CN103316189A - Natural pharmaceutical composition - Google Patents
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- CN103316189A CN103316189A CN201310267230XA CN201310267230A CN103316189A CN 103316189 A CN103316189 A CN 103316189A CN 201310267230X A CN201310267230X A CN 201310267230XA CN 201310267230 A CN201310267230 A CN 201310267230A CN 103316189 A CN103316189 A CN 103316189A
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Abstract
The invention relates to a natural pharmaceutical composition which comprises a Chinese yam and aquilaria sinensis water-decocted concentration extract, Chinese yam polysaccharide, an aquilaria sinensis chloroform extract and an aquilaria sinensis hexane extract by proportion of (1-3):(6-9):(3-9):(2-4). The composition has extremely good curative effect on cancer chemotherapy associated diarrhea and synergistic effect on cancer chemotherapy.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to a kind of natural drug composition of being made up of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing, the preparation method of this natural drug composition and this natural drug composition are for the preparation of reducing cancer chemotherapy dependency diarrhoea and treatment of cancer being played purposes in the medicine of potentiation.
Background technology
Malignant tumor is current harm humans existence, one of healthy principal disease, and its treatment means comprises operation, chemotherapy, radiotherapy, Chinese medicine, and the effect of chemotherapeutic treatment tumor is particularly outstanding.Chemotherapeutic no matter singly with or unite with toxicity such as all can cause that the patient suffers from diarrhoea, diarrhoea makes the chemotherapy dependency suffer from diarrhoea again behind the chemotherapy of tumors.Emerging and applying along with chemotherapeutics such as 5-fluorouracil, taxanes, hydroxy camptothecin, irinotecan, xeloda etc. in recent years, the incidence rate of chemotherapy dependency diarrhoea improves year by year, and if do not carry out active treatment, easily cause patient's dehydration, malnutrition, serum electrolyte disorder, acid base imbalance etc., it is unfavorable greatly not only the rehabilitation of body to be brought, also bring certain difficulty to CC, therefore effective treatment of chemotherapy dependency diarrhoea has been become the important component part of tumor patient wholistic therapy.
Chemotherapy dependency diarrhoea is with regard to its clinical manifestation, surely belongs to the Chinese medicine category of " having loose bowels ", and Chinese medicine attracts people's attention for the research of having loose bowels, but at present still unmatchful anticancer disease chemotherapy have the Chinese patent medicine of alleviating diarrhoea and potentiation.Therefore, research and develop a kind of high-efficiency low-toxicity, cheap, the natural Chinese medicine that can be used for alleviating cancer chemotherapy dependency diarrhoea and playing the chemotherapeutic sensitivity effect that is easy to promote becomes clinical problem demanding prompt solution.
Rhizoma Dioscoreae is perennial voluble herb, and Chinese medicine, vegetable dual-purpose have therapeutical effect to diarrhea due to hypofunction of the spleen.Lignum Aquilariae Resinatum is the dry stem of thymelaeceae plant Lignum Aquilariae Resinatum, the relieving diarrhea with astringents effect is arranged, it is the medicine commonly used of controlling chronic diarrhea, chronic dysentery, proctoptosis, in recent years, Rhizoma Dioscoreae and Lignum Aquilariae Resinatum antitumaous effect are confirmed, and the inventor has obtained optimal drug ratio compositions of the present invention at last through research and the experiment of each a large amount of formula proportion, and proved that it has fabulous curative effect and can finish the present invention thus simultaneously to chemotherapeutic sensitivity cancer chemotherapy dependency diarrhoea.
Summary of the invention
A kind of natural drug composition provided by the invention is made of in the ratio of 1-3:6-9:3-9:2-4 by weight Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing.
Above-mentioned natural drug composition, wherein the usage ratio of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing is 3:9:9:4.
Wherein, Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract can be by well known to a person skilled in the art the conventional method acquisition of purifying, and adopt these compositions that conventional method obtains or the natural drug of the present invention that adopts the commercial one-tenth of buying to be grouped into all can obtain identical curative effect.
Preferably, Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration preparation method of extract is in the above-mentioned natural drug composition:
Be 1-4 according to proportion compatibility: 1 gets Rhizoma Dioscoreae, Lignum Aquilariae Resinatum, distilled water immersion, and heating decocts 1h, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating concentrates, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure are namely.
