CN108030796A - A kind of anaesthetic of resisiting influenza virus and preparation method thereof - Google Patents
A kind of anaesthetic of resisiting influenza virus and preparation method thereof Download PDFInfo
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- CN108030796A CN108030796A CN201711360681.2A CN201711360681A CN108030796A CN 108030796 A CN108030796 A CN 108030796A CN 201711360681 A CN201711360681 A CN 201711360681A CN 108030796 A CN108030796 A CN 108030796A
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- Prior art keywords
- anaesthetic
- influenza virus
- resisiting influenza
- inula britannica
- britannica chinensis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of medicine, i.e., a kind of anaesthetic of resisiting influenza virus and preparation method thereof.Its main feature is that：The bulk pharmaceutical chemicals of the anaesthetic are Inula britannica chinensis.It is effective using modes such as fecula, the water-bindered pill, decoctings, especially with alcohol refer to water carry equal solvent extraction mode prepare, resisiting influenza virus has better effect.Beneficial effect is：Demonstrating traditional mongolian medicine Inula britannica chinensis has the function that resisiting influenza virus, has the effect of notable to polytype influenza, and has no toxic side effect, and does not produce drug resistance, medicine source is sufficient in addition, of low cost, it is expected to as the popular medicine of prevention and treatment influenza.
Description
Technical field
The present invention relates to a kind of medicine, i.e., a kind of anaesthetic of resisiting influenza virus and preparation method thereof.
Background technology
Influenza virus (influenza virus), is the representative of orthomyxoviridae family (Orthomyxoviridae)
Kind, abbreviation influenza virus, including human influenza virus and animal influenza virus, human influenza virus are divided into first (A), second (B), third (C)
Three types, are the pathogen of influenza (influenza).Wherein influenza A virus antigen easily morphs, and repeatedly causes the world
Property is very popular.Influenza B virus is relatively low to human pathogenic;Influenza virus C only causes the mankind unconspicuous or slight
The infection of the upper respiratory tract, seldom causes prevalence.Influenza is mainly the mass-sending disease triggered by influenza A virus.Mesh
Before, the antiviral agent for treating and preventing influenza virus is mostly Western medicine, such as neuraminidase inhibitor (NAI) Ao Sita
Wei and zanamivir, and M2 inhibitors of ion channels adamantane amines.But above combination drug have various side effects with
And limitation, and it is also easy to produce drug resistance.Therefore, development toxic side effect is small and is not likely to produce the new drug of drug resistance, becomes influenza and controls
The important topic for the treatment of.Mongolian medicine's anaesthetic is used as medicine using natural object particularly plant more, and toxic side effect is relatively low, and is not likely to produce drug resistance
Property.Carry out the research of anaesthetic resisiting influenza virus, there is good basic condition and development prospect.
The content of the invention
The object of the present invention is to provide a kind of infected by influenza to have stronger inhibitory action, and then has to influenza notable
Prevention and treatment effect, have no toxic side effect, and be not likely to produce anaesthetic of drug resistance and preparation method thereof.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic of resisiting influenza virus is developed, its main feature is that：It is described
The bulk pharmaceutical chemicals of anaesthetic are Inula britannica chinensis.
The bulk pharmaceutical chemicals of the anaesthetic are the flower or aerial part of Inula britannica chinensis.
Adult's single medicine for oral administration of the anaesthetic is to spend 8-15g of 10-20g or plant by Inula britannica chinensis.
The anaesthetic is the flower of Inula britannica chinensis or the solvent extractable matter of aerial part.
The anaesthetic is the alcohol extract that Inula britannica chinensis is its flower.
The anaesthetic is the water extract of Inula britannica chinensis aerial part.
Concentration >=0.000064mg/ml of the alcohol extract of the flower.
The concentration of the alcohol extract of the flower is 0.00032mg/ml, error≤10%..
The concentration of the water extract of the aerial part is >=0.00032 mg/ml.
The concentration of the water extract of the aerial part is 0.004 mg/ml, error≤10%..
The preparation method of the anaesthetic：The flower of Inula britannica chinensis is used to the ethanol of 70% concentrations above, to flood the amount of Inula britannica chinensis
For lower limit, reflux three times, filters to take filtrate and is condensed into cream.
