CN103211880A - Phyllanthus emblica compound capsule and preparation method thereof - Google Patents
Phyllanthus emblica compound capsule and preparation method thereof Download PDFInfo
- Publication number
- CN103211880A CN103211880A CN2013101224698A CN201310122469A CN103211880A CN 103211880 A CN103211880 A CN 103211880A CN 2013101224698 A CN2013101224698 A CN 2013101224698A CN 201310122469 A CN201310122469 A CN 201310122469A CN 103211880 A CN103211880 A CN 103211880A
- Authority
- CN
- China
- Prior art keywords
- fructus
- capsule
- semen
- compound capsule
- fructus phyllanthi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a phyllanthus emblica compound capsule and a preparation method thereof, and belongs to the technical field of medicines. The phyllanthus emblica compound capsule is prepared from a main material and auxiliary materials, wherein the main material is phyllanthus emblica; the auxiliary materials include fruit of purple perilla, semen raphani, semen cassia and hovenia dulcis thumb. The medicines are compounded with one another to promote and improve the effect, so that the defect of a single medicine is overcome. The phyllanthus emblica compound capsule has a good taste, an obvious effect and a long quality guarantee period. The production process of the phyllanthus emblica compound capsule disclosed by the invention is scientific and effective and is simple and easy to operate. Besides, purifying is carried out for the characteristics of different medicine materials, so that the active ingredients are greatly kept and the health requirements of different consumers can be satisfied.
Description
Technical field:
The present invention relates to a kind of Fructus Phyllanthi compound capsule and preparation method thereof, belong to medical technical field.
Background technology:
China's plant resources vast in territory is very abundant, and utilization rate is scarce relatively low.According to statistics, only higher plant just has 30000 kinds approximately, and in these abundant plants, numerous species has important edible, medical value, and their effect is along with deepening continuously of progress of science and technology and research is found simultaneously.Along with improving constantly of human living standard, the sustainable growth of world population, grain, medicine and raw material of industry demand are increasing.According to the preliminary statistics, China carries out the raw material of industry plant of international trade only about 100 kinds as staple at present.20000 kinds of the medicinal plants that World Health Organization (WHO) formally determines, but have only 200 kinds to do more detailed research, and China's Chinese herbal medicine kind is more than 6000 kinds.
People develop many good edible, medicinal, oil plants, the raw material of industry and ornamental plant gradually from wild plant, for example: A.chinensis Planch., Fructus Rosae Normalis, Fructus Hippophae, Pericarpium Citri tangerinae, Fructus Phyllanthi, Flos Lonicerae, Herb Gynostemmae Pentaphylli, prairie milk vetch etc. all are well-known.The potential value of medicine food dual purpose plant resource is very big, and Reasonable Protection and these plants of development and use have important scientific research and practical significance.Not only can solve the low contradiction of resource utilization of China, satisfy the consumption demand that the numerous common people improve day by day simultaneously again.
The Fructus Phyllanthi medicinal history is long, is distributed in provinces and regions such as Jilin, Liaoning, Hebei, Shanxi, Shandong, Henan, Anhui, Jiangsu, Yunnan, Tibet, and the Fructus Phyllanthi fruit contains tannin 45%, seed oil content 16%.Oil includes linolenic acid, linoleic acid, oleic acid, stearic acid, Palmic acid, myristic acid etc.Leaf contains tannin (tender leaf contains 23%～28%), kaempferol, kaempferide-3-glycoside (kaempferol-3-glucosi-de), cupreol, ellagic acid and lupeol.Bark contains tannin 28～29.36%, lupeol 2.25%, the colourless Herba delphinii grandiflori florigen of d-(d-leucodelphinidin C (15) H (14) O (3) .H (2) O) about 3.75%.Stem contains lupeol, cupreol, ellagic acid.
Prior art is made generally in granule or chewable tablet to the utilization of She Ganzi, and proportioning is single many based on She Ganzi, can not well bring into play the drug effect of She Gan.The sub-oil content of She Gan is bigger simultaneously, and after common chewable tablet or granule resting period were long, obtained medicine was apt to deteriorate, is unfavorable for storing.Do not design process route targetedly, mostly utilize common pharmaceutical technology preparation at the characteristic of She Ganzi.
Summary of the invention:
The invention provides a kind of Fructus Phyllanthi compound capsule, is auxilliary with Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae), adopts the mode of soft capsule.It can satisfy production, packing, and the requirement of accumulating, the drug effect mouthfeel is all good simultaneously.
Technical solution of the present invention is as follows:
A kind of Fructus Phyllanthi compound capsule, with the percentage by weight note, each composition is as follows:
Its preparation method is as follows:
1, raw material is preferred
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) are selected impurity, the product etc. that go mouldy, and sieve dedust bits.Clear water washs rapidly, 60～95 ℃ of dryings.
2, sterilization, dry, pulverizing
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Hoveniae (Fructus Hoveniae) are sprayed the powder medical material for four kinds put into 100～105 ℃ of sterilizations of sterilization cabinet 1 hour, 65～75 ℃ of dryings are pulverized dried medical material in the transposition heated-air circulation oven with pulverizer, pulverize the order number and are not less than 100 orders.
3, Semen Cassiae extracts
Semen Cassiae is dropped in the multi-function extractor, add 10 times of water gagings extractions 3 hours for the first time, add 8 times of water gagings extractions 2 hours for the second time, add 8 times of water gagings for the third time and extracted 1 hour.Gradation is filtered, and merging filtrate is gone into basin.
4, medicinal liquid concentrates
The water that merges is carried medicinal liquid, concentrating under reduced pressure (65 ℃～75 ℃ ,-0.04～-0.08Mpa) to relative density the thick paste of 1.25～1.30 (60 ℃ of heat are surveyed).
5, wet mixing
The four flavor crude drug powder such as Fructus Phyllanthi and the thick paste of Semen Cassiae are put trough type mixing machine to be mixed with 24 rev/mins of rotating speeds and carried out drying behind the stirring and evenly mixing in 30 ± 10 minutes.
6, drying
The cream powder enters (60 ℃～70 ℃ in vacuum drying oven after mixing,-0.04～-0.08Mpa) dry 30～50 hours, take out extractum and break into pieces, the extractum piece continued to enter vacuum drying after 10～12 hours, taking-up is put and is chilled to room temperature or during near room temperature, changes pulverizing process over to.
7, pulverize
Exsiccant extractum piece is put pulverizer pulverize (80-100 order).
8, total mixing
The medicated powder that above-mentioned steps is made is put trough type mixing machine with adjuvant xylitol, sodium carboxymethyl cellulose, xylitol magnesium stearate, micropowder silica gel and is mixed 20 ± 5 minutes mix homogeneously with 20 rev/mins speed, and it is to be tested to change middle database behind the mixing over to.
9, fill
Get the qualified total mixed drug powder of chemical examination and carry out filling by " fully-automatic capsule filling machine standard operating procedure ", control content uniformity well with fully-automatic capsule filling machine.Should keep relative negative pressure with the mistress between filling, dust is got rid of by dust exhaust apparatus.Temperature should be controlled at 18-26 ℃, and humidity should be controlled at 45-65%.
10, polishing
Get populated capsule administration product buffing machine and polish, remove the outer unnecessary powder of capsule shells, and select defective work.
Beneficial effect of the present invention is:
Fructus Phyllanthi compound capsule of the present invention utilizes She Gan to be primary raw material, and the auxilliary Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) of joining forms.The composite mutual promotion of multiple medical material improves drug effect, replenishes the deficiency of single medical material.The product good mouthfeel has a significant effect, long shelf-life.
The sub-compound capsule production technology of She Gan of the present invention scientific and effective, easy easy operating.Purify at the different pharmaceutical Material Characteristics, to greatest extent the effective ingredient of Bao Liuing.
The specific embodiment:
In order to understand technical scheme of the present invention better, below describe in further detail by specific embodiment, specific embodiment does not limit the present invention.
Embodiment 1:
The sub-compound capsule of a kind of She Gan is to be made by following raw material:
The sub-45g of She Gan, xylitol 15g, Fructus Perillae 11g, Semen Raphani 11g, Semen Cassiae 9g, Semen Hoveniae (Fructus Hoveniae) 8g, sodium carboxymethyl cellulose 0.3g, xylitol magnesium stearate 0.2g, micropowder silica gel 0.5g.
The preparation method of the sub-compound capsule of She Gan is as follows:
(1), raw material is preferred
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) are selected impurity, the product etc. that go mouldy, and sieve dedust bits.Clear water washs rapidly, 75 ℃ of dryings.
(2), sterilization, dry, pulverizing
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Hoveniae (Fructus Hoveniae) are sprayed the powder medical material for four kinds put into 100～105 ℃ of sterilizations of sterilization cabinet 1 hour, 70 ℃ of dryings are pulverized dried medical material in the transposition heated-air circulation oven with pulverizer, pulverize the order number and are not less than 100 orders.
(3), Semen Cassiae extracts
Semen Cassiae is dropped in the multi-function extractor, add 10 times of water gagings extractions 3 hours for the first time, add 8 times of water gagings extractions 2 hours for the second time, add 8 times of water gagings for the third time and extracted 1 hour.Gradation is filtered, and merging filtrate is gone into basin.
(4), medicinal liquid concentrates
The water that merges is carried medicinal liquid, concentrating under reduced pressure (70 ℃ ,-0.06Mpa) to relative density the thick paste of 1.30 (60 ℃ of heat are surveyed).
(5), wet mixing
The four flavor crude drug powder such as Fructus Phyllanthi and the thick paste of Semen Cassiae are put trough type mixing machine to be mixed with 24 rev/mins of rotating speeds and carried out drying behind the stirring and evenly mixing in 35 minutes.
(6), drying
Enter after the cream powder mixes vacuum drying oven (70 ℃ ,-0.08Mpa) dry 50 hours, take out extractum and break into pieces, the extractum piece continued to enter vacuum drying after 10 hours, took out to put to be chilled to room temperature or during near room temperature, to change pulverizing process over to.
(7), pulverize
Exsiccant extractum piece is put pulverizer pulverize (90 order).
(8), total mixing
The medicated powder that above-mentioned steps is made is put trough type mixing machine with adjuvant xylitol, sodium carboxymethyl cellulose, xylitol magnesium stearate, micropowder silica gel and is mixed 23 minutes mix homogeneously with 20 rev/mins speed, and it is to be tested to change middle database behind the mixing over to.
(9), fill
Get the qualified total mixed drug powder of chemical examination and carry out filling by " NJP-1200 type fully-automatic capsule filling machine standard operating procedure ", control content uniformity well with NJP-1200 type fully-automatic capsule filling machine.Should keep relative negative pressure with the mistress between filling, dust is got rid of by dust exhaust apparatus.Temperature should be controlled at 22 ℃, and humidity should be controlled at 55%.
(10), polishing
Get populated capsule and polish, remove the outer unnecessary powder of capsule shells, and select defective work with YPJ-II type medicine buffing machine.By the requirement of check character composite medicine, and good mouthfeel.
Embodiment 2:
The sub-compound capsule of a kind of She Gan is to be made by following raw material:
The sub-60g of She Gan, xylitol 10g, Fructus Perillae 8g, Semen Raphani 8g, Semen Cassiae 6g, Semen Hoveniae (Fructus Hoveniae) 6.5g, sodium carboxymethyl cellulose 0.5g, xylitol magnesium stearate 0.5g, micropowder silica gel 0.5g.
Processing method is with embodiment 1.
Claims (5)
1. a Fructus Phyllanthi compound capsule is characterized in that, is following raw material through sterilization, extracts, and concentrating under reduced pressure mixes, and vacuum drying is pulverized, and filling molding forms, and described umber is weight portion:
2. the preparation method of the described a kind of Fructus Phyllanthi compound capsule of claim 1, step is as follows:
1) Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) are selected impurity, the product etc. that go mouldy, and sieve dedust bits, clear water washs rapidly, 60～95 ℃ of dryings;
2) Fructus Phyllanthi, Fructus Perillae, Semen Raphani, four kinds of medical materials of Semen Hoveniae (Fructus Hoveniae) are put into 100～105 ℃ of sterilizations of sterilization cabinet 1 hour, 65～75 ℃ of dryings are pulverized dried medical material in the transposition heated-air circulation oven with pulverizer, pulverize the order number and are not less than 100 orders;
3) Semen Cassiae is dropped in the extraction pot, add 10 times of water gagings extractions 3 hours for the first time, add 8 times of water gagings extractions 2 hours for the second time, add 8 times of water gagings for the third time and extracted 1 hour; Gradation is filtered, and merging filtrate is gone into basin;
4) water of He Binging is carried medicinal liquid, and being evaporated to relative density is the thick paste of 1.25～1.30 (60 ℃ of heat are surveyed);
5) the four flavor crude drug powder such as Fructus Phyllanthi and the thick paste of Semen Cassiae being put trough type mixing machine mixes with 24 rev/mins of rotating speeds and carried out drying in 30 ± 10 minutes behind the stirring and evenly mixing;
6) entered the vacuum drying oven drying 30～50 hours after the cream powder mixes, take out extractum and break into pieces, the extractum piece continued to enter vacuum drying after 10～12 hours, took out to put to be chilled to room temperature or during near room temperature, to change pulverizing process over to;
7) exsiccant extractum piece being put pulverizer pulverizes;
8) medicated powder that above-mentioned steps is made is put trough type mixing machine with adjuvant xylitol, sodium carboxymethyl cellulose, xylitol magnesium stearate, micropowder silica gel and is mixed 20 ± 5 minutes mix homogeneously with 20 rev/mins speed;
9) get the qualified total mixed drug powder of chemical examination and carry out filling with fully-automatic capsule filling machine, should keep relative negative pressure with the mistress between filling, dust is got rid of by dust exhaust apparatus, and temperature should be controlled at 18-26 ℃, and humidity should be controlled at 45-65%;
10) get populated capsule administration product buffing machine and polish, remove the outer unnecessary powder of capsule shells, and select defective work.
3. the preparation method of a kind of Fructus Phyllanthi compound capsule as claimed in claim 2 is characterized in that, described step 4) concentrating under reduced pressure temperature: 65 ℃～75 ℃, and pressure :-0.04～-0.08Mpa.
4. the preparation method of a kind of Fructus Phyllanthi compound capsule as claimed in claim 2 is characterized in that, baking temperature in the described step 6): 60 ℃～70 ℃, and pressure :-0.04～-0.08Mpa.
5. the preparation method of a kind of Fructus Phyllanthi compound capsule as claimed in claim 2 is characterized in that, pulverizes the order number in the described step 7) to be: 80～100 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122469.8A CN103211880B (en) | 2013-03-31 | 2013-03-31 | Phyllanthus emblica compound capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122469.8A CN103211880B (en) | 2013-03-31 | 2013-03-31 | Phyllanthus emblica compound capsule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103211880A true CN103211880A (en) | 2013-07-24 |
| CN103211880B CN103211880B (en) | 2015-05-13 |
Family
ID=48810266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310122469.8A Expired - Fee Related CN103211880B (en) | 2013-03-31 | 2013-03-31 | Phyllanthus emblica compound capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103211880B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610802A (en) * | 2013-11-28 | 2014-03-05 | 王小欧 | Compound radix peucedani heat-clearing and cough-reliving capsule and preparation method thereof |
| CN103656313A (en) * | 2013-12-21 | 2014-03-26 | 山东中大药业有限公司 | Liver-calming and blood-activating compound couchgrass root capsule and preparation method thereof |
| CN103735758A (en) * | 2013-12-12 | 2014-04-23 | 济南新起点医药科技有限公司 | Compound rhizoma typhonii capsule and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422523A (en) * | 2008-12-02 | 2009-05-06 | 昆明振华制药厂有限公司 | Health-care preparation capable of alleviating a hangover and protecting the liver and preparation method thereof |
| CN102008077A (en) * | 2010-09-26 | 2011-04-13 | 何爱霞 | Composition and health care food with the lipid-lowering efficacy as well as preparation method thereof |
| CN102217758A (en) * | 2011-04-30 | 2011-10-19 | 楚雄州百草岭药业发展有限公司 | Emblic leafflower fruit capsule and preparation method thereof |
| CN102283892A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form |
| WO2012145609A1 (en) * | 2011-04-21 | 2012-10-26 | Sunny Biodiscovery, Inc. | Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation |
| CN102793030A (en) * | 2012-07-29 | 2012-11-28 | 天马（安徽）中药饮片科技有限公司 | Wuziyansheng plant teabag and production technology thereof |
-
2013
- 2013-03-31 CN CN201310122469.8A patent/CN103211880B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422523A (en) * | 2008-12-02 | 2009-05-06 | 昆明振华制药厂有限公司 | Health-care preparation capable of alleviating a hangover and protecting the liver and preparation method thereof |
| CN102283892A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form |
| CN102008077A (en) * | 2010-09-26 | 2011-04-13 | 何爱霞 | Composition and health care food with the lipid-lowering efficacy as well as preparation method thereof |
| WO2012145609A1 (en) * | 2011-04-21 | 2012-10-26 | Sunny Biodiscovery, Inc. | Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation |
| CN102217758A (en) * | 2011-04-30 | 2011-10-19 | 楚雄州百草岭药业发展有限公司 | Emblic leafflower fruit capsule and preparation method thereof |
| CN102793030A (en) * | 2012-07-29 | 2012-11-28 | 天马（安徽）中药饮片科技有限公司 | Wuziyansheng plant teabag and production technology thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王立群: "《中医临床常用药对手》", 31 May 2001, 学苑出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610802A (en) * | 2013-11-28 | 2014-03-05 | 王小欧 | Compound radix peucedani heat-clearing and cough-reliving capsule and preparation method thereof |
| CN103610802B (en) * | 2013-11-28 | 2016-03-16 | 王小欧 | A kind of compound recipe Radix Peucedani reducing fever relieving cough capsule and preparation method thereof |
| CN103735758A (en) * | 2013-12-12 | 2014-04-23 | 济南新起点医药科技有限公司 | Compound rhizoma typhonii capsule and preparation method thereof |
| CN103656313A (en) * | 2013-12-21 | 2014-03-26 | 山东中大药业有限公司 | Liver-calming and blood-activating compound couchgrass root capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103211880B (en) | 2015-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104147333B (en) | Preparation method for bulbus fritillariae cirrhosae by honey | |
| CN102776095B (en) | Mulberry wine and preparation method thereof | |
| CN102058759A (en) | Medicinal tea prepared from Chinese medicinal materials by microbial fermentation | |
| CN104524424A (en) | Oral liquid for beautifying features, expelling toxin and removing spot and preparation method thereof | |
| CN101637204A (en) | Method for producing a new generation of Chinese flowering quince tea | |
| CN104304674A (en) | Fermented dairy cow traditional Chinese medicinal feed additive for preventing stealth mastitis | |
| CN105595143A (en) | Solid arecoline beverage and preparation method thereof | |
| CN103211880B (en) | Phyllanthus emblica compound capsule and preparation method thereof | |
| CN103598422B (en) | Chinese herbal medicine feed addictive for river crabs | |
| CN105475589A (en) | Sugar-free shark fin bone meal tablet candy for preventing tumors and improving immunity, and production technology thereof | |
| CN101274028B (en) | Liver health care composition and preparation thereof | |
| CN104171375A (en) | Traditional Chinese medicine feed additive for preventing necrotic enteritis and preparation method thereof | |
| CN106389776A (en) | Tropaeolum granule and preparation method thereof | |
| CN105028845A (en) | Maca health protection tea | |
| CN105213581A (en) | A kind of Chinese medicine formula for the treatment of liver and gall syndrome of fish and preparation method thereof | |
| CN106380324A (en) | Method for preparing organic fertilizer special for Chinese wampee fruit trees and prepared organic fertilizer | |
| CN103690626B (en) | A kind of compound Chinese cassia tree capsule and preparation method thereof | |
| CN102697818A (en) | Honey-stuffed Chinese medicine preparation and production process thereof | |
| CN103392925B (en) | Concentrate supplement special for dairy cow in perinatal period | |
| CN103610802B (en) | A kind of compound recipe Radix Peucedani reducing fever relieving cough capsule and preparation method thereof | |
| CN101396056A (en) | Pine-needle tuckahoe teat and preparation method thereof | |
| CN104222293A (en) | Chewable Qi tonifying yoghourt tablet and production method thereof | |
| CN102823777B (en) | Horsetail composite dairy cow feed additive | |
| CN107593978A (en) | A kind of preparation method of medicine Pu'er cooked tea and medicine Pu'er cooked tea | |
| CN103656313A (en) | Liver-calming and blood-activating compound couchgrass root capsule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Applicant after: Research Institute of Agriculture Quality Standard and Testing Technology, Shandong Academy of Agricultural Sciences Address before: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Applicant before: Centra Lab, Shandong-Prov Academy of Agricutural Sciences |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: CENTRA LAB, SHANDONG-PROV ACADEMY OF AGRICUTURAL SCIENCES TO: SHANDONG ACADEMY OF AGRICULTURAL SCIENCES AGRICULTURAL QUALITY STANDARDS + DETECTION TECHNOLOGY RESEARCH INSTITUTE |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150513 Termination date: 20160331 |