CN103371187A - Bactericidal composition containing agricultural antibiotic - Google Patents
Bactericidal composition containing agricultural antibiotic Download PDFInfo
- Publication number
- CN103371187A CN103371187A CN2012101089189A CN201210108918A CN103371187A CN 103371187 A CN103371187 A CN 103371187A CN 2012101089189 A CN2012101089189 A CN 2012101089189A CN 201210108918 A CN201210108918 A CN 201210108918A CN 103371187 A CN103371187 A CN 103371187A
- Authority
- CN
- China
- Prior art keywords
- antibiotic
- pyrimidine nucleoside
- nucleoside class
- bactericidal composition
- active component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 65
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 239000005761 Dimethomorph Substances 0.000 claims abstract description 32
- QNBTYORWCCMPQP-JXAWBTAJSA-N (Z)-dimethomorph Chemical compound C1=C(OC)C(OC)=CC=C1C(\C=1C=CC(Cl)=CC=1)=C/C(=O)N1CCOCC1 QNBTYORWCCMPQP-JXAWBTAJSA-N 0.000 claims abstract description 31
- PCCSBWNGDMYFCW-UHFFFAOYSA-N 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione Chemical compound O=C1C(C)(C=2C=CC(OC=3C=CC=CC=3)=CC=2)OC(=O)N1NC1=CC=CC=C1 PCCSBWNGDMYFCW-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000005772 Famoxadone Substances 0.000 claims abstract description 31
- OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 claims abstract description 31
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 3
- 239000002718 pyrimidine nucleoside Substances 0.000 claims description 61
- 201000010099 disease Diseases 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 25
- 238000009736 wetting Methods 0.000 claims description 25
- 241000233679 Peronosporaceae Species 0.000 claims description 18
- 239000000375 suspending agent Substances 0.000 claims description 15
- 235000007164 Oryza sativa Nutrition 0.000 claims description 14
- 235000009566 rice Nutrition 0.000 claims description 14
- 241000221785 Erysiphales Species 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 8
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 8
- 239000003094 microcapsule Substances 0.000 claims description 8
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 7
- 241001530056 Athelia rolfsii Species 0.000 claims description 7
- 241000223218 Fusarium Species 0.000 claims description 7
- 206010027146 Melanoderma Diseases 0.000 claims description 7
- 241000582441 Peronospora tabacina Species 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- -1 aqua Substances 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 6
- 238000012360 testing method Methods 0.000 description 38
- 239000003814 drug Substances 0.000 description 37
- 239000000575 pesticide Substances 0.000 description 35
- 239000002131 composite material Substances 0.000 description 34
- 230000003449 preventive effect Effects 0.000 description 23
- 230000007797 corrosion Effects 0.000 description 22
- 238000005260 corrosion Methods 0.000 description 22
- 230000002195 synergetic effect Effects 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 241000209094 Oryza Species 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 12
- 239000013530 defoamer Substances 0.000 description 10
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 7
- 240000003768 Solanum lycopersicum Species 0.000 description 7
- 206010067482 No adverse event Diseases 0.000 description 6
- 230000010165 autogamy Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 241000209140 Triticum Species 0.000 description 5
- 235000021307 Triticum Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 241000219109 Citrullus Species 0.000 description 4
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 4
- 240000008067 Cucumis sativus Species 0.000 description 4
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010011732 Cyst Diseases 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 208000031513 cyst Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical class NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000192128 Gammaproteobacteria Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000194 ovacidal Toxicity 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing an agricultural antibiotic. The bactericidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from the agricultural antibiotic, and the active ingredient B is selected from any one of the following compounds: dimethomorph, fosetyl-aluminium and famoxadone; and the weight ratio of the active ingredient A to the active ingredient B is (1:80)-(60:1). The composition has higher activity towards various pests on various crops, has obvious synergism, expands the bactericidal spectrum and has the characteristics of small dosage, rain wash resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains antibiotic in pyrimidine nucleoside class.
Technical background
Antibiotic in pyrimidine nucleoside class (agricultural antiobiotic 120) another name: pesticide corrosion 120; Antimycoin 120; 120 agricultural antibiotics.Antibiotic in pyrimidine nucleoside class is a kind of efficient, broad spectrum biological disinfection agent, has prevention protection and interior suction treatment double effects, and many phytopathogens are had strong inhibitory action, and is better to cucurbits powdery mildew, flowers powdery mildew and wheat rust preventive effect.
