CN103301279A - Traditional Chinese medicine for preventing and treating bovine forestomach disease and preparation method of compound oral tablet thereof - Google Patents
Traditional Chinese medicine for preventing and treating bovine forestomach disease and preparation method of compound oral tablet thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for preventing and treating a bovine forestomach disease and a preparation method of a compound oral tablet of the traditional Chinese medicine. The traditional Chinese medicine is characterized by comprising the following ingredients in parts by weight: 2-4 parts of codonopsis pilosula, 2-4 parts of white atractylodes rhizome, 2-4 parts of medicated leaven, 1-2 parts of poria cocos, 1-2 parts of semen raphani, 1-2 parts of rhizoma corydalis, 1-2 parts of rheum officinale, 1-2 parts of pericarpium citri reticulatae viride, 1-2 parts of golden cypress, 1-2 parts of liquorice, 1-2 parts of bunge cherry seed, 1-2 parts of fructus aurantii, 1-2 parts of szechwan chinaberry fruit and 1 part of areca-nut. According to the traditional Chinese medicine for preventing and treating the bovine forestomach disease and the preparation method of the compound oral tablet of the traditional Chinese medicine, active ingredients of the Chinese herbal medicines are extracted, further filtered, and condensed to a fluid extract, the fluid extract is then mixed with auxiliary materials to prepare the compound oral tablet of the traditional Chinese medicine, and the compound oral tablet of the traditional Chinese medicine mainly has the efficacies of enhancing the function of the forestomach, promoting digestion, promoting gastrointestinal motility, invigorating spleen, supplementing Qi, and resisting inflammation, and also has the characteristics of safe and convenient medication, low residue and accurate dose.
Description
Technical field
The present invention relates to a kind of Chinese medicine of the preceding gastric disease of cattle and preparation method of compound oral tablet thereof of preventing and treating.
Background technology
Preceding gastric disease is a kind of disease comparatively multiple in the ruminant digestive system disease, is principal character with the digestive system malfunction.Clinical manifestation is that inappetence is to anorexia; Ruminate to be reduced to belch and stop; The cud hypomotility is to disappearing; Feces reduces or increases and feces is dry or diarrhoea.Usually said preceding gastric disease refers to forestomach atony, grainsick, ruminal tympany, traumatic reticulitis and obstruction of omasum.This disease is to the health of cattle and milch cow and influence and the hazardness maximum of fertility performance thereof.Particularly development, the living standards of the people along with economy and society improve day by day, and people have promoted the develop rapidly of national milk cattle cultivating industry to the continuous pursuit of healthy and nutrition.And along with the continuous expansion of culturing industry, thing followed gi system disease becomes the obstacle of its development of restriction again.In the disease of cattle, digestive tract disease will account for more than 80%, and preceding gastric disease accounts for major part in digestive tract disease.
At present, the clinical treatment of gastric disease is mainly based on the Western medicine control before the cattle, and the life-time service Western medicine not only can produce many side effect, the damage Liver and kidney, increase the weight of the Lien Bovis seu Bubali deficiency syndrome of the stomach, antibiotic use also can cause the generation of Resistant strain when handling inflammation simultaneously, and the residual of medicine also can produce harmful effect to food safety and human beings'health.Chinese herbal medicine belongs to pure natural substance, contain multiple bioactive ingredients, have mediation food stagnation removing and sending down the abnormal ascending QI, invigorating the spleen and benefiting QI, enhancing human body immunity power, characteristics such as toxic action is little, environmental protection, and utilize Chinese medicine preparation control digestive system disease to belong to the non-antibiotic therapy, therefore have a extensive future.
Summary of the invention
One of purpose of the present invention provides a kind of Chinese medicine of preventing and treating gastric disease before the cattle, can effectively strengthen the glandular stomach function, promotes gastrointestinal motility, helps digestion, antiinflammatory;
Two of purpose of the present invention provides a kind of preparation method of compound oral tablet of above-mentioned Chinese medicine, and its preparation technology is simple, easy to operate, and clinical effectiveness is remarkable.