The preparation method of the anaesthetic：Water after the aerial part of Inula britannica chinensis is crushed with three times volume soaks 30-60 points
Clock, is heated to boiling and keeps the temperature 40 minutes for more than 70 DEG C again, leaching JUICE CONCENTRATION is into cream repeatedly for three times.
The beneficial effects of the invention are as follows：Demonstrating traditional mongolian medicine Inula britannica chinensis has the function that resisiting influenza virus, to multiple types
The influenza of type has the effect of notable, and has no toxic side effect, and does not produce drug resistance, and medicine source is sufficient in addition, of low cost, it is expected into
To prevent and treat the popular medicine of influenza.
Brief description of the drawings
Fig. 1 is the experiment effect of Inula britannica chinensis inflorescence water extract resisiting influenza virus；
Fig. 2 is the experiment effect of Inula britannica chinensis inflorescence alcohol extracting thing resisiting influenza virus；
Fig. 3 is Inula britannica chinensis aerial part water extract resisiting influenza virus experimental result.
Embodiment
Inula britannica chinensis is feverfew Inula britannica chinensis Inula japonica Thunb. or Inula britannica Inula
Britannica L, " covering " here lead to " multiple ", the printed words for having " inular flower " on many publications, are same plant.It is existing
Generation research shows that the chemical composition of Inula britannica chinensis mainly has flavonoids, Sesquiterpene lactones and terpenoid, also containing cumarin,
Polysaccharide and volatile oil.The aerial part master Brevicornin Britanin of compound containing sesquiterpene lactone of Inula britannica chinensis flowering period
（Britanin）And inulin（Inulicin）.Flower contains Quercetin（Quercetin）, isoquercitin（Isoquercetin）、
Caffeic acid（Caffeic acid）, chlorogenic acid（Chlorogenicacid）, synanthrin and taraxasterol（Taraxasterol）Deng
A variety of sterols.
Inula britannica chinensis is middle Mongolian medicine's traditional medicine, is used as medicine more with dry capitulum.Its nature and flavor slight bitter, flat, soft, rough, dry, tool
" viscous " is killed, stops the functions such as shouting pain, dry " Xieri Wusu Symptom ", callus.Mongolian medicine is clinically mainly used for " gluing " shouting pain, " viscous " heat, hair
Disease, gold wound, fracture, brain shouting pain.
Modern study finds that Inula britannica chinensis has following pharmacological action：
1. relieving asthma, antitussive effect：Inula flavonoid has guinea pig bronchial spasmodic asthma caused by histamine obvious protection to make
With, also there is antagonism to guinea-pig isolated trachea spasm caused by histamine, but it is slow and weak compared with the effect of aminophylline.Mouse ammonium hydroxide sprays
Mist method and the experiment of phenol red excretion method show that inular flower flavones is without antibechic and phlegm-dispelling functions.Mouse peritoneal is injected 150% inular flower and is decocted
Agent 0.1ml, there is significant antitussive effect, but expectorant effect unobvious when 1 is small after administration.
Antibacterial action：Tablet paper disk method or trench method experiment, 1：Inula britannica chinensis decoction is to staphylococcus aureus, bacillus anthracis
There is obvious inhibitory action for II a plants with shigella flexneri.
Insecticidal action：The Inulicin of in vitro test 0.24-7.8 μ g/ml is to Trichomonas vaginalis and Entamoeba histolytica
There is the powerful protozoon that kills to act on.
Antioxidation：Inula britannica general flavone (TFIB) has rat ischemia-reperfusion injury brain notable
Protective effect, its mechanism of action may be related with TFIB antioxidations.Also to having significantly to cerebral ischemia re-pouring injured
Protective effect, its mechanism of action with suppress and reduce body lipid perhydride generation, enhancing body antioxidation activity have
Close.
Anti-proliferative effect：Influence of the inula flower extractive of various concentrations to fibroblast form is have studied, finds energy
Make its change, suppress cell Proliferation, concentration is below 500 μ g/ml without obvious cytotoxicity.
Effect to smooth muscle：Chlorogenic acid can dramatically increase the small bowel peristalsis of rat, mouse；Chlorogenic acid, caffeic acid, quinine
Acid can increase the tension force in uterus, but the effect can be cancelled by papaverine, and atropine then has no significant effect this.
The effect of Central nervous system：Chlorogenic acid and caffeic acid can improve rat to Oral Administration in Rats or intraperitoneal injection
Nerve excitability.
