CN103202868A - Composition for preventing and treating flu as well as preparation method and application thereof - Google Patents
Composition for preventing and treating flu as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a composition for preventing and treating flu as well as a preparation method and an application thereof. The composition comprises the following components in parts by mass: 10 to 20 parts of bupleurum, 10 to 15 parts of libanotis buchtormensis, 10 to 15 parts of artemisia rupestris and 10 to 15 parts of Taiqiang. With the aid of 'Qinling forest herb resource protection and development and utilization technology research thereof' of a special scientific research item in the public forestry welfare industry of State Forestry Bureau, the anti-flu Chinese medicinal preparation consisting of four special Chinese medicinal herbs in Mount Taibai of Qinling and using the bupleurum as a monarch is prepared. Pharmacodynamic animal experiments, acute toxicity experiments and long-term toxicity experiments for pharmacodynamic treatment effect evaluation and toxicity safety evaluation verify that the composition has a remarkable treatment effect of treating flu virus infection, particularly cold caused by H1N1 flu viruses, and is safe and nontoxic.
Description
Technical field
The invention belongs to Chinese herb prevention influenza technical field, relate to a kind of compositions and formulation preparation method and application that prevents and treats influenza.
Background technology
Influenza (Influenza) is a kind of acute respiratory infectious disease that is caused by influenza virus, and infectiousness is strong, the sickness rate height.4 large-scale influenza virus of eighties of last century have attacked the mankind, bring very grave disaster.After entering new century, H5N1 human and bird fluenza virus and influenza A H1N1 influenza virus popular brings great harm to the mankind.In recent years influenza have popular scope wide, propagate fast, the cycle is long, easy characteristics such as recurrence after the drug withdrawal, has brought huge difficulty to control.Safely, Tamiflu receives much concern in medical circle efficiently.
Up to now, the major measure of influenza virus is resisted still based on vaccination and use antiviral drugs in the whole world.Because surface antigen hemagglutinin HA and the neuraminidase NA of influenza virus morph easily, cause the preventive effect of vaccine to reduce.Therefore, the use of antiviral drugs remains the main selection of morbidity crowd prevention and control influenza.China has 8.4 hundred million people need take Tamiflu every year approximately, and effectively the Tamiflu research and development have great realistic meaning.
Current Tamiflu has chemicals, Chinese patent medicine, Chinese medicine etc.Chemicals (as oseltamivir phosphate capsule, amantadine etc.) is expensive, easily produces drug resistance, is difficult to control the popular of influenza.The Chinese patent medicine of clinical treatment influenza often can not show flexible and changeablely as decoct side's medicine because prescription is fixing, with the disease plus-minus, makes the practical application of Chinese patent medicine be subjected to certain restriction.China has seasonal influenza to take place every year.The tradition Chinese medicine has advantages such as safe, efficient, many target spot, difficult generation drug resistance owing to adopt multiple compatibility of drugs to form, and has irreplaceable advantage aspect the treatment influenza.
Summary of the invention
The problem that the present invention solves is to provide a kind of compositions and formulation preparation method and application that prevents and treats human influenza, and the said composition compatibility is proper, and prescription is rigorous, has simultaneously using both cold and hot drugs, the effect of coordination between ascending and descending, and safety non-toxic can be applicable to the control of influenza.
The present invention is achieved through the following technical solutions:
A kind of compositions of preventing and treating influenza in mass fraction, comprises following component:
10～20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes, too Qiang is 10～15 parts.
Further, in mass fraction, comprise following component:
20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes, too Qiang is 10～15 parts.
In mass fraction, comprise following component:
20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～12 parts of Herba Achilleaes, too Qiang is 12～15 parts.
Further, in mass fraction, comprise following component:
20 parts of Radix Bupleuri, 10 parts of Radix Libanotidis buchotomensis, 12 parts of Herba Achilleaes, too Qiang is 15 parts.
