CN103349003A - Deciquam and iodine compound disinfectant and preparation method thereof - Google Patents
Deciquam and iodine compound disinfectant and preparation method thereof Download PDFInfo
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- CN103349003A CN103349003A CN2013102934302A CN201310293430A CN103349003A CN 103349003 A CN103349003 A CN 103349003A CN 2013102934302 A CN2013102934302 A CN 2013102934302A CN 201310293430 A CN201310293430 A CN 201310293430A CN 103349003 A CN103349003 A CN 103349003A
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Abstract
The invention discloses a deciquam and iodine compound disinfectant, which comprises the components by weight percent to prepare an intermediate product: 1.00-4.50 percent of iodine; 0.01-0.10 percent of potassium iodide, 30-50 percent of deciquam; 15-30 percent of surfactant; the balance of solubilizer; the intermediate product is obtained, and then water is added into the intermediate product for dilution so as to obtain the final product. The disinfectant has disinfection efficiency upon the bacteria, and the escherichia coli 8099 is taken as an example and the deciquam solution and the povidone iodine solution are taken as the comparison to conduct a sterilizing experiment to achieve the same disinfection efficiency (sterilizing rate is equal to or greater than 99.9 percent), the minimum concentration of deciquam and iodine of the invention is 25mg/L and 1,25mg/L respectively; the minimum concentration of deciquam in the deciquam solution is 63mg/L, and the minimum concentration of iodine in povidone iodine is 2.5mg/L, and the result indicates that the minimum sterilizing concentration of deciquam and iodine is remarkably reduced. The porcine parvovirus virus is taken as an example to indicate the disinfection efficiency upon the virus of the disinfectant, and the result indicates that the inactivation ratio of the disinfectant reaches over 99.9 percent, while the deciquam solution cannot kill the porcine parvovirus virus. The experiment indicates that iodine and deciquam of the compound disinfectant are subjected to complexing to form an entirety under the action of the surface active agent and the like, and the compound disinfectant has a strong synergistic effect.
Description
Technical field
The present invention relates to a kind of disinfectant, more particularly, relate to first bromine ammonium and the compound disinfectant of iodine and preparation method thereof in a kind of last of the ten Heavenly stems.
Background technology
At present, the kind of disinfectant is numerous on the market, and some are the stronger chemical substances of excitant or corrosivity, and such as formaldehyde, caustic soda, bleaching powder etc., some are the lower chemical substances of excitant or corrosivity, such as the last of the ten Heavenly stems first bromine ammonium, iodine, potassium iodide etc.As the viral therapy of animal and human's class, tend to the disinfectant that uses excitant or the lower chemical substance of corrosivity to make.
The last of the ten Heavenly stems, first bromine ammonium disinfectant character was gentle, therefore, when it is generalized to when clinical as disinfectant, was subject to liking of user, obtained to use more widely, but it has inborn deficiency, that be exactly this type of disinfectant be low effect disinfectants, it can not kill the edema poison.These viruses comprise aphthovirus, PCV-II, bursal disease virus, viral arthritis virus, parvovirus etc., have brought serious epidemic prevention risk.Iodine is broad-spectrum disinfectant, can kill various bacteriums and virus, but iodine is solid, and is insoluble in water, can't be directly used in clinical.Documents and materials show that iodine can not only be dissolved by alcohol, and can be formed the solution that contains iodine by a variety of surface active agent solubilizations, such as, the Betagen Solution that has gone on the market, Povidone-iodine etc.
Although povidone iodine has stronger killing action to staphylococcus aureus, gonococcus, Pseudomonas aeruginosa, microspironema pallidum, AIDS virus etc., but the Betagen Solution less stable, easily make the shortcomings such as sterilization objects is painted.
Summary of the invention
The present invention is intended to solve first bromine ammonium disinfectant and the defects of iodine disinfectant in the last of the ten Heavenly stems, provide a kind of contain the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant of iodine prescription and the preparation method.This prescription or compound disinfectant can remedy the defective of first bromine ammonium disinfectant in the last of the ten Heavenly stems, can bring into play again the advantage of the broad-spectrum disinfectant effect of iodine.
