CN105920123A - Traditional Chinese medicine preparation dripping into rectum and used for treating diabetic nephropathy - Google Patents
Traditional Chinese medicine preparation dripping into rectum and used for treating diabetic nephropathy Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention provides a traditional Chinese medicine preparation dripping into a rectum and used for treating diabetic nephropathy. The traditional Chinese medicine preparation comprises the following bulk drugs by weight: 16 to 22 parts of charred Chinese rhubarb, 10 to 16 parts of rhizoma atractylodis, 10 to 16 parts of Poria cocos, 18 to 25 parts of Radix Astragali, 10 to 15 parts of black monkshood, 12 to 16 parts of epimedium, 12 to 16 parts of Gorgon fruit and 12 to 16 parts of Japanese eupatorium. A preparation method for the traditional Chinese medicine preparation comprises the following steps: weighing the bulk drugs, adding water, heating the water on a strong fire until the water boils, then carrying out decoction on a slow fire for 20 to 40 min and then carrying out filtering so as to obtain a filtrate I and a filter residue I; adding 300 to 500 parts of water into the filter residue I, heating the filter residue I on a strong fire until the filter residue I boils, then carrying out decoction on a slow fire for 20 to 40 min and then carrying out filtering so as to obtain a filter residue II; and uniformly mixing the filtrate I with the filtrate II so as to obtain mixed liquor A and concentrating the mixed liquor A so as to obtain mixed liquor B which is the traditional Chinese medicine preparation dripping into the rectum and used for treating diabetic nephropathy. The traditional Chinese medicine preparation has substantial treatment effect on nephrosis caused by diabetes.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, a kind of Enem-d Chinese medicine preparation treating diabetic nephropathy.
Background technology
The cause of disease of diabetogenous nephrosis disease syndrome should consider from basis sick (diabetes) and two stages of the nephrotic syndrome.The sick diabetes in basis are many because of surfeit or hungry not normal, production of phlegm due to retention of food;Depression or anxiety, transverse invasion of hyperactive liver-QI criminal's spleen, essence of water and grain can not transporting.Stop gathering for phlegm-damp;Accumulateing in phlegm-damp, lung is defended and is lost in regulation, every easy catching a cold wind and cold;Heat-transformation in the strongly fragrant long heat-transformation of phlegm-damp or cold people.Accumulate in expectorant (wet) heat, consume the moon of feeling frustrated.The deficiency of vital energy unable promotion blood;Cloudy Tianjin is impaired, hyperlipidemia;In addition phlegm resistance, three all can cause hematogenous blockage, forms blood stasis.Accumulateing in visible diabetics phlegm-damp for originally, secondary interior-heat, deficiency of both vital energy and Yin, blood stasis are mark.
Diabetogenous nephrosis disease syndrome then produces two aspect changes on the basis of the former.On the one hand dysfunction of the spleen in transportation, retention of water-damp in the body, the most main water of kidney causes that water is wet spreads unchecked;On the other hand, spleen-QI sinking, dysfunction of the kidney in storing essence of suffering from a deficiency of the kidney causes precise and tiny spilling.In urine albumen be into cereal nutrient, a large amount of albumen drain from urine, and healthy energy consumes day by day, and spleen kidney is more shown in empty losing, and forms vicious cycle.Visible process from diabetes to the nephrotic syndrome is exactly the process that deficiency of both vital energy and Yin increases the weight of, and i.e. due to cloudy essence leakage, deficiency of YIN affecting YANG, gradually turns people's accumulation of fluid caused by insufficiency of YANG.Therefore accumulation of fluid caused by insufficiency of YANG is result, accumulate in expectorant (wet) heat, deficiency of both vital energy and Yin cause precise and tiny leakage be pathogenic because of.
Diabetic nephropathy is one of most important complication of diabetic.The sickness rate of China is the most in rising trend, has the most become the second reason of End-stage renal disease, has been only second to various glomerulonephritis.Owing to it exists complicated metabolism disorder, once developing into End-stage renal disease, often more thorny than the treatment of other kidney diseases, therefore preventing and treating in time is for delaying the significant of diabetic nephropathy.
Summary of the invention
The present invention seeks to the deficiency for solving above-mentioned technical problem, it is provided that a kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the nephropathy causing diabetes has significant therapeutic effect.
The present invention solves that above-mentioned technical problem be the technical scheme is that a kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 16-22 part, Rhizoma Atractylodis 10-16 part, Poria 10-16 part, Radix Astragali 18-25 part, Radix Aconiti Lateralis Preparata 10-15 part, Herba Epimedii 12-16 part, Semen Euryales 12-16 part and Herba Lycopi's 12-16 part.
The Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, the parts by weight of each crude drug are preferably: charred Radix Et Rhizoma Rhei 20 parts, Rhizoma Atractylodis 15 parts, 15 parts of Poria, the Radix Astragali 20 parts, Radix Aconiti Lateralis Preparata 15 parts, Herba Epimedii 15 parts, Semen Euryales 15 parts and Herba Lycopi 15 parts.