Effect to digestive system：Chlorogenic acid and caffeic acid take orally, and can increase the secretory volume of hydrochloric acid in people's stomach；Also there is increase
The effect of rat bile secretion.
To the prevention effect of hepatitis：Taraxasteryl acetate in Japanese Inula britannica chinensis has experimental hepatitis prevention to make
With.
Other：Inula britannica chinensis polysaccharide is acted on anti-constipation, and notable hypoglycemic activity, also there is certain improvement to blood fat disorder
Effect, may act on pancreas, have protective effect to injury of pancreas caused by diabetes.Inulin has antitumor action,
And there is cell line selectivity.Inulin also has anti-inflammatory effect.
Although Inula britannica chinensis has multiple pharmacological effect, the report of resisiting influenza virus there is no.
In recent years when treating other indications using Inula britannica chinensis, the flu-like symptom for chancing on patient quickly improves.Hereafter
It is successively 12 on probation.Wherein, Flu-A 10, influenza B 2.The modes such as fecula, the water-bindered pill, decocting, have received satisfaction
The effect of.
Pharmacological evaluation has been carried out on this basis, it was confirmed that Inula britannica chinensis has the function that resisiting influenza virus.Experiment content is very
It is more, three experimental examples are only exemplified by below：
1. taking the flower of Inula britannica chinensis to be extracted with water, dry cream is made in concentration.Specific method can by the aerial part of inular flower crush after with
The water of three times volume soaks 30-60 minutes, is heated to seethe with excitement, then more than 70 DEG C keep the temperature 40 minutes, and leaching juice is dense repeatedly for three times
Shorten dry cream into.Various concentrations are diluted to, carry out resisiting influenza virus experiment in vitro respectively.Experiment is in Jilin University's life science
Institute " AIDS vaccine national engineering laboratory " carries out, and influenza virus used is the Flu-A disease that the laboratory oneself preserves
Poison.Experimental result is shown in Table 1：
1 Inula britannica chinensis of table（Flower）The resisiting influenza virus experimental result of water extract（±s）
Table 1 combine Fig. 1 as it can be seen that the bacteriostasis rate in 0.0016 mg/ml of concentration of the water extract of the flower of Inula britannica chinensis reach 13.57 ±
8.39%, illustrate that there is resisiting influenza virus, but intensity is not high.
The flower of Inula britannica chinensis is taken to be extracted with ethanol, dry cream is made in concentration.Specific practice can be dense with more than 70% by the flower of Inula britannica chinensis
The ethanol of degree, using the amount for flooding Inula britannica chinensis as lower limit, flows back three times, filters to take filtrate and be condensed into cream.Take dry cream gradient dilution into
Various concentrations, carry out resisiting influenza virus experiment in vitro respectively.Experiment is in Jilin University's Life Science College " AIDS vaccine state
Family's engineering experiment room " carries out, and influenza virus used is the influenza A virus that the laboratory oneself preserves.Experimental result is shown in Table 2：
2 Inula britannica chinensis of table（Flower）The resisiting influenza virus experimental result of alcohol extract（±s）
Table 2 combine Fig. 2 as it can be seen that the bacteriostasis rate in 0.00032 mg/ml of concentration of the alcohol extract of the flower of Inula britannica chinensis reach 87.09 ±
11.68%, illustrate that colored alcohol extract resisiting influenza virus effect is stronger.
The aerial part of Inula britannica chinensis is taken to be extracted with water, dry cream is made in concentration.Specific method can be by the aerial part of inular flower
Water after crushing with three times volume soaks 30-60 minutes, is heated to seethe with excitement, then more than 70 DEG C keep the temperature 40 minutes, filter repeatedly for three times
Taking juice is condensed into dry cream.
Dry cream gradient dilution is taken to carry out resisiting influenza virus experiment in vitro respectively into various concentrations.Experiment is in Jilin University
" " AIDS vaccine national engineering laboratory " carries out Life Science College, and influenza virus used is that the laboratory oneself preserves
Alphavirus.Experimental result is shown in Table 3：
3 Inula britannica chinensis of table（Aerial part）The resisiting influenza virus experimental result of water extract（±s）
Table 3 combine Fig. 3 as it can be seen that Inula britannica chinensis aerial part water extract concentration in 0.004 mg/ml bacteriostasis rate reach 97.46 ±
13.11%, illustrate that the water extract resisiting influenza virus effect of aerial part is very strong.
