CN103230584A - Cobalt, copper, selenium, traditional Chinese medicine element, and vitamin leucoderma-treating external medicinal liquor - Google Patents
Cobalt, copper, selenium, traditional Chinese medicine element, and vitamin leucoderma-treating external medicinal liquor Download PDFInfo
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Abstract
The invention discloses a cobalt, copper, selenium, traditional Chinese medicine element, and vitamin leucoderma-treating external medicinal liquor, and belongs to the technical field of medicinal liquor preparation and production. The medicinal liquor is composed of a traditional Chinese medicine fluidextract, macro and trace element groups, a trace element enhancer, pallas pit viper skin, vitamin families, beta-carotene, metallothionein, and high-quality distillate spirit. Leucoderma is a skin chronic disease without a clear cause. Through element detection, the patient population suffers from severe disorders of elements such as copper, cobalt, selenium, and iron in skins. According to the invention, through comprehensive supplementation, regulation, and inhibition, element balance and vitamin balance in patient bodies are assisted, free radicals in bodies are strongly removed, human body immunity is greatly improved, cell viability is enhanced, and diseases can be strongly inhibited. Essential theories of traditional hand-down medical science and modern medical concept of trace element balance are combined, a novel element balance scientific method is adopted, and the prescription provided by the invention is developed. With the medicinal liquor provided by the invention, leucoderma can be completely cured, and reoccurrence is prevented. With a synergetic effect of trace elements and vitamins, leucoderma risk caused by low immunity is substantially ameliorated.
Description
Technical field:
The present invention relates to the medicated wine of a kind of cobalt, copper, selenium Chinese medicine element vitamin externally treating leucoderma, is to belong to medicated wine series preparation production technical field.
Background technology:
As everyone knows, vitiligo is a kind of big pertinacious disease of extremely damaging the human body appearance.Though be the illness of non-inflammation, usually show people's face, neck, back and whole body.It is very unexpected to fall ill, and makes human body skin hypopigmentation, is white, pale yellow, brown or brown.Someone thinks relevant with gene, inherited genetic factors is arranged, may be because the individuality of inherited genetic factors quality, under a large amount of undesired material effects, too much cause cytochrome to destroy by the lipid peroxidation free radical, form secondary antibody and produce, cause that autoimmune function is low, cause chromatophorous destruction, skin pigment is sloughed.Medical circle thinks, and is not too clear and definite on the cause of disease, belongs to skin stubborn disease.Element medicine detects by human elementary, thinks relevant with element imbalances such as the contained copper of human body skin, cobalt, selenium, ferrum.
1, copper (Cu): copper is a kind of vital trace element, form covalent cross-linking between the collagen fiber of skin or molecule and the copper, make it powerful, crosslinked key enzyme---rely in the acyloxylation enzyme and contain abundant copper ion, after lacking copper the activity of this enzyme is descended, cause the sick change of crosslinked partial birth, also can damage Mucocutaneous defensive barrier effect, serious thinning of skin can appear when lacking copper and crisp, formation spot easily voluntarily breaks, clinical in the detection of patients with vitiligo hair, the scarce copper reason of discovery may be that the copper in the serum almost all combines with plasma protein, claim the blue albumen of copper or serum oxidase, scarce copper can influence the instability of copper enzyme, is the key enzyme that melanin forms as tryrosinase, and it plays a part very important in the dermal melanin metabolism, this enzymatic activity reduces the skin pigment Metabolic disorder after lacking copper.So scarce copper is the principal element of vitiligo morbidity.
2, cobalt (Co): cobalt is the indispensable trace element of human body skin, and cobalt is by forming VB
12And the metabolism of participation ribonucleic acid and hemopoietic related substance and ribonucleoprotein (RNP) matter is synthetic.Can cause macrocytic anemia when lacking cobalt, nucleic acid protein be synthesized be affected that this direct and indirect relation can promote leukodermic generation and increase the weight of.Detect to find that by patient's hair it is more low to send out cobalt content, leukodermic area is more big, and focus is delay more, and the state of an illness is more serious, so cobalt element and vitiligo are in close relations.
3, selenium (Se): selenium is indispensable element in skin histology, and content is 0.025 μ m/g.Selenium is the important component of glutathione peroxidase, and this enzyme is conducive to protect the 26S Proteasome Structure and Function of Skin Cell film, can prevent the destruction of cell membrane lipid peroxidase, eliminates superfluous free radical, thereby the protection cell membrane exempts from detrimental effect.The activity of glutathione peroxidase matter reduces when lacking selenium, causes that peroxidation of cellular membranes strengthens, free radical and semiquinone free radical poison melanin precursor increase back effect target cell, cause immune function of human body low, impel vitiligo to form.Work in coordination with shared removing free radical ability with extremely strong power with nanometer selenium and vitamin C, vitamin E, beta-carotene, metallothionein, reach enhancing immunity, forcefully the ability of resist the disease.
