CN103263656B - A kind of preparation method for the treatment of tophaceous medicine for external use film - Google Patents

A kind of preparation method for the treatment of tophaceous medicine for external use film Download PDF

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CN103263656B
CN103263656B CN201310217114.7A CN201310217114A CN103263656B CN 103263656 B CN103263656 B CN 103263656B CN 201310217114 A CN201310217114 A CN 201310217114A CN 103263656 B CN103263656 B CN 103263656B
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lyophilized powder
medicine
female carrot
tophaceous
external use
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CN103263656A (en
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张瑞君
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Shenyang Kangfeng Pei Biotechnology Co.,Ltd.
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张瑞君
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Abstract

The preparation method that <b> mono-kind treats tophaceous medicine for external use film belongs to medical configuration product art; Specifically, relate to a kind of medicine for external use film, refer in particular to one and treat tophaceous medicine for external use film and preparation method thereof.The invention provides a kind of effect significantly, the tophaceous medicine for external use film for the treatment of of instant effect, with and preparation method thereof.The raw material of medicine for external use film of the present invention consists of the following composition: female carrot lyophilized powder, female carrot cherry lyophilized powder, fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Sal, and mannitol and propylene glycol.</b>

Description

A kind of preparation method for the treatment of tophaceous medicine for external use film
Technical field
the invention belongs to medical configuration product art; Specifically, relate to a kind of medicine for external use film, refer in particular to one and treat tophaceous medicine for external use film and preparation method thereof.
Background technology
clinically, because lacking effective remedy measures, the continuous deterioration of the uncontrollable disease of a large amount of goat patients: urate is separated out from body fluid, forms crystallization, is deposited on the places such as joint, stimulates joint to produce inflammation; Along with disease forms tophus further, and constantly " growing up ", with the passing of time can cause joint damage deformity, have a strong impact on normal physiological function.
tophaceous Therapeutic Method: major measure clinical taked at present carries out joint debridement operation, excision hypertrophy and the synovial tissue having crystal deposition, remove simultaneously and be deposited on IA tophus, the tissue of finishing regression, to Cranial defect, corresponding treatment is carried out, fracture operation as micro-in cartilage defect, Cranial defect bone grafting operation etc. to residual cartilage.
but this remedy measures exists serious problem: one is cannot treat from root, and operation is complicated, brings very large misery to patient; Two is only just can implement operation to a certain extent at disease progression, intervening measure actively cannot be moved forward, very passive and passive.
Summary of the invention
the present invention is exactly for the problems referred to above, overcomes the deficiency that prior art exists, provide a kind of effect significantly, the tophaceous medicine for external use film for the treatment of of instant effect, with and preparation method thereof.
for realizing above-mentioned purpose of the present invention, the present invention adopts following technical scheme.
the raw material of medicine for external use film of the present invention consists of the following composition: female carrot lyophilized powder, female carrot cherry lyophilized powder, fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Sal, and mannitol and propylene glycol.
its preparation method is: (1) produces deionization, aseptic distilled water with distillation equipment; Use the distilled water preparation Sal saturated solution prepared, use distilled water compound concentration to be 10% mannitol solution; After the 20:1 mixing by volume of above-mentioned two kinds of solution, add the propylene glycol of overall accumulated amount 1%, stirring and evenly mixing; Device therefor and utensil all use ozonization.
(2) 15:1:1 weighs fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis in mass ratio, pulverizes respectively, uses Ultra-Micro Grinding Equipment, Task-size Controlling 200 ~ 300 order.
(3) the fresh tobacco leaf paste in step (2), Zanthoxyli Bungeani powder, ginger powder are added in the leaching tanks with mixing plant respectively, join in the obtained Sal of step (1), mannitol, mixed with propylene glycol liquid and carry out soaking, extracting, mixed liquor is 10:1 with the mass ratio dipping dry material, and continuous stirring at low speed, rotating speed 15RPM; Temperature controls at 35 ~ 45 DEG C, and immersion and mixing time are 3 ~ 5 hours, and device therefor and utensil all use 0.5% peracetic acid soln to carry out disinfection.
(4), after immersion and stirring terminate, solution obtained to step (3) respectively carries out centrifugalize, and rotating speed is 500 revs/min, after centrifugal 3 ~ 5 minutes, removes larger particle, obtains three kinds of clear solution.
(5), after three kinds of clear solution step (4) obtained are miscible, adopt vacuum concentration to receive cream machine and carry out vacuum concentration, heating-up temperature is 70 ~ 80 DEG C; Volume to mixed liquor remains a half, terminates concentrated.
(6) in the concentrated solution that step (5) is obtained, add female carrot lyophilized powder and female carrot cherry lyophilized powder, addition is the relative scale of female carrot lyophilized powder and female carrot cherry lyophilized powder is 1:1, the ratio of the quality summation of the quality summation of female carrot lyophilized powder and female carrot cherry lyophilized powder and fresh tobacco leaf, Pericarpium Zanthoxyli and Rhizoma Zingiberis is 4 ~ 1:1 ~ 5, use high-speed mixer, make finely dispersed colloid solution.