The preparation method of Chinese yam polysaccharide is in the above-mentioned natural drug composition:
Get the Rhizoma Dioscoreae powder, 95% alcohol reflux 3 times removes supernatant, filtering residue extracts 4 times at 45 ℃ with distilled water, collects extracting solution, and is centrifugal, collect supernatant, with supernatant concentration, add ethanol, 4 ℃ of placements are spent the night, and are centrifugal, collecting precipitation, thing adds the water redissolution and is made into 5% solution, adds Sevag reagent, concussion, centrifugal, get supernatant, add Sevag reagent, so repeat repeatedly, until no white intermediate layer precipitation, collect supernatant concentration, use tap water and distill water dialysis respectively, add ethanol, 4 ℃ of placements are spent the night, centrifugal, collecting precipitation is used ethanol respectively, acetone and ether washing precipitation, lyophilization, namely.
Lignum Aquilariae Resinatum chloroform extract preparation method is in the above-mentioned natural drug composition:
Get the Lignum Aquilariae Resinatum coarse powder, 95% alcohol reflux 3 times, merge extractive liquid, and concentrating under reduced pressure, with the gained crude extract, the suitable quantity of water suspendible is used equal-volume chloroform extraction 3 times, and decompression and solvent recovery namely gets the Lignum Aquilariae Resinatum chloroform extract.
Lignum Aquilariae Resinatum hexane extraction thing preparation method is in the above-mentioned natural drug composition:
The Lignum Aquilariae Resinatum coarse powder methanol room temperature of drying was extracted for 2 weeks, filter methanol extract liquid, reclaim under reduced pressure obtains methanolic extract, the suitable quantity of water suspendible, with hexane extraction 3 times, decompression and solvent recovery namely gets Lignum Aquilariae Resinatum hexane extraction thing.
The present invention also provides the preferred manufacturing procedure of this natural drug composition, comprising:
(1) preparation of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Rhizoma Dioscoreae, Lignum Aquilariae Resinatum, distilled water immersion, and heating decocts 1h, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating concentrates, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure are namely.
(2) preparation of Chinese yam polysaccharide
Get the Rhizoma Dioscoreae powder, 95% alcohol reflux 3 times removes supernatant, filtering residue extracts 4 times at 45 ℃ with distilled water, collects extracting solution, and is centrifugal, collect supernatant, with supernatant concentration, add ethanol, 4 ℃ of placements are spent the night, and are centrifugal, collecting precipitation, thing adds the water redissolution and is made into 5% solution, adds Sevag reagent, concussion, centrifugal, get supernatant, add Sevag reagent, so repeat repeatedly, until no white intermediate layer precipitation, collect supernatant concentration, use tap water and distill water dialysis respectively, add ethanol, 4 ℃ of placements are spent the night, centrifugal, collecting precipitation is used ethanol respectively, acetone and ether washing precipitation, lyophilization, namely.
(3) Lignum Aquilariae Resinatum chloroform extract preparation
Get the Lignum Aquilariae Resinatum coarse powder, 95% alcohol reflux 3 times, merge extractive liquid, and concentrating under reduced pressure, with the gained crude extract, the suitable quantity of water suspendible is used equal-volume chloroform extraction 3 times, and decompression and solvent recovery namely gets the Lignum Aquilariae Resinatum chloroform extract.
(4) Lignum Aquilariae Resinatum hexane extraction thing preparation
The Lignum Aquilariae Resinatum coarse powder methanol room temperature of drying was extracted for 2 weeks, filter methanol extract liquid, reclaim under reduced pressure obtains methanolic extract, the suitable quantity of water suspendible, with hexane extraction 3 times, decompression and solvent recovery namely gets Lignum Aquilariae Resinatum hexane extraction thing.
(5) choose Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing in proportion, evenly mix, namely.
The preparation method of above-mentioned natural drug composition also comprises: the product that step (5) makes is further made capsule or the tablet that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine.
The beneficial effect of natural drug composition of the present invention aspect anti-chemotherapy dependency diarrhoea and inhibition tumor is as follows:
1, natural drug composition of the present invention causes the diarrhea of mouse Study of model to show at irinotecan: the diarrhoea reaction for the irinotecan induced mice has tangible antagonism.
2, proved that this natural drug composition can strengthen chemotherapeutics to the inhibitory action of tumor, adopted mouse tumor model, observed this natural drug composition and cyclophosphamide combined to the inhibitory action of mouse interior tumor.Studies show that: this natural drug composition can obviously increase cyclophosphamide for the inhibitory action of tumor.
