CN104307206A - A static seal multichannel nozzle design used for a chromatographic column - Google Patents

A static seal multichannel nozzle design used for a chromatographic column Download PDF

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Publication number
CN104307206A
CN104307206A CN201410390795.1A CN201410390795A CN104307206A CN 104307206 A CN104307206 A CN 104307206A CN 201410390795 A CN201410390795 A CN 201410390795A CN 104307206 A CN104307206 A CN 104307206A
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CN
China
Prior art keywords
inlet tube
tube road
glue inlet
static seal
chromatographic column
Prior art date
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Application number
CN201410390795.1A
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Chinese (zh)
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CN104307206B (en
Inventor
缪海波
栗云天
曲俊法
刘凤阳
刘咔
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CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY Co Ltd
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CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY Co Ltd
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Priority to CN201410390795.1A priority Critical patent/CN104307206B/en
Publication of CN104307206A publication Critical patent/CN104307206A/en
Application granted granted Critical
Publication of CN104307206B publication Critical patent/CN104307206B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)

Abstract

A static seal multichannel nozzle design used for a chromatographic column is disclosed. The static seal multichannel nozzle comprises a silica gel feeding tube capable of moving up and down, a mobile flange, a mobile flange base, a fixture block, a belleville spring, a nozzle base, a seal ring, screen center nozzles, and the like. One end of the silica gel feeding tube is provided with seal grooves. The mobile flange can move along the axial direction of the silica gel feeding tube. The fixture block can drive the silica gel feeding tube to move along with the mobile flange. The belleville spring is disposed in a folded manner. The silica gel feeding tube passes through the center of the belleville spring. In particular, the pressure of gas provides power for movement of the silica gel feeding tube, thus facilitating automation. The seal grooves in one end of the silica gel feeding tube are matched with small holes in screen center arrays. Silica gel loading, chromatography and silica gel unloading can be performed simply. According to the static seal multichannel nozzle design, the seal form of spraying nozzles is changed from a motive seal form to a static seal form, so that the movement of the silica gel feeding tube is easier and more automatic, and seal effects are good.

