, fluorine bacterium azoles, Prochloraz and prochloraz-manganese chloride complex
Novel formulation can be equally obtained.
The embodiment of the present invention is the method combined using Toxicity Determination and field test.First pass through indoor virulence survey
It is fixed, clear and definite two kinds of medicaments compound by a certain percentage after synergy ratio (SR), SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are potentiation, on this basis, then carry out field test.
Test method：Jing after prerun determines the effective inhibition concentration scope of each medicament, medicament sets 5 respectively by active constituent content
Individual dosage is processed, if clear water control.Reference《Farm-chemical indoor determination test rule antibacterial》Carry out, using mycelial growth speed
Rate method determines virulence of the medicament to crop pathogenic bacteria.Colony diameter is measured with crossing method after 72h, each process is calculated and is grown only
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into into probit value (y), liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley methods
Two medicaments different ratio synergy ratio (SR) are calculated, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 are potentiation.Computing formula is as follows：
Wherein：A, b are respectively the shared ratio in combination of active components A and active component B；
A is antibiotic in pyrimidine nucleoside class；
B is planted selected from one of fluorine bacterium azoles, cyazofamid, Prochloraz and prochloraz-manganese chloride complex, ethirimol and bupirimate.
Application Example two：For trying disease：Pear scab.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：The effective of pesticide corrosion 120 and fluorine bacterium azoles active compound and the two different ratio mixture is determined through pilot study
Inhibition concentration scope.
Toxicity test result
1 pesticide corrosion 120 of table compounds the toxicity test analysis of results table to pear scab with fluorine bacterium azoles
As shown in Table 1, with fluorine bacterium azoles proportioning at 1: 70～70: 1, synergy ratio SR is all higher than antibiotic in pyrimidine nucleoside class
1.5, illustrate that both show potentiation at the mixture in the range of 1: 70～70: 1, when antibiotic in pyrimidine nucleoside class and fluorine bacterium azoles
Proportioning at 1: 10～10: 1, potentiation becomes apparent from projecting, especially when antibiotic in pyrimidine nucleoside class and fluorine bacterium azoles weight
When amount is than being 1: 1, synergy ratio is maximum, and potentiation is the most obvious.Jing applicant's test finds antibiotic in pyrimidine nucleoside class and fluorine
The proportioning of bacterium azoles be 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,
When 1: 8,1: 9,1: 10, antibiotic in pyrimidine nucleoside class is compounded to powdery mildew, anthrax, banded sclerotial blight, droop, rust with fluorine bacterium azoles
Disease, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mould, penicilliosiss, hat are rotten
Disease, the preventing and treating of damping off have obvious potentiation, and synergy ratio is more than 1.90.
Application Example three：
For trying disease：Cucumber downy mildew.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine that antibiotic in pyrimidine nucleoside class is mixed with cyazofamid active compound and the two different ratio through pilot study
Effective inhibition concentration scope of agent.
Toxicity test result
2 antibiotic in pyrimidine nucleoside class of table compounds the toxicity test analysis of results table to cucumber downy mildew with cyazofamid
As shown in Table 2, with cyazofamid proportioning at 1: 70～70: 1, synergy ratio SR is all higher than antibiotic in pyrimidine nucleoside class
1.5, illustrate that both show potentiation at the mixture in the range of 1: 70～70: 1, when antibiotic in pyrimidine nucleoside class and cyazofamid
Proportioning at 1: 10～10: 1, potentiation becomes apparent from projecting, especially when antibiotic in pyrimidine nucleoside class and cyazofamid weight
When amount is than being 1: 1, synergy ratio is maximum, and potentiation is the most obvious.Jing applicant's test finds antibiotic in pyrimidine nucleoside class and cyanogen
The proportioning of white azoles be 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,
When 1: 8,1: 9,1: 10, antibiotic in pyrimidine nucleoside class is compounded to powdery mildew, anthrax, banded sclerotial blight, droop, rust with cyazofamid
Disease, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mould, penicilliosiss, hat are rotten
Disease, the preventing and treating of damping off have obvious potentiation, and synergy ratio is more than 2.10.
Application Example four：
For trying disease：Rice blast.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine antibiotic in pyrimidine nucleoside class with Prochloraz and prochloraz-manganese chloride complex active compound and two through pilot study
Effective inhibition concentration scope of person's different ratio mixture.