The technical scheme that realizes above-mentioned purpose is: a kind of last of the ten Heavenly stems first bromine ammonium with the compound disinfectant of iodine, after it makes intermediate products by following set of dispense, dilute with water again, the one-tenth finished product, intermediate products comprise the component of following each percetage by weight:
Iodine, 1.00 ~ 4.50;
Potassium iodide, 0.01 ~ 0.10;
The last of the ten Heavenly stems first bromine ammonium, 30 ~ 50;
Surfactant: Macrogol 600 and cetomacrogol 1000,15 ~ 30;
Solubilizer, surplus;
The intermediate products that make are with extraordinarily water dilution of weight 1:1 to 1:40, are configured to the first bromine ammonium and the compound disinfectant of iodine in the last of the ten Heavenly stems of finished product.
Compound disinfectant as previously discussed, wherein, described Macrogol 600 and cetomacrogol 1000, Macrogol 600 accounts for 91-92% in percetage by weight 15 ~ 30, and poly-second 2 1000 accounts for 8-9%.
Compound disinfectant as previously discussed, wherein, described solubilizer is propane diols.
Compound disinfectant as previously discussed, wherein, described last of the ten Heavenly stems, first bromine ammonium and iodine were active ingredient, in intermediate products and final products the last of the ten Heavenly stems first bromine ammonium and the quality ratio of iodine be 40/1～5/1.
A kind of last of the ten Heavenly stems first bromine ammonium and iodine the preparation method of compound disinfectant, wherein, its step is as follows:
Step 1, by described each component and content with the last of the ten Heavenly stems first bromine ammonium, iodine, potassium iodide mixed 1-3 hour 70-85 ℃ of lower the heating;
Step 2 adds surfactant and bleeding agent under above-mentioned heating-up temperature, keep continuing under this temperature to stir 2-10 hour;
Step 3 lets cool, and cooling dress room temperature obtains intermediate products,
Step 4, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution finished product join a certain amount of intermediate products in the quantitative pure water, and even namely the stirring 10-60 minute to fully dissolving, must become the finished product disinfectant of finished product.
A kind of last of the ten Heavenly stems first bromine ammonium and iodine compound disinfectant, after it made intermediate products by following set of dispense, dilute with water became finished product again, intermediate products comprise following component take weight in grams as units:
Iodine, 2.1
Potassium iodide, 0.05;
The last of the ten Heavenly stems first bromine ammonium, 40;
Surfactant: Macrogol 600 and cetomacrogol 1000 21.85;
Solubilizer, 36;
The intermediate products that make are with extraordinarily water dilution of weight 1:1 to 1:40, are configured to the first bromine ammonium and the compound disinfectant of iodine in the last of the ten Heavenly stems of finished product.
Compound disinfectant as previously discussed, wherein, described last of the ten Heavenly stems, first bromine ammonium and iodine were that active ingredient is, the gross weight of described surfactant 21.85 is Macrogol 600 and cetomacrogol 1000 weight sum, therefore, in fact Macrogol 600 and cetomacrogol 1000 are respectively 20 grams and 1.85 grams in the gross weight of surfactant 21.85 grams.
Compound disinfectant as previously discussed, wherein, described solubilizer is propane diols.
A kind of above-mentioned last of the ten Heavenly stems first bromine ammonium and the preparation method of the compound disinfectant of iodine, wherein, its step is as follows:
Step 1, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution intermediate products are pressed the intermediate products prescription, and first bromine ammonium in the last of the ten Heavenly stems, potassium iodide, potassium iodide surfactant and bleeding agent in each percetage by weight scope are joined in the reaction tower, are heated to while stirring 70-85 ℃,
Step 2 adds iodine under above-mentioned heating-up temperature, keeps continuing under this temperature to stir 2-10 hour,
Step 3 lets cool, and cooling dress room temperature obtains intermediate products,
Step 4, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution finished product join a certain amount of intermediate products in the quantitative pure water, stir 10-60 minute, to fully dissolving, become finished product.