4, nickel (Ni): nickel is relevant with the metalloenzyme activity, participates in structure and the metabolism of cell membrane, participates in ribonucleic acid, hormone and metabolism of pigment.Nickel content is 0.018 μ m/g in the skin histology, can make the skin pigment Developmental and Metabolic Disorder behind the scarce nickel.
Summary of the invention:
The object of the present invention is to provide the medicated wine of a kind of cobalt, copper, selenium nanometer Chinese medicine element vitamin externally treating leucoderma.
The scheme that the technology of the present invention solves is:
The medicated wine of a kind of cobalt, copper, selenium nanometer Chinese medicine element vitamin externally treating leucoderma is characterized in that: form % by following proportion by weight
Each set of dispense is 100% than sum;
1, wherein the Chinese medicine fluid extract is made up of following proportion by weight
1. Zaocys 180g, Radix Saposhnikoviae, Fructus Atriplicis Sibiricae, Cortex Cinnamomi, each 60g of Cortex Acanthopancis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, each 90g of JUKE, Radix Rehmanniae Preparata 120g,
Effect: YIN nourishing, dispel the wind, antipruritic,
Cure mainly: vitiligo;
2. give birth to Fructus Psoraleae 300g, Fructus Atriplicis Sibiricae, Semen Cuscutae, Semen Astragali Complanati, Semen Cassiae, Rhizoma Drynariae, each 150g of Cortex Dictamni, Cortex Cinnamomi 90g, Mylabris 20g,
Cure mainly: vitiligo;
3. Fructus Psoraleae, each 30g of Lithargyrum, Radix Peucedani 20g, Radix Saposhnikoviae 10g, Rhizoma Typhonii (processed) 15g, Realgar (processed) 6g,
Effect: invigorate blood circulation, dispel the wind,
Cure mainly: vitiligo;
4. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Arnebiae (Radix Lithospermi), Fructus Atriplicis Sibiricae, Radix Polygoni Multiflori, Rhizoma Atractylodis, Radix Ophiopogonis, Herba Ecliptae, Radix Salviae Miltiorrhizae, Semen Persicae, Flos Carthami, Fructus Psoraleae, Radix Glycyrrhizae, each equal portions of Pyritum;
5. the Radix Angelicae Dahuricae, Herba Spirodelae, Radix Clematidis, Rhizoma Atractylodis, Fructus Tribuli, Radix Salviae Miltiorrhizae, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), Semen Astragali Complanati, Radix Polygoni Multiflori, Fructus Psoraleae each minute consumption are identical; (above-mentioned prescription is selected from Xu Sanwen " dermatosis external treatment of Chinese medicine " 2007:514 of Beijing science tech publishing house, and the Chinese medicated wine 2009:181 such as health preserving pandect Beijing Chemical Industry Press that cure the disease) purpose is in order to overcome between medicine the disadvantage of mutual restraint between two drugs, restriction or checking relation in five elements, interpromoting relation in five elements, the mutual-detoxication.
2, microelement enhancer and Dermis Agkistrodon halys is characterized in that: form % by following mass component proportioning
Above-mentioned each component sum is 100%;
3, the proportioning of group vitamins and beta-carotene, metallothionein is 98: 2%
Its technical characterictic is: form % by following proportion by weight
(1) water soluble vitamins:
B
1, B
2, B
6, B
12, niacin (Nicotinicum Acidum), pantothenic acid, folic acid, biotin, each five equilibrium 90 of C;
(2) the proportioning E of fatsoluble vitamin: A, D, E, K is 95%: (A, D, K) is 5% 8;
(3) beta-carotene, metallothionein 2;
4, grand, trace element, the macroelement macroelement jointly mixes compositely by 99.95% of body weight with trace element by 0.05% of body weight, and wherein the macroelement feature is: press following proportion by weight composition %
Macroelement or macroelement claim to make element of volume day demand meter 1 again
Wherein the trace element feature is: form % by following proportion by weight
Human body institute's every day essential trace element is taken in scale 2
Vitiligo (Vitiligo) is common, the frequently-occurring disease that a kind of former, limitation or general property skin pigment take off mistake, also belongs to difficult pertinacious disease in medical circle.It is an ancient disease, and just on the books in No. three tombs in Mawangdui, Changsha are unearthed white book copied on silk " 52 Bingfang ", the Han dynasty claims vitiligo to be: " white place ", for China to its description the earliest; In Sui Dynasty's Chao Yuanfang (550-630 A.D.) in 601 years Christian eras " all source of disease marquis opinion " first with this sick called after " vitiligo "; The traditional Chinese medical science now is called " leucoderma ", " vitiligo " or " vitiligo ".