Toxicity test result
Toxicity test analysis of results table of 3 pesticide corrosion 120 of table with Prochloraz and prochloraz-manganese chloride complex compounding to rice blast
As shown in Table 3, antibiotic in pyrimidine nucleoside class and Prochloraz and prochloraz-manganese chloride complex proportioning be at 1: 70～70: 1, potentiation
Ratio SR is all higher than 1.5, illustrates that both show potentiation at the mixture in the range of 1: 70～70: 1, when pyridimine nucleosides it is anti-
At 1: 20～5: 1, potentiation becomes apparent from projecting the proportioning of rhzomorph and Prochloraz and prochloraz-manganese chloride complex, especially works as pyrimidine
When nucleoside antibiotics are 1: 3 with Prochloraz and prochloraz-manganese chloride complex weight ratio, synergy ratio is maximum, and potentiation is the most obvious.Jing
Applicant's test finds that antibiotic in pyrimidine nucleoside class is 5: 1,4: 1,3: 1,2: 1,1 with the proportioning of Prochloraz and prochloraz-manganese chloride complex:
1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9、1∶10、1∶11、1∶12、1∶13、1∶14、1∶15、1∶16、1∶17、1∶
18th, 1: 19,1: 20 when, antibiotic in pyrimidine nucleoside class and Prochloraz and prochloraz-manganese chloride complex compounding it is withered to powdery mildew, anthrax, stricture of vagina
Disease, droop, rust, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mold
Disease, penicilliosiss, crown rot, the preventing and treating of damping off have obvious potentiation, and synergy ratio is more than 1.9.
Application Example five：
For trying disease：Apple mildew.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Through pilot study determine antibiotic in pyrimidine nucleoside class and ethirimol and bupirimate active compound and
Effective inhibition concentration scope of the two different ratio mixture.
Toxicity test result
Toxicity test analysis of results table of 4 pesticide corrosion 120 of table with ethirimol and bupirimate compounding to apple mildew
As shown in Table 4, antibiotic in pyrimidine nucleoside class increases with ethirimol and bupirimate proportioning at 1: 70～70: 1
Effect ratio SR is all higher than 1.5, both illustrate that mixture shows potentiation in the range of 1: 70～70: 1, works as pyridimine nucleosides
At 1: 20～10: 1, potentiation becomes apparent from projecting the proportioning of antibiotics and ethirimol and bupirimate, especially
When antibiotic in pyrimidine nucleoside class is 1: 2 with ethirimol and bupirimate weight ratio, synergy ratio is maximum, and potentiation is most
For obvious.Jing applicant's test finds that antibiotic in pyrimidine nucleoside class is 10: 1,9 with the proportioning of ethirimol and bupirimate:
1、8∶1、7∶1、6∶1、5∶1、4∶1、3∶1、2∶1、1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9、1∶10、1∶11、1
: 12,1: 13,1: 14,1: 15,1: 16,1: 17,1: 18,1: 19,1: 20 when, antibiotic in pyrimidine nucleoside class is phonetic with ethirimol and second
Sulfocarbolate compounding is to powdery mildew, anthrax, banded sclerotial blight, droop, rust, melasma, epidemic disease, downy mildew, scab, white epidemic disease
Mildew, rice blast, bakanae disease, blossom-end rot, green mould, penicilliosiss, crown rot, the preventing and treating of damping off have obvious potentiation to make
With synergy ratio is more than 1.8.
Application Example Elmidone nucleoside antibiotics and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and
Its compounding preventing and treating pear scab test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Xianyang, Shanxi province city, test medicine
For, 4% antibiotic in pyrimidine nucleoside class water preparation (commercial) of comparison medicament, 30% triflumizole wettable powder (commercial), 100 g/l
Cyazofamid suspending agent (autogamy), 25% Prochloraz and prochloraz-manganese chloride complex cream (commercial), 25% ethirimol and bupirimate
Suspending agent (autogamy).
The pear scab state of an illness is investigated before medicine, in the first time dispenser of state of an illness initial stage, per dispenser in 7 days once, dispenser 3 times altogether.