The described effective ingredient of preventing and treating the compositions of influenza is to use cold water soak 2～4h earlier with Radix Bupleuri, Radix Libanotidis buchotomensis, Herba Achilleae with after too Qiang pulverizes, and decocts then and extracts 30min at least, filters the fried liquid of gained.
A kind of preparation method of preventing and treating the Chinese medicine preparation of influenza may further comprise the steps:
1) according to following mass fraction meter, with 10～20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes with too after 10～15 parts of pulverizing of Qiang, adds the cold water soak 1～2h that is equivalent to 5～8 times of medical material amounts;
2) after immersion finishes, boil 30～60min, filter; Medicinal residues add 3～5 times of quality water and decoct 20～40min again, filter;
3) merge twice fried liquid, in water-bath, be concentrated into extractum.
Described also with prepared extractum as effective ingredient, add adjuvant and make decoct, pill, tablet or capsule.
Described compositions of preventing and treating influenza is prevented and treated application in the medicine of influenza in preparation.
Described medicine has resisiting influenza virus and improves the effect of immunity of organisms.
Described compositions of preventing and treating influenza is used in the medicine of preparation control influenza infection.
Compared with prior art, the present invention has following beneficial technical effects:
Compositions and the formulation preparation method thereof of preventing and treating influenza provided by the invention, optimizing in the four flavor Mount Taibais, the Qinling Mountains that the characteristic Chinese herbal medicine forms with Radix Bupleuri is the influenza Chinese medicinal formulae of monarch drug.Carry out pharmacodynamics therapeutic evaluation and toxicological assessment by animal pharmacodynamics test, acute toxinology experiment and long-term toxicological test, prove conclusively this prescription at the treatment influenza infection, particularly the flu that causes of H1N1 influenza virus has significant curative effect, safety non-toxic.
The present invention is subsidized by State Administration of Forestry's forestry public welfare industry scientific research special project " Qinling Mountains woods medicine protection of resources and evaluation and exploration technology research thereof "; traditional Chinese medicine theory is combined with modern science and technology; in animal body on Shi Yan the basis; each compatibility group of characteristic Chinese herbal medicine is to the inhibitory action of influenza virus in the research Mount Taibai, the Qinling Mountains; filter out the optimal drug compatibility, for clinical application provides theoretical foundation.Disclosed the science and the preciseness that use this prescription treatment influenza simultaneously, the Chinese herbal medicine in the prescription all comes from mountain area, China Qinling Mountains characteristic woods medicine, has great importance for excavating Mount Taibai, Qinling Mountains Chinese herbal medicine resource.
The specific embodiment
The present invention is described in further detail below in conjunction with specific embodiment, and the explanation of the invention is not limited.
The present invention sums up the experience of Mount Taibai, Shaanxi Province district medication among the people, and optimizing in the four flavor Mount Taibais, the Qinling Mountains that the characteristic Chinese herbal medicine forms with Radix Bupleuri is the influenza Chinese medicinal formulae of monarch drug.Carry out pharmacodynamics therapeutic evaluation and toxicological assessment by pharmacodynamics animal experiment, acute toxinology experiment and long-term toxicological test, prove conclusively this prescription at the treatment influenza infection, particularly the flu that causes of H1N1 influenza virus has significant curative effect, safety non-toxic.
Prescription of the present invention is monarch drug with Radix Bupleuri (Radix Bupleuri), by Radix Bupleuri (Radix Bupleuri), Radix Libanotidis buchotomensis (Libanotis spodotrichoma K.T.Fu), Herba Achilleae (Alpine Yarrow Herb) and too Qiang (Rhizoma et Radix Notopterygii) form its weight proportion following (60kg be grown up clinical plan dosage):
Radix Bupleuri has that expelling pathogenic factors from the exterior expels the heat-evil, the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, cures mainly cold, fever, alternate attack of chill and fever, malaria, diseases such as stagnation of QI due to depression of the liver.The modern pharmacology result of study shows: the polysaccharide component in the Radix Bupleuri can strengthen the function of phagocyte and natural killer cell, improves the special viral antibody titre, thereby improves the immunologic function of human body.
