CN104707016A - Preparation method of enema liquid for diabetic nephropathy - Google Patents
Preparation method of enema liquid for diabetic nephropathy Download PDFInfo
- Publication number
- CN104707016A CN104707016A CN201510167964.XA CN201510167964A CN104707016A CN 104707016 A CN104707016 A CN 104707016A CN 201510167964 A CN201510167964 A CN 201510167964A CN 104707016 A CN104707016 A CN 104707016A
- Authority
- CN
- China
- Prior art keywords
- parts
- diabetic nephropathy
- preparation
- enema
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of an enema liquid for diabetic nephropathy to solve the problem about treatment of diabetic nephropathy. The preparation method is characterized by comprising the following steps: mixing the following raw materials in parts by weight: 10-30 parts of fructus cannabis, 6-12 parts of courled mallow seeds, 3-10 parts of sea grass, 6-12 parts of poncirus bark, 3-10 parts of littleflower stringbush bark and root, 6-12 parts of allium victorialis, 6-12 parts of semen cuscutae, 6-12 parts of fagopyrum dibotrys, 6-12 parts of Chinese starjasmine stem, 1-5 parts of gecko, 3-10 parts of vandenboschia auriculata and 10-25 parts of burnt rice sprouts; adding water, decocting for 30 minutes, and taking filtrate; and adding water to residues, further decocting for 20 minutes, taking filtrate, and mixing the filtrates. A clinical experiment proves that the enema liquid has the characteristics of good curative effect and relatively high safety when used for treatment of diabetic nephropathy, and therefore the enema is worthy of clinical application and popularization.
Description
Technical field
The present invention is application for a patent for invention " one treats diabetic nephropathy coloclysis granule and preparation method thereof " (application number: divisional application 2013104795380).Relate to the field of Chinese medicines, be specifically related to a kind of preparation method of diabetic nephropathy enema.
Background technology
Diabetic nephropathy (diabetic nephropathy, DN) is one of most important complication of diabetic, also in rising trend at the sickness rate of China in recent years, has become the second reason of End-stage renal disease at present, has been only second to various glomerulonephritis.Because it exists complicated metabolism disorder, once develop into End-stage renal disease, often more thorny than the treatment of other kidney diseases, therefore control is in time for delaying the significant of diabetic nephropathy.The diabetic nephropathy cause of disease and pathogenesis unclear, think to be multifactor participation at present, cause a disease under the combined effect of certain genetic background and Some Risk Factors.Described risk factor is: renal blood flow kinetics is abnormal, hyperglycemia causes Developmental and Metabolic Disorder, hypertension, vaso-active substance Developmental and Metabolic Disorder.Inventor's clinical research for many years finds, the effect of the Developmental and Metabolic Disorder that hyperglycemia causes in diabetic nephropathy pathogenesis is particularly outstanding, wherein Developmental and Metabolic Disorder causes the mechanism of kidney damage mainly to comprise: 1. nephridial tissue local carbohydrate metabolism disturbance, forms advanced glycosylation endproduct end metabolite (AGES) by nonenzymatic glycosylation; 2. the activation of polyhydric alcohol path; The activation of 3. DG-protein kinase c approach; 4. osamine path Developmental and Metabolic Disorder.Above-mentioned Developmental and Metabolic Disorder is except participating in early stage high filtration, and what is more important promotes that glomerular basement membrane (GBM) thickens and extracellular matrix accumulation.