Dimethomorph (Dimethomorph) chemical name: (E, Z)-4-[3-(4-chlorphenyl) 3-(3,4-Dimethoxyphenyl) acryloyl] morpholine, molecular formula: C
21H
22ClNO
4Dimethomorph is single-minded ovicidal Gammaproteobacteria fungi bactericide, its effect characteristics are to destroy the formation of cell envelope, stages to oomycetes history of life has effect, and particularly responsive at the formation stages of sporangiophore and egg spore, (＜0.25 μ g/ml) namely is suppressed under extremely low concentration.With the phenylamide medicament without cross resistance.
Phosethyl-Al (Fosetyl-aluminium) chemical name: three-(ethylphosphonic acid) aluminium, molecular formula: C
6H
18AlO
9P
3Phosethyl-Al is systemic fungicide, can conduct up and down in plant corpus, has protection and therapeutic action.
Famoxadone (Famoxadone) chemical name: 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone, molecular formula: C
22H
18N
2O
4It is that inhibitor of energy is the mitochondria electron transfer inhibitor, and cromoci oxidoreductase among the complex III is had inhibitory action.Other acts on mechanism in further studying.It has protection, treat, root out, infiltration, systemic activity, with the phenyl amide series bactericidal agent without handing over resistance.
In the real process of agricultural production, prevent and treat disease the problem of easy generation be the generation of disease drug resistance.The different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals all is additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery is mutually composite with antibiotic in pyrimidine nucleoside class and dimethomorph, phosethyl-Al, famoxadone, good synergistic effect is arranged within the specific limits, and relevant composite about antibiotic in pyrimidine nucleoside class and dimethomorph, phosethyl-Al, famoxadone there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains antibiotic in pyrimidine nucleoside class.
A kind of bactericidal composition that contains antibiotic in pyrimidine nucleoside class, it is characterized in that comprising active components A and active component B, active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from antibiotic in pyrimidine nucleoside class, and active component B is selected from a kind of in dimethomorph, phosethyl-Al, the famoxadone.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is characterized in that: the weight ratio of active components A and active component B is 1: 40～30: 1.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is characterized in that: the weight ratio of antibiotic in pyrimidine nucleoside class and dimethomorph is 1: 15～10: 1.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is characterized in that: the weight ratio of antibiotic in pyrimidine nucleoside class and phosethyl-Al is 1: 20～2: 1.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is characterized in that: antibiotic in pyrimidine nucleoside class is Yu the weight ratio of famoxadone is 1: 10～10: 1.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqua, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
The described bactericidal composition that contains antibiotic in pyrimidine nucleoside class is used for the disease of control crop, and described crop comprises vegetables, fruit tree, cereal crops, ornamental plants.
Described disease comprises black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch.
Amount of application when the content of active component depends on independent use in the present composition also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target disease.Usually the weight percentage of active component is 2%～90% of gross weight in the composition, and better is 5%～80%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains by weight 1%～60% active substance, preferably is 5%～50%; Solid pharmaceutical preparation contains by weight 5%～80% active substance, preferably is 10%～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or the defoamer.According to different dosage form, can also contain stabilizing agent known in those skilled in the art, antifreeze etc. in the preparation.
Bactericidal composition of the present invention can be by the user before use through dilution or directly use.Its preparation can by processing method preparation known in those skilled in the art, after being about to active component and liquid flux or solid carrier mixing, add one or more in surfactant such as dispersant, stabilizing agent, wetting agent, binding agent, the defoamer etc. again.
Bactericidal composition of the present invention can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, aqua, microemulsion, aqueous emulsion, microcapsule suspending agent.
When making wetting powder, composition comprises following component and content: active components A 1%～60%, active component B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 1%～60%, active component B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 0～8%, filler surplus.
Comprise following component and content when composition is made suspending agent: active components A 1%～50%, active component B1%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickener 0.05%～2%, antifreeze 0～8%, deionized water add to 100%.
Comprise following component and content when composition is made aqua: active components A 0.5%～40%, active component B 0.5%～40%, dispersant 2%～15%, wetting agent 1%-10%, antifreeze 0～8%, deionized water add to 100%.