(7) by non-woven fabrics or non-woven fabrics hands/foot cover, immerse in the obtained colloid solution of step (6), soak into rear taking-up, hang, complete when dripless is dripped, then with ultraviolet lamps irradiates sterilization 30 ~ 60 seconds.
(8) load in sterile aluminum foil bag, after using vacuum packing machine to carry out evacuation, heat sealing, obtains treatment of the present invention tophaceous medicine for external use film product.
wherein, the production technology of female carrot lyophilized powder (or female carrot ornamental tassels lyophilized powder) comprises Fruit variety, Cultivate administration, pretreatment, low-temperature vacuum dehydration, liquid nitrogen deep pulverizing and nitrogen gas packing six links.
(1) Fruit variety: the seed (i.e. the seed of " wind resistance is red " kind) selecting that preside over research by Zhang Shufang, Zhang Ruijun father and son, that Shenyang green star Chinese cabbage institute is produced " male sterility line " triple crossing female carrot.
(2) Cultivate administration: realize anniversary plantation by protecting field technology, plantation place is east longitude 123 degree, north latitude 43 degree, height above sea level 50 meters, be rich in organic loose fertile sandy soil earth, the deep water conservation of soil and drainage good, maximum water holding capacity 60 ~ 80%, air humidity is 80 ~ 90%, and illumination is sufficient; Insecticide adopts the BT Emulsion meeting organic grow, and fertilizer adopts the chicken manure fully become thoroughly decomposed as fertilizer, and every mu is applied fertilizer at least 5000 kilograms; Female carrot grows to individual weight about 100 ~ 300 grams, and (the Cultivate administration link of female carrot cherry lyophilized powder is when cherry grows to 30cm height, start to pluck), namely carry out gather (testing result shows, the nutrition accumulation being in the female carrot of this growth stage reaches summit).
(3) pretreatment: comprise cleaning and sterilizing, coarse crushing and quick-freezing three links; Female carrot after gathering screens out by disease and pest, and the neat root of Radix Raphani ornamental tassels retains 1 centimeter, and all the other excisions, are respectively charged into carton, are transported to processing factory's (refrigerated storage temperature: 0 ~ 3 DEG C) with refrigerator car; In processing factory, use water rinses the earth that female carrot is sticked well, after eliminating pimple, starts cleaning and sterilizing flow process; The order of cleaning and sterilizing flow process is: once wash, once sterilizing immersion bubble, secondary are washed, secondary sterilization immersion bubble, finally in cleaning line cleaning (4 times), the disinfectant solution that twice sterilization uses is chlorine dioxide 300ppm, and each sterilization soak time is 30 minutes.
by the female carrot dicer after cleaning and sterilizing, be cut into the Radix Raphani fourth of less than 0.6 ~ 1 cubic centimetre, then basin (female carrot ornamental tassels lyophilized powder sterilize in pretreatment link after, ornamental tassels vegetable-chopper is cut to 1 centimeter of length, spreads into basin) is spread.
then, the Radix Raphani fourth cut is carried out quick freezing in the freeze tunnel adopting air cooled chiller, make material center temperature in 30 minutes, be down to less than-4 DEG C (to be namely with by the maximum generation of ice crystal in 30 minutes, form ice crystal less and be dispersed in cell, prevent ice crystal from destroying cytoactive), when material center temperature is down to-25 ~-30 DEG C, quick-freezing terminates, and whole quick-freezing process about needs 2.5 hours.
(4) low-temperature vacuum dehydration: by pretreated Radix Raphani fourth, through vacuum sublimation drying equipment (manufacture of Xin Yang machinery plant of Shenyang City) drying and dehydrating, the temperature that scenario earthquake controls material is 40 ~ 60 DEG C, and about 10 ~ 12 hours drying and dehydrating time, after drying and dehydrating, material moisture should lower than 5%.
(5) liquid nitrogen deep is pulverized: the Radix Raphani fourth after low-temperature vacuum dehydration, liquid nitrogen deep pulverizer (Shanghai Pudong Gaoqiao Testing Machinery Co., Ltd.) is adopted to carry out pulverization process, it is-30 ~-150 DEG C that Radix Raphani fourth after step (4) dehydration pulverizes best brittle point, the particle size range of powder is 300 ~ 1000 orders (wherein, preferably 600 orders).Owing to being to the micronizing that material carries out under the temperature conditions of-100 ~-150 DEG C, therefore nutrition and functional component are without heat loss, the complete breaking cellular wall of cell;-30 DEG C of above smashing fineness of temperature are inadequate, although-150 DEG C of very thin liquid nitrogen costs of the following fineness of temperature can increase substantially, are-135 DEG C through test optimum temperature.
medicine for external use film of the present invention produces effect that is collaborative, that be added by the compatibility of similar effect medicinal plants.Record according to Chinese medicine ancient books and records such as Compendium of Material Medica, the function of fresh tobacco leaf cures mainly: qi and blood circulation promotion, to harness the Yellow River swollen, gout, metrorrhagia, treating swelling and pain by traumatic injury, toothache, scrofula, eczema, dermatitis, detumescence poison, pain relieving, fracture, traumatic injury, carbuncle furuncle and phyma poison, skin ulcer, traumatic hemorrhage etc.Pericarpium Zanthoxyli and Rhizoma Zingiberis all have effect of warming middle-JIAO to relieve pain, dispelling cold and removing dampness, coordinate female carrot lyophilized powder, (female carrot has the tophaceous curative effect of dissolving to female carrot cherry lyophilized powder, through this kind of plant of lyophilization, nitrogen ultra low temperature grinding and processing ultra-micro powder because of its granularity very little, Cutaneous permeation function is stronger, therapeutic effect is better), show stronger antiinflammatory, pain relieving, litholytic effect.Sal mainly plays sterilization and sterilization.The object of mannitol, propylene glycol is for promoting skin attachment and assimilation effect.Also can add natural plant extraction spice in the feed, to loosen calm nerves, to improve the penetrating odor of functional component.