People of every description, various nationalities all have morbidity in the world, and sickness rate is about 1-2%, and patient is up to more than 6,000 ten thousand, and the dark race race shallow than the colour of skin of the colour of skin is high, and white people such as method, U.S. are less than 1%, and Denmark is 0.4%, Japan is 2%, and India reaches 4%, and epidemic diseases was once regarded it as in Africa; China is about 1%, and surplus the patient 1,000 ten thousand, Nanjing is 0.29% according to investigations, the rural area, northern Suzhou is that 0.09-0.15%, Shanghai are 0.54%, the Hubei county is that 0.5-1%, Jinan reach 2.7%; The men and women falls ill about equally, but the women does sth. in advance about 5 years than the male; The no age is defined, and morbidity is arranged from baby to old man, but the adolescent sees more, report is arranged as far back as birth i.e. morbidity one day after, and 15-30 year is the peak period, wherein before 20 years old ill about 50%; Data shows among the 8303 routine patients of Shanxi, 438 people of family history are arranged, and accounts for 5.3%, and wherein relatives account for 57.5-82.5%.Vitiligo is perplexing millions upon millions of patients' soul, makes the patient bear heavy mental pressure, has a strong impact on appearance and marriage, the stable social harmony that reaches of family.
The vitiligo morbidity is closely related with trace element, and Rare Elements Preparations commonly used at present has: copper, zinc preparation, select the quiet notes of 0.5% or 4.4% zinc sulfate or drop for use; Oral MEGADOSE sheet, supplementing iodine, zinc, copper, ferrum, manganese etc.; Oral selenium lipopolysaccharide raises serum selenium content, the remarkable reduction of lipid peroxide etc.; Oral red copper disappears white, the external red copper white tincture etc. that disappears; The doctor who has in the treatment is used calcium, magnesium or with local white macula place iontherapy, but grand, trace element and vitamin merge the effect that reaches complementarity and mutual benefit of using, the balance that comprehensively reaches added body interior element vitamin can effectively be prevented and treated dermatosis chronic disease---vitiligo, significantly reduces consistent according to Hu County, bibliographical information Xi'an in 1998 leucoderma disease Crinis Carbonisatus cobalt.
1, the vitiligo patient lacks cobalt, and cobalt is the indispensable trace element of human body skin, by forming vitamin B
12And participate in that nucleic acid protein is synthetic, the metabolism of hemopoietic related substance, detoxifcation and promote other element absorption, keep bone marrow normal function and pigment homergy; Nucleic acid protein is synthetic behind the scarce cobalt is affected, and directly or indirectly promotes leukodermic generation; It is more low to send out the cobalt amount, and focus is delay more, and the state of an illness is more heavy.Vitamin B12 deficiency can cause scarce cobalt pernicious anemia, influence the carbohydrate metabolism enzyme, also easily send out diabetes, the gastrointestinal epithelial cells obstacle makes hypochlorhydria and brings out gastritis, it is occurred frequently that soil lacks cobalt area " hyperthyroidism ", so vitiligo is sent out well in pernicious anemia, diabetes, achlorhydria and " hyperthyroidism " patient, this from the another side so that proof vitiligo and scarce cobalt closely related.
2, lack copper.Copper is the main prothetic group of tryrosinase, participate in the metabolic process of human body pigment directly, the tyrosine enzyme is the key enzyme of synthetic dermal melanin, its catalysis tyrosine enzymatic conversion is hydrocaffeic acid (DOPA), DOPA and then change a kind of hmw protein melanin into, copper lacks this enzyme and forms difficulty, the active reduction, the melanin biosynthesis block causes skin depigmentation easily to send out vitiligo; With the animal that lacks the nursing of copper food and water long period its fur is bleached, black is obviously high than copper content in its hair of white rabbit; Check to confirm the leucoderma disease human serum and send out copper content all to be starkly lower than the normal person, show that lacking copper should be one of key factor of vitiligo morbidity.