A kind of Chinese medicine of preventing and treating the preceding gastric disease of cattle, its special feature is, consists of according to the weight portion meter: 2-4 part Radix Codonopsis, 2-4 part Rhizoma Atractylodis Macrocephalae, 2-4 part Massa Medicata Fermentata, 1-2 part Poria, 1-2 part Semen Raphani, 1-2 part Rhizoma Corydalis, 1-2 part Radix Et Rhizoma Rhei, 1-2 part Pericarpium Citri Reticulatae Viride, 1-2 part Cortex Phellodendri, 1-2 part Radix Glycyrrhizae, 1-2 part Semen Pruni, 1-2 part Fructus Aurantii, 1-2 part Fructus Toosendan, 1 portion of Semen Arecae.
A kind of preparation method of preventing and treating the Chinese medicine compound oral tablet of the preceding gastric disease of cattle, its special feature is, comprises the steps:
(1) extraction of pharmaceutically active ingredient in each:
1) extraction of Massa Medicata Fermentata:
At first Massa Medicata Fermentata is crushed to the 20-40 order, putting it into volume then is in 15～20 times the distilled water of medical material amount, adopt reflux extraction to extract 3 times, each extraction time is 0.5～1h, extract 40～45 ℃ of temperature, solution mixing, filtering and collecting filter liquid with three extractions place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
2) extraction of Semen Raphani:
At first Semen Raphani is crushed to the 20-40 order, put it into volume then and be in 8～10 times the distilled water of medical material amount and decoct 3 times, each extraction time is 1.5～2h, solution mixing, filtering and collecting filter liquid with 3 extractions, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
3) extraction of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae Viride, Cortex Phellodendri, Semen Arecae:
At first above-mentioned Chinese medicine is crushed to the 20-40 order respectively, put into volume then respectively and be 6～12 times of the medical material amount and volumetric concentration and be 60%～95% alcoholic solution, adopt reflux extraction, extract 2～4 times, each extraction time is 0.5～2.5h, and extracting temperature is 45 ℃～85 ℃, to extract solution mixing, filtering and collecting filter liquid, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
4) extraction of Poria:
At first Poria powder is broken to the 20-40 order, then it is put into 8～10 times the distilled water that volume is the medical material amount respectively, adopt ultrasonic extraction to extract 3 times, each extraction time 20～45min, extract 30～45 ℃ of temperature, ultrasonic power is 200～400W, with solution mixing, the filtration, concentrated of 3 extractions, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
5) extraction of Radix Glycyrrhizae:
At first Radix Glycyrrhizae powder is broken to 20～40 orders, it is 8～10 times of medical material amount that Radix Glycyrrhizae after will pulverizing is then put into volume, volumetric concentration is in 75%～80% the alcoholic solution, adopt ultrasonic extraction to extract 20～40min, extracting temperature is 30～45 ℃, and ultrasonic power is 200～400W, with the solution sucking filtration that extracts, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
6) extraction of Semen Pruni, Fructus Aurantii, Fructus Toosendan:
At first above-mentioned Chinese medicine is crushed to the 20-40 order respectively, put into 8～10 times of weight of medical material amount and volumetric concentration then respectively and be 70%～100% methanol solution, adopt reflux extraction, extract 2～4 times, each extraction time is 20min～90min, and extracting temperature is 50 ℃～85 ℃, to extract solution mixing, filtering and collecting filter liquid, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
(2) preparation method of Chinese medicine extract dry powder is as follows:
Composition and consumption according to record in the claim 1, the fluid extract that extracts respectively in all medical materials is mixed, after leaving standstill 20～24 hours at normal temperatures, with the centrifugal 40～60min of 3000～3500r/min, collect supernatant, supernatant is placed on the Rotary Evaporators to concentrate again, finally make the Chinese medicine compound fluid extract of 2～3:1, namely crude drug 2～3g is equivalent to make 1mL Chinese medicine compound fluid extract;
At first take by weighing following reagent chemicals by mass ratio, Chinese medicine compound fluid extract: microcrystalline Cellulose: pregelatinized Starch: dextrin: micropowder silica gel=10～12:1～2:0.5～1:0.5～1:0.5～1,2%～3% the carboxymethyl starch sodium that adds total composition quality again, stir, place the 50-60 ℃ of dry 12-24h of vacuum drying oven, with dried extractum 40 mesh sieves of pulverizing, can obtain Chinese medicine extract dry powder;
(3) preparation method of extract oral tablet is as follows:
Take by weighing following medicine in proportion, Chinese medicine extract dry powder: the carboxymethyl starch sodium powder: magnesium stearate powder=12:1:0.1, behind the mix homogeneously, make tablet by wet particle method again, every weight is 0.40～0.45g.
