CN103298345B - 组合 - Google Patents
组合 Download PDFInfo
- Publication number
- CN103298345B CN103298345B CN201280004830.0A CN201280004830A CN103298345B CN 103298345 B CN103298345 B CN 103298345B CN 201280004830 A CN201280004830 A CN 201280004830A CN 103298345 B CN103298345 B CN 103298345B
- Authority
- CN
- China
- Prior art keywords
- chloro
- administered
- compound
- methyl
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- GXJABQQUPOEUTA-RDJZCZTQSA-N CC(C)C[C@@H](B(O)O)NC([C@H](Cc1ccccc1)NC(c1nccnc1)=O)=O Chemical compound CC(C)C[C@@H](B(O)O)NC([C@H](Cc1ccccc1)NC(c1nccnc1)=O)=O GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
- LNIFEKHXOSXTPP-GCRRARIESA-N CN/C(/c(cc(C(N[C@@H](Cc1cc(F)ccc1)CN)=O)[s]1)c1Cl)=C(\C=N)/Cl Chemical compound CN/C(/c(cc(C(N[C@@H](Cc1cc(F)ccc1)CN)=O)[s]1)c1Cl)=C(\C=N)/Cl LNIFEKHXOSXTPP-GCRRARIESA-N 0.000 description 1
- ZEESWPRDQGWOMU-AWEZNQCLSA-N Cc([s]c(C(N[C@@H](Cc1cccc(F)c1)CN)=O)c1)c1-c([n](C)nc1)c1Cl Chemical compound Cc([s]c(C(N[C@@H](Cc1cccc(F)c1)CN)=O)c1)c1-c([n](C)nc1)c1Cl ZEESWPRDQGWOMU-AWEZNQCLSA-N 0.000 description 1
- ULDXWLCXEDXJGE-UHFFFAOYSA-N NC1(CCC1)c(cc1)ccc1-c(c(-c1ccccc1)c1)nc(C=CN23)c1C2=NNC3=O Chemical compound NC1(CCC1)c(cc1)ccc1-c(c(-c1ccccc1)c1)nc(C=CN23)c1C2=NNC3=O ULDXWLCXEDXJGE-UHFFFAOYSA-N 0.000 description 1
- GAMHLKCZDZGCFT-NHUVNFLLSA-N Oc1cc(O)c(CC(CC(c(cc2O)cc(O)c2O)=O)[C@@H](c(cc2O)cc(O)c2O)O2)c2c1 Chemical compound Oc1cc(O)c(CC(CC(c(cc2O)cc(O)c2O)=O)[C@@H](c(cc2O)cc(O)c2O)O2)c2c1 GAMHLKCZDZGCFT-NHUVNFLLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (22)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161431508P | 2011-01-11 | 2011-01-11 | |
US61/431,508 | 2011-01-11 | ||
PCT/US2012/020863 WO2012097021A1 (en) | 2011-01-11 | 2012-01-11 | Combination |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103298345A CN103298345A (zh) | 2013-09-11 |
CN103298345B true CN103298345B (zh) | 2016-12-14 |
Family
ID=46507420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280004830.0A Active CN103298345B (zh) | 2011-01-11 | 2012-01-11 | 组合 |
Country Status (15)
Country | Link |
---|---|
US (6) | US20130288984A1 (zh) |
EP (1) | EP2663189B1 (zh) |
JP (1) | JP6100700B2 (zh) |
KR (1) | KR20140053836A (zh) |
CN (1) | CN103298345B (zh) |
AU (1) | AU2012205601B2 (zh) |
BR (1) | BR112013017722A2 (zh) |
CA (1) | CA2824201A1 (zh) |
EA (1) | EA029000B1 (zh) |
ES (1) | ES2689760T3 (zh) |
IL (1) | IL227097B (zh) |
MX (1) | MX356704B (zh) |
SG (2) | SG10201600077RA (zh) |
WO (1) | WO2012097021A1 (zh) |
ZA (1) | ZA201304139B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105792825A (zh) * | 2013-10-01 | 2016-07-20 | 诺华股份有限公司 | 组合 |
CN108464981B (zh) * | 2013-11-07 | 2022-06-24 | 德西费拉制药有限责任公司 | 抑制tie2激酶的组合物在制备治疗癌症的药物中的用途 |
MX2020008016A (es) | 2018-01-31 | 2020-11-09 | Deciphera Pharmaceuticals Llc | Terapia de combinación para el tratamiento de tumores del estroma gastrointestinal. |
TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
BR112022002609A2 (pt) | 2019-08-12 | 2022-08-09 | Deciphera Pharmaceuticals Llc | Métodos de tratamento de tumores estromais gastrointestinais |