For identifying that the compound disinfectant of first bromine ammonium and iodine " last of the ten Heavenly stems " to the disinfection effect of virus, select pig parvoviral as the test seed culture of viruses, take the last of the ten Heavenly stems first bromine ammonium salt solution as contrasting disinfectant, carry out virus and quantitatively kill test.Result of the test is, the last of the ten Heavenly stems, the compound disinfectant of first bromine ammonium and iodine was that doubly (last of the ten Heavenly stems, first bromine ammonium concentration was 50mg/L through 1:1000, iodine concentration is 2.5mg/L) inactivation ratio of pig parvoviral is reached more than 99.9%, and the last of the ten Heavenly stems, first bromine ammonium salt solution doubly diluted (last of the ten Heavenly stems, first bromine ammonium concentration was 625mg/L) through 1:160, can not kill pig parvoviral, not reach the requirement of disinfection effect.
In its disinfection effect test to bacterium, take Escherichia coli 8099 as test strain, and take the last of the ten Heavenly stems first bromine ammonium salt solution and Betagen Solution as the contrast disinfectant, make quantitative disinfecting test, the result shows, when reaching disinfection effect (sterilizing rate 〉=99.9%) by disinfectant of the present invention, the last of the ten Heavenly stems, the least concentration of first bromine ammonium was 25mg/L, and the least concentration of iodine is 1.25mg/L; And contrast disinfectant first in last of the ten Heavenly stems bromine ammonium salt solution is when reaching disinfection effect (sterilizing rate 〉=99.9%), the last of the ten Heavenly stems, the least concentration of first bromine ammonium was 63mg/L, when contrast disinfectant povidone iodine reaches disinfection effect, the least concentration 2.5mg/L of iodine, the result shows, after the last of the ten Heavenly stems, first bromine ammonium and iodine formed compound disinfectant, significantly reduced first bromine ammonium and the minimum bactericidal concentration of iodine in the last of the ten Heavenly stems.
The result show last of the ten Heavenly stems of the present invention first bromine ammonium and the compound disinfectant of iodine in iodine and the complexing under the effect of temperature and surfactant of first bromine ammonium in the last of the ten Heavenly stems be integrated, and has a powerful synergy, thereby enlarged the disinfective action scope of first bromine ammonium in the last of the ten Heavenly stems, so the present invention is the comprehensively disinfectant of good and stable performance of a kind of disinfective action.
Embodiment
Below, the invention will be further described in conjunction with specific embodiments:
A kind of last of the ten Heavenly stems first bromine ammonium and iodine compound disinfectant, after it made intermediate products by following set of dispense, dilute with water became finished product again, intermediate products comprise the component of following each percetage by weight:
Iodine, 1.00 ~ 4.50
Potassium iodide, 0.01 ~ 0.10;
The last of the ten Heavenly stems first bromine ammonium, 30 ~ 50;
Surfactant, 15 ~ 30;
Solubilizer, surplus
The intermediate products that make are with extraordinarily water dilution of weight 1:1 to 1:40, are configured to the first bromine ammonium and the compound disinfectant of iodine in the last of the ten Heavenly stems of finished product.
Wherein, described compound disinfectant as previously discussed, surfactant are Macrogol 600 and cetomacrogol 1000, and Macrogol 600 accounts for 91-92% in its percetage by weight 15 ~ 30, and cetomacrogol 1000 accounts for 8-9%.Described solubilizer is propane diols.Described last of the ten Heavenly stems, first bromine ammonium and iodine were active ingredient, in intermediate products and final products the last of the ten Heavenly stems first bromine ammonium and the quality ratio of iodine be 40/1～5/1.
A kind of above-mentioned last of the ten Heavenly stems first bromine ammonium and iodine one of the preparation method of compound disinfectant, its step is as follows:
Step 1, the intermediate products of the compound disinfectant of configuration first bromine ammonium in the last of the ten Heavenly stems and iodine are pressed the intermediate products prescription, and first bromine ammonium in the last of the ten Heavenly stems, potassium iodide, surfactant and bleeding agent in each percetage by weight scope are joined reaction
TowerIn, be heated to while stirring 70-85 ℃,
Step 2 adds iodine under above-mentioned heating-up temperature, keeps continuing under this temperature to stir 2-10 hour,
Step 3 lets cool, and cooling dress room temperature obtains intermediate products,
Step 4, the finished product of the compound disinfectant of configuration first bromine ammonium in the last of the ten Heavenly stems and iodine joins a certain amount of intermediate products in the quantitative pure water, stirs 10-60 minute, to fully dissolving.
