CN103267149A - Automatic column mounting valve - Google Patents
Automatic column mounting valve Download PDFInfo
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- CN103267149A CN103267149A CN2013101641997A CN201310164199A CN103267149A CN 103267149 A CN103267149 A CN 103267149A CN 2013101641997 A CN2013101641997 A CN 2013101641997A CN 201310164199 A CN201310164199 A CN 201310164199A CN 103267149 A CN103267149 A CN 103267149A
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- valve body
- slide block
- valve
- column
- outer end
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Abstract
The invention discloses an automatic column mounting valve comprising a valve body and a valve seat. The valve body and the valve seat are fixedly connected with each other. A slider is arranged in the valve body, and the outer end of the slider penetrates the valve seat. A column is arranged in the slider, and the outer end of the column penetrates the valve body. A cavity is formed in the hollow inner portion of the column. A through hole is reserved at a near end portion position, communicated with the cavity, of the outer end of the slider. An elastic mechanism is arranged between the slider and the valve body. A limiting mechanism is further arranged between the slider and the inner side of the valve body. The automatic column mounting valve has the advantages that operations of column mounting, column demounting and cleaning of the column mounting valve can be completed automatically only by setting external mechanisms well and switching gas channels, demounting of a piston and a lifting mechanism is not needed as compared with the prior art, and convenience in operation is realized.
Description
Technical field
The present invention relates to a kind of valve mechanism, be specifically related to a kind of automatic dress column valve for chromatographic column.
Background technique
Chromatographic column is the main body in the gel chromatography technology, generally with glass tube or lucite tube.The diameter of chromatographic column does not influence degree of separation, and amount of samples is big, can add the diameter of huge pillar, and general preparation gel column, diameter be greater than 2 centimetres, but sample should be uniformly distributed on the gel column bed surface when application of sample.In addition, enlarged diameter, the eluting liquid volume increases, and the sample dilution is big.Degree of separation depends on the post height, be to separate different component, and the gel column bed must have suitable height, and the square root that degree of separation and post are high is relevant, but owing to the too high extrusion-deformation obstruction of soft gel column, generally is no more than 1 meter.Branch family uses short column when separating, 20-30 centimetre of general gel column length, comparison 5:1-the 10:1 of post height and diameter, gel bed volume are 4-10 times of sample solution volume.The high line with diameter of post was 20:1-100:1 when classification separated, and gel column commonly used has 50 * 25 centimetres, 10 * 25 centimetres.
Cooperate generally with chromatographic column all can to use the dress column valve, traditional dress post unloads post technology and is: traditional dress post can adopt directly to be poured filler solution in the post bucket by hand, perhaps utilizes the intelligence biological pump to be pumped in the post bucket, at this time piston must be disassembled.When unloading post, because filler was in the comparison dry status after chromatography work was finished, just intelligence adopts manual excavation and filling material to go out the post bucket, need dismantle equally piston and lifting gear, also can utilize oppositely pressure water injection in the post bucket of pump, constantly the intelligent pump sucking-off is poured out or utilized to the dilution filler with filler after treating to dilute fully more by hand, and whole process must disassemble piston and lifting gear could realize.
From the above, when adorning post, unloading post or cleaning, all piston and lifting gear must be disassembled just and can carry out at present, extremely inconvenience like this operates.
Summary of the invention
The object of the invention provides a kind of automatic dress column valve, by the improvement to mechanism, make the dress post, unload post and cleaning operation is comparatively convenient.
Technological scheme of the present invention is: a kind of automatic dress column valve, comprise the valve body and the valve seat that are mutually permanently connected, be provided with slide block in the described valve body, described valve seat is run through in described slide block outer end, also be provided with a cylinder in the described slide block, described valve body is run through in described cylinder outer end, described column body hollow constitutes cavity, offer through hole with described cavity conducting at the close end place of described slide block outer end, be provided with elastic mechanism between described slide block and described valve body, also be provided with position-limit mechanism between described slide block and described valve body inboard.
Preferably, described slide block the inner offers groove, offers boss with described groove fit in described valve body inboard, and described boss constitutes described position-limit mechanism with spacing cooperation of groove.
Preferably, described elastic mechanism is a spring.
Preferably, described valve seat sidepiece offers material feeding mouth and gas-tpe fitting.
Preferably, described slide block and described valve body and valve base chamber adopt Stamping Steel Ribbon and O type circle to seal respectively.
Preferably, described valve body outside is provided with silencing apparatus.
