CN103705873A - Traditional Chinese medicine preparation for treating diabetic nephropathy - Google Patents
Traditional Chinese medicine preparation for treating diabetic nephropathy Download PDFInfo
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- CN103705873A CN103705873A CN201410012123.7A CN201410012123A CN103705873A CN 103705873 A CN103705873 A CN 103705873A CN 201410012123 A CN201410012123 A CN 201410012123A CN 103705873 A CN103705873 A CN 103705873A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating diabetic nephropathy. The preparation is prepared from the following raw materials in parts by weight: 20-40 parts of amomum kravanh, 20-40 parts of plantain herb, 20-30 parts of cassia twig, 10-20 parts of sealwort, 10-20 parts of codonopsis pilosula, 10-20 parts of curcuma aromatica, 5-15 parts of longan aril, 5-15 parts of fel ursi, 10-15 parts of semen lepidii and 5-10 parts of salviae miltiorrhizae. The preparation method comprises the following steps: taking the raw material medicines; mixing; adding water to immerse; decocting; filtering; then adding water to dregs of a decoction; decocting; filtering; combining the filtrates obtained twice to obtain the traditional Chinese medicine preparation for treating diabetic nephropathy. The application comprises the following step: carrying out coloclysis every night before sleep, wherein 15 days is a course of treatment, and coloclysis is carried out twice a day for patients with severe symptoms. The traditional Chinese medicine preparation disclosed by the invention has the functions of expelling toxin, inducing diuresis and eliminating swelling, is exact in curative effect, has the advantages of low price, easiness in preparation, easiness in acceptance by the patients and the like, can delay the progress of diabetic nephropathy, can become an important measure for conservative treatment of diabetic nephropathy in azotemia period, and has very high clinical and practical value.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of diabetic nephropathy.
Background technology
Diabetic nephropathy is clinical common and multiple diabetic complication.Be one of complication that diabetes are the most serious, diabetic nephropathy is the main microvascular complications of diabetes, mainly refers to diabetic glomerulosclerosis, a kind ofly take vascular lesion as main Glomerular lesions.In early days how asymptomatic, blood pressure can be normal or higher.Its incidence rate is along with the course of disease of diabetes extends and increases.The early stage kidney volume of diabetes increases, glomerular filtration rate increases, be high filtration state, engender space protein urine or microalbuminuria later, the lasting albuminuria of prolongation appearance, edema, hypertension, glomerular filtration rate reduction along with the course of disease, and then renal insufficiency, uremia, be one of main cause of death of diabetes.
Diabetic nephropathy is the common complication of diabetes, is one of diabetes general microangiopathies performance, and Clinical symptoms is albuminuria, gradual renal function injury, hypertension, edema, occurring severe renal nonfunction late period, is one of major causes of death of diabetics.In recent years along with China's population average life span extends, Diet lifestyle, the change of structure, the prevalence of diabetes is ascendant trend linearly, and due to the improvement of Therapeutic Method, the increase of life span, thus kidney and other complication also increase.According to recent statistics, China approximately has 5,000 ten thousand people being faced with the threat of diabetes at present.In the U.S., diabetic nephropathy accounts for the first place of renal failure in latter stage at end, is about 35%～38%.I type (IDDM) diabetes generation diabetic nephropathy ratio is higher, is about 35%～50%, II type (NIDDM) incidence rate approximately 20% left and right.But in diabetics, II type patient sickness rate far surpasses I type, therefore II type patient accounts for 70%～80% in diabetes renal failure dialysis patient.Diabetic nephropathy, in Chinese medicine document, had both belonged to diabetes, belonged to again the edema in nephropathy category, turbid urine, distension, in the diseases such as obstruction and rejection, pathogenesis be take and is suffered from a deficiency of the kidney as main, precise and tiny leaking of initial stage, disturbance in functioning of QI for a long time, retention of water-damp in the body, very in turbid poison, accumulate, visceral-qi void declines, and the card that easily changes always belongs to the disease of deficiency in origin and excess in superficiality.
Treatment for diabetic nephropathy, the current clinical aggregate measures such as blood glucose, low protein diet of taking to control, End-stage diabetic nephropathy needs of patients carries out hemodialysis or peritoneal dialysis or renal transplantation, but due to reasons such as dialysis is painful greatly, kidney transplantation treatment expense height, patient's compliance is very poor.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of Chinese medicine preparation for the treatment of diabetic nephropathy, its curative effect is determined, can reduce patient's urinary albumin excretion ratio, improve the feeling sick of patient, vomiting, lower limbs edema symptom, reduce the toxicants such as creatinine, blood urea nitrogen, delay the progress of the diabetic nephropathy course of disease.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine preparation for the treatment of diabetic nephropathy, it is to be made by the crude drug of following weight portion: 20～40 parts, Fructus Amomi Rotundus, 20～40 parts of Herba Plantaginiss, 20～30 parts of Ramulus Cinnamomi, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Curcumaes, 5～15 parts of Arillus Longans, 5～15 parts of Fel Ursis, 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～10 parts of Radix Salviae Miltiorrhizaes.
Preferably, be to be made by the crude drug of following weight portion: 30 parts, Fructus Amomi Rotundus, 30 parts of Herba Plantaginiss, 25 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Polygonatis, 15 parts of Radix Codonopsis, 12 parts of Radix Curcumaes, 10 parts of Arillus Longans, 8 parts of Fel Ursis, 12 parts of Semen Lepidii (Semen Descurainiae)s, 8 parts of Radix Salviae Miltiorrhizaes.
Treat the preparation method of the Chinese medicine preparation of diabetic nephropathy: get each crude drug, mix, add water to submerge, decoct 60～90 minutes, filter, in medicinal residues, add water again, submergence, decocts 30 minutes, filter, merge the filtrate of twice, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
Application: coloclysis before sleeping every night, each crude drug amount used is about 160 grams, 15 days is a course for the treatment of, serious symptom person coloclysis every day 2 times.