Wet particle method is made tablet and is referred to volume ratio to be that the ethanol solution of 5%PVP is sprayed in the powder that mixes with Sprayable in the step (3), it is prepared into soft material, obtain the wet granular agent after 14～20 mesh sieves, at last above wet granular agent is placed the dry 2～4h of 50～60 ℃ of thermostatic drying chambers, excessively tabletting behind 20 mesh sieves.
All sucking filtration and filtration step all adopt monolayer filter paper in the step (1).
The invention provides a kind of Chinese medicine of the preceding gastric disease of cattle and preparation method of compound oral tablet thereof of preventing and treating, by pharmaceutically active ingredient in extracting, further filter, be concentrated into fluid extract, again with adjuvant be mixed with out a kind of mainly have strengthen the glandular stomach function, help digestion, promote gastrointestinal motility, invigorating the spleen and benefiting QI, anti-inflammatory properties, also have drug safety, convenience, low-residual and dosage characteristic of accurate.
The specific embodiment
The preparation method of the Chinese medicine compound oral tablet of the preceding gastric disease of control cattle is as follows among the present invention:
By 2-4 part Radix Codonopsis, 2-4 part Rhizoma Atractylodis Macrocephalae, 2-4 part Massa Medicata Fermentata, 1-2 part Poria, 1-2 part Semen Raphani, 1-2 part Rhizoma Corydalis, 1-2 part Radix Et Rhizoma Rhei, 1-2 part Pericarpium Citri Reticulatae Viride, 1-2 part Cortex Phellodendri, 1-2 part Radix Glycyrrhizae, 1-2 part Semen Pruni, 1-2 part Fructus Aurantii, 1-2 part Fructus Toosendan, 1 portion of Semen Arecae, mixed extract behind all medical materials difference effective component extractings, add the filling adjuvant and make dry powder, make with disintegrating agent and mix lubricant tabletting again.
Said herbal medicine Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata, Poria, Semen Raphani, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae Viride, Cortex Phellodendri, Radix Glycyrrhizae, Semen Pruni, Fructus Aurantii, Fructus Toosendan, Semen Arecae are after extracting separately, with collecting filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators and concentrate, make the fluid extract of 1:1, then with the Chinese medicine compound oral tablet of making after adjuvant mixes.
Above-mentioned adjuvant is microcrystalline Cellulose, pregelatinized Starch, dextrin, micropowder silica gel, carboxymethyl starch sodium, magnesium stearate and sodium lauryl sulphate.
Above-mentioned Chinese medicine compound tablet is made up of the magnesium stearate of 60%～65% Chinese medicine compound fluid extract, 10%～15% microcrystalline Cellulose, 4%～6% pregelatinized Starch, 3%～5% dextrin, 2%～3% micropowder silica gel, 4%～6% carboxymethyl starch sodium and 0.2%～0.3% and 0.1%～0.15% sodium lauryl sulphate.
Embodiment 1:
1, Chinese medicine extracts active ingredients: in following extracting method, portion is equivalent to 25g Chinese medicine, the fluid extract of 1:1, and namely crude drug 1g finally makes the fluid extract of 1mL.