7 days after third time dispenser, disease index is investigated respectively and preventive effect is calculated within 14 days, 30 days.Experimental result is as follows：
5 antibiotic in pyrimidine nucleoside class of table and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and its compounding preventing and treating
The pear scab test of pesticide effectiveness
As can be seen from Table 5, antibiotic in pyrimidine nucleoside class with fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt
Pear scab can be effectively prevented and treated after compounding, prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication
It is interior that target crop is had no adverse effects.Seven antibiotic in pyrimidine nucleoside class of Application Example and fluorine bacterium azoles, cyazofamid, ethirimol and
Salt, Prochloraz and salt and its compounding prevent and treat the bakanae disease of rice test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province's Hanzhong City, test medicine
For, 4% antibiotic in pyrimidine nucleoside class water preparation (commercial) of comparison medicament, 30% triflumizole wettable powder (commercial), 100 g/l
Cyazofamid suspending agent (autogamy), 25% Prochloraz and prochloraz-manganese chloride complex cream (commercial), 25% ethirimol and bupirimate
Suspending agent (autogamy).
The bakanae disease of rice state of an illness is investigated before medicine, in the first time dispenser of state of an illness initial stage, per dispenser in 7 days once, dispenser 2 times altogether.
7 days after second dispenser, disease index is investigated respectively and preventive effect is calculated within 14 days, 30 days.Experimental result is as follows：
6 antibiotic in pyrimidine nucleoside class of table and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and its compounding preventing and treating
The bakanae disease of rice test of pesticide effectiveness
As can be seen from Table 6, antibiotic in pyrimidine nucleoside class is multiple with fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt
Bakanae disease of rice can be effectively prevented and treated after matching somebody with somebody, prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication
Target crop is had no adverse effects.
Eight antibiotic in pyrimidine nucleoside class of Application Example and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and
Its compounding prevents and treats the downy mildew of garpe test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province's Weinan City, test medicine
For, 4% antibiotic in pyrimidine nucleoside class water preparation (commercial) of comparison medicament, 30% triflumizole wettable powder (commercial), 100 g/l
Cyazofamid suspending agent (autogamy), 25% Prochloraz and prochloraz-manganese chloride complex cream (commercial), 25% ethirimol and bupirimate
Suspending agent (autogamy).
The downy mildew of garpe state of an illness is investigated before medicine, in the first time dispenser of state of an illness initial stage, per dispenser in 7 days once, dispenser 3 times altogether.
7 days after third time dispenser, disease index is investigated respectively and preventive effect is calculated within 14 days, 30 days.Experimental result is as follows：
7 antibiotic in pyrimidine nucleoside class of table and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and its compounding preventing and treating
The downy mildew of garpe test of pesticide effectiveness
As can be seen from Table 7, antibiotic in pyrimidine nucleoside class is multiple with fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt
Downy mildew of garpe can be effectively prevented and treated after matching somebody with somebody, prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication
Target crop is had no adverse effects.
Nine antibiotic in pyrimidine nucleoside class of Application Example and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and
Its compounding preventing and treating wheat powdery mildew test of pesticide effectiveness
This test arrangement is ground by Shaanxi Welch Crop Protection Co., Ltd. in Xian District, Shanxi Province suburban area, test medicine
Send out, provide, 4% antibiotic in pyrimidine nucleoside class water preparation (commercial) of comparison medicament, 30% triflumizole wettable powder (commercial), 100
G/l cyazofamid suspending agent (autogamy), 25% Prochloraz and prochloraz-manganese chloride complex cream (commercial), 25% ethirimol and ethirimol sulphur
Acid esters suspending agent (autogamy).
The wheat powdery mildew state of an illness is investigated before medicine, in the first time dispenser of state of an illness initial stage, per dispenser in 7 days once, dispenser 2 times altogether.
7 days after second dispenser, disease index is investigated respectively and preventive effect is calculated within 14 days, 30 days.Experimental result is as follows：
8 antibiotic in pyrimidine nucleoside class of table and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and its compounding preventing and treating
The wheat powdery mildew test of pesticide effectiveness
As can be seen from Table 8, antibiotic in pyrimidine nucleoside class is multiple with fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt
Wheat powdery mildew can be effectively prevented and treated after matching somebody with somebody, prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication
Target crop is had no adverse effects.
Ten antibiotic in pyrimidine nucleoside class of Application Example and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and
Its compounding preventing and treating rice blast test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province's Hanzhong City, test medicine
For, 4% antibiotic in pyrimidine nucleoside class water preparation (commercial) of comparison medicament, 30% triflumizole wettable powder (commercial), 100 g/l
Cyazofamid suspending agent (autogamy), 25% Prochloraz and prochloraz-manganese chloride complex cream (commercial), 25% ethirimol and bupirimate
Suspending agent (autogamy).