A kind of above-mentioned last of the ten Heavenly stems first bromine ammonium and iodine compound disinfectant the preparation method two, it is characterized in that its step is as follows:
Step 1, by described each component and content with the last of the ten Heavenly stems first bromine ammonium, iodine, potassium iodide mixed 1-3 hour 70-85 ℃ of lower the heating;
Step 2 adds surfactant and bleeding agent under above-mentioned heating-up temperature, keep continuing under this temperature to stir 2-10 hour;
Step 3 lets cool, and cooling dress room temperature obtains intermediate products,
Step 4, the finished product of the compound disinfectant of configuration first bromine ammonium in the last of the ten Heavenly stems and iodine joins a certain amount of intermediate products in the quantitative pure water, and even namely the stirring 10-60 minute to fully dissolving, must become the finished product disinfectant of finished product.
Embodiment A
Weigh and prepare potassium iodide 0.05 gram, last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 and cetomacrogol 1000 21.85 grams, iodine 1.40 grams and propane diols 36.70 grams, amount to 100 grams.
With potassium iodide 0.05 gram, the last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 20 grams, cetomacrogol 1000 1.85 grams, propane diols 36.70 grams join in the beaker, be heated to while stirring certain temperature, after reaching 70-85 ℃ of temperature of setting, add iodine 1.40 grams, continue to stir 6 hours, until iodine dissolves simultaneously while stirring heating fully, to guarantee abundant complexing, obtain first bromine ammonium and the compound disinfectant intermediate products of iodine in the last of the ten Heavenly stems.Let cool, the check of intermediate products quality standard is pressed in sampling, and is qualified for subsequent use.
Dilute with pure water, the sample of preparation first bromine ammonium in the last of the ten Heavenly stems and the compound disinfectant finished product of iodine: with a certain amount of last of the ten Heavenly stems first bromine ammonium and iodine the intermediate products of compound disinfectant with 1:1 to 1:40 times of ratio thin up to 100%, stirred 10-60 minute, to fully dissolving, sampling, by finished product the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant product quality of iodine test.
Embodiment B
Weigh and prepare potassium iodide 0.05 gram, last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 and cetomacrogol 1000 21.85 grams, iodine 2.10 grams and propane diols 36.00 grams, amount to 100.
With potassium iodide 0.05 gram, the last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 20.00 grams, cetomacrogol 1000 1.85 grams, propane diols 36.00 grams join in the beaker, be heated to while stirring certain temperature, after reaching 70-85 ℃ of temperature of setting, add iodine 2.10 grams, continue to stir 6 hours, until iodine dissolves simultaneously while stirring heating fully, to guarantee abundant complexing, obtain first bromine ammonium and the compound disinfectant intermediate products of iodine in the last of the ten Heavenly stems.Let cool, the check of intermediate products quality standard is pressed in sampling, and is qualified for subsequent use.
Dilute with pure water, the sample of preparation first bromine ammonium in the last of the ten Heavenly stems and the compound disinfectant finished product of iodine: with a certain amount of last of the ten Heavenly stems first bromine ammonium, iodine solution intermediate products with 1:1 to 1:40 times of ratio thin up to 100%, stirred 10-60 minute, to fully dissolving, sampling, by finished product the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant product quality of iodine test.
Embodiment C
Weigh and prepare potassium iodide 0.05 gram, last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 and cetomacrogol 1000 21.85 grams, iodine 4.20 grams and propane diols 33.90 grams, amount to 100.
With potassium iodide 0.05 gram, the last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 20.00 grams, cetomacrogol 1000 1.85 grams, propane diols 33.90 gram grams join in the beaker, be heated to while stirring certain temperature, after reaching 70-85 ℃ of temperature of setting, add iodine 4.20 grams, continue to stir 6 hours, until iodine dissolves simultaneously while stirring heating fully, to guarantee abundant complexing, obtain first bromine ammonium and the compound disinfectant intermediate products of iodine in the last of the ten Heavenly stems.Let cool, the check of intermediate products quality standard is pressed in sampling, and is qualified for subsequent use.
