CN103370084B - 苯胺在肟连接的放射稳定化中的应用 - Google Patents

苯胺在肟连接的放射稳定化中的应用 Download PDF

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Publication number
CN103370084B
CN103370084B CN201180068013.7A CN201180068013A CN103370084B CN 103370084 B CN103370084 B CN 103370084B CN 201180068013 A CN201180068013 A CN 201180068013A CN 103370084 B CN103370084 B CN 103370084B
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China
Prior art keywords
radiolabeled
aniline
organic
aldehyde
biological moiety
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CN201180068013.7A
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English (en)
Chinese (zh)
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CN103370084A (zh
Inventor
T.恩格尔
N.奥斯博恩
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180068013.7A 2010-12-21 2011-12-15 苯胺在肟连接的放射稳定化中的应用 Active CN103370084B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201061425399P 2010-12-21 2010-12-21
US61/425399 2010-12-21
US61/425,399 2010-12-21
PCT/US2011/065036 WO2012087725A1 (en) 2010-12-21 2011-12-15 Use of aniline iν the radiostabilization of oxime ligation

Publications (2)

Publication Number Publication Date
CN103370084A CN103370084A (zh) 2013-10-23
CN103370084B true CN103370084B (zh) 2016-11-09

Family

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Family Applications (1)

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CN201180068013.7A Active CN103370084B (zh) 2010-12-21 2011-12-15 苯胺在肟连接的放射稳定化中的应用

Country Status (14)

Country Link
US (1) US9567372B2 (enExample)
EP (1) EP2654798B1 (enExample)
JP (1) JP6067580B2 (enExample)
KR (1) KR20130132941A (enExample)
CN (1) CN103370084B (enExample)
AU (1) AU2011349698A1 (enExample)
BR (1) BR112013015580A2 (enExample)
CA (1) CA2822583A1 (enExample)
ES (1) ES2739504T3 (enExample)
MX (1) MX2013007364A (enExample)
NZ (1) NZ612151A (enExample)
RU (1) RU2013128354A (enExample)
SG (1) SG191218A1 (enExample)
WO (1) WO2012087725A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201209082D0 (en) * 2012-05-24 2012-07-04 Ge Healthcare Ltd Purification method
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) * 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
GB201805253D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Ltd Ip Solid phase extraction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE78642T1 (de) 1981-10-30 1983-10-27 Amersham International Plc, Amersham, Buckinghamshire Radiopharmazeutische zubereitung auf grund von technetium-99m und reagenz zur herstellung derselben.
GB0015242D0 (en) 2000-06-22 2000-08-16 Nycomed Amersham Plc Stabiliser for radiopharmaceuticals
US20040080492A1 (en) 2002-10-23 2004-04-29 Chen Hung Hua Fingerprint access control mouse
GB0224799D0 (en) 2002-10-25 2002-12-04 Amersham Plc Improved complex compositions
GB0305704D0 (en) 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
GB0420344D0 (en) * 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds
GB0522112D0 (en) 2005-10-29 2005-12-07 Ge Healthcare Ltd Novel imaging agents for cancer
GB0718967D0 (en) 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography";Daniel A. Harki, et al.;《PNAS》;20080902;第105卷(第35期);摘要，第13039页右列第3段，第13040页Fig.1、Scheme 1 *
"Site-Specific (18)F-Labeling of the Protein Hormone Leptin Using a General Two-Step Ligation Procedure";Robert R. Flavell, et al.;《J. AM. CHEM. SOC》;20080621;第130卷(第28期);摘要，第9108页左列第2段、Scheme 1及其注解 *

Also Published As

Publication number Publication date
BR112013015580A2 (pt) 2016-10-04
RU2013128354A (ru) 2015-01-27
JP6067580B2 (ja) 2017-01-25
US9567372B2 (en) 2017-02-14
CA2822583A1 (en) 2012-06-28
ES2739504T3 (es) 2020-01-31
US20130274436A1 (en) 2013-10-17
NZ612151A (en) 2015-08-28
EP2654798A1 (en) 2013-10-30
KR20130132941A (ko) 2013-12-05
CN103370084A (zh) 2013-10-23
MX2013007364A (es) 2014-03-21
AU2011349698A1 (en) 2013-07-25
SG191218A1 (en) 2013-07-31
EP2654798B1 (en) 2019-07-03
WO2012087725A1 (en) 2012-06-28
JP2014508126A (ja) 2014-04-03

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