3, the inventor is originally with Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing make up, and by the consumption proportion between definite these components of a large amount of experiments, make said composition bring into play good synergism, through experimentation repeatedly, ratio between each component of natural drug composition of the present invention has produced unexpected synergism when 1-3:6-9:3-9:2-4, potentiation is obvious, extraordinary effect is played in side effect, especially especially obvious when the usage ratio of each component is 3:9:9:4, this is that the inventor pays a large amount of creative works and obtains, and those of ordinary skills only can't simply obtain this ratio range and optimum amount ratio by disclosed content.
4, this natural drug composition Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and each component of Lignum Aquilariae Resinatum hexane extraction thing all can obtain by conventional means, component such as Chinese yam polysaccharide also can be buied by commerce, and such compositions itself has the convenience of acquisition, lower-cost effect.This also is the product that has splendid curative effect and higher industrial practicality concurrently that the inventor obtains by a large amount of creative work sides.
The specific embodiment
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and the beneficial effect in diarrhea and antitumor, used.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Rhizoma Dioscoreae, Lignum Aquilariae Resinatum, distilled water immersion, and heating decocts 1h, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating concentrates, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure are namely.
(2) preparation of Chinese yam polysaccharide
Get the Rhizoma Dioscoreae powder, 95% alcohol reflux 3 times removes supernatant, filtering residue extracts 4 times at 45 ℃ with distilled water, collects extracting solution, and is centrifugal, collect supernatant, with supernatant concentration, add ethanol, 4 ℃ of placements are spent the night, and are centrifugal, collecting precipitation, thing adds the water redissolution and is made into 5% solution, adds Sevag reagent, concussion, centrifugal, get supernatant, add Sevag reagent, so repeat repeatedly, until no white intermediate layer precipitation, collect supernatant concentration, use tap water and distill water dialysis respectively, add ethanol, 4 ℃ of placements are spent the night, centrifugal, collecting precipitation is used ethanol respectively, acetone and ether washing precipitation, lyophilization, namely.
(3) Lignum Aquilariae Resinatum chloroform extract preparation
Get the Lignum Aquilariae Resinatum coarse powder, 95% alcohol reflux 3 times, merge extractive liquid, and concentrating under reduced pressure, with the gained crude extract, the suitable quantity of water suspendible is used equal-volume chloroform extraction 3 times, and decompression and solvent recovery namely gets the Lignum Aquilariae Resinatum chloroform extract.
(4) Lignum Aquilariae Resinatum hexane extraction thing preparation
The Lignum Aquilariae Resinatum coarse powder methanol room temperature of drying was extracted for 2 weeks, filter methanol extract liquid, reclaim under reduced pressure obtains methanolic extract, the suitable quantity of water suspendible, with hexane extraction 3 times, decompression and solvent recovery namely gets Lignum Aquilariae Resinatum hexane extraction thing.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule preparations of the present invention
Take by weighing Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract 12mg, Chinese yam polysaccharide 36mg, Lignum Aquilariae Resinatum chloroform extract 36mg and the Lignum Aquilariae Resinatum hexane extraction thing 16mg of above-mentioned steps preparation respectively, take by weighing starch 395mg, magnesium stearate 5mg simultaneously, evenly mix, be filled to capsule.
(2) preparation of natural drug composition tablet of the present invention
Take by weighing Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract 12mg, Chinese yam polysaccharide 36mg, Lignum Aquilariae Resinatum chloroform extract 36mg and the Lignum Aquilariae Resinatum hexane extraction thing 16mg of above-mentioned steps preparation respectively, take by weighing starch 295mg, lactose 100mg simultaneously, evenly mix, with wet granulation, drying, mix with the 5mg magnesium stearate behind the granulate, be pressed into tablet.
Drug effect and pharmacology's data:
Compositions is in following test example: the usage ratio of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing is 3:9:9:4.Inventor's compositions that the multiple proportioning combination between 1-3:6-9:3-9:2-4 the time obtains to above-mentioned each composition usage ratio carried out with on identical experiment, find that all the natural drug composition in this amount ranges can obtain good synergism, can play good effect and treatment for cancer is had potentiation cancer chemotherapy dependency diarrhoea.Below be the pharmacodynamics data that preferred embodiment obtains:
Test example 1: the pharmacodynamic study of natural drug composition treatment chemotherapy dependency diarrhoea effect
1, test material
(1) Rhizoma Dioscoreae, Lignum Aquilariae Resinatum is purchased in medical material market.
(2) mice, male, ad lib drinking-water before the experiment.