In the Chinese medicine preparation for the treatment of diabetic nephropathy of the present invention, a few herbs are share, and have the effect of toxin expelling, diuresis, detumescence, are used for the treatment of diabetic nephropathy effective percentage and reach 93.7%.
Chinese medicine preparation of the present invention has the effect of toxin expelling, diuresis, detumescence, curative effect is determined, and there is the advantages such as inexpensive, easy preparation, patient be acceptant, can delay the progress of diabetic nephropathy, can become the important measures of diabetic nephropathy azotemia phase expectant treatment, there is very high value for clinical application.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
The Chinese medicine preparation of embodiment 1 preparation treatment diabetic nephropathy
Formula is: 30 grams, Fructus Amomi Rotundus, 30 grams of Herba Plantaginiss, 25 grams of Ramulus Cinnamomi, 15 grams of Rhizoma Polygonatis, 15 grams of Radix Codonopsis, 12 grams of Radix Curcumaes, 10 grams of Arillus Longans, 8 grams of Fel Ursis, 12 grams of Semen Lepidii (Semen Descurainiae)s, 8 grams of Radix Salviae Miltiorrhizaes.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 75 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
The Chinese medicine preparation of embodiment 2 preparation treatment diabetic nephropathyes
Formula is: 20 grams, Fructus Amomi Rotundus, 40 grams of Herba Plantaginiss, 20 grams of Ramulus Cinnamomi, 20 grams of Rhizoma Polygonatis, 10 grams of Radix Codonopsis, 20 grams of Radix Curcumaes, 5 grams of Arillus Longans, 15 grams of Fel Ursis, 10 grams of Semen Lepidii (Semen Descurainiae)s, 10 grams of Radix Salviae Miltiorrhizaes.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 60 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
The Chinese medicine preparation of embodiment 3 preparation treatment diabetic nephropathyes
Formula is: 40 grams, Fructus Amomi Rotundus, 20 grams of Herba Plantaginiss, 30 grams of Ramulus Cinnamomi, 10 grams of Rhizoma Polygonatis, 20 grams of Radix Codonopsis, 10 grams of Radix Curcumaes, 15 grams of Arillus Longans, 5 grams of Fel Ursis, 15 grams of Semen Lepidii (Semen Descurainiae)s, 5 grams of Radix Salviae Miltiorrhizaes.
Preparation method is: get each crude drug, mix, add water to submerge, decoct 90 minutes, filter, in medicinal residues, add water to submerge again, decoct 30 minutes, merge twice filtrate, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
Clinical data:
Patient's data: patient's 137 examples, be diabetic nephropathy patient, wherein, and male 82 examples, female's 55 examples, 55～72 years old age, diabetes medical history 5～10 years, patient all meets the diagnostic criteria that WHO diabetologist committee formulates for 1999 years.
Therapeutic Method: the Chinese medicine preparation of embodiment 1 preparation is heated to 38 ℃, adopts liquid infusing type clysmata coloclysis, every day 1 time, coloclysis before sleeping, serious symptom person, every day, coloclysis was 2 times, within 15 days, was a course for the treatment of, treated two courses for the treatment of.
Therapeutic evaluation:
Invalid: the state of an illness has no improvement.
Effective: patient feels sick, symptoms of emesis disappears or disappearance substantially, and appetite is improved, and edema alleviates, and urinary albumin excretion ratio (UAER) reduces, and creatinine, blood urea nitrogen obviously decline.
Therapeutic outcome: 137 routine diabetic nephropathy patient, effective 130 examples, invalid 7 examples, effective percentage 94.9%.
Claims (3)
1. a Chinese medicine preparation for the treatment of diabetic nephropathy, it is characterized in that, be to be made by the crude drug of following weight portion: 20～40 parts, Fructus Amomi Rotundus, 20～40 parts of Herba Plantaginiss, 20～30 parts of Ramulus Cinnamomi, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Curcumaes, 5～15 parts of Arillus Longans, 5～15 parts of Fel Ursis, 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～10 parts of Radix Salviae Miltiorrhizaes.
2. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, be to be made by the crude drug of following weight portion: 30 parts, Fructus Amomi Rotundus, 30 parts of Herba Plantaginiss, 25 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Polygonatis, 15 parts of Radix Codonopsis, 12 parts of Radix Curcumaes, 10 parts of Arillus Longans, 8 parts of Fel Ursis, 12 parts of Semen Lepidii (Semen Descurainiae)s, 8 parts of Radix Salviae Miltiorrhizaes.
3. a kind of preparation method for the treatment of the Chinese medicine preparation of diabetic nephropathy described in claim 1 and 2, it is characterized in that: get each crude drug, mix, add water to submerge, decoct 60～90 minutes, filter, in medicinal residues, add again water, submergence, decoct 30 minutes, filter, merge the filtrate of twice, be the Chinese medicine preparation for the treatment of diabetic nephropathy.
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| CN201410012123.7A CN103705873A (en) | 2014-01-10 | 2014-01-10 | Traditional Chinese medicine preparation for treating diabetic nephropathy |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103239669A (en) * | 2013-05-14 | 2013-08-14 | 贾丽丽 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103239669A (en) * | 2013-05-14 | 2013-08-14 | 贾丽丽 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
Non-Patent Citations (2)
| Title |
|---|
| 李显筑: "《糖尿病中西医结合诊疗辑录》", 31 March 2007, 黑龙江人民出版社 * |
| 李龙等: "活血化瘀法防治糖尿病肾病研究进展", 《中国中医急症》 * |
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Application publication date: 20140409 |