CN103263533A - Theobromine composition for treating cough and application and preparation thereof - Google Patents
Theobromine composition for treating cough and application and preparation thereof Download PDFInfo
- Publication number
- CN103263533A CN103263533A CN2013102151228A CN201310215122A CN103263533A CN 103263533 A CN103263533 A CN 103263533A CN 2013102151228 A CN2013102151228 A CN 2013102151228A CN 201310215122 A CN201310215122 A CN 201310215122A CN 103263533 A CN103263533 A CN 103263533A
- Authority
- CN
- China
- Prior art keywords
- theobromine
- cough
- compositions
- preparation
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a theobromine composition for treating the cough and also discloses application and a preparation thereof. The theobromine composition comprises the following effective components in parts by weight: 1 part of theobromine and 1-5 parts of tea polyphenol. The theobromine composition has a good effect of treating the cough and is safe and reliable.
Description
Technical field
The present invention relates to be used for the treatment of the compositions of cough, more specifically, relate to and comprise theobromine as the compositions that is used for the treatment of cough of active component; The present invention relates to purposes and the oral formulations of said composition simultaneously.
Background technology
It is physiological that cough is that human body is subjected to, and the defense reaction the during respiratory tract of mechanical or chemical can be discharged secretions or the foreign body of trachea, bronchus accumulation, with self-protection.But in some situation, particularly human body cough reaction is violent or when more not developing into chronic cough even asthma for a long time owing to disease, can bring many miseries to human body, and quality of life is also adversely effected.In this case, people often look forward to by seeking medical advice and medicine to alleviate or eliminate this misery.
Present widely used antitussive mainly is to act on the central nervous system or peripheral nervous system reaches the antitussive effect.Act on the central nervous system, suppress the medicine that nervus centralis reaches the antitussive effect, such as codeine, dromethan etc. often have undue calmness or/and the side effect of addiction.Because these adverse side effects, some medicines such as codeine etc. have been classified the strict control of control class medicine as.And the cough suppressing medicine that acts on peripheral nervous system obtains the effect of cough-relieving by sensor, nervus centripetalis, the nervus centrifugalis that suppresses coughre flex, and safety is higher.As theobromine, naturally be present in plants such as tea, cacao bean, Chang Zuowei diuretic or crude drug use in pharmacy.Nearest a series of pertinent literature shows that theobromine can suppress coughre flex by suppressing vagus nerve, and the antitussive effect is not less than codeine, and safe.
Respiratory inflammation is a kind of main stimulus that causes cough.Inflammatory reaction can make trachea or bronchus net accumulation secretions, excites nerve and causes cough, discharges secretions.Can effectively treat the corresponding cough of improvement symptom to the inhibition of respiratory inflammation.The effective ingredient of tea such as tea polyphenols etc. have tangible anti-inflammatory function and suppress the pathogen function.According to open source information, tea polyphenols can suppress and kill bacterial infections such as streptococcus, typhoid fever bacterium, bordetella pertussis, Diplococcus pneumoniae, dysentery bacterium, staphylococcus, and general inflammation, nephritis, oral inflammation, oral cavity pathogen are had better curative effect.Tea antiinflammatory mechanism is relevant with comprehensive functions such as the inflammation-inhibiting factor, immunomodulating, antioxidation, bacteriostasis.Anaphylaxis also is a kind of main cause of cough, studies show that tea polyphenols also has antianaphylactic function.
For the treatment cough, do not have medicine satisfactory for result and that be free from side effects at present.
Summary of the invention
The objective of the invention is to, provide a kind of safe and reliable, the theobromine compositions that the treatment cough is satisfactory for result.
The present invention is achieved through the following technical solutions this purpose:
A kind of theobromine compositions for the treatment of cough, its effective ingredient are the 1 part of theobromine that calculates by weight, and 1 part～5 parts tea polyphenols.
Theobromine can suppress coughre flex by suppressing vagus nerve, has antitussive function safely and efficiently; Tea polyphenols can suppress and kill bacterial infections such as streptococcus, typhoid fever bacterium, bordetella pertussis, Diplococcus pneumoniae, dysentery bacterium, staphylococcus, general inflammation, nephritis, oral inflammation, oral cavity pathogen there are better curative effect, and have antianaphylactic function.Theobromine and tea polyphenols are used treatment cough, have good cooperative compensating effect, and theobromine can quick-acting antitussives, and tea polyphenols can effect a permanent cure and radically reform.Described theobromine compositions has good effect to the treatment cough, and safe and reliable.
Further, the every dosage of described theobromine component thing contains theobromine 300mg～900mg.
Further, described theobromine extracts from Mao Yecha or cacao bean and obtains.