Description

A kind of static seal multichannel sprinkler design for chromatographic column
Technical field
The present invention relates to a kind of static seal multichannel sprinkler design for chromatographic column, be specifically related to a kind of glue inlet tube road and can realize declining and promoting under bleed pressure, and realize sealing and the connection of glue-feeder respectively under decline and lifting state.
background of invention
Chromatographic column is the main body in gel chromatography technology, and General Requirements completes the whole chromatographic runs of solution in the factory building of cleaning sterile, therefore avoids human intervention as far as possible, and the automatic capability improving chromatographic column is starved of.
The lifting of shower nozzle conveniently can fill glue automatically, unloads glue, the processes such as cleaning.In prior art, even if full-automatic chromatographic column, the lifting problem of shower nozzle remains manual operation, rely on the rotary handle on rotary nozzle to realize the lifting of shower nozzle.And the lifting structure form of this shower nozzle relies on thread forms, in practical operation, shower nozzle needs the lifting repeated, once screw thread occurs burr or falls into the dust that operating personnel bring into, will occur that shower nozzle lifting is required great effort even stuck, cause the inefficacy of whole shower nozzle, while shower nozzle is elevated repeatedly, shower nozzle hoop ring wear is very serious, and resistance is very large, and the life-span is very short, even have chip time serious to drop out, pollute sizing material.
For solving an above-mentioned difficult problem, the invention provides a kind of static seal multichannel sprinkler design for chromatographic column, by the unique design to shower nozzle lifting form and the sealing of glue inlet tube road, preferred seal form, can solve an above-mentioned difficult problem.
Summary of the invention
The invention provides a kind of static seal multichannel sprinkler design for chromatographic column, a kind of glue inlet tube road can realize declining and promoting under bleed pressure particularly, and realizes sealing and the connection of glue-feeder respectively under decline and lifting state, and then realizes dress glue, chromatography, unloads the automation of glue.
The technical solution used in the present invention is as follows:
For a static seal multichannel sprinkler design for chromatographic column, comprise glue inlet tube road moving up and down, removable flange, fixture block, disc spring, showerhead base, sealing ring, screen cloth central jets etc.
One end, described glue inlet tube road has seal groove.
Described rotary flange can move along described glue inlet tube road axis direction.
Described rotary flange pedestal and rotary flange formation activity air cavity.
Described fixture block can drive described glue inlet tube road with rotary flange action.
Described disc spring is put stacking, and center is penetrated by glue inlet tube road.
Described rotary flange can force described disc spring to be out of shape according to the size of supply gas pressure, thus realizes rotary flange and move along described glue inlet tube road axis direction, and then realizes the movement in glue inlet tube road under the effect of described fixture block.
The movement in described glue inlet tube road provides power by gas pressure, conveniently realizes automation;
Under the decline in glue inlet tube road of the sealing ring of described glue inlet tube road end face and lifting state, coordinate the sealing and connection that can realize glue-feeder with screen cloth central jets.
Described screen cloth central jets is fixed in showerhead base, and screen cloth central jets open loop shape glue feeding opening, coordinates with glue inlet tube road end-face seal ring.
Patent of the present invention is used for the static seal multichannel sprinkler design of chromatographic column, comprises glue inlet tube road moving up and down, removable flange, fixture block, disc spring, showerhead base, sealing ring, screen cloth central jets etc.One end, described glue inlet tube road has trapezoidal seal groove; Described rotary flange can move along described glue inlet tube road axis direction; Described fixture block can drive described glue inlet tube road with rotary flange action; Described disc spring is put stacking, and center is penetrated by glue inlet tube road; Especially, the movement in described glue inlet tube road provides power by gas pressure, conveniently realizes automation; Especially, the seal groove of one end, described glue inlet tube road design coordinates with the aperture of screen cloth central jets, and can easily realize filling glue, chromatography, unloads glue process.
Advantage of the present invention is this static seal multichannel sprinkler design for chromatographic column, changes the seal form of mouth spray into static seal form by movable sealing form, make the movement in glue inlet tube road more light, automation more, and sealing effectiveness is better.
Below in conjunction with the drawings and specific embodiments, the invention will be further elaborated.
Accompanying drawing explanation
Figure 1 shows that overall graphics of the present invention
Figure 2 shows that glue inlet tube road of the present invention end part seal schematic diagram
Figure 3 shows that chromatography flow circuit diagram 1 of the present invention
Figure 4 shows that dress solation road Fig. 2 of the present invention
Figure 5 shows that and of the present inventionly unload solation road Fig. 3
Detailed description of the invention
A kind of static seal multichannel sprinkler design for chromatographic column as depicted in figs. 1 and 2, particularly: 1. screen cloth central jets; 2. trapezoidal seal groove; 3.O RunddichtringO; 4. showerhead base; 5. disc spring; 6. glue inlet tube road; 7. fixture block; 8. rotary flange; 9. rotary flange pedestal; 10. distributor; 11. upper distributor backboard.
Particularly as shown in Figure 3, regulate bleed pressure, make source outlet pressure be zero, make glue inlet tube road move down under disc spring resilient force, the mouth spray of screen cloth central jets is sealed, glue inlet tube road is closed, and chromatography stream as see arrows 17 in fig 3.
Particularly as shown in Figure 4, regulate bleed pressure, source outlet pressure is made to be setting pressure, gas pressure forces disc spring to be out of shape, and rotary flange moves, and road moves glue inlet tube, the mouth spray of glue inlet tube road port and screen cloth central jets is connected, glue-feeder is opened, and available pump pumps into sizing material or cleaning fluid from glue inlet tube road, and dress solation road is as shown in Fig. 4 arrow.
Particularly as shown in Figure 5, regulate bottom bleed pressure, source outlet pressure is made to be setting pressure, gas pressure forces disc spring to be out of shape, and rotary flange moves down, and glue inlet tube road moves down, the mouth spray of glue inlet tube road port and screen cloth central jets is connected, enter (going out) Jiao Kou to open, available pump extracts scrap rubber out from glue inlet tube road, unloads solation road as arrows in fig. 5.
The present invention is different from prior art, and screen cloth central jets is without the need to action, and everything all completes in inside; The decline in glue inlet tube road and be promoted to pneumatic auto-action, without the need to human intervention; Mouth spray adopts static seal design, better tightness, and the sealing ring life-span is longer, there will not be lifting difficulty or stuck, and can realize filling glue, chromatography, unloads the automation of glue.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention and accompanying drawing content to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.