(1) extraction of Radix Codonopsis (CODONOPSIS RADIX): at first 4 parts of Radix Codonopsis powder are broken to 40 orders, it is that 10 times of the medical material amount, volumetric concentration are 75% alcoholic solution that Radix Codonopsis after will pulverizing is then put into volume, adopt reflux extraction to extract 3 times, extraction time 2h for the first time, second and third time extraction time is 1.5h, extract 80 ℃ of temperature, then the solution that extracts for 3 times mixed, collect filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(2) extraction of the Rhizoma Atractylodis Macrocephalae (ATRACTYLODIS MACROCEPHALAE RHIZOMA): at first 4 parts of Rhizoma Atractylodis Macrocephalaes are crushed to 20 orders, it is 4.5 times of medical material amount that the Rhizoma Atractylodis Macrocephalae after will pulverizing is then put into volume, volumetric concentration is in 95% the alcoholic solution, adopt reflux extraction to extract 2 times, each extraction time 1.5h, extract 70 ℃ of temperature, the solution that extracts for 2 times is mixed, collects filtrate after using monolayer filter paper sucking filtration while hot, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(3) extraction of Massa Medicata Fermentata (Medicated Leaven): at first 4 parts of Massa Medicata Fermentata are crushed to 40 orders, Massa Medicata Fermentata after will pulverizing is then put into 20 times the distilled water that volume is the medical material amount, adopt reflux extraction to extract 3 times, extraction time is 1h for the first time, second and third time extraction time 0.5h, extract 45 ℃ of temperature, the solution that extracts for three times is mixed, collects filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(4) extraction of Poria (PORIA): at first 2 parts of Poria powders are broken to 20 orders, Poria after will pulverizing is then put into 10 times the distilled water that volume is the medical material amount, adopt ultrasonic extraction to extract 3 times, extraction time is 45min for the first time, second and third time extraction time is 20min, extract 40 ℃ of temperature, ultrasonic power is 200W, the solution that extracts for three times is mixed, collects filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(5) extraction of Semen Raphani (RAPHANI SEMEN): at first 2 parts of Semen Raphanis are crushed to 40 orders, Semen Raphani after will pulverizing is then put into the distilled water that volume is 10 times of medical material amounts, soak 1h earlier, adopt the decocting cooking method to extract then 3 times, each extraction time 1.5h keeps slight boiling condition, the solution that extracts for 3 times is mixed, collects filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(6) extraction of Rhizoma Corydalis (CORYDALIS RHIZOMA): at first 2 parts of Rhizoma Corydalis are crushed to 40 orders, it is 6 times of medical material amount that Rhizoma Corydalis after will pulverizing is then put into volume, volumetric concentration is in 50% the alcoholic solution, adopt reflux extraction to extract 3 times, each extraction time 2h, extract 80 ℃ of temperature, the solution that extracts for 3 times is mixed, collects filtrate after using monolayer filter paper sucking filtration while hot, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(7) extraction of Radix Et Rhizoma Rhei (RHEI RADIX ET RHIZOMA): at first 2 parts of Radix Et Rhizoma Rhei powder are broken to 40 orders, it is 8 times of medical material amount that Radix Et Rhizoma Rhei after will pulverizing is then put into volume, volumetric concentration is in 90% the alcoholic solution, adopt reflux extraction to extract 3 times, extraction time 2.5h for the first time, second and third time extraction time is 2h, extract 80 ℃ of temperature, the solution that extracts for 3 times is mixed, collects filtrate after using monolayer filter paper sucking filtration while hot, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(8) extraction of Pericarpium Citri Reticulatae Viride (CITRI RETICULATAE PERICARPIUM VIRIDE): 2 parts of Pericarpium Citri Reticulatae Virides are crushed to 40 orders, it is 8 times of medical material amounts that Pericarpium Citri Reticulatae Viride after will pulverizing is then put into volume, volumetric concentration is in 60% the alcoholic solution, adopt reflux extraction to extract 3 times, each extraction time 1h, extract 65 ℃ of temperature, the