Current diabetic nephropathy treatment is clinically mainly for following several respects: 1. control blood glucose; 2. blood pressure is controlled; 3. dietetic therapy.The diabetic complication of diabetic nephropathy patients undergoing itself is common, and symptoms of uremia occurs comparatively early, and general endogenous creatinine clearance rate is down to 10 ~ 15ml/min will maintenance dialysis, patient economy burden weight.The traditional Chinese medical science is many to be recorded without primary disease, and treatment is many to duplicate with diabetes, and opinion is controlled from the scorching deficiency of YIN, with the passing of time consumption gas and cause deficiency of both QI and YIN, PD then deficiency of YIN affecting YANG and see deficiency of both YIN and YANG, and even sun declines turbid malicious stasis blocking.Owing to not fully taking into account the effect of Developmental and Metabolic Disorder in diabetic nephropathy pathogenesis that hyperglycemia causes, so there is no help for delaying kidney damage.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and little treatment diabetic nephropathy coloclysis granule of side effect and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of preparation method of diabetic nephropathy enema, it is characterized in that: Fructus Cannabis 10 ~ 30 parts, certain herbaceous plants with big flowers colza 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Cortex Ponciri trifoliatae 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, Semen Cuscutae 6 ~ 12 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Trichomanes auriculatum Bl-Cop 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts of mixing and water addings are decocted, filtrate is got after 30 minutes, medicinal residues add water and continue decoction and get filtrate after 20 minutes, and twice filtrate merges.
Wherein said: Fructus Cannabis is the dry mature fruit of moraceae plants Fructus Cannabis Cannabis sativa L..Nature and flavor are sweet, flat.Return spleen, stomach, large intestine channel.Merit can loosening bowel to relieve constipation.
Certain herbaceous plants with big flowers colza is the mature seed of Malvaceae herbaceous plant Semen Abutili AbutilontheophrastiiMedic.Nature and flavor are sweet, cold.Return large intestine, small intestine meridian.Merit can clearing away heat and promoting diuresis treating stranguria, lactogenesis, intestine moistening.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Cortex Seu Radix Wikstroemiae Micranthae is peel of stem and the root of Isolated From Thymelaeaceae Species little Huang structure Wikstroemia micrantha Hemsl..Sweet in the mouth; Property is put down.Return lung meridian.Merit can relieving cough and resolving phlegm; Heat reliving and toxin-eliminating.
Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.Merit can dissipating blood stasis; Hemostasis; Removing toxic substances.
Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Nature and flavor are sweet, temperature.Return liver,kidney,spleen warp.Merit can nourishing the liver and kidney, and controlling nocturnal emission with astringent drugs reducing urination is antiabortive, improving eyesight, antidiarrheal.
Rhizoma Fagopyri Dibotryis stem and leaf is the stem and leaf of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.Return kidney, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.
Gecko is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.Nature and flavor are salty, flat.Return lung, kidney channel.Merit can invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.
Trichomanes auriculatum Bl-Cop is the herb of hymenophyllaceae plant Trichomanes auriculatum Bl-Cop Trichomanes uriculatum Bl..Property mildly bitter flavor; Flat.Return Liver Channel.Merit can promoting regeneration of the tissue and arresting bleeding.
Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through drying of germinateing, fries to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Clinical the past research shows, DN is mainly present in type i diabetes, and natural history starts for 10 ~ 15 years, and type i diabetes patient starts to occur continuous micro albuminuria, and glomerule nodule-like lesions and small artery vitreous degeneration appear in Pathological.The basis of this pathological change is that hyperglycemia causes Developmental and Metabolic Disorder, promotes that glomerular basement membrane (GBM) thickens and extracellular matrix accumulation.At present, Chinese traditional treatment is not for the medicine typing of DN, and treatment is many to duplicate with diabetes, and opinion is controlled from the scorching deficiency of YIN, with the passing of time consumption gas and cause deficiency of both QI and YIN, PD then deficiency of YIN affecting YANG and see deficiency of both YIN and YANG, and even sun declines turbid malicious stasis blocking.Owing to not fully taking into account the effect of Developmental and Metabolic Disorder in diabetic nephropathy pathogenesis that hyperglycemia causes, so there is no help for delaying kidney damage.
Inventor thinks: existing traditional Chinese medical therapeutic program is many starts with from the deficiency of YIN; but ignore another pathological factor " expectorant coagulates " of primary disease; the diabetes that various pathological factors causes controls protracted course of disease for a long time; deficiency in both YIN and YANG; QI and blood is not all right; expectorant coagulates venation, then water-damp not being transformed of a specified duration, stops giving birth to him in long-pending body and becomes.So inventor starts with from this angle, carry out the innovation on prescription.
