CN102989199A - Inner storage constant-pressure preparative column device - Google Patents
Inner storage constant-pressure preparative column device Download PDFInfo
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- CN102989199A CN102989199A CN2012105330371A CN201210533037A CN102989199A CN 102989199 A CN102989199 A CN 102989199A CN 2012105330371 A CN2012105330371 A CN 2012105330371A CN 201210533037 A CN201210533037 A CN 201210533037A CN 102989199 A CN102989199 A CN 102989199A
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Abstract
The invention relates to an inner storage constant-pressure preparative column device, and provides a miniaturization device. The device comprises a bracket, a preparative column and a hydraulic cylinder. The hydraulic cylinder is vertically mounted on the bracket, and a U notch for fixing the preparative column is arranged at a distance under the hydraulic cylinder; and the hydraulic cylinder acts on the preparative column and drives the preparative column to compress. The preparative column has functions of automatic inner column pressure compensation and automatic column bed defect repair, and also can ensure constant pressure state of packing in the column. The device is especially suitable for development and research on different target products and different processes in a laboratory, so as to greatly reduce development costs, and improve development efficiency.
Description
Technical field
The present invention relates to the high performance liquid preparative chromatography technical field, specifically a kind of novel interior energy storage constant voltage preparative column device.
Background technology
The high performance liquid chromatography technology of preparing is a kind of isolation technics that can obtain high-purity compound, many pharmaceuticals researchers wish oneself to have a cover preparative chromatography equipment, in order to carry out the development of production technology and technique for applying on chemico-analytic basis.
Chromatogram is the same with analyzing, and chromatographic column is the core component of chromatographic system.The post bed height of modern high performance liquid preparative chromatography post equates with the conventional analysis post that generally (be generally 20-25cm), main purpose is the difficulty of amplifying from the manufacturability that analyzes preparation in order to reduce.At present, that application is more in the preparative chromatography industry is dynamic axial compression column (DAC), in use, piston dependence in the chromatographic column is attached thereto the hydraulic jack that connects and produces all the time a relatively constant pressure compression post bed fillers, eliminates at any time in the elution process because the dead space that filler particles relatively moves and produces.Dynamic axial compression column uses good, can satisfy the purifies and separates requirement of a lot of target products, and maximum advantage is to be applicable to large-scale industrial production.But the manufacturability for the product in laboratory research stage is separated, the dynamic axial compression column thick heaviness that then seems, and inconvenient operation, and also expensive.Because under lab, different objects, different processes needs different fillers as the mutually fixing or fixing carrier of phase.
Interior energy storage constant voltage preparative column is developed in order to meet the need just, before this this type not on the market.
Summary of the invention
The object of the present invention is to provide a kind of small-sized high performance liquid preparative chromatography column device, under the prerequisite that guarantees product yield and purity, to reduce production costs, for the separation and purification of products technical study in laboratory and pilot scale stage provides easy appointed condition, be particularly useful in the smaller situation in space.
The technical solution adopted for the present invention to solve the technical problems is:
Energy storage constant voltage preparative column device in being somebody's turn to do comprises support, preparative column and hydraulic jack, it is characterized in that the vertical state of described hydraulic jack is rack-mount, and a distance is provided with a fixedly U-shaped breach of preparative column below described hydraulic jack; Described hydraulic jack acts on preparative column and drives preparative column and compresses.
Further, described preparative column by column jecket, piston, energy-stored spring group, column jecket upper press cover and post at the bottom of flange form, the up and down two ends of described column jecket are respectively equipped with flange at the bottom of column jecket upper press cover and the post, described piston is plugged in the column jecket, and be provided with the energy-stored spring assembly at the piston head that cooperates with column jecket, sieve plate at the bottom of flange at the bottom of described piston and the post is respectively equipped with the piston sieve plate that is oppositely arranged and post, flange is provided with out liquid interface at the bottom of described post.
Described column jecket top is provided with the snap ring projection of a ring-type, is used for and the cooperation of U-shaped breach.
The hand oil pump of control hydraulic jack is fixed on the bracket base.
Further, described support comprises horizontally disposed base, upper backup pad and lower supporting plate, connects by column between the described upper and lower support plate, and hydraulic jack is installed on the upper backup pad, the U-shaped breach is positioned on the lower supporting plate, and connects by C shape rod member between lower supporting plate and base.
Described energy-stored spring assembly is a rubber seal.