Radix Libanotidis buchotomensis is one of Shaanxi " too white seven medicines ", and the sweet temperature of this moral character, bitter in the mouth have expelling wind and cold, expelling wind and removing dampness, and the effect of activating collaterals to relieve pain is used for anemofrigid cold, general aching, arthroncus, traumatic injury, treatment of diseases such as rheumatism bones and muscles pain.
Herba Achilleae has the effect of expelling pathogenic wind from the body surface, promoting blood circulation to remove blood stasis, cures mainly anemofrigid cold, traumatic injury congestive edema, the existing clinical various acute and chronic inflammation that are used for the treatment of more.
Qiang's one medicine too can relieving the exterior syndrome by diaphoresis, but wind-damp dispelling and pain relieving again.According to clinical practical experiences in recent years, the effect that this medicine is brought down a fever is fine, can cooperate other antiviral Chinese herbal treatment wind heat table diseases.
Effects such as the influenza of the above-mentioned Chinese medicine of respectively distinguishing the flavor of, analgesic, analgesia, antiinflammatory all have research, but as prescription unmanned use the still.The compatibility of medicines in a prescription of the present invention is proper, and prescription is rigorous, has simultaneously using both cold and hot drugs, and the effect of coordination between ascending and descending uses prescription treatment influenza of the present invention to have feasibility in theory.Further with H1N1 influenza infection mice as the evaluating drug effect model; by indexs such as infecting mouse survival rate, survival natural law, lungs index, the variations of Antibody of Influenza titre; having estimated prescription of the present invention has significant protective effect to H1N1 influenza infection mice, for the clinical treatment of influenza provides certain support.
Provide some concrete prescription embodiment below.
Embodiment 1
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 10g, Herba Achilleae 12g, the too 15g of Qiang.
Embodiment 2
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 10g, Herba Achilleae 15g, the too 12g of Qiang.
Embodiment 3
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 15g, Herba Achilleae 10g, the too 12g of Qiang.
Embodiment 4
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 15g, Herba Achilleae 12g, the too 10g of Qiang.
Embodiment 5
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 12g, Herba Achilleae 15g, the too 10g of Qiang.
Embodiment 6
This example needed raw material medicine is Radix Bupleuri 20g, Radix Libanotidis buchotomensis 12g, Herba Achilleae 10g, the too 15g of Qiang.
Embodiment 7
This example needed raw material medicine is Radix Bupleuri 15g, Radix Libanotidis buchotomensis 12g, Herba Achilleae 10g, the too 10g of Qiang.
Embodiment 8
This example needed raw material medicine is Radix Bupleuri 10g, Radix Libanotidis buchotomensis 10g, Herba Achilleae 10g, the too 10g of Qiang.
The preparation technology of above embodiment is as follows:
After the four Chinese medicine pulverizing, accurately weighing is put and is decocted in the container, and decocting container is good with crock, marmite, adds the cold water soak 2h that is equivalent to 5～8 times of medical material amounts, boils 30～60min, filters; Medicinal residues add 3～5 times of water gagings to be continued to decoct, and boils 20～40min, filters.Merge fried liquid twice, in water-bath, be concentrated into the water decoction that every 1ml is equivalent to medical material amount 1～2g.
Above-mentioned Chinese medicinal formulae, can utilize general pharmaceutical technology (tcd) and equipment to make different dosage form: water decoction, pill, tablet and capsule etc., can satisfy different patients' needs.
Provide zoopery below.
In the hope of 8 embodiment gained of prescription of the present invention water decoction is carried out the influenza therapeutic evaluation, and further screen the optimal drug compatibility by the pharmacodynamics animal experiment; Verify the safety of this prescription by acute toxinology experiment and long-term toxicological test.