Compared with prior art, the present invention has following characteristics:
1, set forth one's views unique: controlling from " QI and blood is not all right, and expectorant coagulates venation " opinion diabetic nephropathy, is that tangible heresy blocks kidney network, causes kidney network not all right and his change raw, so get rid of evils as key element.But the pathologic basis of DN is again deficiency in both YIN and YANG, and simulataneous insufficiency and excessive, needs strengthening vital QI to eliminate pathogenic factors.
2, with Fructus Cannabis, certain herbaceous plants with big flowers colza for monarch: inventor's clinical experience gained, Fructus Cannabis, certain herbaceous plants with big flowers colza are good at except the visible phlegm among venation, and without the anxiety of impairment of YIN, are suitable for DN and use; And Basic pharmacology test confirms: compare with GBM nephritis blank group after rats underwent Fructus Cannabis (20g crude drug/kg/d) and certain herbaceous plants with big flowers colza (10g crude drug/kg/d) mixing water decocting liquid gavage 4w after injection nephrolytic sera, Rat 24 h urine protein level is only 43.33% of blank group.
3, using sea, alizarin hard masses softening and resolving, Cortex Seu Radix Wikstroemiae Micranthae digestion visible phlegm, Caulis Trachelospermi dispelling wind dredging collateral, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, Bulbus Allii Victorialis dissipating blood stasis, Rhizoma Fagopyri Dibotryis stem and leaf dispelling wind and removing obstruction in the collateral assist monarch drug as ministerial drug: accumulation of phlegm blocks, breath does not reach, of a specified duration then can produce blood stasis, the stasis of blood then water retention of a specified duration, so select Cortex Seu Radix Wikstroemiae Micranthae, Cortex Ponciri trifoliatae, the alizarin visible phlegm removed in the kidney pulse network in sea, Caulis Trachelospermi, Rhizoma Fagopyri Dibotryis stem and leaf increase the ability of medicine walking venation.Bulbus Allii Victorialis has the advantages that dissipating blood stasis does not consume gas, is particularly suitable for the treatment of DN deficiency in both YIN and YANG and uses.
4, with Gecko invigorating the lung and the kidney, Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, wherein the aminoacid that contains of Gecko and phospholipid composition can reduce the content of malonaldehyde in cell membrane (MDA), play the effect of stable glomerular basement membrane.
5, basic research display: low dose of Trichomanes auriculatum Bl-Cop can contribute to enema intestinal absorption.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, in one cold and cool medicine, get protect sun defend in meaning, and contained coking composition has astriction, has the meaning of receipts in loose.
7, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase Liver and kidney burden.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
9, in order to reduce diabetic nephropathy renal metabolism burden, so adopt coloclysis dosage form, use safety, is convenient to the consolidation of the course for the treatment of.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Fructus Cannabis 20 parts, certain herbaceous plants with big flowers colza 10 parts, alizarin 6 parts of sea, Cortex Ponciri trifoliatae 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, Semen Cuscutae 10 parts, Rhizoma Fagopyri Dibotryis stem and leaf 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Trichomanes auriculatum Bl-Cop 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
The preparation method of embodiment 1 is: Fructus Cannabis, certain herbaceous plants with big flowers colza, Hai Qian, Cortex Ponciri trifoliatae, Cortex Seu Radix Wikstroemiae Micranthae, Bulbus Allii Victorialis, Semen Cuscutae, Rhizoma Fagopyri Dibotryis stem and leaf, Caulis Trachelospermi, Gecko, Trichomanes auriculatum Bl-Cop, Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts and sooner or later uses.
Embodiment 2, crude drug weight proportion: Fructus Cannabis 10 parts, certain herbaceous plants with big flowers colza 6 parts, alizarin 3 parts of sea, Cortex Ponciri trifoliatae 6 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 parts, Bulbus Allii Victorialis 6 parts, Semen Cuscutae 6 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 parts, Caulis Trachelospermi 6 parts, Gecko 1 part, Trichomanes auriculatum Bl-Cop 3 parts, Fructus Setariae Germinatus (parched to brown) 10 parts.