2, test method:
Mice is divided into 5 groups at random, and 5 every group, the A group is model group, and the B group is Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract 10g.kg
-1(being equivalent to contain the crude drug amount), the C group is Chinese yam polysaccharide 10g.kg
-1(being equivalent to contain the crude drug amount), D group Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing are pressed 9:4 mixed 10g.kg
-1(being equivalent to contain the crude drug amount), the E group is natural drug composition 10g.kg of the present invention
-1(being equivalent to contain the crude drug amount), irinotecan intraperitoneal injection (75mg/kg), continuous 4 days, copies chemotherapy dependency diarrhoea model at every day 1 time.B, C, D, E group were irritated stomach 8 days with corresponding extract continuously, and mice is placed metabolic cage, spread white filter paper at the bottom of the cage with observation stool situation, and observed mice crissum situation and Mus tail fecal pollution situation, stimulated the anus defecation in conjunction with cotton swab, and every day, observed and recorded was 2 times.Diarrhoea degree standard scoring is as follows: 0 minute: stool is normal or do not have; 1 minute: laxativeness, stool is visible slight wet soft; 2 minutes: the wet and not molding of moderate diarrhoea, stool.And there is slight crissum painted; 3 minutes, severe diarrhoea, watery stool is also painted with the severe crissum.
3, experimental result
Compare with model group, natural drug composition group diarrhoea incidence rate of the present invention obviously alleviates.The results are shown in Table 1.
Table 1 present composition is to mice chemotherapy dependency diarrhoea incidence rate and scoring influence
Annotate: a is equivalent to contain the crude drug amount
Test example 2: the pharmacodynamic study of natural drug composition antitumor action of the present invention
1, experiment material
(1) Kunming mouse, body weight 20 ± 2g, ad lib drinking-water before the experiment, 24h natural light irradiation.
(2) cyclophosphamide, the permanent auspicious medical Pharmacy stock Co., Ltd in Jiangsu product.
2, test method:
To mice S
180The inhibition test of sarcoma growth
Employing was gone down to posterity 5-7 days, and well-grown milky ascites is diluted to tumor cell suspension with an amount of physiological saline solution, and cell number is 10
7/ mL, 5 every group, the right axillary fossa subcutaneous vaccination of every Mus 0.2mL(contains oncocyte 2 * 10
6Individual).Inoculation random packet next day, experimental group natural drug composition of the present invention is divided into (200,100mg/mL) two dosage groups, every Mus is irritated stomach 0.5 ml, gives cyclophosphamide 10gkg simultaneously
-1D
-1Negative control group gives 0.5 mL distilled water; The positive drug group gives cyclophosphamide 10gkg
-1D
-1, successive administration 10 days.The conventional raising, drinking-water, food is not limit.Drug withdrawal next day, mice all takes off cervical vertebra puts to death, and strips subcutaneous solid tumor tumor piece, weighs, and calculates tumor control rate (%) by following formula:
Tumor control rate=(the average tumor of the matched group average tumor of heavy (C)-experimental group heavy (T))/average tumor of matched group heavy (C)
3, result of the test
Natural drug composition of the present invention is low, high dose group all can strengthen the cyclophosphamide agent with to S
180The effect of inhibition degree, especially the strongest with the high dose group effect.(as table 2)
Table 2 natural drug composition of the present invention is to S
180The tumor inhibition effect of mice
| Group | Suppression ratio (%) |
| Cyclophosphamide | 31.5 |
| Compositions is low+cyclophosphamide | 39.6 |
| Height+cyclophosphamide | 48.5 |
Claims (5)
1. natural drug composition that reduces cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation, it is characterized in that said composition is made of in the ratio of 1-3:6-9:3-9:2-4 by weight Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing
Wherein Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration preparation method of extract is:
Be 1-4 according to proportion compatibility: 1 gets Rhizoma Dioscoreae, Lignum Aquilariae Resinatum, distilled water immersion, and heating decocts 1h, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating concentrates, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure are namely;
Wherein the preparation method of Chinese yam polysaccharide is:
Get the Rhizoma Dioscoreae powder, 95% alcohol reflux 3 times removes supernatant, filtering residue extracts 4 times at 45 ℃ with distilled water, collects extracting solution, and is centrifugal, collect supernatant, with supernatant concentration, add ethanol, 4 ℃ of placements are spent the night, and are centrifugal, collecting precipitation, thing adds the water redissolution and is made into 5% solution, adds Sevag reagent, concussion, centrifugal, get supernatant, add Sevag reagent, so repeat repeatedly, until no white intermediate layer precipitation, collect supernatant concentration, use tap water and distill water dialysis respectively, add ethanol, 4 ℃ of placements are spent the night, centrifugal, collecting precipitation is used ethanol respectively, acetone and ether washing precipitation, lyophilization, namely;
Wherein the preparation method of Lignum Aquilariae Resinatum chloroform extract is:
Get the Lignum Aquilariae Resinatum coarse powder, 95% alcohol reflux 3 times, merge extractive liquid, and concentrating under reduced pressure, with the gained crude extract, the suitable quantity of water suspendible is used equal-volume chloroform extraction 3 times, decompression and solvent recovery, namely;
Wherein the preparation method of Lignum Aquilariae Resinatum hexane extraction thing is:
The Lignum Aquilariae Resinatum coarse powder methanol room temperature of drying was extracted for 2 weeks, filter methanol extract liquid, reclaim under reduced pressure obtains methanolic extract, the suitable quantity of water suspendible is with hexane extraction 3 times, decompression and solvent recovery, namely.