Claims (8)

1., for a static seal multichannel sprinkler design for chromatographic column, comprise glue inlet tube road moving up and down, removable flange, rotary flange pedestal, fixture block, disc spring, showerhead base, sealing ring.Screen cloth central jets etc.
2. a kind of static seal multichannel sprinkler design for chromatographic column according to claim 1, is characterized in that one end, described glue inlet tube road has seal groove.
3. a kind of static seal multichannel sprinkler design for chromatographic column according to claim 1, is characterized in that described rotary flange can move along described glue inlet tube road axis direction.
4. a kind of static seal multichannel sprinkler design for chromatographic column according to claim 1, is characterized in that described fixture block can drive described glue inlet tube road with rotary flange action.
5. a kind of static seal multichannel sprinkler design for chromatographic column according to claim 1, it is characterized in that described disc spring is put stacking, center is penetrated by glue inlet tube road.
6. according to claim 3 and a kind of static seal multichannel sprinkler design for chromatographic column according to claim 5, it is characterized in that the movable air cavity that described rotary flange and rotary flange pedestal are formed can force described disc spring to be out of shape according to the size of supply gas pressure, thus realize rotary flange and move along described glue inlet tube road axis direction, and then realize the movement in glue inlet tube road under the effect of described fixture block.
7. a kind of static seal multichannel sprinkler design for chromatographic column according to claim 3, is characterized in that the movement in described glue inlet tube road provides power by gas pressure, conveniently realizes automation.
8. according to claim 2 and a kind of static seal multichannel sprinkler design for chromatographic column according to claim 6, under it is characterized in that the decline of the trapezoidal seal groove of described glue inlet tube road end face in glue inlet tube road and lifting state, sealing and the connection of glue-feeder can be realized.
CN201410390795.1A 2014-02-17 2014-08-11 A kind of static seal multichannel sprinkler design for chromatographic column Expired - Fee Related CN104307206B (en)

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CN201410052372.9 2014-02-17
CN201410052372 2014-02-17
CN2014100523729 2014-02-17
CN201410390795.1A CN104307206B (en) 2014-02-17 2014-08-11 A kind of static seal multichannel sprinkler design for chromatographic column

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107982961A (en) * 2018-01-08 2018-05-04 湖南科众源创科技有限公司 The full-automatic chromatographic column of movable beam type

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7841698A (en) * 1994-10-03 1998-11-05 Ge Healthcare Bio-Sciences Ab Chromatography apparatus
CN101238366A (en) * 2005-10-21 2008-08-06 通用电气健康护理生物科学股份公司 Automated packing system and method for chromatography columns
CN103267149A (en) * 2013-05-07 2013-08-28 荣捷生物工程(苏州)有限公司 Automatic column mounting valve
WO2013191631A1 (en) * 2012-06-21 2013-12-27 Ge Healthcare Bio-Sciences Ab Chromatography column nozzle
CN204337831U (en) * 2014-02-17 2015-05-20 长沙市源创精科生物技术有限公司 A kind of static seal multichannel sprinkler design for chromatographic column

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7841698A (en) * 1994-10-03 1998-11-05 Ge Healthcare Bio-Sciences Ab Chromatography apparatus
CN101238366A (en) * 2005-10-21 2008-08-06 通用电气健康护理生物科学股份公司 Automated packing system and method for chromatography columns
WO2013191631A1 (en) * 2012-06-21 2013-12-27 Ge Healthcare Bio-Sciences Ab Chromatography column nozzle
CN103267149A (en) * 2013-05-07 2013-08-28 荣捷生物工程(苏州)有限公司 Automatic column mounting valve
CN204337831U (en) * 2014-02-17 2015-05-20 长沙市源创精科生物技术有限公司 A kind of static seal multichannel sprinkler design for chromatographic column

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107982961A (en) * 2018-01-08 2018-05-04 湖南科众源创科技有限公司 The full-automatic chromatographic column of movable beam type
WO2019134418A1 (en) * 2018-01-08 2019-07-11 湖南科众源创科技有限公司 Fully automatic chromatography column having movable beam

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Address after: 410000 Hunan province Changsha Wenxuan High-tech Development Zone, Road No. 27 Building No. 101 Yuyuan Lu Valley A2

Applicant after: Biotechnology (Changsha) Co., Ltd of Yuan Chuanjing section

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Free format text: CORRECT: APPLICANT; FROM: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. TO: YUANCHUANG JINGKE BIO-TECHNOLOGY (CHANGSHA) CO., LTD.

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Granted publication date: 20170405

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