Pharmacodynamics test
1, experiment material
1.1 animal
340 of BALB/c mouse, the SPF level, body weight (13 ± 2) g, male and female half and half are provided by Xi'an Jiaotong University Medical College's Experimental Animal Center, the animal quality certification number: SCXK(Shan) 2007-001.
1.2 Strain
H1Nl strains of influenza viruses A/swine/Shaanxi/sf/2011 (H1N1), GenBank serial number: JX860700.1 is H1Nl influenza virus Local Isolates.Above-mentioned Strain is rised in value in mdck cell and Embryo Gallus domesticus, and the HA test records virus titer and reaches 8Log2, and-80 ℃ frozen standby.
1.3 medicine and reagent
Prescription by Radix Bupleuri, Radix Libanotidis buchotomensis, Herba Achilleae and too Qiang form, all pluck from Mount Taibai, the Qinling Mountains at favorable season, dry in the shade naturally in dry ventilation, preserve.With reference to body surface area computing method of introducing in Li Yikui chief editor " herbal pharmacology experimental methodology ", people's dosage is converted into the dose,equivalent of BALB/c mouse, prepare water decoction, high pressure steam sterilization (110 ℃, 15min), 4 ℃ of preservations, standby;
Oseltamivir phosphate capsule (Tamiflu, oseltamivir phosphate capsule): Basel, SUI Hao Fumailuoshi company limited product, the company limited packing of Shanghai Roche Group, lot number B1162, lot number of the repackaged products SH0033.
1.4 instrument
TGL-19 desk type high speed refrigerated centrifuger (ShangHai City centrifugal Machine Institute product); Electric heating constant temperature water bath (the auspicious instrument plant in Shanghai side product); MP2000D electronic balance (Shanghai Hengping Science Instrument Co., Ltd.'s product); IVC mice rearging cage, Suzhou teaching cage tool factory product.
2, experimental technique
2.1 prescription of the present invention is to the influence of Antibody of Influenza level, lung index in influenza virus infecting mouse body weight, the serum
Get 132 BALB/c mouse, be divided into 11 groups at random, be respectively blank group, model group, oseltamivir phosphate capsule-positive drug matched group and each embodiment group, 12 every group.Except the blank group, mice is slightly anaesthetized with ether, with 15 LD
50H1N1 influenza virus collunarium infect every 35uL.Infect and began administration the same day, continuous 5d, blank group and model group filling hello equal-volume distilled water.Observe mice existence and active situation every day and weigh, plucked eyeball on the 6th day and get blood and prepare serum, Antibody of Influenza level in the HI test determination serum.Dissect mice, claim the lung quality, calculate lung index and lung index suppression ratio.
Lung index=lung wet weight (g)/body weight (g)
2.2 prescription of the present invention is to the influence of influenza virus infecting mouse pneumonia model mortality rate, time-to-live and increase in life span
Get 200 BALB/c mouse, be divided into 10 groups at random, be respectively model group, oseltamivir phosphate capsule-positive drug matched group and each embodiment group, 20 every group.Each is organized mice and slightly anaesthetizes with ether, with 15 LD
50Influenza virus drop nose infects, every 35uL.Infect and began administration the same day, continuous 5d, model group filling hello equal-volume distilled water.Observe to infect the death condition of back animals in 2 weeks, calculate mortality rate, on average survive natural law and increase in life span.
2.3 date processing
All data all with
Expression, group difference carries out one factor analysis of variance with SPSS20.0 statistics software.
3, result
3.1 prescription of the present invention is to the influence of influenza virus infecting mouse body weight
As can be seen from Table 1: model group and each test group mice body weight behind influenza virus infection all descends to some extent, and after prescription treatment of the present invention, each test group mice body weight level is progressively gone up, and wherein one group of weight of mice of embodiment is the most obvious.After treatment finished, each test group mice body weight was compared with model group: embodiment one, two, three, five, six, seven, eight groups and oseltamivir phosphate capsule group inequality heteropole remarkable (P ﹤ 0.01), and embodiment four significant differences (P ﹤ 0.05).Above result of the test prompting: prescription of the present invention has certain effect for the body weight gain of protection influenza model mice.