Drug resistance experiment has been carried out on this basis, and virus has been contacted using small dose drug is repeated multiple times, then uses
Dosage experiments are stated, inhibition does not find significant difference, it was demonstrated that does not produce drug resistance.
Claims (12)
- A kind of 1. anaesthetic of resisiting influenza virus, it is characterised in that：The bulk pharmaceutical chemicals of the anaesthetic are Inula britannica chinensis.
- 2. the anaesthetic of resisiting influenza virus according to claim 1, it is characterised in that：The bulk pharmaceutical chemicals of the anaesthetic are Inula britannica chinensis Flower or aerial part.
- 3. the anaesthetic of resisiting influenza virus according to claim 1, it is characterised in that：Adult's single medicine for oral administration of the anaesthetic is 8-15g of 10-20g or plant is spent by Inula britannica chinensis.
- 4. the anaesthetic of resisiting influenza virus according to claim 1, it is characterised in that：The anaesthetic is the flower or ground of Inula britannica chinensis The solvent extractable matter of upper part.
- 5. the anaesthetic of resisiting influenza virus according to claim 4, it is characterised in that：The anaesthetic is the alcohol extracting of the flower of Inula britannica chinensis Thing.
- 6. the anaesthetic of resisiting influenza virus according to claim 4, it is characterised in that：The anaesthetic is Inula britannica chinensis aerial part Water extract.
- 7. the anaesthetic of resisiting influenza virus according to claim 5, it is characterised in that：The concentration of the alcohol extract of the flower >= 0.000064mg/ml。
- 8. the anaesthetic of resisiting influenza virus according to claim 7, it is characterised in that：The concentration of the alcohol extract of the flower is 0.00032mg/ml, error≤10%.
- 9. the anaesthetic of resisiting influenza virus according to claim 6, it is characterised in that：The concentration of the water extract of the aerial part For >=0.00032 mg/ml.
- 10. the anaesthetic of resisiting influenza virus according to claim 9, it is characterised in that：The water extract of the aerial part it is dense Spend for 0.004 mg/ml, error≤10%.
- 11. the preparation method of resisiting influenza virus anaesthetic as claimed in claim 1, it is characterised in that：The preparation method of the anaesthetic： The flower of Inula britannica chinensis is used to the ethanol of 70% concentrations above, using the amount for flooding Inula britannica chinensis as lower limit, flows back three times, filters to take filtrate It is condensed into cream.
- 12. the preparation method of resisiting influenza virus anaesthetic as claimed in claim 1, it is characterised in that：By the aerial part of Inula britannica chinensis Water after crushing with three times volume soaks 30-60 minutes, is heated to boiling and keeps the temperature 40 minutes for more than 70 DEG C again, filters repeatedly for three times Taking juice is condensed into cream.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711360681.2A CN108030796A (en) | 2017-12-18 | 2017-12-18 | A kind of anaesthetic of resisiting influenza virus and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773258A (en) * | 2020-08-11 | 2020-10-16 | 包书茵 | Mongolian medicine and pharmaceutical composition for resisting influenza virus, and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223546A (en) * | 1996-05-08 | 1999-07-21 | 梅里尔·斯奎尔斯 | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
| KR20110008483A (en) * | 2009-07-20 | 2011-01-27 | 건국대학교 산학협력단 | A composition containing extracts of inula japonica thunberg for preventing and treating infection with highly pathogenic avian influenza virus h5n1 |
-
2017
- 2017-12-18 CN CN201711360681.2A patent/CN108030796A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223546A (en) * | 1996-05-08 | 1999-07-21 | 梅里尔·斯奎尔斯 | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
| KR20110008483A (en) * | 2009-07-20 | 2011-01-27 | 건국대학교 산학협력단 | A composition containing extracts of inula japonica thunberg for preventing and treating infection with highly pathogenic avian influenza virus h5n1 |
Non-Patent Citations (1)
| Title |
|---|
| 周广泰: ""青海省防治流行性感冒的中草药"", 《中国高原医学与生物学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773258A (en) * | 2020-08-11 | 2020-10-16 | 包书茵 | Mongolian medicine and pharmaceutical composition for resisting influenza virus, and preparation method and application thereof |
| CN111773258B (en) * | 2020-08-11 | 2022-07-22 | 包书茵 | Mongolian medicine for resisting influenza virus, pharmaceutical composition, preparation method and application thereof |
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