CN103347899B - 葡聚糖凝胶 - Google Patents

葡聚糖凝胶 Download PDF

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Publication number
CN103347899B
CN103347899B CN201180056825.XA CN201180056825A CN103347899B CN 103347899 B CN103347899 B CN 103347899B CN 201180056825 A CN201180056825 A CN 201180056825A CN 103347899 B CN103347899 B CN 103347899B
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CN
China
Prior art keywords
dextran
gel
glucosan
glucan
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180056825.XA
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English (en)
Chinese (zh)
Other versions
CN103347899A (zh
Inventor
罗尔夫·英斯塔德
斯坦因·特勒·索利姆
达戈·埃里克·拉姆塞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beta Glucan Biology Co ltd
Original Assignee
Biotec Pharmacon ASA
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Publication of CN103347899A publication Critical patent/CN103347899A/zh
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Publication of CN103347899B publication Critical patent/CN103347899B/zh
Expired - Fee Related legal-status Critical Current
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
CN201180056825.XA 2010-11-29 2011-11-29 葡聚糖凝胶 Expired - Fee Related CN103347899B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1020191.1 2010-11-29
GBGB1020191.1A GB201020191D0 (en) 2010-11-29 2010-11-29 Glucan gels
PCT/GB2011/052358 WO2012073019A1 (en) 2010-11-29 2011-11-29 Glucan gels

Publications (2)

Publication Number Publication Date
CN103347899A CN103347899A (zh) 2013-10-09
CN103347899B true CN103347899B (zh) 2016-08-17

Family

ID=43500783

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180056825.XA Expired - Fee Related CN103347899B (zh) 2010-11-29 2011-11-29 葡聚糖凝胶

Country Status (8)

Country Link
US (2) US9314432B2 (enExample)
EP (1) EP2646476B1 (enExample)
JP (1) JP5932825B2 (enExample)
KR (1) KR20130121138A (enExample)
CN (1) CN103347899B (enExample)
CA (1) CA2818648C (enExample)
GB (1) GB201020191D0 (enExample)
WO (1) WO2012073019A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT514137A1 (de) 2013-04-05 2014-10-15 Lenzing Akiengesellschaft Polysaccharidfaser und Verfahren zu ihrer Herstellung
AT514468A1 (de) 2013-06-17 2015-01-15 Lenzing Akiengesellschaft Hochsaugfähige Polysaccharidfaser und ihre Verwendung
AT514474B1 (de) 2013-06-18 2016-02-15 Chemiefaser Lenzing Ag Polysaccharidfaser und Verfahren zu ihrer Herstellung
AT518612B1 (de) 2015-02-06 2019-03-15 Chemiefaser Lenzing Ag Polysaccharid-Suspension, Verfahren zu ihrer Herstellung und ihre Verwendung
CN112402443B (zh) * 2019-08-22 2024-12-31 广州立恩生物科技有限公司 用于预防和治疗口腔疾病的生物多糖及其应用
CN111329875B (zh) * 2020-02-26 2023-07-21 好维股份有限公司 用于修复口腔软组织细胞的口腔护理组合物及应用
US11572420B1 (en) 2021-07-30 2023-02-07 Tissue repair ltd Isolated biological polysaccharide compound, methods of use and methods of manufacture thereof
US11384160B1 (en) 2021-07-30 2022-07-12 Tissue repair ltd Method of making a beta glucan compound
CN116239706B (zh) * 2022-10-24 2024-06-21 湖北中医药大学 一种直链茯苓β-葡聚糖及其提取方法和应用
CN116584552B (zh) * 2023-05-19 2024-03-26 江南大学 一种基于葡聚糖自主装交联多维度乳液凝胶的制备及应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158772A (en) * 1991-09-23 1992-10-27 Davis Walter B Unique bacterial polysaccharide polymer gel in cosmetics, pharmaceuticals and foods
CN101353383A (zh) * 2008-09-17 2009-01-28 山东京博控股发展有限公司 水溶性酵母β-葡聚糖及其制备方法
CN101394898A (zh) * 2005-11-30 2009-03-25 西巴控股公司 葡聚糖组合物
CN101426510A (zh) * 2006-01-17 2009-05-06 斯隆-凯特林癌症研究院 增强治疗的酵母葡聚糖
CN101878033A (zh) * 2007-11-13 2010-11-03 生物科技医药公司 治疗或预防肠道炎症性疾病的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503952A (ja) 1989-09-08 1993-06-24 アルファ ベータ テクノロジー,インコーポレイティッド 可溶性グルカン類の製造方法
NO300692B1 (no) 1994-04-29 1997-07-07 Biotec Mackzymal As Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan
AUPN166195A0 (en) * 1995-03-13 1995-04-06 Norvet Research Pty Limited Process for glucan extraction
US5980918A (en) 1997-10-24 1999-11-09 Brennen Medical, Inc. β-D-glucan topical composition
US6875754B1 (en) 1999-03-12 2005-04-05 Biotec Asa Use of water-soluble β-(1,3) glucans as agents for producing therapeutic skin treatment agents
AU2001282708B2 (en) * 2000-07-03 2007-01-04 Granate Seed Limited Cold water soluble beta-glucan product and process for preparing the same
EP1357919B1 (en) 2001-01-16 2017-04-05 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
GB0225502D0 (en) 2002-11-01 2002-12-11 Zoolife Internat Ltd Therapeutic and prophylactic preparations
US8323644B2 (en) * 2006-01-17 2012-12-04 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
WO2008102151A1 (en) 2007-02-21 2008-08-28 Biotec Pharmacon Asa Medical uses of glucans

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158772A (en) * 1991-09-23 1992-10-27 Davis Walter B Unique bacterial polysaccharide polymer gel in cosmetics, pharmaceuticals and foods
CN101394898A (zh) * 2005-11-30 2009-03-25 西巴控股公司 葡聚糖组合物
CN101426510A (zh) * 2006-01-17 2009-05-06 斯隆-凯特林癌症研究院 增强治疗的酵母葡聚糖
CN101878033A (zh) * 2007-11-13 2010-11-03 生物科技医药公司 治疗或预防肠道炎症性疾病的方法
CN101353383A (zh) * 2008-09-17 2009-01-28 山东京博控股发展有限公司 水溶性酵母β-葡聚糖及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
热凝胶多糖(Curdlan)生产工艺及其分子结构的研究;李卫旗;《中国优秀博硕士学位论文全文数据库 (博士) 工程科技Ⅰ辑 》;20040915(第 03 期);全文 *

Also Published As

Publication number Publication date
EP2646476B1 (en) 2017-01-25
US9750688B2 (en) 2017-09-05
JP5932825B2 (ja) 2016-06-08
WO2012073019A1 (en) 2012-06-07
CA2818648C (en) 2016-11-15
KR20130121138A (ko) 2013-11-05
CN103347899A (zh) 2013-10-09
EP2646476A1 (en) 2013-10-09
GB201020191D0 (en) 2011-01-12
JP2013544937A (ja) 2013-12-19
US20130315979A1 (en) 2013-11-28
US20160256385A1 (en) 2016-09-08
US9314432B2 (en) 2016-04-19
CA2818648A1 (en) 2012-06-07

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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Effective date of registration: 20210303

Address after: Tromso

Patentee after: Beta glucan biology Co.,Ltd.

Address before: Tromso

Patentee before: BIOTEC PHARMACON ASA

TR01 Transfer of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160817

CF01 Termination of patent right due to non-payment of annual fee