Table 1 prescription of the present invention is to the influence of influenza model mice body weight
Annotate: 1) compare with the blank group: * represents P ﹤ 0.05, and * * represents P ﹤ 0.01, and * * * represents P ﹥ 0.05;
2) compare with model group: A represents P ﹤ 0.05, and B represents P ﹤ 0.01.
3.2 prescription of the present invention is to the influence of Antibody of Influenza level in the influenza virus infecting mouse serum
As can be seen from Table 2: prescription of the present invention can improve behind the influenza infection Antibody of Influenza level in the mice serum, points out prescription of the present invention that the immune protective efficiency of mice is had potentiation.
The influence of Antibody of Influenza level in the table 2 pair influenza virus infecting mouse serum
3.3 prescription of the present invention is to the influence of influenza virus Lung Index of mice infected by Influenza virus
As can be seen from Table 3: after adopting H1N1 influenza infection BALB/c mouse, the lung index of mice obviously increases.Behind prescription treatment 5d of the present invention, each embodiment group and oseltamivir phosphate capsule group mouse lung index all have reduction in various degree, compare inequality heteropole significantly (P ﹤ 0.01) with model group, and wherein that the biggest drop is one group of embodiment.
Table 3 prescription of the present invention is to the influence of influenza virus Lung Index of mice infected by Influenza virus
Annotate: compare with model group: 1 expression P ﹤, 0.05,2 expression P ﹤ 0.01.
3.4 prescription of the present invention is to the influence of influenza virus infecting mouse mortality rate
As can be seen from Table 4: after adopting HlNl influenza infection mice 14d, mouse death rate is 90%, and the natural law of on average surviving is 7.97d; Take each embodiment gained water decoction of prescription of the present invention after 5 days, the dead mouse number obviously reduces, and mortality rate all obviously descends; Each embodiment group all can prolong the animal natural law of on average surviving, with the poor heteropole of model group significantly (P＜0.01).
Table 4 prescription of the present invention is to influenza virus infecting mouse mortality rate, the influence of time-to-live
Annotate: compare with model group: * represents P ﹤ 0.05, and * * represents P ﹤ 0.01.
4, conclusion
Each embodiment gained water decoction of prescription of the present invention can obviously reduce mice behind the H1N1 influenza infection the lung index, reduce mortality rate, prolong the time-to-live, can keep mice body weight steady growth behind the influenza infection simultaneously.In addition, prescription of the present invention can improve behind the influenza infection Antibody of Influenza level in the mice serum.Above result of the test prompting: the viral influenza animal model that prescription of the present invention causes HlNl influenza infection mice has remarkable therapeutical effect, and what wherein action effect was best is embodiment one gained water decoction.
Acute toxinology experiment
According to above therapeutic test result as can be known, the action effect that the resisiting influenza virus of prescription embodiment one of the present invention infects is best, and it is carried out acute toxinology experiment, checks the safety of this prescription.Process of the test and result are as follows:
Do not go out the LD of recipe drug because of the prerun test
50, only do the maximum dosage-feeding experiment.Can irritate concentration (4.5g/ml) with the maximum that can make, the maximum gastric capacity (0.4ml/20g) of irritating of mice gavages medicine twice altogether through stomach, wherein for the second time irritates the stomach volume and reduces by half.
The result: the dead mouse situation does not appear in mice outward appearance, behavioral activity, breathing, secretions, Excreta no abnormality seen behind the filling stomach.Record maximum tolerated dose 〉=135g/kg, this dosage is more than 409 times of dosage 0.33g/kg of the clinical plan of adult's (calculating with 60kg).According to acute toxicity grading criteria, think that this is subjected to the reagent thing that animal subject is not had acute toxicity.
