CN103342679A - 可用作血管加压素拮抗剂的苯并氮杂*衍生物 - Google Patents
可用作血管加压素拮抗剂的苯并氮杂*衍生物 Download PDFInfo
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- CN103342679A CN103342679A CN2013101948844A CN201310194884A CN103342679A CN 103342679 A CN103342679 A CN 103342679A CN 2013101948844 A CN2013101948844 A CN 2013101948844A CN 201310194884 A CN201310194884 A CN 201310194884A CN 103342679 A CN103342679 A CN 103342679A
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- Prior art keywords
- methyl
- compound
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- benzo
- salt
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- 229940116211 Vasopressin antagonist Drugs 0.000 title description 5
- 239000003038 vasopressin antagonist Substances 0.000 title description 5
- 150000008038 benzoazepines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 44
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 19
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 18
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- 229910052760 oxygen Inorganic materials 0.000 claims description 55
- 150000003839 salts Chemical class 0.000 claims description 42
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 23
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
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- 239000003071 vasodilator agent Substances 0.000 claims description 4
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims description 3
- 239000003146 anticoagulant agent Substances 0.000 claims description 2
- 229940127219 anticoagulant drug Drugs 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
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- -1 benzazepine compound Chemical class 0.000 abstract description 195
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 14
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- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 12
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- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 11
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- 238000003756 stirring Methods 0.000 description 11
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| JP2007167207 | 2007-06-26 | ||
| JP2007-167207 | 2007-06-26 |
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| CN200880022253A Division CN101687805A (zh) | 2007-06-26 | 2008-06-26 | 可用作血管加压素拮抗剂的苯并氮杂衍生物 |
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| CN2013101949565A Pending CN103342680A (zh) | 2007-06-26 | 2008-06-26 | 可用作血管加压素拮抗剂的苯并氮杂*衍生物 |
| CN2013101948844A Pending CN103342679A (zh) | 2007-06-26 | 2008-06-26 | 可用作血管加压素拮抗剂的苯并氮杂*衍生物 |
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| CN200880022253A Pending CN101687805A (zh) | 2007-06-26 | 2008-06-26 | 可用作血管加压素拮抗剂的苯并氮杂衍生物 |
| CN2013101949565A Pending CN103342680A (zh) | 2007-06-26 | 2008-06-26 | 可用作血管加压素拮抗剂的苯并氮杂*衍生物 |
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| EP (3) | EP2374797B1 (OSRAM) |
| JP (3) | JP5653043B2 (OSRAM) |
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| CN (3) | CN101687805A (OSRAM) |
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| AT (1) | ATE545633T1 (OSRAM) |
| AU (1) | AU2008269918B2 (OSRAM) |
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| DK (3) | DK2374797T3 (OSRAM) |
| ES (3) | ES2431515T3 (OSRAM) |
| HR (3) | HRP20120310T1 (OSRAM) |
| IL (1) | IL202561A0 (OSRAM) |
| MY (3) | MY152805A (OSRAM) |
| NZ (3) | NZ598064A (OSRAM) |
| PH (2) | PH12012501362A1 (OSRAM) |
| PL (3) | PL2170831T3 (OSRAM) |
| PT (3) | PT2170831E (OSRAM) |
| RU (1) | RU2471784C2 (OSRAM) |
| SG (2) | SG182230A1 (OSRAM) |
| SI (3) | SI2374798T1 (OSRAM) |
| TW (1) | TWI459947B (OSRAM) |
| UA (1) | UA98966C2 (OSRAM) |
| WO (1) | WO2009001968A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022171160A1 (zh) * | 2021-02-10 | 2022-08-18 | 上海森辉医药有限公司 | 苯并氮杂䓬类化合物及其制备方法和医药用途 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI459947B (zh) * | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | 苯并氮呯化合物及藥學製劑 |