Embodiment 3, crude drug weight proportion: Fructus Cannabis 20 parts, certain herbaceous plants with big flowers colza 10 parts, alizarin 6 parts of sea, Cortex Ponciri trifoliatae 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, Semen Cuscutae 10 parts, Rhizoma Fagopyri Dibotryis stem and leaf 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Trichomanes auriculatum Bl-Cop 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
Embodiment 4, crude drug weight proportion: Fructus Cannabis 30 parts, certain herbaceous plants with big flowers colza 12 parts, alizarin 10 parts of sea, Cortex Ponciri trifoliatae 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 10 parts, Bulbus Allii Victorialis 12 parts, Semen Cuscutae 12 parts, Rhizoma Fagopyri Dibotryis stem and leaf 12 parts, Caulis Trachelospermi 12 parts, Gecko 5 parts, Trichomanes auriculatum Bl-Cop 10 parts, Fructus Setariae Germinatus (parched to brown) 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Cuscutae, certain herbaceous plants with big flowers colza, Cortex Seu Radix Wikstroemiae Micranthae coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Fructus Cannabis, Hai Qian, Cortex Ponciri trifoliatae, Bulbus Allii Victorialis, Rhizoma Fagopyri Dibotryis stem and leaf, Caulis Trachelospermi, Trichomanes auriculatum Bl-Cop and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 to be added in step 3 mixing of gained extractum, 60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, mix, subpackage and get final product.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of diabetic nephropathy, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: case is selected from December, a 2006 ~ 2011 year December and is diagnosed as early diabetic nephropathy 97 example.
1.1.2 diabetic nephropathy diagnostic criteria: diagnosis all meets " Chinese Medical Association's diabetic nephropathy diagnostic criteria ", namely the diagnostic criteria of early stage DN is: 1. diabetes medical history, and occurs persistence Microalbuminuria (UAER reaches 20 ~ 200/ μ g/min or 30 ~ 300 mg/d); 2. glomerular filtration rate (GRF) rises more than 20%; 3. conventional UAER detects negative.Except standard: 1. severe hypertension; 2. severe infection or other diseases; 3. BAOSHENKANG is used during person; 4. the kidney disease of other reasons.
1.1.3 three groups are divided at random: matched group 35 example, decoction group 31 example, coloclysis groups of grains 31 example.Compare in sex, age, the state of an illness, the course of disease before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: three groups of patients all adopt standard diabetic+high-quality Low protein and low phosphorus diet, be strict with less salt and ankyrin diet control blood glucose and blood pressure medication, parallel 150ml enema 37 DEG C of retention enemas, retention time is 30min, once a day, continuous 30d is a course for the treatment of.The selection of enema: matched group is normal saline diluent carbon plate powder (Ai Xi Te); Decoction group is embodiment 1 gained decoction; Coloclysis groups of grains is the embodiment 3 gained coloclysis granule described in brewed in hot water.All patients all do not adopt ACEI and/or ARB class Drug therapy and hemodialysis and peritoneal dialysis treatment.
1.2.2 observation item: the front and rear change observing three groups of patient 24 h urine protein quantitation (TP/24 h), glomerular filtration rate (GFR), cholesterol (TC), triglyceride (TG) for the treatment of respectively at treatment, and the change of ALT, AST.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
The change of three groups of patient TP/24 h, GFR, TC, TG after 2.1 treatment 30d: see the following form.Result shows: treat after 30 days, the level of the 24 h urine protein quantitation (TP/24 h) of decoction group and coloclysis groups of grains, glomerular filtration rate (GFR), cholesterol (TC), triglyceride (TG) obviously reduces (P<0.05) before comparatively treating, simultaneously also lower than matched group with time point level (P<0.05).
2.2 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur obvious adverse reaction record, and before and after treatment, ALT, AST level has no significant change.