The invention has the beneficial effects as follows:
1) employing energy-stored spring group structure replaces the hydraulic jack in the dynamic axial compression column, storage power when the dress post had both guaranteed the constant pressure in the post bed, had guaranteed separating effect, greatly reduce simultaneously equipment operating cost, be applicable to the research and development of laboratory and pilot-scale.
2) special-purpose packing column machine can load the interior energy storage constant voltage preparative column of multiple different size, also can load different types of filler, more is applicable to the separating technology requirement of different products and different scales.
3) dress post process is simple to operation, and the post bed accessory after the filling has with the DAC post and is close to identical effect, but with low cost, obtains especially easily rapid promotion and application.
In sum, interior energy storage constant voltage preparative column has auto-compensation post internal pressure, and the function of self-regeneration post bed defective guarantees the pressure constant state of filler in the post simultaneously.Be specially adapted in the laboratory developmental research to different target products and different process, greatly reduce R﹠D costs, improve development efficiency.
Description of drawings
Fig. 1 is the full sectional view of preparative column;
Fig. 2 is schematic perspective view of the present invention;
Fig. 3 is filler process schematic diagram;
Fig. 4 is for installing preparative column process schematic diagram;
Fig. 5 is compression preparation look post process schematic diagram.
Among the figure: 11 bases, 12 upper backup pads, 13 lower supporting plates, 14U v notch v, 15C shape rod member, 16 columns, 2 hydraulic jacks, 21 hand oil pumps, 3 preparative columns, 31 column jeckets, 311 snap ring projections, 32 pistons, 33 energy-stored spring groups, 34 column jecket upper press covers, flange at the bottom of 35 posts, 351 go out liquid interface, 36 piston rods, 37 piston sieve plates, sieve plate at the bottom of 38 posts, 4 fillers, 5 homogenate buckets.
The specific embodiment
Such as Fig. 1～shown in Figure 5,
Energy storage constant voltage preparative column device in being somebody's turn to do comprises support, preparative column and hydraulic jack.
Support comprises horizontally disposed base 11, upper backup pad 12 and lower supporting plate 13, connects by three root posts 16 between the upper and lower support plate, and upper backup pad is circular, and hydraulic jack 2 is installed in the centre of upper backup pad 12, is in vertical state.Be provided with U-shaped breach 14 in lower supporting plate 13 centre, this U-shaped breach is positioned at hydraulic jack below certain distance, and this distance is used for fixedly preparative column 3 less than the sphere of action of hydraulic jack.Connect by some C shape rod members 15 between lower supporting plate 13 and base 11, C shape rod member is outstanding backward, can obtain larger operating space like this.The hand oil pump 21 of control hydraulic jack 2 also is fixed on the bracket base 11 convenient operation and take full advantage of the space, small and exquisite practicality on the structure.
Because the effect of energy-stored spring assembly by parameter reasonable in design, so that the pressure at filler position and frictional force reach balance, can realize the purpose of constant voltage.When the pressure in the column jecket changed, the hydraulic jack perseveration on top had auto-compensation post internal pressure, the function of self-regeneration post bed defective.
Interior energy storage constant voltage preparative column device dress post process is: the filler 4 that homogenate is the good homogenate bucket 5 of packing into, then inject fast in the column jecket 31, the column jecket 31 that homogenate is housed is put on the dress column system with piston rod rapidly, wherein column jecket snap ring projection cooperates with the U-shaped breach of lower supporting plate, guarantees simultaneously column jecket 31 and piston rod, hydraulic jack concentric; Operate the handle on the hand oil pump 21 this moment, makes hydraulic cylinder piston rod descending, and the filler in the compacting column jecket is observed the oil circuit Pressure gauge simultaneously, and the pressure in the control post bed behind post bed internal pressure stable equilibrium, screws in column jecket upper press cover 34.Leave standstill after 20 minutes and take off the constant voltage preparative column, the sealing liquid import and export is prepared to use.
Embodiment recited above is described preferred embodiment of the present invention; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; the relevant technical staff in the field all should expand as in the determined protection domain of claims of the present invention various distortion of the present invention and improvement.
Claims (6)
1. energy storage constant voltage preparative column device in a kind comprises support, preparative column and hydraulic jack, it is characterized in that the vertical state of described hydraulic jack is rack-mount, and a distance is provided with a fixedly U-shaped breach of preparative column below described hydraulic jack; Described hydraulic jack acts on preparative column and drives preparative column and compresses.