The preparation method of the Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, comprises the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, together put into container, add 500-1000 part water, it is heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300-500 part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, the 1/6-1/5 being concentrated into mixed liquor A volume obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
Adding water preferably 1000 parts in step one, slow fire boils preferably 30min；Adding water preferably 500 parts in step 2, slow fire boils preferably 30min.
The dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the using method of the Enem-d Chinese medicine preparation of diabetic nephropathy is, the Enem-d next day of each 200 milliliters, treatment 2 months continuously.
Provide the benefit that:
1, the present invention treats the Enem-d Chinese medicine preparation of diabetic nephropathy, with the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii and charred Radix Et Rhizoma Rhei as principal agent, and warming the kidney and strengthening the spleen purging FU-organs toxin expelling；With Rhizoma Atractylodis and Poria as accessory drugs, invigorating the spleen to clear away damp pathogen；And add and make medicine Herba Lycopi；Fuzheng Prescription of getting rid of evils is reasonable, and medication is gentle.
2, the present invention treats the Enem-d Chinese medicine preparation of diabetic nephropathy, is adjusted to basis with health whole to patient, interacts with the common each crude drug of conventional Chinese medicine prescription and coordinates can at utmost play a role together；Verifying through clinical practice for many years, the Enem-d Chinese medicine preparation effect of present invention treatment diabetic nephropathy is notable, and effective percentage, up to 95%, takes effect rapidly, and with low cost, and toxic and side effects is little.
Detailed description of the invention
A kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 16-22 part, Rhizoma Atractylodis 10-16 part, Poria 10-16 part, Radix Astragali 18-25 part, Radix Aconiti Lateralis Preparata 10-15 part, Herba Epimedii 12-16 part, Semen Euryales 12-16 part and Herba Lycopi's 12-16 part.
The Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, the parts by weight of each crude drug are preferably: charred Radix Et Rhizoma Rhei 20 parts, Rhizoma Atractylodis 15 parts, 15 parts of Poria, the Radix Astragali 20 parts, Radix Aconiti Lateralis Preparata 15 parts, Herba Epimedii 15 parts, Semen Euryales 15 parts and Herba Lycopi 15 parts.
The preparation method of the Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, comprises the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, together put into container, add 500-1000 part water, it is heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300-500 part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, the 1/6-1/5 being concentrated into mixed liquor A volume obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
Adding water preferably 1000 parts in step one, slow fire boils preferably 30min；Adding water preferably 500 parts in step 2, slow fire boils preferably 30min.
The dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the using method of the Enem-d Chinese medicine preparation of diabetic nephropathy is, the Enem-d next day of each 200 milliliters, treatment 2 months continuously.
Herbal raw material medicine used by the present invention all can be buied from Chinese medicine shop, and its specification meets country's medical standards；Below in conjunction with embodiment, the present invention is further detailed.
Embodiment 1
A kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 20 parts, Rhizoma Atractylodis 15 parts, 15 parts of Poria, the Radix Astragali 20 parts, Radix Aconiti Lateralis Preparata 15 parts, Herba Epimedii 15 parts, Semen Euryales 15 parts and Herba Lycopi 15 parts.
The preparation method of the Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, comprises the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, together put into container, add 1000 parts of water, it is heated to boiling the most with high heat, then change slow fire into and boil 40 minutes, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 500 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 40 minutes, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, be concentrated into mixed liquor A volume 1/5 obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
The dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the using method of the Enem-d Chinese medicine preparation of diabetic nephropathy is, the Enem-d next day of each 200 milliliters, treatment 2 months continuously.
Embodiment 2
A kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 22 parts, Rhizoma Atractylodis 16 parts, 16 parts of Poria, the Radix Astragali 25 parts, Radix Aconiti Lateralis Preparata 12 parts, Herba Epimedii 16 parts, Semen Euryales 16 parts and Herba Lycopi 16 parts.
The preparation method of the Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, comprises the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, together put into container, add 800 parts of water, it is heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, be concentrated into mixed liquor A volume 1/5 obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
The dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the using method of the Enem-d Chinese medicine preparation of diabetic nephropathy is, the Enem-d next day of each 200 milliliters, treatment 2 months continuously.
Embodiment 3
A kind of Enem-d Chinese medicine preparation treating diabetic nephropathy, the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 16 parts, Rhizoma Atractylodis 10 parts, 106 parts of Poria, the Radix Astragali 18 parts, Radix Aconiti Lateralis Preparata 10 parts, Herba Epimedii 12 parts, Semen Euryales 12 parts and Herba Lycopi 12 parts.
The preparation method of the Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, comprises the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, together put into container, add 500 parts of water, it is heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, be concentrated into mixed liquor A volume 1/5 obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
The dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the using method of the Enem-d Chinese medicine preparation of diabetic nephropathy is, the Enem-d next day of each 200 milliliters, treatment 2 months continuously.