compared with prior art beneficial effect of the present invention.
the present invention treats tophaceous medicine for external use film and leads group medicine, the capable stagnant through focus of relieving accumulation of pathogens with the thick medicine of abnormal smells from the patient tool for guiding.Spread on the medicine irritation teleneuron of body surface, by reflection, blood vessel dilating, promotes local blood circulation, improves surrounding tissue nutrition, reach detumescence, antiinflammatory and analgesic object.Medicine reaches subcutaneous tissue in affected part by Cutaneous permeation simultaneously, produces the relative potence of drug level in local, thus plays stronger pharmacological action.
the present invention utilizes the physical characteristic of the good infiltration function of female carrot lyophilized powder and female carrot cherry lyophilized powder, make and directly can spread on the hands of common tophus formation, the hands film of foot position and foot mask, by the direct administration of focus, fast softening dissipation tophus.In order to better play its effect, combining the natural plant composition such as fresh tobacco leaf, Zanthoxyli Bungeani powder, Rhizoma Zingiberis powder with effects such as promoting the flow of QI in the collateral by warming the meridian, removing summer-heat pathogenic heat, dispelling cold and absorbing clot, anti-inflammatory analgesics simultaneously, making the compound recipe application compress film of determined curative effect, eliminate local symptom fast.
Detailed description of the invention
embodiment 1: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 1:1 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.Choosing treatment target, to be the gout course of disease longer, there is tophaceous patient in various degree, occupation mode in hand or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removes after two hours, period notices that hands (foot) is warming, and every day carries out for twice sooner or later.
choose hand or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 70 people reduced obviously, and 6 people of all dissipating, all the other 24 people's pain all have to be alleviated in various degree.Have 76% of remarkable result, effective 24%.
embodiment 2: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 1:2 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.Choosing treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 80 people reduced obviously, and 12 people of all dissipating, all the other 8 people's pain all have to be alleviated in various degree.92% of Be very effective, effective 8%.
embodiment 3: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 1:3 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.
choosing treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 82 people reduced obviously, and 4 people of all dissipating, all the other 14 people's pain all have to be alleviated in various degree.86% of Be very effective, effective 14%.
embodiment 4: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 1:4 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.
choosing treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 80 people reduced obviously, and 8 people of all dissipating, all the other 12 people's pain all have to be alleviated in various degree.88% of Be very effective, effective 12%.
embodiment 5: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 2:1 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.Choosing treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 60 people reduced obviously, and 2 people of all dissipating, all the other 38 people's pain all have to be alleviated in various degree.62% of Be very effective, effective 38%.
case study on implementation 6: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 3:1 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.Choosing treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 75 people reduced obviously, and 1 people of all dissipating, all the other 24 people's pain all have to be alleviated in various degree.76% of Be very effective, effective 24%.
case study on implementation 7: raw material is the female carrot cherry lyophilized powder of female carrot lyophilized powder and equal quality; The mass ratio of fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis is 15:1:1, and the gross mass of three kinds of materials and the gross mass of first two material press 4:1 compatibility, according to above-mentioned preparation procedure, makes hands (foot) film.。
adopt this kind of compatibility than arranging hands (foot) film made, the clinical pain patient to there being tophus to be formed treats.Getting treatment target, to be the gout course of disease longer, and occupation mode appears tophaceous patient in various degree, in hands or foot: hands (foot) puts " gout hands (foot) Sal Nitri film " after cleaning, and removing after two hours, period notices that hands (foot) is warming.Every day carries out for twice sooner or later.
choose hands or foot tophus obvious patient 100 people altogether, treated by said method, after 30 days, tophus is softening 81 people reduced obviously, and 3 people of all dissipating, all the other 16 people's pain all have to be alleviated in various degree.84% of Be very effective, effective 16%.
implement 1 ~ 7 to show, by female carrot lyophilized powder, female carrot cherry lyophilized powder and fresh tobacco leaf, Zanthoxyli Bungeani powder, Rhizoma Zingiberis powder, refined salt compatibility and hands (foot) film made, be enclosed within hands (foot) position that tophus occurs, have remarkable efficacy to the tophaceous softening dissipation in this position, the anti-inflammatory analgetic for tophus outbreak position has good effect.