Advantage of the present invention is: by slide block is set in valve body, be provided with cylinder in the slide block, be provided with elastic mechanism between slide block and the valve body, the valve seat outside is provided with material feeding mouth and gas-tpe fitting, only need set external agency, switching gas circuit, the operation of just can finish the dress post automatically, unloading post and cleaning the dress column valve, do not need as compared with the past to dismantle piston and lifting gear, easy to operate.
Description of drawings
Below in conjunction with drawings and Examples the present invention is further described:
Fig. 1 is the structural scheme of mechanism of the embodiment of the invention one;
Fig. 2 is along the sectional view of A-A among Fig. 1.
Wherein: 1, valve body; 2, silencing apparatus; 3, hexagon socket cap head screw; 4, hexagon socket cap head screw; 5, gas-tpe fitting; 6, material feeding mouth; 7, O type circle; 8, O type circle; 9, valve seat; 10, slide block; 11, spring; 12, cylinder; 13, (cylinder) cavity; 14, groove; 15, boss; 16, through hole.
Embodiment
Shown in Fig. 1,2, a kind of automatic dress column valve comprises the valve body 1 and the valve seat 9 that are mutually permanently connected, be provided with slide block 10 in the described valve body 1, one end of described slide block 10 runs through described valve seat 9, also is provided with a cylinder 12 in the described slide block 10, and described valve body 1 is run through in described cylinder 12 outer ends.
Described cylinder 12 inner hollow constitute cavity 13, offer through hole 16 with described cavity 13 conductings at the close end place of described slide block 10 outer ends.An end that passes described valve body 1 of described cavity 13 is the filter washing water inlet.
Described slide block 10 can relatively move in described valve body 1,1 of described slide block 10 and described valve body are provided with spring 11, described slide block 10 the inners offer groove 14, are engaged in described valve body 1 inboard with described groove 14 and offer boss 15, and described boss 15 constitutes position-limit mechanism with 14 spacing cooperations of groove.
Described valve seat 1 sidepiece offers material feeding mouth 6 and gas-tpe fitting 5,9 of slide block 10 and described valve body 1 and valve seats are respectively equipped with Stamping Steel Ribbon and O type circle, 9 of valve body 1 and described valve seats are provided with O type circle, be provided with O type circle between cylinder 12 inner close end places and described slide block, slide block 10 inner bottom are provided with gasket seal, close end place, slide block 10 outer end is provided with O type circle, and valve body 1 outside is provided with silencing apparatus 2.
In the present embodiment, the use step of dress column valve is as described below:
⑴ adorn post: chromatographic column cleans up, each connecting pipeline connects inspection and finishes, open the source of the gas supply arrangement, air reducing valve is connected automatically the air pressure of dress column valve slowly be transferred to 4bar, guarantee to adorn column valve and open simultaneously by visual, recycling intelligence biological pump is injected into filler solution in the post bucket with certain flow velocity, adorned filler solution, shed the external air pressure of dress column valve, make the dress column valve be in closed condition, this fashionable dress post process finishes;
⑵ unload post: before unloading post, earlier inject water from the material liquid outlet prescription to pressurization by intelligent pump, constantly dilute filler solution, treat that filler dilutes fully after, stop pressure water injection.Check again at this time whether unload the column jecket road connects and finish, open the source of the gas supply arrangement, air reducing valve is connected the air pressure of adorning column valve automatically slowly be transferred to 4bar, guarantee to adorn column valve and open simultaneously by visual, recycling intelligence biological pump is retracted to filler solution outside the post bucket with certain flow velocity, and disposable extraction finishes, the bottom has on a small quantity and can't extract out, need after diluting, water filling in the post bucket extract out again, back and forth several times, and till the solution that is drawn out of is clear water;
⑶ clean the dress column valve: guarantee that earlier adorning column valve is in closed condition, check the cavity of cylinder, pipeline between intelligence biological pump and the cavity connects, liquid entering hole is connected with water pipe, be discharged to waste liquid guarantee to connect correct after, open the intelligence biological pump, rinse water is injected in the dress column valve, the waste liquid after noting simultaneously cleaning needs properly to collect and concentrate and handle.
Above-described embodiment only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the people who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.The all spiritual essence of main technical schemes is done according to the present invention equivalent transformation or modification all should be encompassed within protection scope of the present invention.