Comprise following component and content when composition is made microemulsion: active components A 0.5%～50%, active component B0.5%～50%, emulsifier 1%～15%, solvent 1%～10%, antifreeze 0～8%, stabilizing agent 0～3%, defoamer 0.01%～2%, deionized water add to 100%.
Comprise following component and content when composition is made aqueous emulsion: active components A 0.5%～50%, active component B0.5%～50%, solvent 1%～20%, emulsifier 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, thickener 0.05%～2%, deionized water add to 100%.
Comprise following component and content when composition is made microcapsule suspending agent: active components A 0.5%～50%, active component B0.5%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifier 1%～7%, pH adjusting agent 0.1%～5%, defoamer 0.01%～2%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqua the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) the agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) enlarged fungicidal spectrum, multiple diseases such as black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch have been had greater activity.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
Application Example one
Example 1～8 wetting powder
Antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into wetting powder product of the present invention.Specifically see Table 1,2.
Table 1 example 1～4 each component and content
Table 2 example 5～8 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 9～16 water dispersible granules
Antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, disintegrant, filler are obtained the particle diameter that needs through air-flow crushing together, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make water dispersible granules product of the present invention.Specifically see Table 3,4.
Table 3 example 9～12 each component and content
Table 4 example 13～16 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 17～22 suspending agents
Dispersant, wetting agent, defoamer, thickener, antifreeze are mixed through high speed shear, add antibiotic in pyrimidine nucleoside class, active component B, surplus is supplied with deionized water, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.Specifically see Table 5.
Table 5 example 17～22 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 23～27 aquas
Antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, antifreeze are mixed through high speed shear, supply surplus with deionized water, make aqua product of the present invention.Specifically see Table 6.
Table 6 example 23～27 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 28～30 microemulsions
Antibiotic in pyrimidine nucleoside class, active component B are dissolved in the homogenizer that solvent is housed, emulsifier, antifreeze, defoamer are joined in the homogenizer that mentioned solution is housed, strongly mix after surplus is supplied with deionized water and homogenize, obtain at last the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically see Table 7.
Table 7 example 28～30 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 31～33 aqueous emulsions
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifier are added together, make and be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, make aqueous emulsion product of the present invention.Specifically see Table 8.
Table 8 example 31～33 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
Example 34～36 microcapsule suspending agents
With antibiotic in pyrimidine nucleoside class, active component B, macromolecule cyst material, solvent, make and be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied with deionized water, bi-material reacts at oil-water interfaces, forms the macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically see Table 9.
Table 9 example 32～34 each component and content
Dimethomorph, phosethyl-Al, famoxadone exchange in will showing, and can make novel formulation.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Test method: after each medicament establishment concentration range was determined in prerun, medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is antibiotic in pyrimidine nucleoside class;
B selects a kind of to dimethomorph, phosethyl-Al, the famoxadone.
Application Example two:
For trying disease: tomato blight.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining the former medicine of pesticide corrosion 120 and dimethomorph and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to tomato blight of table 10 pesticide corrosion 120 and dimethomorph
As shown in Table 10, pesticide corrosion 120 and dimethomorph proportioning 1: 80～60: 1 o'clock to tomato blight synergy ratio SR all greater than 1.5, illustrating that both were mixed in the scope at 1: 80～60: 1 all shows synergistic effect, when the proportioning of pesticide corrosion 120 and dimethomorph during at 1: 15～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.20.Wherein synergy ratio is maximum when pesticide corrosion 120 and dimethomorph weight ratio are 2: 3, and synergistic effect is the most obvious.Testing the proportioning of finding pesticide corrosion 120 and dimethomorph through the applicant is 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,2: 3,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15 o'clock, the composite control to black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch of pesticide corrosion 120 and dimethomorph has obvious synergistic effect, and synergy ratio is all more than 1.50.