2. interior energy storage constant voltage preparative column device according to claim 1, it is characterized in that, described preparative column by column jecket, piston, energy-stored spring group, column jecket upper press cover and post at the bottom of flange form, the up and down two ends of described column jecket are respectively equipped with flange at the bottom of column jecket upper press cover and the post, described piston is plugged in the column jecket, and be provided with the energy-stored spring assembly at the piston head that cooperates with column jecket, sieve plate at the bottom of flange at the bottom of described piston and the post is respectively equipped with the piston sieve plate that is oppositely arranged and post, flange is provided with out liquid interface at the bottom of described post.
3. interior energy storage constant voltage preparative column device according to claim 1 and 2 is characterized in that described column jecket top is provided with the snap ring projection of a ring-type, cooperates with U-shaped breach.
4. interior energy storage constant voltage preparative column device according to claim 1 and 2 is characterized in that, the hand oil pump of control hydraulic jack is fixed on the bracket base.
5. interior energy storage constant voltage preparative column device according to claim 1 and 2, it is characterized in that, described support comprises horizontally disposed base, upper backup pad and lower supporting plate, connect by column between the described upper and lower support plate, hydraulic jack is installed on the upper backup pad, the U-shaped breach is positioned on the lower supporting plate, and connects by C shape rod member between lower supporting plate and base.
6. interior energy storage constant voltage preparative column device according to claim 2 is characterized in that described energy-stored spring assembly is a rubber seal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210533037.1A CN102989199B (en) | 2012-12-11 | 2012-12-11 | Inner storage constant-pressure preparative column device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210533037.1A CN102989199B (en) | 2012-12-11 | 2012-12-11 | Inner storage constant-pressure preparative column device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102989199A true CN102989199A (en) | 2013-03-27 |
| CN102989199B CN102989199B (en) | 2014-09-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210533037.1A Active CN102989199B (en) | 2012-12-11 | 2012-12-11 | Inner storage constant-pressure preparative column device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103267149A (en) * | 2013-05-07 | 2013-08-28 | 荣捷生物工程（苏州）有限公司 | Automatic column mounting valve |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822914A (en) * | 2010-04-23 | 2010-09-08 | 聊城万合工业制造有限公司 | High-efficiency liquid-phase preparation device of axial pressurizing chromatographic column |
| CN101954202A (en) * | 2009-07-16 | 2011-01-26 | 中国科学院化学研究所 | Constant-pressure closed ascending chromatographic column device and application method thereof |
| CN202136832U (en) * | 2010-11-23 | 2012-02-08 | 孙俊 | Normal pressure column chromatography device under closed environment |
| CN102500135A (en) * | 2011-10-24 | 2012-06-20 | 利穗科技(苏州)有限公司 | Fast dynamic compression chromatography column |
| CN203090528U (en) * | 2012-12-11 | 2013-07-31 | 聊城万合工业制造有限公司 | Internal energy-storing constant pressure preparative column apparatus |
-
2012
- 2012-12-11 CN CN201210533037.1A patent/CN102989199B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954202A (en) * | 2009-07-16 | 2011-01-26 | 中国科学院化学研究所 | Constant-pressure closed ascending chromatographic column device and application method thereof |
| CN101822914A (en) * | 2010-04-23 | 2010-09-08 | 聊城万合工业制造有限公司 | High-efficiency liquid-phase preparation device of axial pressurizing chromatographic column |
| CN202136832U (en) * | 2010-11-23 | 2012-02-08 | 孙俊 | Normal pressure column chromatography device under closed environment |
| CN102500135A (en) * | 2011-10-24 | 2012-06-20 | 利穗科技(苏州)有限公司 | Fast dynamic compression chromatography column |
| CN203090528U (en) * | 2012-12-11 | 2013-07-31 | 聊城万合工业制造有限公司 | Internal energy-storing constant pressure preparative column apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103267149A (en) * | 2013-05-07 | 2013-08-28 | 荣捷生物工程（苏州）有限公司 | Automatic column mounting valve |
| CN103267149B (en) * | 2013-05-07 | 2015-09-30 | 荣捷生物工程（苏州）有限公司 | Automatic dress column valve |
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| Publication number | Publication date |
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| CN102989199B (en) | 2014-09-03 |
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