Mao Yecha (Camellia ptilophylla, different name cocoa tea Camellia ptilophylla chan) is the tea kind of new discovery selection-breeding in recent years, with conventional tea (Camellia sinensis) be the provenance relation of homology on the same group.The Mao Yecha inclusions is abundant, and wherein the main biological substance of two classes is theobromine and tea polyphenols, and the content of its theobromine is far above the common tea kind, also is higher than the content of high value plant such as cacao bean, and more particularly, Mao Yecha is decaffeinated.Because natural theobromine and the tea polyphenols of being rich in of hair leaf tea extract, extracting theobromine, tea polyphenols from Mao Yecha is feasible economically, meet people simultaneously to the pursuit of natural safety, also meet the trend of dietetic therapy, avoid the potential risk of the synthetic source of chemical industry medicine.
Another object of the present invention is to, described theobromine compositions is as the purposes of the medicine for the treatment of cough.
Another object of the present invention is to, described theobromine compositions is as the purposes of the health product of prevention cough.
Another object of the present invention is to, the preparation that comprises described theobromine compositions is provided.Described preparation adopts conventional pharmaceutical technology and adjuvant, is prepared into medicine.
Present relatively technology, theobromine compositions of the present invention has good effect to the treatment cough, and safe and reliable.
The specific embodiment
Adopt common process and the adjuvant of pharmaceutics that theobromine and tea polyphenols are prepared theobromine compositions A, B, C by weight 1:1,1:2,1:5 respectively, it is wherein a kind of that these theobromine compositionss can be into tablet, capsule, one-tenth pill, granule, syrup.
During with theobromine combination treatment adult's (calculating with body weight 70kg) cough, needing its every dosage to contain theobromine is 300mg～900mg; When converting the cough for the treatment of mice (body weight 22-26g) to, needing the every dosage of theobromine compositions to contain theobromine is 39mg/kg～117mg/kg.
With the mice random packet that experimentizes, the theobromine of the 1st group of feeding 39mg/kg dosage wherein, the tea polyphenols of the 2nd group of feeding 78mg/kg dosage, 3rd, 4,5 groups of theobromine compositions B that distinguish feeding 117mg/kg, 234mg/kg, 351mg/kg dosage, the theobromine compositions A of the 6th group of feeding 78mk/kg dosage, the theobromine compositions C of the 7th group of feeding 234mk/kg dosage, the 8th group of feeding placebo handled 7 continuously.
Lure mouse cough into the strong aqua ammonia spraying behind the last feeding, record mouse cough incubation period and cough-relieving number of times again, data record sees Table 1.Experimental result shows, utilizes the theobromine compositions can treat cough, and compares the better effects if of theobromine compositions with the theobromine of independent use isodose.
Table 1
| Group | Dosage | Cough latent period (s) | The cough-relieving number of times (inferior/5min) |
| The 1st group | The 39mg/kg theobromine | 90.5±16.3 | 17.3±3.8 |
| The 2nd group | The 78mg/kg tea polyphenols | 63.6±13.5 | 25.8±7.6 |
| The 3rd group | 117mg/kg theobromine compositions B | 100.1±18.2 | 13.7±3.2 |
| The 4th group | 234mg/kg theobromine compositions B | 108±23.3 | 12.1±3.3 |
| The 5th group | 351mg/kg theobromine compositions B | 122.7±21.8 | 10.1±3.0 |
| The 6th group | 78mg/kg theobromine compositions A | 94.3±15.8 | 15.7±4.1 |
| The 7th group | 234mg/kg theobromine compositions C | 98.4±17.5 | 14.9±3.5 |
| The 8th group | Placebo | 54.4±9.3 | 32.6±8.1 |
Claims (10)
1. a theobromine compositions for the treatment of cough is characterized in that: the 1 part theobromine of its effective ingredient for calculating by weight, and 1 part～5 parts tea polyphenols.
2. theobromine compositions according to claim 1, it is characterized in that: the every dosage of described theobromine component thing contains theobromine 300mg～900mg.
3. theobromine compositions according to claim 1, it is characterized in that: described theobromine extracts from Mao Yecha or cacao bean and obtains.
4. according to each described theobromine compositions of claim 1 to 3, it is characterized in that: described theobromine compositions is as the purposes of the medicine for the treatment of cough.
5. according to each described theobromine compositions of claim 1 to 3, it is characterized in that: described theobromine compositions is as the purposes of the health product of prevention cough.
6. according to each described theobromine compositions of claim 1 to 3, it is characterized in that: adopt common process and the adjuvant of pharmaceutics, be prepared into any oral formulations on the pharmaceutics.
7. theobromine compositions according to claim 6 is characterized in that: adopt common process and the adjuvant of preparation tablet, be prepared into tablet.
8. theobromine compositions according to claim 6 is characterized in that: adopt common process and the adjuvant of preparation capsule, be prepared into capsule.
