CN103298794A - 作为tyk2抑制剂的吡啶化合物及其氮杂类似物 - Google Patents

作为tyk2抑制剂的吡啶化合物及其氮杂类似物 Download PDF

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Publication number
CN103298794A
CN103298794A CN2011800645538A CN201180064553A CN103298794A CN 103298794 A CN103298794 A CN 103298794A CN 2011800645538 A CN2011800645538 A CN 2011800645538A CN 201180064553 A CN201180064553 A CN 201180064553A CN 103298794 A CN103298794 A CN 103298794A
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methyl
pyrimidine
pyrazoles
amino
isophthalic acid
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K·艾拉迪
J·梅约尔
A·琼斯
R·林奇
N·拉姆斯登
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Cellzome Ltd
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Cellzome Ltd
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CN2011800645538A 2010-11-09 2011-11-07 作为tyk2抑制剂的吡啶化合物及其氮杂类似物 Pending CN103298794A (zh)

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EP10190460 2010-11-09
EP10190460.5 2010-11-09
PCT/EP2011/069553 WO2012062704A1 (fr) 2010-11-09 2011-11-07 Composés de pyridine et leurs analogues aza en tant qu'inhibiteurs de tyk2

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EP (1) EP2638018A1 (fr)
JP (1) JP2014500254A (fr)
CN (1) CN103298794A (fr)
AU (1) AU2011328237A1 (fr)
CA (1) CA2815330A1 (fr)
WO (1) WO2012062704A1 (fr)

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WO2017114510A1 (fr) * 2015-12-31 2017-07-06 中国科学院上海药物研究所 Composé présentant une activité inhibitrice de l'erk kinase, son procédé de préparation et utilisation associée
CN110330484A (zh) * 2019-07-18 2019-10-15 中国药科大学 取代类苯基嘧啶衍生物作为jak激酶抑制剂或其可药用的盐、制备方法及用途
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN110734428A (zh) * 2019-10-24 2020-01-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物
WO2020118683A1 (fr) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides de dérivés de pyrazolyl-amino-pyrimidinyle, compositions et procédés associés
CN113993861A (zh) * 2019-04-08 2022-01-28 凌科药业(杭州)有限公司 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法
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WO2023208244A1 (fr) * 2022-04-29 2023-11-02 南京明德新药研发有限公司 Composé macrocyclique et son utilisation
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TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
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EP4011865A4 (fr) * 2019-08-09 2022-11-02 The National Institutes of Pharmaceutical R&D Co., Ltd Composé de pyrimidine substitué par hétérocyclyle ponté, son procédé de préparation et son utilisation pharmaceutique
MX2022001940A (es) 2019-08-14 2022-05-10 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
PE20221905A1 (es) 2019-10-11 2022-12-23 Incyte Corp Aminas biciclicas como inhibidoras de la cdk2
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WO2017114510A1 (fr) * 2015-12-31 2017-07-06 中国科学院上海药物研究所 Composé présentant une activité inhibitrice de l'erk kinase, son procédé de préparation et utilisation associée
CN107922405A (zh) * 2015-12-31 2018-04-17 中国科学院上海药物研究所 具有erk激酶抑制活性的化合物、其制备方法和用途
CN107922405B (zh) * 2015-12-31 2021-02-19 中国科学院上海药物研究所 具有erk激酶抑制活性的化合物、其制备方法和用途
CN113227074A (zh) * 2018-12-14 2021-08-06 凌科药业(杭州)有限公司 吡唑基-氨基-嘧啶基衍生物的苯甲酰胺及其组合物和方法
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WO2020118683A1 (fr) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides de dérivés de pyrazolyl-amino-pyrimidinyle, compositions et procédés associés
CN113993861B (zh) * 2019-04-08 2024-05-14 凌科药业(杭州)有限公司 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法
CN113993861A (zh) * 2019-04-08 2022-01-28 凌科药业(杭州)有限公司 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法
CN110330484A (zh) * 2019-07-18 2019-10-15 中国药科大学 取代类苯基嘧啶衍生物作为jak激酶抑制剂或其可药用的盐、制备方法及用途
CN110330484B (zh) * 2019-07-18 2022-08-26 中国药科大学 取代类苯基嘧啶衍生物作为jak激酶抑制剂或其可药用的盐、制备方法及用途
CN110734428A (zh) * 2019-10-24 2020-01-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
WO2021078022A1 (fr) * 2019-10-24 2021-04-29 嘉兴特科罗生物科技有限公司 Composé à petites molécules
WO2021078023A1 (fr) * 2019-10-24 2021-04-29 嘉兴特科罗生物科技有限公司 Composé à petites molécules
WO2021078020A1 (fr) * 2019-10-24 2021-04-29 嘉兴特科罗生物科技有限公司 Composé à petites molécules
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
WO2022057770A1 (fr) * 2020-09-17 2022-03-24 嘉兴特科罗生物科技有限公司 Composé pharmaceutique utilisé comme inhibiteur de la kinase jak
WO2023208244A1 (fr) * 2022-04-29 2023-11-02 南京明德新药研发有限公司 Composé macrocyclique et son utilisation
WO2024041397A1 (fr) * 2022-08-22 2024-02-29 Hangzhou Highlightll Pharmaceutical Co., Ltd Inhibiteurs de jak1/jak2/tyk2 pour le traitement topique de maladies dermatologiques
WO2023151724A1 (fr) * 2023-05-19 2023-08-17 凌科药业(杭州)有限公司 Formes cristallines de dérivé pyrazolyl-amino-pyrimidinyle, et procédé de préparation et utilisation associés

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