The rice blast state of an illness is investigated before medicine, in the first time dispenser of state of an illness initial stage, per dispenser in 7 days once, dispenser 2 times altogether.
7 days after second dispenser, disease index is investigated respectively and preventive effect is calculated within 14 days, 30 days.Experimental result is as follows：
9 antibiotic in pyrimidine nucleoside class of table and fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt and its compounding preventing and treating
The rice blast test of pesticide effectiveness
As can be seen from Table 9, antibiotic in pyrimidine nucleoside class is multiple with fluorine bacterium azoles, cyazofamid, ethirimol and salt, Prochloraz and salt
Rice blast can be effectively prevented and treated after matching somebody with somebody, prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication
Target crop is had no adverse effects.
Test through different places throughout the country afterwards draws, antibiotic in pyrimidine nucleoside class and fluorine bacterium azoles, cyazofamid, miaow
It is withered to the powdery mildew in various crop, anthrax, stricture of vagina after fresh amine and prochloraz-manganese chloride complex, ethirimol and bupirimate compounding
Disease, droop, rust, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mold
, more than 95%, better than single dose preventive effect, potentiation is bright for the preventive effect of the Common Diseases such as disease, penicilliosiss, crown rot, damping off
It is aobvious.
Claims (7)
1. a kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, it is characterised in that：Effective active composition for activity into
Divide A and active component B, active components A is 1 ︰, 70 ~ 70 ︰ 1 with active component B weight ratio, and described active components A is pyrimidine core
Glycoside antibiotics, active component B are fluorine bacterium azoles.
2. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 1, it is characterised in that：Activity into
The weight ratio for dividing A and active component B is 1 ︰, 40 ~ 40 ︰ 1.
3. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 2, it is characterised in that：Activity into
The weight ratio for dividing A and active component B is 1 ︰, 30 ~ 30 ︰ 1.
4. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 3, it is characterised in that：
Antibiotic in pyrimidine nucleoside class is 1 ︰, 10 ~ 10 ︰ 1 with the weight ratio of fluorine bacterium azoles.
5. any one according to Claims 1-4 contains the Synergistic bactericidal composition of antibiotic in pyrimidine nucleoside class, and its feature exists
In：Compositionss make wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, micro-
Capsule suspension-suspending agent.
6. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class described in claim 5 is used to prevent and treat answering for crop pest
With.
7. application according to claim 6, it is characterised in that：Described disease include powdery mildew, anthrax, banded sclerotial blight,
Droop, rust, melasma, epidemic disease, downy mildew, scab, peronospora tabacina, rice blast, bakanae disease, blossom-end rot, green mould, green grass or young crops
Mildew, crown rot, damping off.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1695446A (en) * | 2004-05-14 | 2005-11-16 | 北京化工大学 | Compsn. of agricultural pesticide and preparation method |
| WO2008096675A1 (en) * | 2007-02-06 | 2008-08-14 | Nippon Soda Co., Ltd. | Broad-leaved perennial weed control agent for grass, and method for control of broad-leaved perennial weed in grass |
| CN101647441A (en) * | 2009-07-31 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilization combination containing azoxystrobin and application thereof |
| CN102067840A (en) * | 2011-02-17 | 2011-05-25 | 德强生物股份有限公司 | Compound pesticide containing triflumizole and ningnanmycin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695446A (en) * | 2004-05-14 | 2005-11-16 | 北京化工大学 | Compsn. of agricultural pesticide and preparation method |
| WO2008096675A1 (en) * | 2007-02-06 | 2008-08-14 | Nippon Soda Co., Ltd. | Broad-leaved perennial weed control agent for grass, and method for control of broad-leaved perennial weed in grass |
| CN101647441A (en) * | 2009-07-31 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilization combination containing azoxystrobin and application thereof |
| CN102067840A (en) * | 2011-02-17 | 2011-05-25 | 德强生物股份有限公司 | Compound pesticide containing triflumizole and ningnanmycin |
Non-Patent Citations (1)
| Title |
|---|
| 保护地小西葫芦主要病害的防治;金坪 等;《农村.农业.农民》;20050531(第1期);第33页 * |
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