Application Example three:
For trying disease: rice sheath blight disease.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining the former medicine of pesticide corrosion 120 and phosethyl-Al and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to rice sheath blight disease of table 11 pesticide corrosion 120 and phosethyl-Al
As shown in Table 11, pesticide corrosion 120 and phosethyl-Al to the proportioning of rice sheath blight disease at 1: 80～60: 1 o'clock, synergy ratio SR is all greater than 1.5, illustrating that both were mixed in the scope at 1: 80～60: 1 all shows synergistic effect, when the proportioning of pesticide corrosion 120 and phosethyl-Al during at 1: 20～2: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Wherein synergy ratio is maximum when pesticide corrosion 120 and phosethyl-Al weight ratio are 1: 10, and synergistic effect is the most obvious.Test through the applicant, the proportioning of finding pesticide corrosion 120 and phosethyl-Al is 2: 1,1: 1,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 11,1: 12,1: 13,1: 14,1: 15,1: 20 o'clock, the composite control to black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch of pesticide corrosion 120 and phosethyl-Al has obvious synergistic effect, and synergy ratio is all more than 1.50.
Application Example four:
For trying disease: downy mildew of garpe.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining the former medicine of pesticide corrosion 120 from famoxadone and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 12 pesticide corrosion 120 is Yu the composite toxicity test analysis of results table to downy mildew of garpe of famoxadone
As shown in Table 12, pesticide corrosion 120 Yu famoxadone to the proportioning of downy mildew of garpe at 1: 80～60: 1 o'clock, synergy ratio SR is all greater than 1.5, illustrating that both were mixed in the scope at 1: 80～60: 1 all shows synergistic effect, when pesticide corrosion 120 Yu the proportioning of famoxadone in the time of 1: 10～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.20.Wherein synergy ratio is maximum when pesticide corrosion 120 and famoxadone weight ratio are 1: 1, and synergistic effect is the most obvious.Test the discovery pesticide corrosion 120 Yu the proportioning of famoxadone is at 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10 o'clock through the applicant, the composite control to black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch of pesticide corrosion 120 and famoxadone has obvious synergistic effect, and synergy ratio is all more than 1.50.
Application Example five antibiotic in pyrimidine nucleoside class and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement is in the Tai Er village, Zaozhuang City, Shandong Province; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation wheat powdery mildew state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 13 antibiotic in pyrimidine nucleoside class and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 13, can effectively prevent and treat wheat powdery mildew after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example Elmidone ucleosides antibiotic and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This test arrangement is in Weinan City suburb, Shaanxi Province; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation downy mildew of garpe state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 14 antibiotic in pyrimidine nucleoside class and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 14, can effectively prevent and treat downy mildew of garpe after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example seven antibiotic in pyrimidine nucleoside class and active component B and the composite control tomato blight test of pesticide effectiveness thereof
This test arrangement is at the Xian District, Shanxi Province suburban area; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation tomato blight state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 15 antibiotic in pyrimidine nucleoside class and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 15, can effectively prevent and treat tomato blight after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example eight antibiotic in pyrimidine nucleoside class and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation rice blast state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 16 antibiotic in pyrimidine nucleoside class and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 16, can effectively prevent and treat rice blast after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example nine antibiotic in pyrimidine nucleoside class and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement is in the Jingyang County, Shaanxi Province; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation cucumber downy mildew state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 17 antibiotic in pyrimidine nucleoside class and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 17, can effectively prevent and treat cucumber downy mildew after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example ten antibiotic in pyrimidine nucleoside class and active component B and the composite control watermelon blight test of pesticide effectiveness thereof
This test arrangement is at Heze city of Shandong province; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 50% dimethomorph wetting powder (commercial), 40% phosethyl-Al wetting powder (commercial), 30% famoxadone wetting powder (autogamy).
The investigation watermelon blight state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 18 antibiotic in pyrimidine nucleoside class and active component B and the composite control watermelon blight test of pesticide effectiveness thereof
As can be seen from Table 18, can effectively prevent and treat watermelon blight after antibiotic in pyrimidine nucleoside class and active component B are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
After draw through different local throughout the country tests, the composite rear preventive effect to Common Diseases such as the black spot on the various crop, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotchs of antibiotic in pyrimidine nucleoside class and dimethomorph, phosethyl-Al, famoxadone is all more than 95%, be better than the single dose preventive effect, synergistic effect is obvious.
Claims (8)
1. bactericidal composition that contains antibiotic in pyrimidine nucleoside class, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from antibiotic in pyrimidine nucleoside class, and active component B is selected from a kind of in dimethomorph, phosethyl-Al, the famoxadone.
