CN103347499B - 通过错流过滤进行的液体介质交换在制备药物混悬液中的用途 - Google Patents

通过错流过滤进行的液体介质交换在制备药物混悬液中的用途 Download PDF

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Publication number
CN103347499B
CN103347499B CN201280005390.0A CN201280005390A CN103347499B CN 103347499 B CN103347499 B CN 103347499B CN 201280005390 A CN201280005390 A CN 201280005390A CN 103347499 B CN103347499 B CN 103347499B
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China
Prior art keywords
suspension
liquid medium
diafiltration
drug
particles
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CN201280005390.0A
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English (en)
Chinese (zh)
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CN103347499A (zh
Inventor
H·P·尼伊德曼恩
H·博特
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Intervet International BV
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Intervet International BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
CN201280005390.0A 2011-01-12 2012-01-11 通过错流过滤进行的液体介质交换在制备药物混悬液中的用途 Active CN103347499B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161431942P 2011-01-12 2011-01-12
US61/431,942 2011-01-12
PCT/EP2012/050336 WO2012095439A1 (en) 2011-01-12 2012-01-11 Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions

Publications (2)

Publication Number Publication Date
CN103347499A CN103347499A (zh) 2013-10-09
CN103347499B true CN103347499B (zh) 2017-04-05

Family

ID=45478323

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CN201280005390.0A Active CN103347499B (zh) 2011-01-12 2012-01-11 通过错流过滤进行的液体介质交换在制备药物混悬液中的用途

Country Status (10)

Country Link
US (1) US9066864B2 (enExample)
EP (1) EP2663287A1 (enExample)
JP (1) JP5934719B2 (enExample)
CN (1) CN103347499B (enExample)
AU (1) AU2012206621B2 (enExample)
BR (1) BR112013016851B1 (enExample)
CA (1) CA2823972C (enExample)
MX (1) MX346749B (enExample)
SG (2) SG10201807631SA (enExample)
WO (1) WO2012095439A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6478959B2 (ja) * 2016-09-07 2019-03-06 株式会社富士薬品 粒子含有組成物を製造するためのシステム及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705483A (zh) * 2002-10-25 2005-12-07 阿克佐诺贝尔公司 延长释放的药物组合物
CN1735403A (zh) * 2002-12-18 2006-02-15 奇斯药制品公司 用于吸入的含有微粒化结晶活性组分的无菌含水悬浮液的制备

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340580B1 (en) 1999-05-12 2002-01-22 Metabolix, Inc. Methods for purifying polyhydroxy alkanoates
WO2001021290A1 (en) * 1999-09-17 2001-03-29 Danish Separation Systems As A method and an apparatus for continuous cross-flow diafiltration
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
WO2003055469A1 (en) * 2001-12-21 2003-07-10 Celator Technologies Inc. Improved polymer-lipid delivery vehicles
WO2003063877A1 (en) 2002-02-01 2003-08-07 Akzo Nobel N.V. Cefquinome composition for intra-mammary administration in cattle
WO2011072218A2 (en) * 2009-12-11 2011-06-16 Bind Biosciences Stable formulations for lyophilizing therapeutic particles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705483A (zh) * 2002-10-25 2005-12-07 阿克佐诺贝尔公司 延长释放的药物组合物
CN1735403A (zh) * 2002-12-18 2006-02-15 奇斯药制品公司 用于吸入的含有微粒化结晶活性组分的无菌含水悬浮液的制备

Also Published As

Publication number Publication date
BR112013016851B1 (pt) 2021-08-31
US20130281425A1 (en) 2013-10-24
WO2012095439A1 (en) 2012-07-19
SG10201807631SA (en) 2018-10-30
US9066864B2 (en) 2015-06-30
EP2663287A1 (en) 2013-11-20
CN103347499A (zh) 2013-10-09
BR112013016851A2 (pt) 2016-10-04
CA2823972C (en) 2019-05-28
CA2823972A1 (en) 2012-07-19
JP5934719B2 (ja) 2016-06-15
JP2014502624A (ja) 2014-02-03
SG191963A1 (en) 2013-08-30
MX346749B (es) 2017-03-29
MX2013008118A (es) 2013-08-12
AU2012206621B2 (en) 2017-04-27
AU2012206621A1 (en) 2013-07-04

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