3. conclusion.
This result of study shows, after using decoction of the present invention or coloclysis granule, diabetic nephropathy patient TP/24 h, GFR, TC, TG are starkly lower than matched group, and there is not obvious adverse reaction record, illustrate that enema prepared by the inventive method has the lighter advantage of good effect, untoward reaction in treatment diabetic nephropathy.
Claims (1)
1. the preparation method of a diabetic nephropathy enema, it is characterized in that: Fructus Cannabis 10 ~ 30 parts, certain herbaceous plants with big flowers colza 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Cortex Ponciri trifoliatae 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, Semen Cuscutae 6 ~ 12 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Trichomanes auriculatum Bl-Cop 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts of mixing and water addings are decocted, filtrate is got after 30 minutes, medicinal residues add water and continue decoction and get filtrate after 20 minutes, and twice filtrate merges.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510167964.XA CN104707016A (en) | 2013-10-15 | 2013-10-15 | Preparation method of enema liquid for diabetic nephropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510167964.XA CN104707016A (en) | 2013-10-15 | 2013-10-15 | Preparation method of enema liquid for diabetic nephropathy |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310479538.0A Division CN103495065B (en) | 2013-10-15 | 2013-10-15 | Enema particles for treating diabetic nephropathy and preparation method for enema particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104707016A true CN104707016A (en) | 2015-06-17 |
Family
ID=53407060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510167964.XA Pending CN104707016A (en) | 2013-10-15 | 2013-10-15 | Preparation method of enema liquid for diabetic nephropathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104707016A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239669A (en) * | 2013-05-14 | 2013-08-14 | 贾丽丽 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
-
2013
- 2013-10-15 CN CN201510167964.XA patent/CN104707016A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239669A (en) * | 2013-05-14 | 2013-08-14 | 贾丽丽 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
Non-Patent Citations (2)
| Title |
|---|
| 宋宗良 等: "中西医结合治疗早期糖尿病肾病48例临床研究", 《四川中医》 * |
| 赵美云 等: "中医药治疗糖尿病肾病", 《长春中医药大学学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN104208302A (en) | Fructus rosae laevigatae healthy oral solution for reducing blood fat and preparation method thereof | |
| CN104352991A (en) | Traditional Chinese medicine preparation for treating gout and preparation method thereof | |
| CN103041208B (en) | Chinese herbal preparation for treating climacteric syndrome of women, and preparation method thereof | |
| CN102205108B (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| CN101979020B (en) | Chinese medicinal preparation for treating high blood pressure | |
| CN103120732B (en) | Chinese medicinal composition for treating jaundice and preparation method thereof | |
| CN103585495B (en) | Capsule for treating diabetic kidney damage | |
| CN103749819A (en) | Cornus officinalis sieb health-care tea capable of lowering blood sugar and lowering lipid and preparation method of tea | |
| CN106540181A (en) | A kind of Chinese medicine for treating diabetes | |
| CN103495065B (en) | Enema particles for treating diabetic nephropathy and preparation method for enema particles | |
| CN103055176B (en) | Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN102274396B (en) | Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof | |
| CN104324261A (en) | Pharmaceutical composition for treating high blood sugar and preparation method of pharmaceutical composition | |
| CN103520538B (en) | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage | |
| CN103495066B (en) | Enema liquid for treating diabetic nephropathy | |
| CN102935214B (en) | Traditional Chinese medicinal composition for treating uremia | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN105311470A (en) | Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy | |
| CN104707016A (en) | Preparation method of enema liquid for diabetic nephropathy | |
| CN104606571A (en) | Fresh spinach root tea substituted drink with effects of helping produce saliva and slaking thirst and preparation method thereof | |
| CN1259961C (en) | Medicination for curing kidney disease and preparation method | |
| CN108853380B (en) | Pharmaceutical composition for treating diabetes and preparation method and application thereof | |
| CN104784567B (en) | A kind of pharmaceutical composition for the treatment of urinary system infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150617 |