CN103239669B - Traditional Chinese medicinal preparation for treating diabetic nephropathy - Google Patents
Traditional Chinese medicinal preparation for treating diabetic nephropathy Download PDFInfo
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- CN103239669B CN103239669B CN201310177306.XA CN201310177306A CN103239669B CN 103239669 B CN103239669 B CN 103239669B CN 201310177306 A CN201310177306 A CN 201310177306A CN 103239669 B CN103239669 B CN 103239669B
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating diabetic nephropathy. The traditional Chinese medicinal preparation is prepared from the following raw material medicines in parts by weight: 20-40 parts of amomum kravanh, 20-40 parts of shepherd's purse, 20-30 parts of cassia twig, 10-20 parts of seed of Chinese dodder, 10-20 parts of codonopsis pilosula, 10-20 parts of gordon euryale seed, 5-15 parts of bezoar, 5-15 parts of bear gall, 10-15 parts of pepperweed seed and 5-10 parts of shrub althea flower. The preparation method comprises the steps of: mixing various raw materials medicines, immersing in water, decocting and filtering; adding water to dreg, decocting and filtering; and combining filtrates to obtain the traditional Chinese medicinal preparation for treating diabetic nephropathy. The traditional Chinese medicinal preparation is applied by implementing coloclysis before sleep in every night, with 15 days as a course of treatment, and twice everyday for fatal symptoms. The traditional Chinese medicinal preparation has functions of detoxifying, promoting diuresis and diminishing swelling, and is concrete in curative effect; the traditional Chinese medicinal preparation has advantages of being low in cost, easy to prepare, easy to be accepted by patients and the like, and is capable of delaying the progress of disease; and the traditional Chinese medicinal preparation can be taken as an important measure for conservative treatment of the diabetic nephropathy in nephropathy azotemia, and has quite high clinical application value.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of diabetic nephropathy.
Background technology
Diabetic nephropathy is clinical common and multiple diabetic complication.Be one of complication that diabetes are the most serious, diabetic nephropathy is the main microvascular complications of diabetes, mainly refers to diabetic glomerulosclerosis, a kind of taking vascular lesion as main Glomerular lesions.In early days how asymptomatic, blood pressure can be normal or higher.Its incidence rate is along with the course of disease of diabetes extends and increases.The early stage kidney volume of diabetes increases, glomerular filtration rate increases, be high filtration state, engender space protein urine or microalbuminuria later, along with albuminuria, edema, hypertension, glomerular filtration rate reduction appear continuing in the prolongation of the course of disease, and then renal insufficiency, uremia, be one of main cause of death of diabetes.
Diabetic nephropathy is the common complication of diabetes, is one of diabetes general microangiopathies performance, and Clinical symptoms is albuminuria, gradual renal function injury, hypertension, edema, occurring severe renal nonfunction late period, is one of major causes of death of diabetics.In recent years along with China's population average life span extends, Diet lifestyle, the change of structure, linearly ascendant trend of the prevalence of diabetes, and due to the improvement of Therapeutic Method, the increase of life span, thus kidney and other complication also increase.According to recent statistics, China approximately has 5,000 ten thousand people being faced with the threat of diabetes at present.In the U.S., diabetic nephropathy accounts for the first place of renal failure in latter stage at end, is about 35%～38%.I type (IDDM) diabetes generation diabetic nephropathy ratio is higher, is about 35%～50%, II type (NIDDM) incidence rate approximately 20% left and right.But in diabetics, II type patient sickness rate far exceedes I type, therefore II type patient accounts for 70%～80% in diabetes renal failure dialysis patient.Diabetic nephropathy, in Chinese medicine document, had both belonged to diabetes, belonged to again the edema in nephropathy category, turbid urine, distension, in the diseases such as obstruction and rejection, pathogenesis is to suffer from a deficiency of the kidney as main, precise and tiny leaking of initial stage, disturbance in functioning of QI for a long time, retention of water-damp in the body, very in turbid poison, accumulate, visceral-qi void declines, and the card that easily changes always belongs to the disease of deficiency in origin and excess in superficiality.