2. the bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 1, it is characterized in that: the weight ratio of active components A and active component B is 1: 40～30: 1.
3. the bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 2, it is characterized in that: the weight ratio of antibiotic in pyrimidine nucleoside class and dimethomorph is 1: 15～10: 1.
4. the bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 2, it is characterized in that: the weight ratio of antibiotic in pyrimidine nucleoside class and phosethyl-Al is 1: 20～2: 1.
5. the bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 2, it is characterized in that: antibiotic in pyrimidine nucleoside class is Yu the weight ratio of famoxadone is 1: 10～10: 1.
6. contain the bactericidal composition of antibiotic in pyrimidine nucleoside class to 5 described each according to claim 3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqua, microemulsion, aqueous emulsion, microcapsule suspending agent.
7. the bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 6 is used for preventing and treating the application of crop pest.
8. application according to claim 7 is characterized in that: described disease comprises black spot, powdery mildew, anthracnose, banded sclerotial blight, fusarium wilt, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210108918.9A CN103371187B (en) | 2012-04-13 | 2012-04-13 | Bactericidal composition containing antibiotic in pyrimidine nucleoside class |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210108918.9A CN103371187B (en) | 2012-04-13 | 2012-04-13 | Bactericidal composition containing antibiotic in pyrimidine nucleoside class |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103371187A true CN103371187A (en) | 2013-10-30 |
| CN103371187B CN103371187B (en) | 2017-03-08 |
Family
ID=49457508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210108918.9A Active CN103371187B (en) | 2012-04-13 | 2012-04-13 | Bactericidal composition containing antibiotic in pyrimidine nucleoside class |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103371187B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104336080A (en) * | 2014-10-30 | 2015-02-11 | 陕西绿盾生物制品有限责任公司 | Bactericidal composition containing pyrimidine nucleoside antibiotic and hymexazol and application of bactericidal composition |
| CN108178698A (en) * | 2018-03-19 | 2018-06-19 | 联保作物科技有限公司 | Complex composition, agricultural bacteriocide and its application containing antibiotic in pyrimidine nucleoside class and dipotassium hydrogen phosphate |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731230A (en) * | 2009-12-30 | 2010-06-16 | 深圳诺普信农化股份有限公司 | Famoxadone-containing sterilizing composition |
| CN101828575A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and propiconazole compound bactericide |
| CN101828557A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and hexaconazole compound bactericide |
| CN101849543A (en) * | 2010-05-27 | 2010-10-06 | 浙江省桐庐汇丰生物化工有限公司 | Compounded sterilizing agent of pyrimidine nucleoside antibiotics and alkene oxime amine |
| WO2011095134A1 (en) * | 2010-02-05 | 2011-08-11 | Rotam Agrochem International Co.,Ltd | Method for treating fungal infections, fungicidal compositions and their use |
-
2012
- 2012-04-13 CN CN201210108918.9A patent/CN103371187B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731230A (en) * | 2009-12-30 | 2010-06-16 | 深圳诺普信农化股份有限公司 | Famoxadone-containing sterilizing composition |
| WO2011095134A1 (en) * | 2010-02-05 | 2011-08-11 | Rotam Agrochem International Co.,Ltd | Method for treating fungal infections, fungicidal compositions and their use |
| CN101828575A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and propiconazole compound bactericide |
| CN101828557A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and hexaconazole compound bactericide |
| CN101849543A (en) * | 2010-05-27 | 2010-10-06 | 浙江省桐庐汇丰生物化工有限公司 | Compounded sterilizing agent of pyrimidine nucleoside antibiotics and alkene oxime amine |
Non-Patent Citations (2)
| Title |
|---|
| 韩新才等: ""农抗120与多菌灵混配与棉花枯萎病的增效作用研究"", 《棉花学报》 * |
| 韩新才等: ""农抗120和百菌清对辣椒炭疽病菌联合毒力的测定"", 《华中农业大学学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104336080A (en) * | 2014-10-30 | 2015-02-11 | 陕西绿盾生物制品有限责任公司 | Bactericidal composition containing pyrimidine nucleoside antibiotic and hymexazol and application of bactericidal composition |