Dilute with pure water, the sample of preparation first bromine ammonium in the last of the ten Heavenly stems and the compound disinfectant finished product of iodine: with a certain amount of last of the ten Heavenly stems first bromine ammonium and iodine the intermediate products of compound disinfectant with 1:1 to 1:40 times of ratio thin up to 100%, stirred 10-60 minute, to fully dissolving, sampling, by finished product the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant product quality of iodine test;
Embodiment D
Weigh and prepare potassium iodide 0.05 gram, last of the ten Heavenly stems first bromine ammonium 20 grams, Macrogol 600 and cetomacrogol 1000 21.85 grams, iodine 4.20 grams and propane diols 53.90 grams, amount to 100.
With potassium iodide 0.05 gram, the last of the ten Heavenly stems first bromine ammonium 40 grams, 4.20, Macrogol 600 20.00 grams, cetomacrogol 1000 1.85 grams, propane diols 53.90 grams join in the beaker, be heated to while stirring certain temperature, after reaching 70-85 ℃ of temperature of setting, add iodine 4.20 grams, continue to stir 8 hours, until iodine dissolves simultaneously while stirring heating fully, to guarantee abundant complexing, obtain first bromine ammonium and the compound disinfectant intermediate products of iodine in the last of the ten Heavenly stems.Let cool, the check of intermediate products quality standard is pressed in sampling, and is qualified for subsequent use.
Dilute with pure water, the sample of preparation first bromine ammonium in the last of the ten Heavenly stems and the compound disinfectant finished product of iodine: with a certain amount of last of the ten Heavenly stems first bromine ammonium and iodine the intermediate products of compound disinfectant with 1:1 to 1:40 times of ratio thin up to 100%, stirred 10-60 minute, to fully dissolving, sampling, by finished product the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant product quality of iodine test.
Embodiment E
Weigh and prepare potassium iodide 0.05 gram, last of the ten Heavenly stems first bromine ammonium 20 grams, Macrogol 600 and cetomacrogol 1000 21.85 grams, iodine 8.40 grams and propane diols 49.70 grams, amount to 100.
With potassium iodide 0.05 gram, the last of the ten Heavenly stems first bromine ammonium 40 grams, Macrogol 600 20.00 grams, cetomacrogol 1000 1.85 grams, propane diols 49.70 grams join in the beaker, be heated to while stirring certain temperature, after reaching 70-85 ℃ of temperature of setting, add iodine 8.40 grams, continue to stir 7 hours, until iodine dissolves simultaneously while stirring heating fully, to guarantee abundant complexing, obtain first bromine ammonium and the compound disinfectant intermediate products of iodine in the last of the ten Heavenly stems.Let cool, the check of intermediate products quality standard is pressed in sampling, and is qualified for subsequent use.
Dilute with pure water, the sample of preparation first bromine ammonium in the last of the ten Heavenly stems and the compound disinfectant finished product of iodine: with a certain amount of last of the ten Heavenly stems first bromine ammonium and iodine the intermediate products of compound disinfectant with 1:1 to 1:40 times of ratio thin up to 100%, stirred 10-60 minute, to fully dissolving, sampling, by finished product the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant product quality of iodine test.
In five prescriptions of the A-E of preparation, from five aspects tests such as proterties, color, clarity and the emulsion stability of solution, stable content intermediate products, prescription A, prescription B and prescription C are preferably, and solution is reddish brown, the dissolving clear, stable content.
1, by aspects such as its proterties, the color of the solution, clarity, pH value, assay, emulsion stabilities, test.
1.1. prescription A, prescription B, prescription C, prescription D and prescription E preparation technology are by the above technical process preparation first bromine ammonium in the last of the ten Heavenly stems that provides and the compound disinfectant of iodine, sampling, packing.
1.2. outward appearance, color, clarity are observed, get the last of the ten Heavenly stems first bromine ammonium and the sample of the compound disinfectant intermediate products of iodine and finished product (finished product) a small amount of, put in the test tube, observe solution colour and clarity, take solution clarification and be brownish red as qualified, occur muddy and color is not rufous is defective.In five prescriptions of the A-E for preparing, from five aspects test intermediate products such as proterties, color, clarity and the emulsion stability of solution, stable content and finished product, prescription A, prescription B and prescription C are preferably, and solution is reddish brown, the dissolving clear, stable content; The color of prescription D sample is relatively poor between reddish brown and khaki; The color of prescription E intermediate products sample is khaki, and the finished product sample that is made into also for khaki, is judged undesirable.