2. natural drug composition as claimed in claim 1 is characterized in that wherein the usage ratio of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract and Lignum Aquilariae Resinatum hexane extraction thing is 3:9:9:4.
3. as the preparation method of the natural drug composition of claim 1 or 2, it is characterized in that this method comprises:
(1) preparation of Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets Rhizoma Dioscoreae, Lignum Aquilariae Resinatum, distilled water immersion, and heating decocts 1h, and silk filters, and medicinal residues are adding distil water again, soaks, decocts, filters with method, and twice filtrate is mixed, and heating concentrates, ultrafiltration membrance filter, 70 ℃ of drying under reduced pressure are namely;
(2) preparation of Chinese yam polysaccharide
Get the Rhizoma Dioscoreae powder, 95% alcohol reflux 3 times removes supernatant, filtering residue extracts 4 times at 45 ℃ with distilled water, collects extracting solution, and is centrifugal, collect supernatant, with supernatant concentration, add ethanol, 4 ℃ of placements are spent the night, and are centrifugal, collecting precipitation, thing adds the water redissolution and is made into 5% solution, adds Sevag reagent, concussion, centrifugal, get supernatant, add Sevag reagent, so repeat repeatedly, until no white intermediate layer precipitation, collect supernatant concentration, use tap water and distill water dialysis respectively, add ethanol, 4 ℃ of placements are spent the night, centrifugal, collecting precipitation is used ethanol respectively, acetone and ether washing precipitation, lyophilization, namely;
(3) preparation of Lignum Aquilariae Resinatum chloroform extract
Get the Lignum Aquilariae Resinatum coarse powder, 95% alcohol reflux 3 times, merge extractive liquid, and concentrating under reduced pressure, with the gained crude extract, the suitable quantity of water suspendible is used equal-volume chloroform extraction 3 times, decompression and solvent recovery, namely;
(4) preparation of Lignum Aquilariae Resinatum hexane extraction thing
The Lignum Aquilariae Resinatum coarse powder methanol room temperature of drying was extracted for 2 weeks, filter methanol extract liquid, reclaim under reduced pressure obtains methanolic extract, the suitable quantity of water suspendible is with hexane extraction 3 times, decompression and solvent recovery, namely;
(5) choose Rhizoma Dioscoreae Lignum Aquilariae Resinatum water boiling concentration extract, Chinese yam polysaccharide, Lignum Aquilariae Resinatum chloroform extract in proportion and evenly mix with Lignum Aquilariae Resinatum hexane extraction thing, namely.
4. the preparation method of natural drug composition as claimed in claim 3 is characterized in that also comprising: the product that step (5) makes is further made capsule or the tablet that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine.
5. as the purposes of each described natural drug composition of claim 1-2 in preparing the medicine that reduces the reaction of cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation.
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| CN102145159A (en) * | 2011-03-31 | 2011-08-10 | 青岛大学 | Ginger and elecampane composition, preparation method of ginger and elecampane composition and use of ginger and elecampane composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102145159A (en) * | 2011-03-31 | 2011-08-10 | 青岛大学 | Ginger and elecampane composition, preparation method of ginger and elecampane composition and use of ginger and elecampane composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy |
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| CN103655933A (en) * | 2013-12-14 | 2014-03-26 | 张宗升 | Traditional Chinese medicine composition as well as preparation method and application thereof |
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Application publication date: 20130925 |