9. theobromine compositions according to claim 6 is characterized in that: adopt common process and the adjuvant of preparation pill, be prepared into pill.
10. theobromine compositions according to claim 6 is characterized in that: adopt common process and the adjuvant of preparation granule, be prepared into granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310215122.8A CN103263533B (en) | 2013-05-31 | 2013-05-31 | Theobromine composition for treating cough and application and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310215122.8A CN103263533B (en) | 2013-05-31 | 2013-05-31 | Theobromine composition for treating cough and application and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103263533A true CN103263533A (en) | 2013-08-28 |
| CN103263533B CN103263533B (en) | 2014-11-05 |
Family
ID=49007227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310215122.8A Expired - Fee Related CN103263533B (en) | 2013-05-31 | 2013-05-31 | Theobromine composition for treating cough and application and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103263533B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112383A (en) * | 2006-07-25 | 2008-01-30 | 安国药品株式会社 | Compositions for treating of cough |
| CN102802625A (en) * | 2009-12-14 | 2012-11-28 | 比蔻匹亚有限公司 | Therapeutic combinations of theobromine and an antihistamine |
-
2013
- 2013-05-31 CN CN201310215122.8A patent/CN103263533B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112383A (en) * | 2006-07-25 | 2008-01-30 | 安国药品株式会社 | Compositions for treating of cough |
| CN102802625A (en) * | 2009-12-14 | 2012-11-28 | 比蔻匹亚有限公司 | Therapeutic combinations of theobromine and an antihistamine |
Non-Patent Citations (2)
| Title |
|---|
| 张宏达等: "中国发现新的茶叶资源——可可茶", 《中山大学学报》, no. 3, 31 December 1988 (1988-12-31), pages 131 - 132 * |
| 赵军: "茶多酚药理作用研究进展", 《实用中医药杂志》, vol. 19, no. 3, 31 March 2003 (2003-03-31), pages 164 - 165 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103263533B (en) | 2014-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102754888A (en) | Beautiful millettia root tea bag and preparation method thereof | |
| Frieri | Herbal therapies: what allergist-immunologists should know regarding patient use of complementary and alternative medicine | |
| Tangpu et al. | Antidiarrhoeal activity of Cymbopogon citratus and its main constituent, citral | |
| CN104107216A (en) | Traditional Chinese medicine compound preparation and its preparation method and use | |
| Abascal et al. | Herbs and drug resistance: Part 2—Clinical implications of research on microbial resistance to antibiotics | |
| CN103263533B (en) | Theobromine composition for treating cough and application and preparation thereof | |
| CN105816489A (en) | Preparation method of durio zibethinus murr shell extract and application of durio zibethinus murr shell extract | |
| CN104547683B (en) | A kind of Chinese medicine composition for treating chronic gastritis and preparation method thereof | |
| CN104274750B (en) | A kind of Chinese medicine composition for treating acute bronchitis, the infection of the upper respiratory tract | |
| CN111514246A (en) | Traditional Chinese medicine composition and mask for preventing novel coronavirus pneumonia | |
| CN103893353A (en) | Traditional Chinese medicinal composition for bringing down fever and relieving pain and application thereof | |
| CN104162131A (en) | Medicinal tea for curing rhinitis | |
| CN103599288A (en) | Traditional Chinese medicine oral liquid for treating chicken infectious laryngotracheitis and preparation method thereof | |
| CN108030796A (en) | A kind of anaesthetic of resisiting influenza virus and preparation method thereof | |
| CN101721437A (en) | Medicine composition used for treating chronic pharyngitis and preparation method thereof | |
| KR20190016754A (en) | A pharmaceutical composition comprising tetragonia tetragonoides extract for preventing or treating depression | |
| CN105796894B (en) | A kind of antipyretic Chinese medicine composition and preparation | |
| CN104958654B (en) | A kind of Chinese medicine composition for treating active tuberculosis | |
| CN101007062A (en) | Traditional Chinese medicine composition capable of resisting infection | |
| CN105267608A (en) | Composition for clearing lungs and removing dust | |
| CN104644926A (en) | Spray for treating bronchial asthma | |
| CN105749007A (en) | Drug for preventing and treating fowl plague | |
| CN105533066A (en) | Folium artemisiae argyi herbal tea and making method thereof | |
| CN104491198A (en) | Gmelina-based medicine capable of relieving cough and asthma and preparation method thereof | |
| CN105106486A (en) | Rose tea with constipation preventing and treating functions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 510000 Guangdong city of Guangzhou province Tianhe District Tao Yuk Road No. 97 403 Applicant after: Yang Hongwei Address before: 510000 Guangdong city of Guangzhou province Tianhe District Tao Yuk Road No. 91 403 Applicant before: Yang Hongwei |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141105 Termination date: 20160531 |