1.3. emulsion stability inspection: get first bromine ammonium and the compound disinfectant finished product of iodine in the last of the ten Heavenly stems, the emulsion stability detection method is carried out routinely respectively, the result as can be known, by prescription A, prescription B and the finished product that is made into of prescription C, the solution clear, without any precipitation, layering without muddy, without phenomenons such as oil slick.The finished product sample that prescription D, prescription E are made into, solution is clear not, and precipitation is arranged, and the E that especially fills a prescription is the most serious.
1.4. assay: under different pH values on assay result's the impact of compound disinfectant of last of the ten Heavenly stems first bromine ammonium and iodine.In experiment, respectively in 0-10 days, the temperature of regulation and pH value 1.5-6.5 situation, measuring respectively prescription B and prescription C finished product sample sample time, consequently in the pH value scope, pH has no appreciable impact to the content of compound disinfectant of the last of the ten Heavenly stems first bromine ammonium and iodine.
1.5. determining of pH value scope
Get the finished product sample of preliminary qualified prescription, with soda acid the pH value of solution is adjusted to respectively 1.5,2,2.5,3,3.5,4,4.5,5,5.5,6.5, observe the pH value to the impact of the proterties of finished product sample.Test shows in the scope of pH value 1.5～6.5, on get the last of the ten Heavenly stems first bromine ammonium and the proterties of the compound disinfectant of iodine without impact.
2, the last of the ten Heavenly stems first bromine ammonium and iodine the clinical practice of compound disinfectant:
In the quantitative disinfecting test, the last of the ten Heavenly stems first bromine ammonium and iodine compound disinfectant when reaching disinfection effect (sterilization Shuai＞=99.9%), the last of the ten Heavenly stems, the least concentration of first bromine ammonium was 25mg/L, the least concentration of iodine is 1.25mg/L, and contrast disinfectant first in last of the ten Heavenly stems bromine ammonium salt solution is when reaching disinfection effect (sterilization Shuai＞=99.9%), the last of the ten Heavenly stems, the least concentration of first bromine ammonium was 62.5mg/L, and when contrast disinfectant Betagen Solution reached the disinfection effect of virus, the least concentration of iodine was 2.5mg/L..Above result shows that the last of the ten Heavenly stems, first bromine ammonium significantly reduced first bromine ammonium and the minimum bactericidal concentration of iodine in the last of the ten Heavenly stems with the compound disinfectant of iodine, therefore tests to show that this disinfectant demonstrates good synergy at disinfection effect.
At the scene in the sterilizing test, with the last of the ten Heavenly stems first bromine ammonium and iodine compound disinfecting agent concentration 25mg/L(in first bromine ammonium in the last of the ten Heavenly stems) dilution sparge bird colony house and sparging in the air, the 10 minutes sterilization Shuai to colony house surface natural bacteria＞=99.94% of sterilizing, prove that thus this compound disinfectant is good to the Disinfection Effect of environment.
In the disinfection of drinking water test, the compound disinfectant of first bromine ammonium and iodine is made into 0.0005% solution (in first bromine ammonium in the last of the ten Heavenly stems) with the last of the ten Heavenly stems, to natural water-like sterilization 10 minutes, and can 100% bacterium of killing in the drinking water.
Compound disinfectant and the water of first bromine ammonium and iodine can 99.97% be killed the hydrophilic viruseses such as pig parvoviral the last of the ten Heavenly stems with 1:1000 dilution, can not kill the deficiency of hydrophilic viruses thereby overcome last of the ten Heavenly stems first bromine ammonium.
The last of the ten Heavenly stems, first bromine ammonium was with after the compound disinfectant available water of iodine is converted into the solution of requirement concentration, used in modes such as immersion, sprinkling or sprayings.
Claims (10)
- One kind the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant of iodine, after it made intermediate products by following set of dispense, dilute with water became finished product again, intermediate products comprise the component of following each percetage by weight:Iodine, 1.00 ~ 4.50;Potassium iodide, 0.01 ~ 0.10;The last of the ten Heavenly stems first bromine ammonium, 30 ~ 50;Surfactant: Macrogol 600 and cetomacrogol 1000,15 ~ 30;Solubilizer, surplus;The intermediate products that make are with extraordinarily water dilution of weight 1:1 to 1:40, are configured to the first bromine ammonium and the compound disinfectant of iodine in the last of the ten Heavenly stems of finished product.