Claims (6)
1. adorn column valve automatically for one kind, comprise the valve body (1) and the valve seat (9) that are mutually permanently connected, it is characterized in that: be provided with slide block (10) in the described valve body (1), described valve seat (9) is run through in described slide block (10) outer end, also be provided with a cylinder (12) in the described slide block (10), described valve body (1) is run through in described cylinder (12) outer end, described cylinder (12) inner hollow constitutes cavity (13), offer through hole (16) with described cavity (13) conducting at the close end place of described slide block (10) outer end, be provided with elastic mechanism between described slide block (10) and described valve body (1), also be provided with position-limit mechanism between described slide block (10) and described valve body (1) inboard.
2. automatic dress column valve according to claim 1, it is characterized in that: described slide block (10) the inner offers groove (14), be engaged in described valve body (1) inboard with described groove (14) and offer boss (15), described boss (15) constitutes described position-limit mechanism with spacing cooperation of groove (14).
3. automatic dress column valve according to claim 1, it is characterized in that: described elastic mechanism is a spring (11).
4. automatic dress column valve according to claim 1, it is characterized in that: described valve seat (9) sidepiece offers material feeding mouth (6) and gas-tpe fitting (5).
5. automatic dress column valve according to claim 1 is characterized in that: adopt Stamping Steel Ribbon and O type circle to seal between described slide block (10) and described valve body (1) and valve seat (9) respectively.
6. automatic dress column valve according to claim 1, it is characterized in that: described valve body (1) outside is provided with silencing apparatus (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310164199.7A CN103267149B (en) | 2013-05-07 | 2013-05-07 | Automatic dress column valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310164199.7A CN103267149B (en) | 2013-05-07 | 2013-05-07 | Automatic dress column valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103267149A true CN103267149A (en) | 2013-08-28 |
| CN103267149B CN103267149B (en) | 2015-09-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310164199.7A Active CN103267149B (en) | 2013-05-07 | 2013-05-07 | Automatic dress column valve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103267149B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104307206A (en) * | 2014-02-17 | 2015-01-28 | 长沙市源创精科生物技术有限公司 | A static seal multichannel nozzle design used for a chromatographic column |
| CN105435488A (en) * | 2015-12-22 | 2016-03-30 | 荣捷生物工程（苏州）有限公司 | Discharging column valve, automatic chromatography apparatus containing discharging column valve and apparatus usage method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080264837A1 (en) * | 2007-04-25 | 2008-10-30 | Bio-Rad Laboratories, Inc. | Chromatography column with pack, unpack, and clean-in-place features |
| CN202128946U (en) * | 2011-01-27 | 2012-02-01 | 北京清博华科技有限公司 | Dynamic axial compressed chromatographic column and column installation system |
| US20120292242A1 (en) * | 2010-01-28 | 2012-11-22 | Ge Healthcare Bio-Sciences Ab | Column for liquid chromatography |
| CN102989199A (en) * | 2012-12-11 | 2013-03-27 | 聊城万合工业制造有限公司 | Inner storage constant-pressure preparative column device |
| CN203240013U (en) * | 2013-05-07 | 2013-10-16 | 荣捷生物工程（苏州）有限公司 | Automatic column-installing valve |
-
2013
- 2013-05-07 CN CN201310164199.7A patent/CN103267149B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080264837A1 (en) * | 2007-04-25 | 2008-10-30 | Bio-Rad Laboratories, Inc. | Chromatography column with pack, unpack, and clean-in-place features |
| US20120292242A1 (en) * | 2010-01-28 | 2012-11-22 | Ge Healthcare Bio-Sciences Ab | Column for liquid chromatography |
| CN202128946U (en) * | 2011-01-27 | 2012-02-01 | 北京清博华科技有限公司 | Dynamic axial compressed chromatographic column and column installation system |
| CN102989199A (en) * | 2012-12-11 | 2013-03-27 | 聊城万合工业制造有限公司 | Inner storage constant-pressure preparative column device |
| CN203240013U (en) * | 2013-05-07 | 2013-10-16 | 荣捷生物工程（苏州）有限公司 | Automatic column-installing valve |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104307206A (en) * | 2014-02-17 | 2015-01-28 | 长沙市源创精科生物技术有限公司 | A static seal multichannel nozzle design used for a chromatographic column |
| CN105435488A (en) * | 2015-12-22 | 2016-03-30 | 荣捷生物工程（苏州）有限公司 | Discharging column valve, automatic chromatography apparatus containing discharging column valve and apparatus usage method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103267149B (en) | 2015-09-30 |
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