solution that extracts for 3 times is mixed, collects filtrate after using monolayer filter paper sucking filtration while hot, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(9) extraction of Cortex Phellodendri (PHELLODENDRI CHINENSIS CORTEX): at first 2 portions of Cortex Phellodendris being cut into length is 2～3mm thin segment, then the Cortex Phellodendri of cutting being put into volume is that 10 times of medical material amounts, volumetric concentration are 75% alcoholic solution, adopt reflux extraction to extract 3 times, each extraction time 1.5h, extract 80 ℃ of temperature, the solution that extracts for 3 times is mixed, collects filtrate behind the monolayer filter paper sucking filtration, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(10) extraction of Radix Glycyrrhizae (GLYCYRRHIZAE RADIX ET RHIZOMA): at first 2 parts of Radix Glycyrrhizae powder are broken to 40 orders, it is 10 times of medical material amounts that Radix Glycyrrhizae after will pulverizing is then put into volume, volumetric concentration is in 80% the alcoholic solution, adopt ultrasonic extraction to extract 20min, extracting temperature is 30 ℃, and ultrasonic power is 200W, with the solution monolayer filter paper sucking filtration that extracts, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(11) extraction of Semen Pruni (PRUNI SEMEN): Semen Pruni is crushed to 40 orders, Semen Pruni after 2 parts of pulverizing being put into volume then is 10 times of medical material amounts, volumetric concentration is in 80% the methanol solution, adopts reflux extraction to extract 3 times, and each extraction time is 1h, extracting temperature is 30 ℃, the solution of 3 extractions is merged, with monolayer filter paper sucking filtration, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(12) extraction of Fructus Aurantii (AURANTII FRUCTUS): at first 2 parts of Fructus Aurantiis are crushed to 40 orders, it is 10 times of medical material amounts that Fructus Aurantii after will pulverizing is then put into volume, volumetric concentration is in 100% the methanol solution, soak 8h, adopt reflux extraction to extract 3 times, extraction time is 1.5h for the first time, second and third time extraction time is 15min, extracting temperature is 60 ℃, the solution of 3 extractions is merged, with monolayer filter paper sucking filtration, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(13) extraction of Fructus Toosendan (TOOSENDAN FRUCTUS): 2 parts of Fructus Toosendans are crushed to 40 orders, it is 8 times of medical material amount that Fructus Toosendan after will pulverizing is then put into volume, volumetric concentration is in 70% the methanol solution, adopts reflux extraction to extract 3 times, and each extraction time is 30min, extracting temperature is 80 ℃, the solution of 3 extractions is merged, with monolayer filter paper sucking filtration, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g;
(14) extraction of Semen Arecae (ARECAE SEMEN): 1 part of areca powder is broken to 40 orders, it is 14 times of medical material amounts that Semen Arecae after will pulverizing is then put into volume, volumetric concentration is in 85% the alcoholic solution, adopts reflux extraction to extract 3 times, and each extraction time is 1h, extracting temperature is 85 ℃, the solution of 3 extractions is merged, with monolayer filter paper sucking filtration, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely the 1mL fluid extract is equivalent to crude drug 1g.
2, the preparation of herbal mixture:
Fluid extract after above-mentioned concentrate is mixed 825mL altogether, leave standstill 24h at normal temperatures after, with the centrifugal 30min of 3500r/min, collect supernatant, discard residue.It is 413mL-275mL that supernatant is placed the fluid extract that is concentrated into 1:2～3 on the Rotary Evaporators.
3, the preparation of tablet:
In above-mentioned compound recipe fluid extract, add 15% microcrystalline Cellulose, 5% pregelatinized Starch, 5% dextrin, 3% micropowder silica gel, 4% carboxymethyl starch sodium by mass ratio, stir, place 55 ℃ of dry 12h of vacuum drying oven, pulverize dried Chinese medical concrete standby.
Take by weighing 1.5% carboxymethyl starch sodium, 0.3% magnesium stearate and 0.15% sodium lauryl sulphate by mass ratio, the Chinese medicine compound extractum powder good with above-mentioned prior drying evenly mixes the powder that obtains mixing.