Claims (2)

1. treat the preparation method of tophaceous medicine for external use film for one kind, it is characterized in that: the raw material of medicine for external use film consists of the following composition: female carrot lyophilized powder, female carrot ornamental tassels lyophilized powder, fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis, Sal, and mannitol and propylene glycol;
Its preparation method is: (1) produces deionization, aseptic distilled water with distillation equipment; Use the distilled water preparation Sal saturated solution prepared, use distilled water compound concentration to be 10% mannitol solution; After the 20:1 mixing by volume of above-mentioned two kinds of solution, add the propylene glycol of overall accumulated amount 1%, stirring and evenly mixing; Device therefor and utensil all use ozonization;
(2) 15:1:1 weighs fresh tobacco leaf, Pericarpium Zanthoxyli, Rhizoma Zingiberis in mass ratio, pulverizes respectively, uses Ultra-Micro Grinding Equipment, Task-size Controlling 200 ~ 300 order;
(3) the fresh tobacco leaf paste in step (2), Zanthoxyli Bungeani powder, ginger powder are added in the leaching tanks with mixing plant respectively, join in the obtained Sal of step (1), mannitol, mixed with propylene glycol liquid and carry out soaking, extracting, mixed liquor is 10:1 with the mass ratio dipping dry material, and continuous stirring at low speed, rotating speed 15RPM; Temperature controls at 35 ~ 45 degree, and immersion and mixing time are 3 ~ 5 hours, and device therefor and utensil all use 0.5% peracetic acid soln to carry out disinfection;
(4), after immersion and stirring terminate, solution obtained to step (3) respectively carries out centrifugalize, and rotating speed is 500 revs/min, after centrifugal 3 ~ 5 minutes, removes larger particle, obtains three kinds of clear solution;
(5), after three kinds of clear solution step (4) obtained are miscible, adopt vacuum concentration to receive cream machine and carry out vacuum concentration, heating-up temperature is 70 ~ 80 degree; Volume to mixed liquor remains a half, terminates concentrated;
(6) in the concentrated solution that step (5) is obtained, add female carrot lyophilized powder and female carrot cherry lyophilized powder, addition is the relative scale of female carrot lyophilized powder and female carrot ornamental tassels lyophilized powder is 1:1, the ratio of the quality summation of the quality summation of female carrot lyophilized powder and female carrot ornamental tassels lyophilized powder and fresh tobacco leaf, Pericarpium Zanthoxyli and Rhizoma Zingiberis is 4 ~ 1:1 ~ 5, use high-speed mixer, make finely dispersed colloid solution;
(7) by non-woven fabrics or non-woven fabrics hands/foot cover, immerse in the obtained colloid solution of step (6), soak into rear taking-up, hang, complete when dripless is dripped, then with ultraviolet lamps irradiates sterilization 30 ~ 60 seconds;
(8) load in sterile aluminum foil bag, after using vacuum packing machine to carry out evacuation, heat sealing, must treat tophaceous medicine for external use film product.
2. a kind of preparation method for the treatment of tophaceous medicine for external use film according to claim 1, it is characterized in that: in step (6), the ratio of the quality summation of the quality summation of female carrot lyophilized powder and female carrot ornamental tassels lyophilized powder and fresh tobacco leaf, Pericarpium Zanthoxyli and Rhizoma Zingiberis can be 2:1.
CN201310217114.7A 2013-06-04 2013-06-04 A kind of preparation method for the treatment of tophaceous medicine for external use film Active CN103263656B (en)

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"抗风红"降血尿酸作用研究;郑俊波等;《求医问药下半月刊》;20111130;第9卷(第11期);第17页左栏第2段和第18页右栏第1段 *
痛风病的治疗;黄存垣;《老友》;20030831;第47页右栏第1段 *

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