For the treatment of diabetic nephropathy, the current clinical aggregate measures such as blood glucose, low protein diet of taking to control, End-stage diabetic nephropathy needs of patients carries out hemodialysis or peritoneal dialysis or renal transplantation, but due to reasons such as dialysis is painful greatly, kidney transplantation treatment expense height, patient's compliance is very poor.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of Chinese medicine preparation for the treatment of diabetic nephropathy, its curative effect is determined, can reduce patient's urinary albumin excretion ratio, improve the feeling sick of patient, vomiting, lower limbs edema symptom, reduce the toxicants such as creatinine, blood urea nitrogen, delay the progress of the diabetic nephropathy course of disease.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine preparation for the treatment of diabetic nephropathy; it is to be made by the crude drug of following weight portion: 20～40 parts, Fructus Amomi Rotundus; 20～40 parts, Herba Capsellae, 20～30 parts of Ramulus Cinnamomi, 10～20 parts of Semen Cuscutae; 10～20 parts of Radix Codonopsis; 10～20 parts of Semen Euryaless, 5～15 parts of Calculus Boviss, 5～15 parts of Fel Ursis; 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～10 parts of Flos Hibisci.
Preferably, be to be made by the crude drug of following weight portion: 30 parts, Fructus Amomi Rotundus, 30 parts, Herba Capsellae, 25 parts of Ramulus Cinnamomi, 15 parts of Semen Cuscutae, 15 parts of Radix Codonopsis, 12 parts of Semen Euryaless, 10 parts of Calculus Boviss, 8 parts of Fel Ursis, 12 parts of Semen Lepidii (Semen Descurainiae)s, 8 parts of Flos Hibisci.
Treat the preparation method of the Chinese medicine preparation of diabetic nephropathy: get each crude drug, mix, add water to submerge, decoct 60～90 minutes, filter, in medicinal residues, add water again, submergence, decocts 30 minutes, filter, merge the filtrate of twice, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
Application: coloclysis before sleeping every night, each crude drug amount used is about 160 grams, 15 days is a course for the treatment of, serious symptom person coloclysis every day 2 times.
In the Chinese medicine preparation for the treatment of diabetic nephropathy of the present invention, a few herbs are share, and have effect of toxin expelling, diuresis, detumescence, are used for the treatment of diabetic nephropathy effective percentage and reach 93.7%.
Chinese medicine preparation of the present invention has effect of toxin expelling, diuresis, detumescence, curative effect is determined, and there is the advantages such as inexpensive, easy preparation, patient be acceptant, can delay the progress of diabetic nephropathy, can become the important measures of diabetic nephropathy azotemia phase expectant treatment, there is very high value for clinical application.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
The Chinese medicine preparation of embodiment 1 preparation treatment diabetic nephropathy
Formula is: 30 grams, Fructus Amomi Rotundus, 30 grams, Herba Capsellae, 25 grams of Ramulus Cinnamomi, 15 grams of Semen Cuscutae, 15 grams of Radix Codonopsis, 12 grams of Semen Euryaless, 10 grams of Calculus Boviss, 8 grams of Fel Ursis, 12 grams of Semen Lepidii (Semen Descurainiae)s, 8 grams of Flos Hibisci.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 75 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
The Chinese medicine preparation of embodiment 2 preparation treatment diabetic nephropathyes
Formula is: 20 grams, Fructus Amomi Rotundus, 40 grams, Herba Capsellae, 20 grams of Ramulus Cinnamomi, 20 grams of Semen Cuscutae, 10 grams of Radix Codonopsis, 20 grams of Semen Euryaless, 5 grams of Calculus Boviss, 15 grams of Fel Ursis, 10 grams of Semen Lepidii (Semen Descurainiae)s, 10 grams of Flos Hibisci.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 60 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
The Chinese medicine preparation of embodiment 3 preparation treatment diabetic nephropathyes
Formula is: 40 grams, Fructus Amomi Rotundus, 20 grams, Herba Capsellae, 30 grams of Ramulus Cinnamomi, 10 grams of Semen Cuscutae, 20 grams of Radix Codonopsis, 10 grams of Semen Euryaless, 15 grams of Calculus Boviss, 5 grams of Fel Ursis, 15 grams of Semen Lepidii (Semen Descurainiae)s, 5 grams of Flos Hibisci.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 90 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
Clinical data:
Patient's data: patient's 159 examples, be diabetic nephropathy patient, wherein, and male 103 examples, female's 56 examples, 55～72 years old age, diabetes medical history 5～10 years, patient all meets the diagnostic criteria that WHO diabetologist committee formulates for 1999 years.