- 2. compound disinfectant according to claim 1 is characterized in that, described Macrogol 600 and cetomacrogol 1000 Macrogol 600 in percetage by weight 15 ~ 30 accounts for 91-92%, and cetomacrogol 1000 accounts for 8-9%.
- 3. compound disinfectant according to claim 1 is characterized in that, described solubilizer is propane diols.
- 4. each described compound disinfectant in 3 according to claim 1 is characterized in that, described last of the ten Heavenly stems, first bromine ammonium and iodine were active ingredient, in intermediate products and in the final products last of the ten Heavenly stems first bromine ammonium and the quality ratio of iodine be 40/1～5/1.
- One kind last of the ten Heavenly stems according to claim 1 first bromine ammonium and the preparation method of the compound disinfectant of iodine, it is characterized in that its step is as follows:Step 1, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution intermediate products are pressed the intermediate products prescription, and first bromine ammonium in the last of the ten Heavenly stems, potassium iodide, surfactant and bleeding agent in each percetage by weight scope are joined in the device, are heated to while stirring 70-85 ℃,Step 2 adds iodine under above-mentioned heating-up temperature, keeps continuing under this temperature to stir 2-10 hour,Step 3 lets cool, and cooling dress room temperature obtains intermediate products,Step 4, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution finished product join a certain amount of intermediate products in the quantitative pure water, stir 10-60 minute, to fully dissolving.
- One kind last of the ten Heavenly stems according to claim 1 first bromine ammonium and the preparation method of the compound disinfectant of iodine, it is characterized in that its step is as follows:Step 1, by described each component and content with the last of the ten Heavenly stems first bromine ammonium, iodine, potassium iodide mixed 1-3 hour 70-85 ℃ of lower the heating;Step 2 adds surfactant and bleeding agent under above-mentioned heating-up temperature, keep continuing under this temperature to stir 2-10 hour;Step 3 lets cool, and cooling dress room temperature obtains intermediate products,Step 4, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution finished product join a certain amount of intermediate products in the quantitative pure water, and even namely the stirring 10-60 minute to fully dissolving, gets the finished product disinfectant.
- One kind the last of the ten Heavenly stems first bromine ammonium and the compound disinfectant of iodine, after it made intermediate products by following set of dispense, dilute with water became finished product again, intermediate products comprise following component take weight in grams as unit:Iodine, 2.1;Potassium iodide, 0.05;The last of the ten Heavenly stems first bromine ammonium, 40;Surfactant: Macrogol 600 and cetomacrogol 1000,21.85;Solubilizer, 36;The intermediate products that make are with extraordinarily water dilution of weight 1:1 to 1:40, are configured to the first bromine ammonium and the compound disinfectant of iodine in the last of the ten Heavenly stems of finished product.
- 8. compound disinfectant according to claim 7 is characterized in that, described Macrogol 600 and cetomacrogol 1000 are respectively 20 grams and 1.85 grams in the gross weight of surfactant 21.85 grams.
- 9. according to claim 7 or 8 described compound disinfectants, it is characterized in that described solubilizer is propane diols.
- One kind last of the ten Heavenly stems according to claim 7 first bromine ammonium and the preparation method of the compound disinfectant of iodine, it is characterized in that its step is as follows:Step 1, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution intermediate products are pressed the intermediate products prescription, and first bromine ammonium in the last of the ten Heavenly stems, potassium iodide, potassium iodide surfactant and bleeding agent in each percetage by weight scope are joined in the reaction tower, are heated to while stirring 70-85 ℃,Step 2 adds iodine under above-mentioned heating-up temperature, keeps continuing under this temperature to stir 2-10 hour,Step 3 lets cool, and cooling dress room temperature obtains intermediate products,Step 4, configuration first bromine ammonium in the last of the ten Heavenly stems, iodine solution finished product join a certain amount of intermediate products in the quantitative pure water, stirred 10-60 minute, to fully dissolving,, as the one-tenth finished product of finished product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN108077252A (en) * | 2017-12-22 | 2018-05-29 | 北京长江脉医药科技有限责任公司 | Double-chain quaternary ammonium salt thimerosal |
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