3, zinc deficiency.Zinc is that plurality of enzymes is brought into play bioactive indispensable element, some oxidase of passing hydrogen all contains zinc in chromogenesis, and zinc concentration is quite high in the melanosome, illustrates that zinc has important function in melanin chemosynthesis process, and the zinc reduction may cause pigment to cause obstacle; It is all low or be starkly lower than normal group that many scholars detect vitiligo serum, hair zinc content, and zinc deficiency may be again one of vitiligo pathogenic factors.
4, lack selenium.Selenium has good treatment and preventive effect to more than 80 kinds of diseases.Selenium and E have share fine removing interior free yl.Selenium is the important component of glutathione peroxidase (GSH-PX), and this enzyme can prevent that the peroxidating of cell membrane lipid from destroying, and eliminates superfluous free radical, makes cell membrane exempt from infringement, is conducive to protect the 26S Proteasome Structure and Function of skin; It is significantly low that patients with vitiligo is sent out selenium; Scarce selenium GSH-PX is active to be reduced, and causes cell membrane lipid peroxidating reinforcement, and free radical, semiquinone free radical, toxicity melanocyte precursor increase, and act on target cell, cause immune function of human body low, causes skin pigment to take off one of another reason of losing and falling ill.
In a word, trace element and combination of vitamins use, not only influence hormonal system, the two is the metabolism of energy catalytic specie all, promote cell viability, improve the human body immunity, tangible complementary action is arranged, solved because of hypoimmunity, easily suffered from leukodermic disadvantage, simultaneously because of people's in-vivo element balance, various antibody strengthen in the balanced body of vitamin, disease has been improved the condition of enough healings, the cooperation of the valuable traditional medicine of motherland is arranged in addition, this dermatosis chronic disease of the practice of the traditional Chinese medical science, doctor trained in Western medicine, modern element medicine is captured surely.
The present invention namely is exactly mineral, vitamin in conjunction with necessary grand, the trace element of human body, and suffers from the element that this disease lacks at human body, after having replenished mineral, vitamin comprehensively, replenish in addition as microelement enhancer, and added the Periostracum Serpentis that the obstinate dermatosis of human body is had the Agkistrodon halys of fine treatment.
Below in conjunction with examples of implementation the present invention is further illustrated:
Specific implementation method:
Embodiment 1:,
(1) its technical characterictic of Chinese medicine fluid extract is: form % by following proportion by weight
1. Zaocys 180g, Radix Saposhnikoviae, Fructus Atriplicis Sibiricae, Cortex Cinnamomi, each 60g of Cortex Acanthopancis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, each 90g of JUKE, Radix Rehmanniae Preparata 120g,
2. give birth to Fructus Psoraleae 300g, Fructus Atriplicis Sibiricae, Semen Cuscutae, Semen Astragali Complanati, Semen Cassiae, Rhizoma Drynariae, each 150g of Cortex Dictamni, Cortex Cinnamomi 90g, Mylabris 20g,
3. Fructus Psoraleae, each 30g of Lithargyrum, Radix Peucedani 20g, Radix Saposhnikoviae 10g, Rhizoma Typhonii (processed) 15g, Realgar (processed) 6g,
4. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Arnebiae (Radix Lithospermi), Fructus Atriplicis Sibiricae, Radix Polygoni Multiflori, Rhizoma Atractylodis, Radix Ophiopogonis, Herba Ecliptae, Radix Salviae Miltiorrhizae, Semen Persicae, Flos Carthami, Fructus Psoraleae, Radix Glycyrrhizae, each equal portions of Pyritum;
5. the Radix Angelicae Dahuricae, Herba Spirodelae, Radix Clematidis, Rhizoma Atractylodis, Fructus Tribuli, Radix Salviae Miltiorrhizae, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), Semen Astragali Complanati, Radix Polygoni Multiflori, Fructus Psoraleae each minute consumption are identical;
Below 1.-5. Chinese medicinal formulae animal drugs oven dry, grinding mix with other Chinese medicines, the conventional carbon dioxide abstraction of reuse or with the method extraction of 60% ethanol extraction, filtrate is through thin film evaporation, reclaim ethanol, and be condensed into 1: 1, be every milliliter and contain source crude drug 1g, relative density is that the fluid extract of 1.03-1.05 is standby.