Be that the 5%PVP ethanol solution is sprayed in the above-mentioned powder that mixes with Sprayable then with volume ratio, it is prepared into soft material, cross 20 mesh sieves and obtain the wet granular agent, at last above wet granular agent is placed 50 ℃ of dry 3h of thermostatic drying chamber, pour tabletting in the one-shot formula tablet machine into behind 20 mesh sieves excessively.Every weight of medicine is 0.40-0.45g.
4, the quality examination of oral tablet:
⑴ visual examination: this oral tablet is complete bright and clean, and color and luster is even, no piebaldism and special foreign body;
⑵ hardness test: this oral tablet has suitable hardness, falls from the 1.5m eminence, and tablet is complete, does not have phenomenons such as fragment, unfilled corner, loose sheet substantially;
⑶ weight differential checks: get for 20 of examination oral tablets, the weight that precision weighing is every, every weight all be no more than or be lower than average sheet heavy 3%, up to specification.
⑷ inspection technique disintegration (oral tablet): 8 of the things of getting it filled, place the 250mL beaker respectively, fill 250mL water in the beaker, water temperature 15-25 ℃, have minute bubbles to emit, when tablet or fragment ambient gas stop to overflow, tablet dissolves fully, is dispersed in the water, does not have the particle residue of assembling, and this disintegration time is up to specification at 8-10 minute.
5, amount of drug and method:
2h oral administration before the feeding is looked the each 15-25 sheet of severity extent, uses for two weeks continuously every day twice, decrement gradually behind the satisfactory effect.Every weight of medicine is 0.40-0.45g, and drug content is 60%, is equivalent to the about 0.24g of crude drug that adjuvant content is 40%.
6, clinical effectiveness is observed:
Choose cattle farm, Yinchuan, Ningxia and suffer from 20 of the milch cows of preceding gastric disease, oral administration is looked the each 20-25 sheet of severity extent, every day twice, be used in conjunction two week the back cure rates reach 75%; The milch cow that suffers from obstruction of omasum is chosen 5, carry out oral perfusion, each 20-25 sheet is used in conjunction seven times every day twice, and cure rate reaches 80%.Take this tablet during the milch cow abomasum inflammation, can play the effect of antiinflammatory.This extract oral tablet carries out antibiotic to milk and measures when control milch cow gastrointestinal disease, and antibiotic-free is residual.
Characteristics of the present invention mainly show as: (1) preparation technology is simple, steady quality, long shelf-life; (2) drug level height, consumption are little, easy to use; (3) take, carry, storage etc. is more convenient; (4) dosage is accurate, and medicament contg difference is little.
Claims (4)
1. Chinese medicine of preventing and treating gastric disease before the cattle, it is characterized in that, consist of according to the weight portion meter: 2-4 part Radix Codonopsis, 2-4 part Rhizoma Atractylodis Macrocephalae, 2-4 part Massa Medicata Fermentata, 1-2 part Poria, 1-2 part Semen Raphani, 1-2 part Rhizoma Corydalis, 1-2 part Radix Et Rhizoma Rhei, 1-2 part Pericarpium Citri Reticulatae Viride, 1-2 part Cortex Phellodendri, 1-2 part Radix Glycyrrhizae, 1-2 part Semen Pruni, 1-2 part Fructus Aurantii, 1-2 part Fructus Toosendan, 1 portion of Semen Arecae.
