CN103201696B - 化学检测系统的温度控制 - Google Patents

化学检测系统的温度控制 Download PDF

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Publication number
CN103201696B
CN103201696B CN201180050892.0A CN201180050892A CN103201696B CN 103201696 B CN103201696 B CN 103201696B CN 201180050892 A CN201180050892 A CN 201180050892A CN 103201696 B CN103201696 B CN 103201696B
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China
Prior art keywords
temperature
detection device
chemical detection
fluid
sensor
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Expired - Fee Related
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CN201180050892.0A
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English (en)
Chinese (zh)
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CN103201696A (zh
Inventor
T·里尔里克
J·乔丹
J·诺比雷
W·J·米莱斯基
L·霍
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Life Technologies Corp
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Life Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/20—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using microanalysis, e.g. drop reaction
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1927—Control of temperature characterised by the use of electric means using a plurality of sensors
    • G05D23/193—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces
    • G05D23/1931—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces to control the temperature of one space
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automation & Control Theory (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Remote Sensing (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Electrochemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicinal Chemistry (AREA)
CN201180050892.0A 2010-08-23 2011-08-23 化学检测系统的温度控制 Expired - Fee Related CN103201696B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37618510P 2010-08-23 2010-08-23
US61/376,185 2010-08-23
PCT/US2011/048840 WO2012027391A1 (en) 2010-08-23 2011-08-23 Temperature control of chemical detection system

Publications (2)

Publication Number Publication Date
CN103201696A CN103201696A (zh) 2013-07-10
CN103201696B true CN103201696B (zh) 2015-09-23

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CN201180050892.0A Expired - Fee Related CN103201696B (zh) 2010-08-23 2011-08-23 化学检测系统的温度控制

Country Status (5)

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US (2) US9494951B2 (enExample)
EP (1) EP2609476B1 (enExample)
JP (1) JP5889306B2 (enExample)
CN (1) CN103201696B (enExample)
WO (1) WO2012027391A1 (enExample)

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US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
US8432149B2 (en) 2010-06-30 2013-04-30 Life Technologies Corporation Array column integrator
US9494951B2 (en) 2010-08-23 2016-11-15 Life Technologies Corporation Temperature control of chemical detection system
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
WO2014112199A1 (ja) * 2013-01-17 2014-07-24 株式会社日立ハイテクノロジーズ 生体分子計測装置
EP2972281B1 (en) 2013-03-15 2023-07-26 Life Technologies Corporation Chemical device with thin conductive element
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US11135592B2 (en) * 2013-06-27 2021-10-05 Quark Biosciences Taiwan, Inc. Multiplex slide plate device having storage tank
CN103752360B (zh) * 2013-12-30 2015-08-19 西安天隆科技有限公司 一种用于生物化学反应的热学模块
TWI515041B (zh) * 2014-01-29 2016-01-01 國立屏東科技大學 微流體混合裝置
TWI697668B (zh) * 2014-12-18 2020-07-01 美商生命技術公司 感測器裝置及用於操作包含一核酸定序系統的方法
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
TWI756167B (zh) 2014-12-18 2022-03-01 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
CN105626226B (zh) * 2015-12-25 2018-06-08 潍柴动力股份有限公司 一种发动机散热控制系统及其控制方法
DE102017108120A1 (de) * 2017-04-13 2018-10-18 Laser-Laboratorium Göttingen e.V. Analysevorrichtung
CN107941380A (zh) * 2017-12-18 2018-04-20 天津市计量监督检测科学研究院 一种聚合酶链式反应分析仪多通道温度校准装置
JP7080334B2 (ja) * 2018-09-25 2022-06-03 京セラ株式会社 検体処理デバイスへの検体導入方法
CN109405906B (zh) * 2018-11-23 2024-08-06 宁波水表(集团)股份有限公司 一种流量计量装置以及流量计量方法
EP3899032A2 (en) * 2018-12-20 2021-10-27 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
CN112175816B (zh) * 2019-07-05 2025-10-10 赛纳生物科技(北京)有限公司 一种试剂控温的核酸测序系统
CN110763641B (zh) * 2019-11-29 2024-04-09 京东方科技集团股份有限公司 检测装置和检测方法
CN114981011B (zh) * 2019-12-30 2024-03-29 伊鲁米那有限公司 流通池组件和相关试剂选择器阀
CN113583855A (zh) * 2021-08-03 2021-11-02 河南赢闻信息科技有限公司 一种水浴式pcr扩增仪
CN114452913A (zh) * 2022-02-23 2022-05-10 厦门芯曙光科技有限公司 一种流动化学反应模块及其自动化实验装置
US20230296489A1 (en) * 2022-03-18 2023-09-21 Elephas Biosciences Corporation Flow cell and sample sorting system
CN117126726B (zh) * 2023-08-29 2024-11-12 杭州智灵龙生物科技有限公司 检测装置及其电化学发光检测方法
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US5641400A (en) * 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
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CN101196750A (zh) * 2006-12-07 2008-06-11 北京北方微电子基地设备工艺研究中心有限责任公司 反应腔室

Also Published As

Publication number Publication date
US9494951B2 (en) 2016-11-15
EP2609476A1 (en) 2013-07-03
US10578578B2 (en) 2020-03-03
JP5889306B2 (ja) 2016-03-22
EP2609476B1 (en) 2022-04-20
WO2012027391A1 (en) 2012-03-01
JP2013536441A (ja) 2013-09-19
US20170059516A1 (en) 2017-03-02
US20120067723A1 (en) 2012-03-22
EP2609476A4 (en) 2017-08-16
CN103201696A (zh) 2013-07-10

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