Clinical trial
1, experimental subject: be the patient of diabetic nephropathy after diagnosing；Use the present invention to treat the Chinese medicine preparation of DIABETES Diabetes nephropathy and treat case for many years as many as 800 examples, as statistics treatment patient 200 example altogether；
2, Therapeutic Method: the Enem-d next day of each 200 milliliters, 60 days is a course for the treatment of.
3, treatment evaluation criterion:
Effective: edema alleviates earlier above, microdose urine protein, serum creatinine blood urea nitrogen reduce by less than 30% earlier above.
Effective: edema the most substantially alleviates, microdose urine protein, serum creatinine blood urea nitrogen reduce by more than 30% earlier above.
Invalid: edema is earlier above without substantially alleviating, and microdose urine protein, serum creatinine blood urea nitrogen are earlier above without being decreased obviously.
4, therapeutic effect: the 200 example patients that the present invention is treated, the most effective 90 examples, effective 100, invalid 10 examples, treated effect reaches 95%.Result shows, Chinese medicine formula reasonable recipe of the present invention, evident in efficacy to treatment diabetic vascular neuropathy.
5, model case:
Going into business so-and-so, female, within 43 years old, people from village opens in Shengchi County, suffers from diabetes 12 years edema albuminuria azotemia 2 years repeatedly, and face of having a medical check-up edema, microdose urine protein 805.0mg/l serum creatinine 180.0umol/l carbamide 8.9mmol/l diagnose diabetic nephropathy 5 phase.Blood glucose fluctuation is controlled with insulin.Coordinate the Enem-d Chinese medicine preparation treatment renal complications of diabetic nephropathy.Enem-d treatment treatment 2 months continuously next day of each 200 milliliters, subjective symptoms disappears, and urine protein examination is clearly better.
Claims (4)
1. the Enem-d Chinese medicine preparation treating diabetic nephropathy, it is characterised in that: the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 16-22 part, Rhizoma Atractylodis 10-16 part, Poria 10-16 part, Radix Astragali 18-25 part, Radix Aconiti Lateralis Preparata 10-15 part, Herba Epimedii 12-16 part, Semen Euryales 12-16 part and Herba Lycopi's 12-16 part.
2. treat the Enem-d Chinese medicine preparation of diabetic nephropathy as claimed in claim 1, it is characterised in that: the parts by weight of each crude drug are: charred Radix Et Rhizoma Rhei 20 parts, Rhizoma Atractylodis 15 parts, 15 parts of Poria, the Radix Astragali 20 parts, Radix Aconiti Lateralis Preparata 15 parts, Herba Epimedii 15 parts, Semen Euryales 15 parts and Herba Lycopi 15 parts.
3. treat the preparation method of the Enem-d Chinese medicine preparation of diabetic nephropathy as claimed in claim 1 or 2, it is characterised in that: comprise the following steps:
Step one, take charred Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Poria, the Radix Astragali, Radix Aconiti Lateralis Preparata, Herba Epimedii, Semen Euryales and Herba Lycopi according to the parts by weight of each crude drug of Enem-d Chinese medicine preparation of described treatment diabetic nephropathy, together put into container, add 500-1000 part water, it is heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby；
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300-500 part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate II, standby；
Step 3, filtrate I and filtrate II mix homogeneously being obtained mixed liquor A, concentrate gained mixed liquor A, the 1/6-1/5 being concentrated into mixed liquor A volume obtains mixed liquid B, is the Enem-d Chinese medicine preparation for the treatment of diabetic nephropathy.
4. as described in right 3, treat the preparation method of the Enem-d Chinese medicine preparation of diabetic nephropathy, it is characterised in that: adding water 1000 parts in described step one, slow fire boils 30min；Adding water 500 parts in step 2, slow fire boils 30min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938914A (en) * | 2018-09-29 | 2018-12-07 | 河南中医药大学 | A kind of Chinese medicine by Enem-d treatment diabetic nephropathy |
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|---|---|---|---|---|
| CN102205005A (en) * | 2011-05-24 | 2011-10-05 | 山东省千佛山医院 | Chinese medicinal preparation for treating diabetic nephropathy |
| CN102847132A (en) * | 2012-10-12 | 2013-01-02 | 潍坊复能肾病研究院 | Preparation method of traditional Chinese medicine composition for treating nephropathy through targeted transferring in renal region and rehabilitation |
| CN103239669A (en) * | 2013-05-14 | 2013-08-14 | 贾丽丽 | Traditional Chinese medicinal preparation for treating diabetic nephropathy |
| CN104107227A (en) * | 2014-06-28 | 2014-10-22 | 河南中医学院 | Traditional Chinese medicine rectum drop for treating diabetic nephropathy, and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938914A (en) * | 2018-09-29 | 2018-12-07 | 河南中医药大学 | A kind of Chinese medicine by Enem-d treatment diabetic nephropathy |
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Application publication date: 20160907 |