(2) preparation preparation microelement enhancer and Dermis Agkistrodon halys
Preparation microelement enhancer and Dermis Agkistrodon halys is characterized in that: form % by following proportion by weight
Above-mentioned each component sum is 100%;
(3) preparation group vitamins and beta-carotene and metallothionein:
Its technical characterictic of group vitamins and beta-carotene and metallothionein is: form % by following mass component proportioning
1. water soluble vitamins:
B
1, B
2, B
6, B
12, niacin (Nicotinicum Acidum), pantothenic acid, folic acid, biotin, each identical five equilibrium nano powder 90 of C;
2. the proportioning E of fatsoluble vitamin: A, D, E, K is 95: (A, D, K) is the 5% common nano powder 8 that mixes;
3. the identical five equilibrium mixing of beta-carotene and metallothionein nano powder 2;
Above-mentioned each component sum is 100%;
(4) grand, the trace element group of preparation
Macroelement jointly mixes compositely by 99.95% of body weight with trace element by 0.05% of body weight, wherein the macroelement feature is: press following proportion by weight composition %
Macroelement or macroelement claim to make element of volume day requirement again
Wherein the trace element feature is: form % by following proportion by weight
Human body institute's every day essential trace element intake
(5) preparation is with Chinese medicine fluid extract, grand, trace element group and microelement enhancer, metallothionein, group vitamins and β one carotene, the medicated wine medicated wine by following cobalt, copper, selenium nanometer Chinese medicine element vitamin externally treating leucoderma, by following proportion by weight composition %
Embodiment 2:
Embodiment 3:
Embodiment 4:
Embodiment 5:
Claims (1)
1. the medicated wine of a cobalt, copper, selenium Chinese medicine element vitamin externally treating leucoderma is characterized in that forming % by following proportion by weight
(1) wherein the Chinese medicine fluid extract is made up of following proportion by weight
1. Zaocys 180g, Radix Saposhnikoviae, Fructus Atriplicis Sibiricae, Cortex Cinnamomi, each 60g of Cortex Acanthopancis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, each 90g of JUKE, Radix Rehmanniae Preparata 120g,
2. give birth to Fructus Psoraleae 300g, Fructus Atriplicis Sibiricae, Semen Cuscutae, Semen Astragali Complanati, Semen Cassiae, Rhizoma Drynariae, each 150g of Cortex Dictamni, Cortex Cinnamomi 90g, Mylabris 20g,
3. Fructus Psoraleae, each 30g of Lithargyrum, Radix Peucedani 20g, Radix Saposhnikoviae 10g Rhizoma Typhonii (processed) 15g, Realgar (processed) 6g,
4. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Arnebiae (Radix Lithospermi), Fructus Atriplicis Sibiricae, Radix Polygoni Multiflori, Rhizoma Atractylodis, Radix Ophiopogonis, Herba Ecliptae, Radix Salviae Miltiorrhizae, Semen Persicae, Flos Carthami, Fructus Psoraleae, Radix Glycyrrhizae, each equal portions of Pyritum;
5. the Radix Angelicae Dahuricae, Herba Spirodelae, Radix Clematidis, Rhizoma Atractylodis, Fructus Tribuli, Radix Salviae Miltiorrhizae, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), Semen Astragali Complanati, Radix Polygoni Multiflori, each amounts of components of Fructus Psoraleae are identical;
(2) preparation microelement enhancer and Dermis Agkistrodon halys is characterized in that: form % by following proportion by weight
Above-mentioned each component sum is 100%;
(3) proportioning of preparation group vitamins and beta-carotene and metallothionein is 98: 2
It is characterized in that: form % by following proportion by weight
1. water soluble vitamins:
B
1, B
2, B
6, B
12, niacin (Nicotinicum Acidum), pantothenic acid, folic acid, biotin, each identical five equilibrium 90 of C;
2. the proportioning E of fatsoluble vitamin: E and A, D, K is 95: (A, D, K) is 5% 8;
3. beta-carotene 2;
(4) proportioning grand, trace element is 99.95: 0.05%
Macroelement by body weight 99.95% with trace element 0.05% composite jointly by body weight,
Wherein the macroelement feature is: form % by following proportion by weight
Wherein the trace element feature is: form % by following proportion by weight
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| CN107693668A (en) * | 2017-11-10 | 2018-02-16 | 深圳靶向基因技术有限公司 | A kind of integration of drinking and medicinal herbs active compound of Mutiple Targets therapeutic intervention leucoderma |
| CN111840560A (en) * | 2020-07-24 | 2020-10-30 | 广州医科大学 | Application of calcium ionophore in leucoderma treatment |
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| CN107693668A (en) * | 2017-11-10 | 2018-02-16 | 深圳靶向基因技术有限公司 | A kind of integration of drinking and medicinal herbs active compound of Mutiple Targets therapeutic intervention leucoderma |
| CN111840560A (en) * | 2020-07-24 | 2020-10-30 | 广州医科大学 | Application of calcium ionophore in leucoderma treatment |
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Application publication date: 20130807 |