CN103360609A - 一种新型的双亲性的蛋白质-高分子键合体及其制备方法 - Google Patents
一种新型的双亲性的蛋白质-高分子键合体及其制备方法 Download PDFInfo
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- CN103360609A CN103360609A CN2013102990957A CN201310299095A CN103360609A CN 103360609 A CN103360609 A CN 103360609A CN 2013102990957 A CN2013102990957 A CN 2013102990957A CN 201310299095 A CN201310299095 A CN 201310299095A CN 103360609 A CN103360609 A CN 103360609A
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- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 117
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- 108091003079 Bovine Serum Albumin Proteins 0.000 claims abstract description 43
- 229940098773 bovine serum albumin Drugs 0.000 claims abstract description 43
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000000502 dialysis Methods 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 7
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 29
- 238000005576 amination reaction Methods 0.000 claims description 26
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 24
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 24
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000004108 freeze drying Methods 0.000 claims description 14
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112442180A (zh) * | 2019-09-04 | 2021-03-05 | 北京化工大学 | 一种用于促进干细胞界面粘附生长的双亲性聚合物及其制备方法和用途 |
WO2021175275A1 (zh) * | 2020-03-06 | 2021-09-10 | 昆山新蕴达生物科技有限公司 | 疏水性修饰的白蛋白及其制备方法和用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005298486A (ja) * | 2004-03-15 | 2005-10-27 | Nipro Corp | リポソームを含む癌治療用医薬組成物 |
WO2011015634A2 (en) * | 2009-08-05 | 2011-02-10 | Pieris Ag | Controlled release formulations of lipocalin muteins |
CN102697735A (zh) * | 2012-06-18 | 2012-10-03 | 南京大学医学院附属鼓楼医院 | 负载碱性抗肿瘤药物的高分子纳米粒子 |
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- 2013-07-16 CN CN201310299095.7A patent/CN103360609B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005298486A (ja) * | 2004-03-15 | 2005-10-27 | Nipro Corp | リポソームを含む癌治療用医薬組成物 |
WO2011015634A2 (en) * | 2009-08-05 | 2011-02-10 | Pieris Ag | Controlled release formulations of lipocalin muteins |
CN102697735A (zh) * | 2012-06-18 | 2012-10-03 | 南京大学医学院附属鼓楼医院 | 负载碱性抗肿瘤药物的高分子纳米粒子 |
Non-Patent Citations (1)
Title |
---|
侯冬枝等: "牛血清白蛋白脂质体包封率的测定方法研究", 《药学学报》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112442180A (zh) * | 2019-09-04 | 2021-03-05 | 北京化工大学 | 一种用于促进干细胞界面粘附生长的双亲性聚合物及其制备方法和用途 |
WO2021175275A1 (zh) * | 2020-03-06 | 2021-09-10 | 昆山新蕴达生物科技有限公司 | 疏水性修饰的白蛋白及其制备方法和用途 |
CN115397846A (zh) * | 2020-03-06 | 2022-11-25 | 昆山新蕴达生物科技有限公司 | 疏水性修饰的白蛋白及其制备方法和用途 |
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Effective date of registration: 20210908 Address after: Room 109, no.1866, Bohai 12th Road, Port Economic Zone, Binhai New Area, Tianjin 300452 Patentee after: Tianjin Bohua Xinchuang Technology Co.,Ltd. Address before: 300072 Tianjin City, Nankai District Wei Jin Road No. 92, Tianjin University Patentee before: Tianjin University |
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Application publication date: 20131023 Assignee: TIANJIN SHENGJI GROUP Co.,Ltd. Assignor: Tianjin Bohua Xinchuang Technology Co.,Ltd. Contract record no.: X2024980002161 Denomination of invention: A amphiphilic protein polymer bond complex and its preparation method Granted publication date: 20150819 License type: Common License Record date: 20240222 |
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Application publication date: 20131023 Assignee: Tianjin Haiguang Technology Development Co.,Ltd. Assignor: Tianjin Bohua Xinchuang Technology Co.,Ltd. Contract record no.: X2024980003898 Denomination of invention: A amphiphilic protein polymer bond complex and its preparation method Granted publication date: 20150819 License type: Common License Record date: 20240403 |
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