Long-term toxicological test
Prescription embodiment one gained water decoction of the present invention is carried out long-term toxicological test, irritate stomach by, high dose long-term to the SD rat and observe its clinical response.Test divides 4 groups: blank group, 12.5 times of people's pharmaceutical quantities groups, 25 times of people's pharmaceutical quantities groups and 50 times of people's pharmaceutical quantities groups, the blank group gives the equal-volume distilled water.Irritate stomach every day once, continuous 90 days.
The result: indexs such as the body weight gain level of each administration group SD rat, organ index, routine blood test, liver function, renal function, myocardial enzymes are compared there was no significant difference (P＞0.05) with the blank group, and main organs histopathologic examination does not also have pathology and changes.
Conclusion: prescription safety non-toxic of the present invention generally can not produce untoward reaction under clinical dosage.
Claims (10)
1. a compositions of preventing and treating influenza is characterized in that, in mass fraction, comprises following component:
10～20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes and 10～15 parts of Qiang too.
2. compositions of preventing and treating influenza as claimed in claim 1 is characterized in that, in mass fraction, comprises following component:
20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes and 10～15 parts of Qiang too.
3. compositions of preventing and treating influenza as claimed in claim 1 is characterized in that, in mass fraction, comprises following component:
20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～12 parts of Herba Achilleaes and 12～15 parts of Qiang too.
4. compositions of preventing and treating influenza as claimed in claim 1 is characterized in that, in mass fraction, comprises following component:
20 parts of Radix Bupleuri, 10 parts of Radix Libanotidis buchotomensis, 12 parts of Herba Achilleaes and 15 parts of Qiang too.
5. compositions of preventing and treating influenza as claimed in claim 1 is characterized in that, the effective ingredient of said composition is to use earlier cold water soak with Radix Bupleuri, Radix Libanotidis buchotomensis, Herba Achilleae with after too Qiang pulverizes, and decocts then and extracts 30min at least, filters the fried liquid of gained.
6. a preparation method of preventing and treating the Chinese medicine preparation of influenza is characterized in that, may further comprise the steps:
1) according to following mass fraction meter, with 10～20 parts of Radix Bupleuri, 10～15 parts of Radix Libanotidis buchotomensis, 10～15 parts of Herba Achilleaes with too after 10～15 parts of pulverizing of Qiang, adds the cold water soak 1～2h that is equivalent to 5～8 times of medical material amounts;
2) after immersion finishes, boil 30～60min, filter; Medicinal residues add 3～5 times of quality water and decoct 20～40min again, filter;
3) merge twice fried liquid, in water-bath, be concentrated into extractum.
7. preparation method of preventing and treating the Chinese medicine preparation of influenza as claimed in claim 6 is characterized in that,, adds adjuvant and makes decoct, pill, tablet or capsule as effective ingredient with prepared extractum.
8. the described application of compositions in the medicine of preparation control influenza virus that prevents and treats influenza of claim 1.
9. application as claimed in claim 8 is characterized in that, described medicine is for improving the medicine of immunity.
10. the described application of compositions in the medicine of the flu that preparation control influenza virus causes that prevents and treats influenza of claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015109900A1 (en) * | 2014-01-24 | 2015-07-30 | 华南农业大学 | Use of saikosaponin a in prepaing medicaments for preventing and treating influenza in humans and animals |
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| CN101829185A (en) * | 2010-06-02 | 2010-09-15 | 赵敬民 | Medicinal composition for resisting influenza virus |
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| CN101125167A (en) * | 2006-08-17 | 2008-02-20 | 王玉怀 | Medicine for treating influenza |
| CN101829185A (en) * | 2010-06-02 | 2010-09-15 | 赵敬民 | Medicinal composition for resisting influenza virus |
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| WO2015109900A1 (en) * | 2014-01-24 | 2015-07-30 | 华南农业大学 | Use of saikosaponin a in prepaing medicaments for preventing and treating influenza in humans and animals |
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