| JP5656399B2 (ja) * | 2008-12-26 | 2015-01-21 | 大塚製薬株式会社 | 医薬及び医薬製剤 |
| CN102030709B (zh) * | 2009-09-25 | 2013-10-16 | 江苏豪森医药集团有限公司 | 用作加压素受体拮抗剂的苯并氮杂卓类化合物 |
| SG10201406839VA (en) * | 2009-10-26 | 2014-12-30 | Otsuka Pharma Co Ltd | Benzazepine compound |
| GB201105537D0 (en) | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
| CN102260213B (zh) * | 2011-05-31 | 2013-05-15 | 重庆福安药业(集团)股份有限公司 | 一种托伐普坦的制备方法 |
| TWI704919B (zh) | 2012-05-31 | 2020-09-21 | 日商大塚製藥股份有限公司 | 用於預防及/或治療多囊性腎臟病之藥物 |
| WO2014104412A1 (en) * | 2012-12-28 | 2014-07-03 | Otsuka Pharmaceutical Co., Ltd. | Injectable depot formulation comprising optically active tolvaptan and process of producing the same |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| TWI660748B (zh) * | 2013-03-01 | 2019-06-01 | 日商大塚製藥股份有限公司 | 用於口服投藥之包含非晶型托伐普坦（Ｔｏｌｖａｐｔａｎ）的懸浮液 |
| TW201605488A (zh) | 2013-10-15 | 2016-02-16 | 大塚製藥股份有限公司 | 用以預防及／或治療多囊腎病之藥物 |
| US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
| WO2019003433A1 (ja) * | 2017-06-30 | 2019-01-03 | 大塚製薬株式会社 | ベンゾアゼピン誘導体 |
| CN107540672A (zh) * | 2017-10-10 | 2018-01-05 | 牡丹江医学院 | 一种治疗肝硬化的药物及其合成方法 |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| JP2020011957A (ja) * | 2019-07-22 | 2020-01-23 | コルセア ファーマ インコーポレイテッド | トレプロスチニル誘導体化合物およびその使用方法 |
| CN112851583B (zh) * | 2021-01-19 | 2023-09-08 | 徐州医科大学 | 新型苯并氮杂䓬类化合物、组合物及其用途 |
| CN113112528A (zh) * | 2021-04-26 | 2021-07-13 | 中南财经政法大学 | 异常行为监控方法、装置、设备及存储介质 |
Citations (3)
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| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| CN1091288A (zh) * | 1992-07-02 | 1994-08-31 | 大制药株式会社 | 催产素对抗剂 |
| US5622947A (en) * | 1992-10-16 | 1997-04-22 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds and vasopressin antagonist and oxytocin antagonist compositions containing a benzoheterocyclic compound |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045478A (en) * | 1986-03-03 | 1991-09-03 | Becton Dickinson And Company | Vesicles and use thereof in an assay |
| GB9726695D0 (en) * | 1997-12-17 | 1998-02-18 | Smithkline Beecham Plc | Novel compounds |
| JP4210355B2 (ja) | 1997-07-03 | 2009-01-14 | 大塚製薬株式会社 | 固形製剤組成物 |
| PT1117659E (pt) * | 1998-09-29 | 2004-04-30 | Wyeth Corp | Cianoquinolinas substituidas como inibidores de tirosina-quinases de proteinas |
| ATE264295T1 (de) * | 2000-05-15 | 2004-04-15 | Paratek Pharm Innc | 7-substituierte kondensierte ring-tetrazyclin- verbindungen |
| WO2006050421A1 (en) * | 2004-11-02 | 2006-05-11 | New River Pharmaceuticals Inc. | Prodrugs of ribavirin with improved hepatic delivery |
| AU2006330277B2 (en) * | 2005-12-27 | 2011-10-06 | Otsuka Pharmaceutical Co., Ltd. | Water-soluble benzoazepine compound and its pharmaceutical composition |
| TWI459947B (zh) * | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | 苯并氮呯化合物及藥學製劑 |
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Patent Citations (3)
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| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| CN1091288A (zh) * | 1992-07-02 | 1994-08-31 | 大制药株式会社 | 催产素对抗剂 |
| US5622947A (en) * | 1992-10-16 | 1997-04-22 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds and vasopressin antagonist and oxytocin antagonist compositions containing a benzoheterocyclic compound |
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| MATSUBARA, JUN ET AL: "An efficient synthesis of optical isomers of vasopressin V2 receptor antagonist OPC-41061 by lipase-catalyzed enantioselective transesterification", 《HETEROCYCLES》 * |
| YAMASHITA, HIROSHI ET AL: "Practical synthesis of both enantiomers of vasopressin V2 receptor antagonist OPC-41061 using the catalytic asymmetric hydrogenation", 《HETEROCYCLES》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022171160A1 (zh) * | 2021-02-10 | 2022-08-18 | 上海森辉医药有限公司 | 苯并氮杂䓬类化合物及其制备方法和医药用途 |
| CN116744935A (zh) * | 2021-02-10 | 2023-09-12 | 上海森辉医药有限公司 | 苯并氮杂䓬类化合物及其制备方法和医药用途 |
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