AU2020417282B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
US6328590B1 (en) | 2000-07-20 | 2001-12-11 | Emc Corporation | Methods and apparatus for controlling attachment of an electronic module with a circuit board connector |
CA2560691A1 (en) * | 2004-03-24 | 2005-10-13 | Abbott Laboratories | Tricyclic pyrazole kinase inhibitors |
WO2006040649A1 (en) | 2004-10-13 | 2006-04-20 | Pharmacia & Upjohn Company Llc | Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
EP2275095A3 (en) * | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1840114A1 (en) | 2006-03-30 | 2007-10-03 | LTB4 Sweden AB | Crystalline Leukotriene B4 |
RU2008143554A (ru) | 2006-04-05 | 2010-05-10 | Новартис АГ (CH) | Комбинации терапевтических агентов для лечения рака |
WO2007122686A1 (ja) | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | ベンズイミダゾール化合物 |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
AU2007287098C1 (en) | 2006-08-25 | 2018-03-15 | Janssen Pharmaceutica Nv | Methods and compositions for treating cancer |
JP4299327B2 (ja) | 2006-08-31 | 2009-07-22 | トヨタ自動車株式会社 | 可変バルブタイミング装置 |
WO2008094321A2 (en) | 2006-10-04 | 2008-08-07 | Universtiy Of South Florida | Akt sensitization of cancer cells |
TWI423765B (zh) | 2006-10-13 | 2014-01-21 | Basf Ag | 2-氯-5-〔3,6-二氫-3-甲基-2,6-二酮基-4-(三氟甲基)-1-(2h)-嘧啶基〕-4-氟-n-〔〔甲基(1-甲基乙基)胺基〕磺醯基〕苯甲醯胺之水合物 |
AR064010A1 (es) * | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
JP4705695B2 (ja) | 2007-10-11 | 2011-06-22 | アストラゼネカ アクチボラグ | プロテインキナーゼb阻害剤としてのピロロ[2,3−d]ピリミジン誘導体 |
US20090131367A1 (en) * | 2007-11-19 | 2009-05-21 | The Regents Of The University Of Colorado | Combinations of HDAC Inhibitors and Proteasome Inhibitors |
DE102008044901A1 (de) | 2008-08-29 | 2010-03-04 | Siemens Aktiengesellschaft | Verfahren und Vorrichtung zur Auswahl eines Bestrahlungsplans sowie Bestrahlungsanlage |
JP2012516344A (ja) * | 2009-01-30 | 2012-07-19 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩 |
WO2010149755A1 (en) | 2009-06-26 | 2010-12-29 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
KR101696003B1 (ko) | 2009-10-08 | 2017-01-13 | 노파르티스 아게 | 조합물 |
JP6143739B2 (ja) | 2011-04-01 | 2017-06-07 | ジェネンテック, インコーポレイテッド | Akt阻害剤化合物及びベムラフェニブの組み合わせ、及び使用方法 |
US9463242B2 (en) | 2011-05-03 | 2016-10-11 | University Of Rochester | Methods for treating prostate cancer |
AU2012283775A1 (en) | 2011-07-13 | 2014-01-23 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
PL2766381T3 (pl) | 2011-10-10 | 2016-12-30 | Sposób wytwarzania steroidów podstawionych w pozycji 17 | |
EP2785349B2 (en) | 2011-11-30 | 2022-11-09 | Astrazeneca AB | Combination treatment of cancer |
SG11201408067YA (en) | 2012-06-04 | 2015-01-29 | Pharmacyclics Inc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
US20160235714A1 (en) | 2013-10-01 | 2016-08-18 | Novartis Ag | Enzalutamide in combination with afuresertib for the treatment of cancer |
-
2012
- 2012-01-11 JP JP2013549503A patent/JP6100700B2/ja active Active
- 2012-01-11 EP EP12733916.6A patent/EP2663189B1/en active Active
- 2012-01-11 MX MX2013008074A patent/MX356704B/es active IP Right Grant