| CN104336080B (en) * | 2014-10-30 | 2016-08-24 | 陕西麦可罗生物科技有限公司 | A kind of containing antibiotic in pyrimidine nucleoside class and the bactericidal composition of hymexazol and application |
| CN108178698A (en) * | 2018-03-19 | 2018-06-19 | 联保作物科技有限公司 | Complex composition, agricultural bacteriocide and its application containing antibiotic in pyrimidine nucleoside class and dipotassium hydrogen phosphate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103371187B (en) | 2017-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103518770B (en) | Bactericidal composition containing fluopyram and triazole | |
| CN103416428A (en) | Fluxapyroxad-containing sterilization composition | |
| CN103371153A (en) | Sterilization composition with thifluzamide and methoxy acrylics | |
| CN103651538B (en) | A kind of bactericidal composition containing zoxamide | |
| CN103518724B (en) | Bactericidal composition containing fluopyram and methoxyacrylate | |
| CN104336049A (en) | A sterilization composition containing oxathiapiprolin | |
| CN103371187A (en) | Bactericidal composition containing agricultural antibiotic | |
| CN103518741A (en) | Fluopyram-containing high-efficiency bactericidal composition | |
| CN104814019A (en) | Pesticide composition containing fluorine azole activated ester and strobilurin | |
| CN104285954A (en) | Efficient fungicidal composition | |
| CN103355355A (en) | High-efficiency bactericidal composition | |
| CN103444743A (en) | Sterilization composition containing quinoxyfen and methoxy acrylate | |
| CN103843790A (en) | Fungicidal composition containing ametoctradin | |
| CN103651417A (en) | Bactericidal composition containing zoxamide and methoxyacrylate | |
| CN103371189A (en) | Bactericidal composition containing agricultural antibiotic | |
| CN103535362A (en) | Efficient bactericidal composition | |
| CN103371185A (en) | Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics | |
| CN103461338A (en) | Bactericidal composition comprising fenamidone | |
| CN103416427A (en) | Tiadinil containing fungicidal composition | |
| CN103416417A (en) | Sterilization composition containing xemium | |
| CN103688962B (en) | Bactericidal composition containing 1,2,3-benzothiadiazole-7-carboxylic acid, 2,2,2-trifluoroethyl ester | |
| CN105724386A (en) | Fluxapyroxad-containing bacteriocidal composition | |
| CN103651371B (en) | High-efficiency bactericidal composition containing zoxamide | |
| CN103875691B (en) | A kind of high-efficient pesticide composition containing amine benzene pyrrole bacterium ketone | |
| CN104106583A (en) | High-efficiency sterilization composition containing tricyclopyricarb |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Lin Fenlan Inventor before: Zhang Wei |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20170207 Address after: 325025 Zhejiang Binhai Economic and Technological Development Zone of Wenzhou road two building 8 Room 105 Ruifeng Jinyuan Applicant after: Lin Fenlan Address before: 715500 Shaanxi city of Weinan province Shaanxi Pucheng agricultural base industrial park Applicant before: Shaanxi Welch Crop Protection Co., Ltd. |
|
| TA01 | Transfer of patent application right | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181207 Address after: Room 1402, Ziyang Building, 99 Mingzhu Road, Huaishang District, Bengbu City, Anhui Province Patentee after: Bengbu HRABERO Intellectual Property Service Co. Ltd. Address before: 325025 Zhejiang Wenzhou economic and Technological Development Zone two Binhai Ruifeng Jinyuan 8 Building 105 room. Patentee before: Lin Fenlan |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181226 Address after: Room A208, Xuzhou Kechuang Software Park Management Co., Ltd. in Science Park of National University of China Mining University, Jiefangnan Road, Xuzhou City, Jiangsu Province, 221000 Patentee after: Li Yunhao Address before: Room 1402, Ziyang Building, 99 Mingzhu Road, Huaishang District, Bengbu City, Anhui Province Patentee before: Bengbu HRABERO Intellectual Property Service Co. Ltd. |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20191031 Address after: 221000, Jiangsu City, Xuzhou province Pizhou Town Industrial Park Patentee after: Jiangsu love Biotechnology Co., Ltd. Address before: 221000 Jiangsu city in Xuzhou Province, the liberation of South Road, China University of Mining and Technology National University Science and Technology Park Xuzhou Branch Software Park Management Limited A208 room Patentee before: Li Yunhao |
|
| TR01 | Transfer of patent right |