2. a preparation method of preventing and treating the Chinese medicine compound oral tablet of the preceding gastric disease of cattle is characterized in that, comprises the steps:
(1) extraction of pharmaceutically active ingredient in each:
1) extraction of Massa Medicata Fermentata:
At first Massa Medicata Fermentata is crushed to the 20-40 order, putting it into volume then is in 15～20 times the distilled water of medical material amount, adopt reflux extraction to extract 3 times, each extraction time is 0.5～1h, extract 40～45 ℃ of temperature, solution mixing, filtering and collecting filter liquid with three extractions place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
2) extraction of Semen Raphani:
At first Semen Raphani is crushed to the 20-40 order, put it into volume then and be in 8～10 times the distilled water of medical material amount and decoct 3 times, each extraction time is 1.5～2h, solution mixing, filtering and collecting filter liquid with 3 extractions, place on the Rotary Evaporators and concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
3) extraction of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae Viride, Cortex Phellodendri, Semen Arecae:
At first above-mentioned Chinese medicine is crushed to the 20-40 order respectively, put into volume then respectively and be 6～12 times of the medical material amount and volumetric concentration and be 60%～95% alcoholic solution, adopt reflux extraction, extract 2～4 times, each extraction time is 0.5～2.5h, and extracting temperature is 45 ℃～85 ℃, to extract solution mixing, filtering and collecting filter liquid, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
4) extraction of Poria:
At first Poria powder is broken to the 20-40 order, then it is put into 8～10 times the distilled water that volume is the medical material amount respectively, adopt ultrasonic extraction to extract 3 times, each extraction time 20～45min, extract 30～45 ℃ of temperature, ultrasonic power is 200～400W, with solution mixing, the filtration, concentrated of 3 extractions, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
5) extraction of Radix Glycyrrhizae:
At first Radix Glycyrrhizae powder is broken to 20～40 orders, it is 8～10 times of medical material amount that Radix Glycyrrhizae after will pulverizing is then put into volume, volumetric concentration is in 75%～80% the alcoholic solution, adopt ultrasonic extraction to extract 20～40min, extracting temperature is 30～45 ℃, and ultrasonic power is 200～400W, with the solution sucking filtration that extracts, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
6) extraction of Semen Pruni, Fructus Aurantii, Fructus Toosendan:
At first above-mentioned Chinese medicine is crushed to the 20-40 order respectively, put into 8～10 times of weight of medical material amount and volumetric concentration then respectively and be 70%～100% methanol solution, adopt reflux extraction, extract 2～4 times, each extraction time is 20min～90min, and extracting temperature is 50 ℃～85 ℃, to extract solution mixing, filtering and collecting filter liquid, place on the Rotary Evaporators to concentrate, finally make the fluid extract of 1:1, namely crude drug 1g makes the fluid extract of 1mL;
(2) preparation method of Chinese medicine extract dry powder is as follows:
Composition and consumption according to record in the claim 1, the fluid extract that extracts respectively in all medical materials is mixed, after leaving standstill 20～24 hours at normal temperatures, with the centrifugal 40～60min of 3000～3500r/min, collect supernatant, supernatant is placed on the Rotary Evaporators to concentrate again, finally make the Chinese medicine compound fluid extract of 2～3:1, namely crude drug 2～3g is equivalent to make 1mL Chinese medicine compound fluid extract;
At first take by weighing following reagent chemicals by mass ratio, Chinese medicine compound fluid extract: microcrystalline Cellulose: pregelatinized Starch: dextrin: micropowder silica gel=10～12:1～2:0.5～1:0.5～1:0.5～1,2%～3% the carboxymethyl starch sodium that adds total composition quality again, stir, place the 50-60 ℃ of dry 12-24h of vacuum drying oven, with dried extractum 40 mesh sieves of pulverizing, can obtain Chinese medicine extract dry powder;
(3) preparation method of extract oral tablet is as follows:
Take by weighing following medicine in proportion, Chinese medicine extract dry powder: the carboxymethyl starch sodium powder: magnesium stearate powder=12:1:0.1, behind the mix homogeneously, make tablet by wet particle method again, every weight is 0.40～0.45g.
3. a kind of preparation method of preventing and treating the Chinese medicine compound oral tablet of gastric disease before the cattle as claimed in claim 2, it is characterized in that: wet particle method is made tablet and is referred to volume ratio to be that the ethanol solution of 5%PVP is sprayed in the powder that mixes with Sprayable in the step (3), it is prepared into soft material, obtain the wet granular agent after 14～20 mesh sieves, at last above wet granular agent is placed the dry 2～4h of 50～60 ℃ of thermostatic drying chambers, excessively tabletting behind 20 mesh sieves.
4. a kind of preparation method of preventing and treating the Chinese medicine compound oral tablet of gastric disease before the cattle as claimed in claim 2, it is characterized in that: all sucking filtration and filtration step all adopt monolayer filter paper in the step (1).
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