- 2012-01-11 US US13/978,765 patent/US20130288984A1/en not_active Abandoned
- 2012-01-11 WO PCT/US2012/020863 patent/WO2012097021A1/en active Application Filing
- 2012-01-11 CN CN201280004830.0A patent/CN103298345B/zh active Active
- 2012-01-11 SG SG10201600077RA patent/SG10201600077RA/en unknown
- 2012-01-11 KR KR1020137021098A patent/KR20140053836A/ko active IP Right Grant
- 2012-01-11 CA CA2824201A patent/CA2824201A1/en not_active Abandoned
- 2012-01-11 EA EA201391027A patent/EA029000B1/ru not_active IP Right Cessation
- 2012-01-11 BR BR112013017722A patent/BR112013017722A2/pt not_active IP Right Cessation
- 2012-01-11 AU AU2012205601A patent/AU2012205601B2/en not_active Ceased
- 2012-01-11 ES ES12733916.6T patent/ES2689760T3/es active Active
- 2012-01-11 SG SG2013043856A patent/SG191724A1/en unknown
- 2012-02-08 US US13/368,434 patent/US20120258933A1/en not_active Abandoned
-
2013
- 2013-06-06 ZA ZA2013/04139A patent/ZA201304139B/en unknown
- 2013-06-20 IL IL227097A patent/IL227097B/en active IP Right Grant
-
2015
- 2015-01-06 US US14/590,143 patent/US20150119337A1/en not_active Abandoned
- 2015-08-20 US US14/831,261 patent/US20160022641A1/en not_active Abandoned
-
2016
- 2016-09-08 US US15/259,694 patent/US20160375086A1/en not_active Abandoned
- 2016-12-20 US US15/385,205 patent/US10449226B2/en active Active
Non-Patent Citations (1)
Title |
---|
《Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenibexhibits strong antiproliferative action in human cholangiocarcinoma》;antoni castells;《world journal of gastroenterology》;20070907;第13卷(第33期);第4413-4536页 * |
Also Published As
Publication number | Publication date |
---|---|
US20160022641A1 (en) | 2016-01-28 |
WO2012097021A1 (en) | 2012-07-19 |
JP2014507412A (ja) | 2014-03-27 |
JP6100700B2 (ja) | 2017-03-22 |
BR112013017722A2 (pt) | 2016-07-12 |
EP2663189A4 (en) | 2014-06-11 |
CN103298345A (zh) | 2013-09-11 |
US10449226B2 (en) | 2019-10-22 |
US20120258933A1 (en) | 2012-10-11 |
IL227097B (en) | 2018-02-28 |
US20170100449A1 (en) | 2017-04-13 |
MX356704B (es) | 2018-06-11 |
AU2012205601A1 (en) | 2013-08-01 |
US20160375086A1 (en) | 2016-12-29 |
SG191724A1 (en) | 2013-08-30 |
CA2824201A1 (en) | 2012-07-19 |
KR20140053836A (ko) | 2014-05-08 |
ZA201304139B (en) | 2014-02-26 |
US20150119337A1 (en) | 2015-04-30 |
SG10201600077RA (en) | 2016-02-26 |
EP2663189B1 (en) | 2018-07-04 |
MX2013008074A (es) | 2013-08-09 |
EP2663189A1 (en) | 2013-11-20 |
ES2689760T3 (es) | 2018-11-15 |
AU2012205601B2 (en) | 2016-03-24 |
EA201391027A1 (ru) | 2014-01-30 |
US20130288984A1 (en) | 2013-10-31 |
EA029000B1 (ru) | 2018-01-31 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151022 Address after: Basel, Switzerland Applicant after: NOVARTIS AG Address before: Basel, Switzerland Applicant before: NOVA LABORATORIES SDN BHD Effective date of registration: 20151022 Address after: Basel, Switzerland Applicant after: NOVA LABORATORIES SDN BHD Address before: American Pennsylvania Applicant before: GLAXOSMITHKLINE LLC |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |