CN103202991A - Drug for treatment of coronary heart disease and preparation method thereof - Google Patents
Drug for treatment of coronary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug for treatment of coronary heart disease. The drug consists of the following components by weight: 13.0-18.1 parts of Salvia miltiorrhiza, 6.0-10.1 parts of Radix Paeoniae, 3.6-7.2 parts of Ligusticum wallichii, 4.3-6.0 parts of lignum acronychiae, 14.5-16.9 parts of hawthorn, 5.8-9.6 parts of cattail pollen, 8.4-13.0 parts of excrementum pteropi, 14.5-16.9 parts of pericarpium trichosanthis, 6.0-10.1 parts of radix curcumae and 7.2-8.4 parts of rhizoma cyperi. The prescription is scientific and reasonable, and has effects of activating blood circulation to dissipate blood stasis, smoothing channels, killing pains, opening chest and benefiting qi. The invention also discloses a preparation method of the drug. The method comprises the steps of: drying, pulverizing and mixing the components by weight; placing the powder material in an ultrasonic extractor, adding 70% alcohol to extract effective components, so as to produce an alcohol extract of effective components; standing for 48-72 h to obtain an alcohol precipitation supernate; and filtering and recovering alcohol to produce a concentrated extract of the effective components.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate generally to a kind of medicine for the treatment of coronary heart disease and preparation method thereof.
Background technology
Cardiovascular disease is called blood circulation diseases again, is a series of diseases that relate to blood circulation.Blood circulation refers to hemophoric organ and tissue in the human body, mainly comprises heart, blood vessel (tremulous pulse, vein, blood capillary).Cardiovascular disease mainly refers to coronary heart disease, often is subdivided into acutely and chronic, generally all is relevant with arteriosclerosis.Common coronary heart disease has angina pectoris, myocardial infarction, arrhythmia, sudden cardiac death etc., and its cause of disease mostly is reasons such as long-term hypertension, hyperlipidemia, smoking, the improper metabolism of vascular smooth muscle cell.
Chinese medicine is classified as the thoracic obstruction, cardio palmus with the angina pectoris of coronary heart disease, myocardial infarction, arrhythmia etc.Chinese medicine thinks, obstruction of qi in the chest and cardialgia is that expectorant is turbid because healthy energy is lost emptyly, blood stasis, the stagnation of QI, cold coagulation and cause that blockage of the cardiac vessels is not smooth, clinical with left chest ictally feel oppressed, pain serve as a kind of disease that mainly shows, and is equivalent to diseases such as doctor trained in Western medicine angina pectoris, myocardial infarction.How with age its cause of disease body void, addiction to greasy and sweet foods savoury, anxiety and rage, inward invasion of pathogenic cold etc., and it is empty to cause healthy energy to be lost, and the expectorant stasis of blood is handed over resistance, caused by qi and cold stagnation, and blockage of the cardiac vessels forms.Its main pathogenesis is blockage of the cardiac vessels, and sick position is based on the heart, with suffer from a deficiency of the kidney, stagnation of liver-QI, dysfunction of the spleen in transportation etc. are relevant.Pathological characteristic is mainly deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive.Deficiency in origin has the deficiency of vital energy, yang deficiency, the deficiency of YIN, blood deficiency, but and deficiency of YIN affecting YANG, deficiency of YANG affecting YIN shows as that deficiency of both QI and YIN, QI and blood twoly lose, deficiency of both YIN and YANG, and very then weakened YANG QI the moon exhausts, heart-yang gets over outward.Mark is real to be the stagnation of QI, cold coagulation, turbid, the blood stasis of expectorant, and can be sick each other mutually, hands over resistance etc. as caused by qi and cold stagnation, QI stagnated by cold, the expectorant stasis of blood.Usually be subdivided into types such as cold coagulation heart arteries and veins, stagnation of QI ambition, phlegm-turbidity and blood stasis resistance, stagnation of heart-blood, deficiency of heart-QI, heart-Yin deficiency, flaccidity of the heart-yang.The Therapeutic Principle answers tonifying for deficiency syndrome, reducing for the excess syndrome.Stage of attack, is real to mark, and commonly usedly regulates the flow of vital energy, invigorates blood circulation, temperature is led to, reduce phlegm the method for outstanding taskwork blood collateral dredging.Catabasis is based on deficiency in origin, should regulate yin-yang, fill blood, adjust declining partially of internal organs, answer the deficiency of reinforce functional activities of the heart especially.Simulataneous insufficiency and excessive person, suitable invigorating middle warmer residence is logical, and logical middle residence is mended through-supplementation.
It is empty that cardiopalmus refers to that negative and positive of qi and blood loses, or the fluid-retention and blood stasis retardance, and the heart is become homeless foster, and heart arteries and veins is not smooth, causes in the heart and sharply beats, and is panic-stricken, and can not independently be a kind of disease of main performance.The various arrhythmia that roughly are equivalent to doctor trained in Western medicine, diseases such as cardiac insufficiency.Etiology and pathogenesis and the thoracic obstruction are similar, are subdivided into types such as timidness due to deficiency of the heart, deficiency of both the heart and spleen, hyperactivity of fire caused by deficiency of YIN, flaccidity of the heart-yang, stagnation of heart-blood, the heart disturbed by phlegm-fire usually.In the treatment, deficiency syndrome many with enrich blood, nourish blood, methods such as YIN nourishing, warming YANG, excess syndrome cooperates the method for tranquillization with heavy prescription mainly to reduce phlegm, to wash methods such as drink, blood circulation promoting and blood stasis dispelling, pathogenic fire purging.
At present, the Therapeutic Method of cardiovascular disease mainly contains: 1, interventional therapy: the common air bag that has expands, lays support etc.; 2, operative therapy: comprise bridging, implant a pacemaker etc.; Three, Drug therapy: comprise Western medicine, treatment by Chinese herbs etc.
The western medicine characteristics are symptomatic treatments, cure the symptoms, not the disease, and drug resistance has been taken in recurrence for a long time easily, and side effect is big.Adopt treatment by Chinese herbs, though onset is slower, lasting, the difficult recurrence of effect; The multiple action for the treatment of, conditioning, maintenance is arranged; Side effect is little, can take for a long time.
Summary of the invention
One of purpose of the present invention is to provide a kind of Chinese patent medicine for the treatment of cardiovascular stasis coronary heart disease, and this medicine prescription is scientific and reasonable, has blood circulation promoting and blood stasis dispelling, and coronary circulation-promoting pain-relieving is opened the effect of breast promoting the circulation of QI.
Another object of the present invention provides a kind of preparation method for the treatment of the cardiovascular stasis coronary heart disease medicine.
The invention is for realizing one of goal of the invention, by the following technical solutions:
The medicine for the treatment of cardiovascular stasis coronary heart disease of the present invention, made by following each component by weight:
Radix Salviae Miltiorrhizae 13.0-18.1, Radix Paeoniae Rubra 6.0-10.1, Rhizoma Chuanxiong 3.6-7.2, Lignum Dalbergiae Odoriferae 4.3-6.0, Fructus Crataegi 14.5-16.9, Pollen Typhae 5.8-9.6, Oletum Trogopterori 8.4-13.0, Pericarpium Trichosanthis 14.5-16.9, Radix Curcumae 6.0-10.1, Rhizoma Cyperi 7.2-8.4.
Further, each component by weight is preferably:
Radix Salviae Miltiorrhizae 13.9-17.5, Radix Paeoniae Rubra 6.8-9.2, Rhizoma Chuanxiong 4.3-6.4, Lignum Dalbergiae Odoriferae 4.7-5.8, Fructus Crataegi 15.3-16.3, Pollen Typhae 6.9-8.8, Oletum Trogopterori 9.4-11.8, Pericarpium Trichosanthis 15.3-16.3, Radix Curcumae 6.9-9.0, Rhizoma Cyperi 7.6-8.1.
Further, each component by weight is more preferably:
Radix Salviae Miltiorrhizae 14.8-16.7, Radix Paeoniae Rubra 7.3-8.5, Rhizoma Chuanxiong 4.7-5.8, Lignum Dalbergiae Odoriferae 5.0-5.5, Fructus Crataegi 15.5-16.0, Pollen Typhae 7.4-8.3, Oletum Trogopterori 9.9-11.2, Pericarpium Trichosanthis 15.5-16.0, Radix Curcumae 7.3-8.5, Rhizoma Cyperi 7.7-8.1.
The preparation method of the medicine of the treatment cardiovascular stasis coronary heart disease of the invention:
Comprise will be by weight each component oven dry, make the step of coarse powder 250-850um or 24 orders-65 order, mixing; Powder is inserted in the supersound extraction device, add 70% ethanol extraction effective ingredient, make the step of effective ingredient alcohol extract; Left standstill 48-72 hour, and made the precipitate with ethanol supernatant; Filter, reclaim ethanol, make the step of effective ingredient concentrated extract.
Further, when making the effective ingredient alcohol extract, comprise that adding 5-7 doubly measures 70% soak with ethanol 0.5-1.0 hour of ingredients weight parts, continue to add 70% ethanol and doubly measure to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract one.
Further, when making the effective ingredient alcohol extract, also comprise adding 70% ethanol that 5-7 doubly measures ingredients weight parts again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract two.
Further, also comprise the step of the effective ingredient concentrated extract being made oral liquid, pill, tablet, granule dosage form.
The characteristic of each component of preparation medicine of the present invention is as follows:
Radix Salviae Miltiorrhizae: bitterness, be slightly cold; Go into the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, diseases such as angina pectoris.The master contains fat-soluble Diterpenes composition and water miscible phenolic acid composition, also contains flavonoid, triterpenes, other compositions such as sterol.Act on cardiovascular system, have heart tonifying, blood vessel dilating, increase myocardial flow, antithrombotic formation, blood fat reducing, improve hemorheological properties (blood viscosity reduces, erythrocyte electrophoretic time shorten), improve microcirculatory effect.In addition, protect the liver, improve liver microcirculation, effect such as antibiotic in addition.
Radix Paeoniae Rubra: bitter in the mouth, be slightly cold; Return Liver Channel.The function clearing away heat and cooling blood, eliminating stasis to stop pain.Cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, injury from falling down, carbuncle skin infection.Root contains paeoniflorin, dextrorotation cachou extract and volatile oil.Volatile oil mainly contains benzoic acid, totally 33 of paeonol and other alcohols and phenols components.Have antithrombotic, antiplatelet aggregation, blood fat reducing and arteriosclerosis effect, and influence systema cariovasculare functional, effect such as protect the liver.
Fructus Crataegi: sour in the mouth, sweet; Slightly warm in nature; Return spleen, stomach, Liver Channel.Appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.Contain chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.In addition, contain organic acid tannin, the acid anhydride of tanning, epicatechol, choline, acetylcholine, Sitosterolum, carotene and lot of V it C etc. in the Fructus Crataegi.Have blood vessel dilating, heart tonifying, increase coronary flow, improve heart vigor, stimulating central nervous system system, bring high blood pressure down and cholesterol, vessel softening and diuresis and sedation; Doublely can prevent and treat the immunity of arteriosclerosis, enhancing body, anti-aging, anticancer effect; The composition that other has heart tonifying, appetite-stimulating indigestion-relieving, activating blood circulation to dissipate blood stasis, contraction uterus, relievings asthma and reduce phlegm, suppress antibacterial, alleviate abdominal pain diarrhea.
Pollen Typhae: sweet in the mouth, little suffering; Property is put down; Return liver, the heart, spleen channel.Effect hemostasis, blood stasis dispelling, diuresis, treating stranguria.Be used for haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, gastral cavity ventral spine pain, treating swelling and pain by traumatic injury, the wet pain of stranguria with blood.Main naringenin, isorhamnetin, Quercetin, the Sitosterolum etc., Palmic acid, succinic acid and amino acids and inorganic elements etc. of containing; Pharmacological action has increases uterine contraction and anastalsis, influence cardiovascular system, blood fat reducing, anticoagulant coagulant, fibrinolysis activity, atherosclerosis, hemostasis, antiinflammatory, function of gallbladder promoting, enhancing immunologic function, effect such as antibacterial.
Oletum Trogopterori: nature and flavor are sweet, warm; Nontoxic; Go into Liver Channel; Have the mediation blood vessels, the effect of eliminating stasis to stop pain.Cure mainly stasis, amenorrhea, stomachache; Diseases such as breast side of body twinge tumbling and swelling and snake bite and insect sting.Main retinoid, resin, carbamide, the uric acid etc. of containing; Pharmacological action has bacteriostasis, anticoagulant, antianginal, increase blood flow volume, alleviates uterus tension force effect.
The fruit-rind of Chinese trichosanthes: sweet cold, attach to the lung and stomach meridians.The effect moistening the lung and resolving phlegm, the promoting the circulation of QI the chest stuffiness relieving.Control phlegm-heat cough, pharyngalgia, chest pain is spitted blood, and epistaxis is quenched one's thirst, constipation, carbuncle pyogenic infections from tumour or sore.The master contains triterpene saponin, organic acid and salt, resin, saccharide, fatty oil, amino acids and inorganic elements etc., acts on cardiovascular system, and inhibitory action arrhythmia, blood vessel dilating, raising coronary flow and resisting oxygen lack are arranged; Rush down effects such as following, antibiotic, antitumor in addition.
Rhizoma Chuanxiong: acrid in the mouth; Warm in nature; Return liver, gallbladder, heart channel.The fragrant liter of gas loose, and has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia stomachache, lump, ambition side of body pain, injury from falling down swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores.Rhizome contains volatile oil, ligustrazine, caffeic acid, vanillic acid, ferulic acid, neutral wet goods.Contain 5,5 in addition in addition '-the Lian furan feeds compositions such as formyl ether, spathulenol, Sitosterolum, sucrose and a kind of fatty glyceride.Calmness, heart tonifying arranged, influence the smooth muscle function, effect such as antibiotic, anti-radiation.
Radix Curcumae: acrid in the mouth, hardship; Cool in nature; GUIXIN, liver, gallbladder meridian.Fragrance reaches thoroughly, can rise to fall.Has promoting flow of QI and blood, dispersing the stagnated live-QI to relieve the stagnation of QI, removing heat from the heart to restore the consciousness, the effect of clearing away heat and cooling blood.Cure mainly breast side of body epigastric pain, menoxenia, the dysmenorrhea amenorrhea, traumatic injury, the calentura coma, infantile convulsion, demented, heat in blood is told nosebleed, stranguria with blood, sand Stranguria, jaundice.Mainly contain volatile oil, camphene, Camphora, curcumene etc. still contain starch, fatty oil, rubber, weld, Eucarvone and phellandrene etc.Pharmacological action has effect, the antifungic action of blood fat reducing.
Rhizoma Cyperi: hot, little hardship; Sweet flat.The resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.Main volatile oil, fatty oil, starch, saccharide and the protein etc. of containing.Pharmacological action has syngignoscism, anesthetic action, antipyretic-antalgic, cooling effect to central nervous system's effect, also has cardiotonic or decreased heart rate effect, estrogen-like effects and suppresses effects such as uterine contraction, antibiotic, antiinflammatory.
Lignum Dalbergiae Odoriferae: acrid in the mouth; Warm in nature; Return liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.Be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.Main component is single aggressiveness, dimer, cinnamene analog derivative of isoflavone derivative etc.Antithrombotic, anticoagulation are arranged, can significantly increase coronary flow, decreased heart rate slightly increases the heart beating amplitude, does not cause arrhythmia.Also have convulsion, analgesic activity.
Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling in the side, removing heat from blood nourish blood and are monarch; Rhizoma Chuanxiong, the logical dissipating blood stasis of Lignum Dalbergiae Odoriferae temperature, removing obstruction in the collateral to relieve pain is minister; Be aided with Radix Curcumae, Rhizoma Cyperi (vinegar) depressed liver-energy dispersing and QI regulating, resolving depression pain relieving, Pollen Typhae, Oletum Trogopterori stasis-dispelling and pain-killing, furthermore Fructus Crataegi removing blood stasis and activating blood flow, relieving dyspepsia, reduce phlegm, open breast at the Pericarpium Trichosanthis promoting the circulation of QI, are all assistant and make.All medicines share, and play blood circulation promoting and blood stasis dispelling altogether, and coronary circulation-promoting pain-relieving is opened the merit of breast promoting the circulation of QI.
The technology of the ultrasonic extraction effective ingredient that adopts in the process for preparing medicine of the present invention be utilize that ultrasound wave produces special role such as accelerated particle motion, cavitation effect, vibration homogenize, come for material chemical constituent extraction process, with the new extractive technique of ingredient to extract quickly and efficiently.
Adopt this extractive technique, prepare medicine of the present invention, obvious with the traditional handicraft comparative advantages:
1, extraction efficiency height: the unique physical characteristic of ultrasound wave can be impelled plant cell tissue's breaking cellular wall or distortion, makes the Chinese medicine extracts active ingredients more abundant, and extraction ratio significantly improves than traditional handicraft and reaches 50-500%.
2, extraction time is short: the intensified by ultrasonic wave Chinese medicine extraction can obtain the optimum extraction rate at 24-40 minute usually, and extraction time shortens more than 2/3 greatly than traditional method, and medical material raw material treating capacity is big.
3, the extraction temperature is low: the optimum temperature of supersound extraction Chinese crude drug has protective effect at 40-60 ℃ to effective ingredient in the medical material of case of thermal instability, facile hydrolysis or oxidation, simultaneously energy-conservation greatly energy consumption.
4, wide adaptability: the supersound extraction Chinese crude drug is not subjected to the restriction of compositional polarity, molecular weight size, is applicable to the extraction of most kind Chinese crude drugs and each constituents, and is applicable to multiple solvent.
5, extraction medicinal liquid impurity is few, and effective ingredient is easy to separate, purification.
6, extraction process operating cost is low, and overall economic efficiency is remarkable.
7, operation is simple, plant maintenance, easy maintenance.
Pharmacological research:
Experiment shows that medicine of the present invention has following pharmacological action:
1, analgesic activity: mouse peritoneal injection medicine decocting liquid 1.3g/kg of the present invention, the pain threshold after the administration 30,60, behind the 90min improves 63.35%, 132.62%, 98.53% respectively.
The result shows: remarkable analgesic activity.
2, to cardiovascular effect: 25% medicine decocting liquid of the present invention is made the peripheral blood vessel perfusion experiment to Bufo siccus.
The result shows: the diastole at once of whole body blood vessel, blood flow strengthens.
3, arrhythmia: after 50% medicine decocting liquid of the present invention gavages mice 45min, put into the airtight bottle that contains a certain amount of chloroform, after stopping to exhale, open breast immediately and observe the ventricular fibrillation incidence rate.Administration group incidence rate is 10%, and the normal saline matched group is 90%.
The result shows: antiarrhythmic effect is remarkable.
4, to microcirculatory influence: the quiet notes of 10% high molecular dextran rat causes acute model of microcirculation obstacle, and small intestinal is injected medicine 100% decocting liquid of the present invention, observes the mesentery microcirculation behind the 20min.
The result shows: the open quantity of blood capillary increases, and blood flow rate is accelerated, and hair cell is assembled, phenomenons such as leukocyte is adherent, accumulation are obviously improved, the blood flow stagnation behavior disappears.
5, improve blood flow and become characteristic: mix for the hyperlipemia rabbit and raise medicine concentrated solution of the present invention 20ml/2 time/day, observe after 3 weeks.Its whole blood reduced viscosity is starkly lower than matched group.
The result shows: can improve blood flow and become characteristic.
6, blood fat reducing: normal mouse gavages medicine 15ml/kg of the present invention, every day 1 time, observes after 10 days.The result shows: serum cholesterol content significantly reduces, several no changes of triglyceride.
Clinical observation:
Drug therapy type of obstruction of heart-blood thoracic obstruction disease 133 examples of the present invention, the clinical observation brief summary.
Data, method and conclusion
1 physical data
1.1 case source: all patients all are clinic case over 3 years, totally 133 examples, 29～75 years old age, the course of disease 1 year～5 years.
1.2 case is selected
1.2.1 diagnostic criteria: with reference to " internal medicine " (1978 Shanghai science tech publishing house).
Diagnosis basis
1.2.1.1 chest pain is fixed and is not moved, and goes into Night Watch very.
1.2.1.2 sensation of oppression over the chest with shortness of breath, or palpitation and uneasiness.
1.2.1.3 body of the tongue is dark violet, deep and hesitant pulse.
1.2.1.4 pulse is accelerated, hypertension.
1.2.1.5 Electrocardioscopy display abnormality.
Dialectical foundation:
Assertive evidence is many by the stagnation of QI with the passing of time, and blood stasis is at a stop, due to venation is obstructed.So see stabbing pain over the chest, blood vessels stagnate, so pain in fixed position; That blood stasis blocks, the heart is become homeless is foster, so palpitation and uneasiness, body of the tongue are dark violet, deep and hesitant pulse, be in the blood stasis stop, the time of stagnation of heart-blood.The coronary heart disease of modern medicine can be demonstrate,proved dialectical executing with reference to this and control.
1.2.2 get rid of the case standard:
1.2.2.1 get rid of cold coagulation heart arteries and veins, stagnation of QI ambition, phlegm-turbidity and blood stasis resistance, deficiency of heart-QI, heart-Yin deficiency.Type thoracic obstruction diseases such as flaccidity of the heart-yang.
1.2.2.2 get rid of type cardiopalmus diseases such as timidness due to deficiency of the heart, deficiency of both the heart and spleen, hyperactivity of fire caused by deficiency of YIN, flaccidity of the heart-yang the heart disturbed by phlegm-fire.
1.2.2.3 the anemia of pregnant woman reaches the said medicine allergy sufferers.
1.2.2.4 not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.
2. Therapeutic Method:
Consumption: a 20～40ml, 3 times on the one.
Usage: oral.
The course for the treatment of: taking 10 days continuously is a course for the treatment of.
3 observation indexs:
3.1 curative effect determinate standard
3.1.1 cure: transference cure.
3.1.2 take a turn for the better: cardinal symptom has improvement.
3.1.3 it is invalid: the symptom no change.
4.1 treatment back clinical efficacy: see Table 1.
Table 1 clinical treatment curative effect (%)
From clinical treatment result (table 1) as can be seen: medicine of the present invention is 83.5% to the angina pectoris total effective rate.Wherein, cure rate 35.3%, improvement rate 48.1%, inefficiency 16.5%, general curative effect is remarkable.
In addition, concrete experiment shows that medicine of the present invention is better to light moderate curative effect to treat angina pectoris, and is relatively poor to curative effect to treat angina pectoris behind serious symptom or the myocardial infarction; It is 47.2% that nitroglycerin stops lapse rate, and it is 43.2% that electrocardiogram improves total effective rate, and the purplish tongue alleviator is 67.3%.Other symptoms of big half patient such as uncomfortable in chest, breathe hard, tired, dizzy, headache, irritated, having a sleepless night has in various degree improvement.
4.2 untoward reaction: do not see obvious side reaction in the therapeutic process.
4.3 conclusion: angina pectoris, myocardial infarction, the arrhythmia of medicine of the present invention pair and cardiovascular stasis coronary heart disease, disease is seen diseases such as sensation of oppression over the chest with shortness of breath, cardiopalmus chest pain, body of the tongue are dark violet, deep and hesitant pulse, determined curative effect, treating both the principal and secondary aspects of a disease, side effect is little, by clinical observation, follow up a case by regular visits to feedback, add up to efficient and reach more than 80.0%.
The case case
Patient: man, 40 years old, workman.
On October 9th, 2011, the outpatient.Pain uncomfortable in chest was shown effect 3 years repeatedly, increased the weight of 2 days.
The patient is over nearly 3 years, repeated relapsing chest pain, discomfort uncomfortable in chest.Yesterday is because of happiness, excessive diet and bring out chest pain, and sharp ache, uncomfortable in chest as stop up, pain is drawn the shoulder back of the body, and the expression anxiety is very brief with asthma simultaneously, and limbs are heavy, have a rest can alleviate after 5 minutes.Patient's obesity, abundant expectoration, food delicious food savoury is had a liking in happiness usually.
Have a medical check-up: T:36.7 ℃, P:115 time/minute, R:23 time/minute, BP:120/80mmHg, light red tongue, dirty and greasy fur, rolling pulse.The electrocardio diagram: II, III, aVF S-T section moves down, and the T ripple is inverted.
Western medicine diagnose: angina pectoris-coronary atherosclerotic heart disease.
Tcm diagnosis: the type of obstruction of heart-blood thoracic obstruction.
Method for the treatment of: blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving is opened the breast promoting the circulation of QI.Give medicine of the present invention (40ml tid) treatment, 10 days is a course for the treatment of.
Further consultation on October 19 in 2011, symptom disappears substantially.10 days (dosage 20ml tid) of continuous clothes, course for the treatment of of after treatment.
On the November 29th, 2011 of all symptom complete obiterations of precious patient again.Dose successively decreases subsequently, keeps 10mlbid, takes all the year round.Followed up a case by regular visits to all symptom complete obiterations, not recurrence again 1 year.
The patient: the week certain, man, 57 years old, cadre.
First visit on November 11 in 2009
The patient is old, body is empty, overwork, comes the left side chest pain violent on 2nd, and heart beating is violent, pants, goes out profuse sweating.Check: 36 ℃ of body temperature, pulse 96 times/minute, blood pressure 160/95 millimetres of mercury.B/B/S is clear, and heart enlarges slightly to the left, and idol has early rich, and apex has II level blowing murmur.Electrocardioscopy is acute myocardial infarction of inferior wall, and idol has premature ventricular beat.And pain in fixed position, go into nyctalgia very; Dark violet, the deep and hesitant pulse of body of the tongue.
Western medicine diagnose: angina pectoris-coronary atherosclerotic.
Tcm diagnosis: the type of obstruction of heart-blood thoracic obstruction.
Give medicine of the present invention (30ml tid) treatment, 10 days is a course for the treatment of.
21 days two November in 2009 examined
Symptom disappears substantially.10 days (20ml tid) of continuous clothes, course for the treatment of of after treatment.
December was examined in 2 days three in 2009
All symptom complete obiterations of patient.Dose successively decreases subsequently, keeps 10ml bid, takes all the year round.Followed up a case by regular visits to all symptom complete obiterations, not recurrence again 1 year.
Patient: Lee, woman, 60 years old, retired worker.
First visit: on March 3rd, 2010.The time have nervous, uncomfortable in chest, surplus the chest pain 10 year.Recently chest pain radiating to the back, and localized pain, pain can be alleviated after rest.Dim complexion, body of the tongue is dark violet, stringy and hesitant pulse.The electrocardio diagram: II, III, aVF S-T section moves down, and the T ripple is inverted.
Western medicine diagnose: angina pectoris-coronary atherosclerotic.
Tcm diagnosis: the type of obstruction of heart-blood thoracic obstruction.
Give medicine of the present invention (30ml tid) treatment, 10 days is a course for the treatment of.
Two examine (on March 14th, 2010)
Symptom disappears substantially.10 days (20ml tid) of continuous clothes, course for the treatment of of after treatment.
Three examine (on March 24th, 2010)
All symptom complete obiterations of patient.
Dose successively decreases subsequently, keeps 10ml bid, takes all the year round.Followed up a case by regular visits to all symptom complete obiterations, not recurrence again 2 years.
Description of drawings
Fig. 1 is the invention pharmaceutical preparation schematic flow sheet;
The specific embodiment
Embodiment one
The medicine of the treatment cardiovascular stasis coronary heart disease of present embodiment, made by following each component by weight:
Radix Salviae Miltiorrhizae 16.7, Radix Paeoniae Rubra 7.3, Rhizoma Chuanxiong 4.7, Lignum Dalbergiae Odoriferae 5.5, Fructus Crataegi 16.0, Pollen Typhae 8.3, Oletum Trogopterori 9.9, Pericarpium Trichosanthis 16.0, Radix Curcumae 7.3, Rhizoma Cyperi 8.1.
Embodiment two
The medicine of the treatment cardiovascular stasis coronary heart disease of present embodiment, made by following each component by weight:
Radix Salviae Miltiorrhizae 14.8, Radix Paeoniae Rubra 8.5, Rhizoma Chuanxiong 5.8, Lignum Dalbergiae Odoriferae 5.0, Fructus Crataegi 15.5, Pollen Typhae 7.4, Oletum Trogopterori 11.2, Pericarpium Trichosanthis 15.50, Radix Curcumae 8.5, Rhizoma Cyperi 7.7.
Embodiment three
The medicine of the treatment cardiovascular stasis coronary heart disease of present embodiment, made by following each component by weight:
Radix Salviae Miltiorrhizae 15.8, Radix Paeoniae Rubra 7.9, Rhizoma Chuanxiong 5.3, Lignum Dalbergiae Odoriferae 5.3, Fructus Crataegi 15.8, Pollen Typhae 7.9, Oletum Trogopterori 10.5, Pericarpium Trichosanthis 15.8, Radix Curcumae 7.9, Rhizoma Cyperi 7.9.
The medicine of above-described embodiment 1-3, in conjunction with Fig. 1, the preparation method of making mixture is:
At first the component of each weight portion is dried, is made coarse powder 250-850um or 24 orders-65 order, mixing; Powder is put into the supersound extraction device, add 5-7 and doubly measured 70% soak with ethanol 30-60 minute, continue to add 70% ethanol and doubly measure to 8-10, extraction is 1.0-1.5 hour under 45-55 ℃, collects effective ingredient alcohol extract one; Add 5-7 again and doubly measure 70% ethanol, extracted 0.5-1.0 hour down at 45-55 ℃, collect effective ingredient alcohol extract two; Merge extracted twice liquid, low temperature 2-8 ℃ storage was left standstill 48-72 hour, made the precipitate with ethanol supernatant; Incline and get supernatant, filter, reclaim ethanol, make the effective ingredient concentrated extract.The purified water that adds 3-4 times of effective ingredient concentrated extract weight portion, mixing left standstill 24-36 hour, made the water precipitating supernatant; Incline and get supernatant, filter, add purified water to nearly full dose, regulate pH value to 4.0-6.0, standardize solution, fill namely gets the mixture finished product.
Medicine of the present invention needs at concrete treatment, can be made into dosage forms such as oral liquid, pill, tablet, granule, so that take and carry.
Pharmaceutical preparation of the present invention as extracting solvent, adopts ultrasonic extraction (being also referred to as extraction) Chinese crude drug effective ingredient with 70% ethanol.With 70% ethanol as extracting solvent, wide adaptability, impurity is few, the finished product mouthfeel is limpid, color and luster is shinny.Ultrasonic extraction has extracts the unique advantage that temperature is low, extraction ratio is high, extraction time is short, is applicable to the extraction of Chinese crude drug and various animal and plant effective contents.With technology such as traditional water extract-alcohol precipitation relatively; extraction ratio improves 50%-100%; extraction time (minute) shorten more than 1/2; extract temperature and be reduced to 40-60 ℃; being more conducive to the protection of active ingredient, is to substitute traditional aqueous extraction-alcohol precipitation technology method to realize modern high technology means efficient, that the energy-saving and environmental protection formula is extracted.
Claims (7)
1. medicine for the treatment of coronary heart disease is characterized in that: made by following each component by weight:
Radix Salviae Miltiorrhizae 13.0-18.1, Radix Paeoniae Rubra 6.0-10.1, Rhizoma Chuanxiong 3.6-7.2, Lignum Dalbergiae Odoriferae 4.3-6.0, Fructus Crataegi 14.5-16.9, Pollen Typhae 5.8-9.6, Oletum Trogopterori 8.4-13.0, Pericarpium Trichosanthis 14.5-16.9, Radix Curcumae 6.0-10.1, Rhizoma Cyperi 7.2-8.4.
2. the medicine for the treatment of coronary heart disease according to claim 1, it is characterized in that: each component by weight is preferably:
Radix Salviae Miltiorrhizae 13.9-17.5, Radix Paeoniae Rubra 6.8-9.2, Rhizoma Chuanxiong 4.3-6.4, Lignum Dalbergiae Odoriferae 4.7-5.8, Fructus Crataegi 15.3-16.3, Pollen Typhae 6.9-8.8, Oletum Trogopterori 9.4-11.8, Pericarpium Trichosanthis 15.3-16.3, Radix Curcumae 6.9-9.0, Rhizoma Cyperi 7.6-8.1.
3. the medicine for the treatment of coronary heart disease according to claim 1 is characterized in that: each component by weight more preferably:
Radix Salviae Miltiorrhizae 14.8-16.7, Radix Paeoniae Rubra 7.3-8.5, Rhizoma Chuanxiong 4.7-5.8, Lignum Dalbergiae Odoriferae 5.0-5.5, Fructus Crataegi 15.5-16.0, Pollen Typhae 7.4-8.3, Oletum Trogopterori 9.9-11.2, Pericarpium Trichosanthis 15.5-16.0, Radix Curcumae 7.3-8.5, Rhizoma Cyperi 7.7-8.1.
4. prepare the preparation method of the medicine of the described treatment coronary heart disease of claim 1-3, it is characterized in that:
Comprise each component oven dry, powder process that will be by weight, the step of mixing; Powder is inserted in the supersound extraction device, add 70% ethanol extraction effective ingredient, make the step of effective ingredient alcohol extract; Left standstill 48-72 hour, and made the precipitate with ethanol supernatant; Filter, reclaim ethanol, make the step of effective ingredient concentrated extract.
5. the preparation method of the medicine for the treatment of coronary heart disease according to claim 4, it is characterized in that: when making the effective ingredient alcohol extract, comprise that adding 5-7 doubly measures 70% soak with ethanol 0.5-1.0 hour of ingredients weight parts, continue adding 70% ethanol doubly measures to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract one.
6. the preparation method of the medicine for the treatment of coronary heart disease according to claim 4, it is characterized in that: when making the effective ingredient alcohol extract, also comprise adding 70% ethanol that 5-7 doubly measures ingredients weight parts again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract two.
7. the preparation method of the medicine for the treatment of coronary heart disease according to claim 4 is characterized in that: also comprise the step of the effective ingredient concentrated extract being made oral liquid, pill, tablet, granule dosage form.
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Application publication date: 20130717 |