CN103339148A - 特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体的alphabody - Google Patents

特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体的alphabody Download PDF

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Publication number
CN103339148A
CN103339148A CN2012800046860A CN201280004686A CN103339148A CN 103339148 A CN103339148 A CN 103339148A CN 2012800046860 A CN2012800046860 A CN 2012800046860A CN 201280004686 A CN201280004686 A CN 201280004686A CN 103339148 A CN103339148 A CN 103339148A
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CN
China
Prior art keywords
alphabody
cytokine
chemokine
motif
polypeptide
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Pending
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CN2012800046860A
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English (en)
Chinese (zh)
Inventor
I·拉斯特斯
J·德斯梅特
M·亨德里克斯
A·韦纳特
G·梅尔瑟曼
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Complix NV
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Complix NV
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Publication of CN103339148A publication Critical patent/CN103339148A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2012800046860A 2011-01-06 2012-01-06 特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体的alphabody Pending CN103339148A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2011/050138 2011-01-06
EP2011050138 2011-01-06
PCT/EP2012/050193 WO2012093172A1 (en) 2011-01-06 2012-01-06 Alphabodies specifically binding to cytokines or growth factors and/or cytokine or growth factor receptors

Publications (1)

Publication Number Publication Date
CN103339148A true CN103339148A (zh) 2013-10-02

Family

ID=44242740

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012800046860A Pending CN103339148A (zh) 2011-01-06 2012-01-06 特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体的alphabody

Country Status (9)

Country Link
US (1) US20140057830A1 (enExample)
JP (1) JP2014504869A (enExample)
CN (1) CN103339148A (enExample)
AU (1) AU2012204846B2 (enExample)
BR (1) BR112013017367A2 (enExample)
CA (1) CA2821646A1 (enExample)
DK (1) DK2661447T3 (enExample)
IN (1) IN2013MN01394A (enExample)
WO (1) WO2012093172A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113315431A (zh) * 2021-04-22 2021-08-27 湖南工业大学 基于等价输入干扰系统的pmsm失磁故障控制方法、电机
CN114544812A (zh) * 2022-02-18 2022-05-27 复旦大学附属中山医院 一种代谢组合式标志物在诊断哮喘中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012103165A2 (en) 2011-01-26 2012-08-02 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
CA2860666A1 (en) 2012-01-06 2013-07-11 Complix Nv Binding agents to intracellular target molecules
WO2014018625A1 (en) 2012-07-25 2014-01-30 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
EP2909235B1 (en) 2012-10-22 2017-03-29 Complix NV Polypeptides specifically binding to il-23
AU2013336753B2 (en) 2012-10-22 2018-02-01 Complix Nv Polypeptides capable of cellular internalization
US10239943B2 (en) 2014-05-23 2019-03-26 Celldex Therapeutics, Inc. Treatment of eosinophil or mast cell related disorders
WO2017102835A1 (en) * 2015-12-14 2017-06-22 Complix Nv Binding molecule comprising an alphabody-polypeptide and an antibody
CN116406378A (zh) 2020-10-19 2023-07-07 硕腾服务有限责任公司 犬和猫抑瘤素M受体β的抗体及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161287A1 (en) * 2007-06-15 2010-03-10 Yantai Rongchang Biotechnologies Co., Ltd. OPTIMIZED TACI-Fc FUSION PROTEINS
WO2010066740A1 (en) * 2008-12-08 2010-06-17 Complix Nv Single-chain antiparallel coiled coil proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161278B1 (en) * 2008-09-08 2012-05-23 Complix N.V. Single-chain coiled coil scaffold
BR112013017363A2 (pt) * 2011-01-06 2016-08-30 Complix Sa biblioteca de alphabody de cadeia única, mistura de bibliotecas de alphabody, ácido nucleico ou biblioteca de vetor, biblioteca de células hospedeiras, uso de uma biblioteca de alphabody de cadeia única, método para a produção de uma biblioteca de alphabody de cadeia única, método para a produção de um ou mais polipeptídeos de alphabody de cadeia única, polipeptíceo de alphabody de cadeia única, ácido nucleico, vetor e célula hospedeira

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161287A1 (en) * 2007-06-15 2010-03-10 Yantai Rongchang Biotechnologies Co., Ltd. OPTIMIZED TACI-Fc FUSION PROTEINS
WO2010066740A1 (en) * 2008-12-08 2010-06-17 Complix Nv Single-chain antiparallel coiled coil proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OBDULIO PILOTO ET AL.: "IMC-EB10,an anti-FLT3 monoclonal antibody,prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some actue lymphoblastic leukemia cell lines and primary leukemic samples", 《CANCER RESEARCH》 *
YI CHEN ET AL.: "Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis", 《THE JOURNAL OF CLINICAL INVESTIGATION》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113315431A (zh) * 2021-04-22 2021-08-27 湖南工业大学 基于等价输入干扰系统的pmsm失磁故障控制方法、电机
CN113315431B (zh) * 2021-04-22 2023-07-28 湖南工业大学 基于等价输入干扰系统的pmsm失磁故障控制方法、电机
CN114544812A (zh) * 2022-02-18 2022-05-27 复旦大学附属中山医院 一种代谢组合式标志物在诊断哮喘中的应用
CN114544812B (zh) * 2022-02-18 2023-06-30 复旦大学附属中山医院 一种代谢组合式标志物在诊断哮喘中的应用

Also Published As

Publication number Publication date
BR112013017367A2 (pt) 2016-11-22
DK2661447T3 (en) 2015-11-02
CA2821646A1 (en) 2012-07-12
AU2012204846B2 (en) 2016-09-08
IN2013MN01394A (enExample) 2015-06-12
AU2012204846A1 (en) 2013-07-04
WO2012093172A1 (en) 2012-07-12
US20140057830A1 (en) 2014-02-27
JP2014504869A (ja) 2014-02-27

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Application publication date: 20131002