CN103284997B - 地来西坦在治疗慢性疼痛中的应用 - Google Patents

地来西坦在治疗慢性疼痛中的应用 Download PDF

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Publication number
CN103284997B
CN103284997B CN201310182360.3A CN201310182360A CN103284997B CN 103284997 B CN103284997 B CN 103284997B CN 201310182360 A CN201310182360 A CN 201310182360A CN 103284997 B CN103284997 B CN 103284997B
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CN
China
Prior art keywords
dimiracetam
pain
purposes
medicine
dosage form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201310182360.3A
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English (en)
Chinese (zh)
Other versions
CN103284997A (zh
Inventor
C·法里纳
C·格拉蒂尼
P·佩特利罗
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Neurotune AG
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Neurotune AG
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Publication of CN103284997A publication Critical patent/CN103284997A/zh
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201310182360.3A 2007-04-16 2008-04-15 地来西坦在治疗慢性疼痛中的应用 Expired - Fee Related CN103284997B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2007A000770 2007-04-16
IT000770A ITMI20070770A1 (it) 2007-04-16 2007-04-16 Impiego di dimiracetam nel trattamento del dolore cronico

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880015837A Division CN101677984A (zh) 2007-04-16 2008-04-15 地来西坦在治疗慢性疼痛中的应用

Publications (2)

Publication Number Publication Date
CN103284997A CN103284997A (zh) 2013-09-11
CN103284997B true CN103284997B (zh) 2015-06-03

Family

ID=39628738

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201310182360.3A Expired - Fee Related CN103284997B (zh) 2007-04-16 2008-04-15 地来西坦在治疗慢性疼痛中的应用
CN200880015837A Pending CN101677984A (zh) 2007-04-16 2008-04-15 地来西坦在治疗慢性疼痛中的应用

Family Applications After (1)

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CN200880015837A Pending CN101677984A (zh) 2007-04-16 2008-04-15 地来西坦在治疗慢性疼痛中的应用

Country Status (15)

Country Link
US (2) US7989421B2 (cg-RX-API-DMAC7.html)
EP (3) EP2146706B1 (cg-RX-API-DMAC7.html)
JP (1) JP5409602B2 (cg-RX-API-DMAC7.html)
CN (2) CN103284997B (cg-RX-API-DMAC7.html)
AU (1) AU2008237901B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0810475A2 (cg-RX-API-DMAC7.html)
CA (1) CA2684363C (cg-RX-API-DMAC7.html)
EA (2) EA019354B1 (cg-RX-API-DMAC7.html)
ES (2) ES2584161T3 (cg-RX-API-DMAC7.html)
IL (2) IL201498A (cg-RX-API-DMAC7.html)
IT (1) ITMI20070770A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009011380A (cg-RX-API-DMAC7.html)
PL (2) PL2857017T3 (cg-RX-API-DMAC7.html)
WO (1) WO2008125674A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200906991B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
PL2598504T3 (pl) 2010-07-26 2014-10-31 Neurotune Ag Sposób otrzymywania dimiracetamu
EP2658540A1 (en) * 2010-10-29 2013-11-06 Neurotune AG Therapeutic use of dimiracetam to prevent the hand&foot syndrome caused by sorafenib
JPWO2012137645A1 (ja) * 2011-04-07 2014-07-28 旭化成ファーマ株式会社 抗癌剤に起因する異痛症の予防及び/又は治療剤
CN102743372B (zh) * 2012-06-30 2015-09-09 江苏省中医药研究院 一种化疗致血痹动物模型建立方法
JOP20190251A1 (ar) * 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
MX2020005310A (es) * 2017-11-21 2020-10-08 Medoncare Pharmaceutical Co Ltd Producto de combinacion que comprende dicicloplatino y metodo de preparacion y uso del mismo.
DE102019107619A1 (de) 2019-03-25 2020-10-01 Mondi Ag Verpackungsbeutel aus einem Kunststoffgewebeverbund
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

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Publication number Priority date Publication date Assignee Title
DE3324219A1 (de) * 1983-07-05 1985-01-17 Hoechst Ag, 6230 Frankfurt Mehrlagige elektroisolierfolie
US5028595A (en) * 1987-09-18 1991-07-02 Hoffmann-La Roche Inc. Method for preventing AIDS in a subject or treating a subject infected with the AIDS virus
IT1233860B (it) 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
GB9123641D0 (en) 1991-11-07 1992-01-02 Isf Spa Process
CA2392879C (en) * 1999-12-01 2005-03-29 Ucb, S.A. A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
KR100823668B1 (ko) * 2000-12-28 2008-04-21 해밀턴 파마슈티컬스 인코포레이티드 신경성 통증 치료 및 예방약
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Gabapentin Attenuates Nociceptive Behaviors in an Acute Arthritis Model in Rats;Ying Lu et al;《The Journal of Pharmacology and Experimental Therapeutics》;19991231;第290卷(第1期);第214-219页 *

Also Published As

Publication number Publication date
CA2684363A1 (en) 2008-10-23
PL2146706T3 (pl) 2015-07-31
US7989421B2 (en) 2011-08-02
PL2857017T3 (pl) 2016-11-30
EP2857017A2 (en) 2015-04-08
IL218851A (en) 2013-09-30
IL201498A (en) 2013-10-31
EA019354B1 (ru) 2014-03-31
EP2857017A3 (en) 2015-05-06
ES2536631T3 (es) 2015-05-27
EP2146706B1 (en) 2015-02-25
IL218851A0 (en) 2012-05-31
US20110251250A1 (en) 2011-10-13
EA022867B1 (ru) 2016-03-31
JP5409602B2 (ja) 2014-02-05
AU2008237901A1 (en) 2008-10-23
ZA200906991B (en) 2011-03-30
ES2584161T3 (es) 2016-09-26
AU2008237901B2 (en) 2013-06-27
CN101677984A (zh) 2010-03-24
EP2620149A2 (en) 2013-07-31
ITMI20070770A1 (it) 2008-10-17
EA200901237A1 (ru) 2010-04-30
EP2146706A1 (en) 2010-01-27
EP2620149A3 (en) 2013-08-07
US8222241B2 (en) 2012-07-17
HK1209053A1 (en) 2016-03-24
WO2008125674A1 (en) 2008-10-23
MX2009011380A (es) 2010-07-06
EA201300826A1 (ru) 2013-11-29
IL201498A0 (en) 2010-05-31
CA2684363C (en) 2016-02-09
BRPI0810475A2 (pt) 2015-10-20
US20100129469A1 (en) 2010-05-27
JP2010524882A (ja) 2010-07-22
CN103284997A (zh) 2013-09-11
EP2857017B1 (en) 2016-05-25

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