Therapeutic Method: Chinese medicine preparation prepared by embodiment 1 is heated to 38 DEG C, adopts liquid infusing type clysmata coloclysis, every day 1 time, and coloclysis before sleeping, serious symptom person, every day, coloclysis 2 times, 15 days was a course for the treatment of, treated two courses for the treatment of.
Therapeutic evaluation:
Invalid: the state of an illness has no improvement.
Effective: patient feels sick, symptoms of emesis disappears or disappearance substantially, and appetite is improved, and edema alleviates, and urinary albumin excretion ratio (UAER) reduces, and creatinine, blood urea nitrogen obviously decline.
Therapeutic outcome: 159 routine diabetic nephropathy patient, effective 149 examples, invalid 10 examples, effective percentage 93.7%.
Claims (3)
1. treat the Chinese medicine preparation of diabetic nephropathy for one kind; it is characterized in that, be to be made up of the crude drug of following weight portion: 20～40 parts, Fructus Amomi Rotundus, 20～40 parts, Herba Capsellae; 20～30 parts of Ramulus Cinnamomi; 10～20 parts of Semen Cuscutae, 10～20 parts of Radix Codonopsis, 10～20 parts of Semen Euryaless; 5～15 parts of Calculus Boviss; 5～15 parts of Fel Ursis, 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～10 parts of Flos Hibisci.
2. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1; it is characterized in that, be to be made up of the crude drug of following weight portion: 30 parts, Fructus Amomi Rotundus, 30 parts, Herba Capsellae; 25 parts of Ramulus Cinnamomi; 15 parts of Semen Cuscutae, 15 parts of Radix Codonopsis, 12 parts of Semen Euryaless; 10 parts of Calculus Boviss; 8 parts of Fel Ursis, 12 parts of Semen Lepidii (Semen Descurainiae)s, 8 parts of Flos Hibisci.
3. the preparation method of a kind of Chinese medicine preparation for the treatment of diabetic nephropathy described in claim 1 or 2, it is characterized in that: get each crude drug, mix, add water to submerge, decoct 60～90 minutes, filter, in medicinal residues, add water again, submergence, decoct 30 minutes, filter, merge the filtrate of twice, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310177306.XA CN103239669B (en) | 2013-05-14 | 2013-05-14 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
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| CN201310177306.XA CN103239669B (en) | 2013-05-14 | 2013-05-14 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
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| CN103239669B true CN103239669B (en) | 2014-06-11 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104707016A (en) * | 2013-10-15 | 2015-06-17 | 刘宝琴 | Preparation method of enema liquid for diabetic nephropathy |
| CN103705873A (en) * | 2014-01-10 | 2014-04-09 | 肖冻 | Traditional Chinese medicine preparation for treating diabetic nephropathy |
| CN104489196A (en) * | 2014-12-20 | 2015-04-08 | 济南伟传信息技术有限公司 | Tea for treating cold of children |
| CN105920123A (en) * | 2016-04-29 | 2016-09-07 | 汝州市济仁糖尿病医院 | Traditional Chinese medicine preparation dripping into rectum and used for treating diabetic nephropathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101940716A (en) * | 2010-09-19 | 2011-01-12 | 薛红云 | Medicament for treating diabetic nephropathy |
| CN102846946A (en) * | 2011-06-28 | 2013-01-02 | 河北以岭医药研究院有限公司 | Application of Chinese medicine composition in preparation of diabetic nephropathy treatment drug |
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