CN103201378B - 用于制备树突细胞的组合物和方法 - Google Patents
用于制备树突细胞的组合物和方法 Download PDFInfo
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- CN103201378B CN103201378B CN201180046061.6A CN201180046061A CN103201378B CN 103201378 B CN103201378 B CN 103201378B CN 201180046061 A CN201180046061 A CN 201180046061A CN 103201378 B CN103201378 B CN 103201378B
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- dendritic cells
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- cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1013443.5 | 2010-08-11 | ||
| GBGB1013443.5A GB201013443D0 (en) | 2010-08-11 | 2010-08-11 | Compositions and methods for producing dendritic cells |
| PCT/EP2011/063867 WO2012020100A2 (en) | 2010-08-11 | 2011-08-11 | Compositions and methods for producing dendritic cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103201378A CN103201378A (zh) | 2013-07-10 |
| CN103201378B true CN103201378B (zh) | 2016-06-15 |
Family
ID=42931452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180046061.6A Expired - Fee Related CN103201378B (zh) | 2010-08-11 | 2011-08-11 | 用于制备树突细胞的组合物和方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9567567B2 (enExample) |
| EP (1) | EP2603582B1 (enExample) |
| JP (1) | JP6060077B2 (enExample) |
| KR (1) | KR20130103492A (enExample) |
| CN (1) | CN103201378B (enExample) |
| AU (1) | AU2011288416B2 (enExample) |
| BR (1) | BR112013003385A2 (enExample) |
| CA (1) | CA2807892A1 (enExample) |
| EA (1) | EA201390215A1 (enExample) |
| GB (1) | GB201013443D0 (enExample) |
| SG (1) | SG187839A1 (enExample) |
| WO (1) | WO2012020100A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102925412A (zh) * | 2012-11-19 | 2013-02-13 | 昆明理工大学附属医院 | 一种制备肿瘤特异性抗原致敏dc的方法 |
| JP2017507950A (ja) * | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションLycera Corporation | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
| US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| AU2016257997A1 (en) | 2015-05-05 | 2017-11-09 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| AU2016276947A1 (en) | 2015-06-11 | 2017-12-14 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| CN105039256A (zh) * | 2015-07-13 | 2015-11-11 | 中政道和(北京)生物科技有限公司 | 一种支气管镜下获取肿瘤组织进行树突细胞培养扩增方法 |
| CA3037882A1 (en) * | 2016-09-23 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing an isolated population of dendritic cells and methods of treating cancer using same |
| CA3087418A1 (en) * | 2018-01-18 | 2019-07-25 | University Of South Florida | Dead antigen stimulated immature heterogenous dendritic cells as therapeutics for diseases |
| BR112021000620A2 (pt) * | 2018-07-15 | 2021-04-20 | Enochian BioPharma, Inc. | métodos e composições com uso de células dendríticas recombinantes para terapia contra câncer |
| US12282027B2 (en) | 2021-02-19 | 2025-04-22 | University Of South Florida | High-throughput NMR approach for in-membrane protein ligand screening |
| WO2025076303A1 (en) * | 2023-10-05 | 2025-04-10 | Amgen Inc. | Major histocompatibility complex (mhc)-associated peptide proteomics (mapps) assay for immunogenicity risk assessment of biotherapeutic attributes |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006826A1 (en) * | 1996-08-14 | 1998-02-19 | Nexell Therapeutics Inc. | Dendritic cells produced in serum-free culture |
| WO1998023728A1 (en) * | 1996-11-27 | 1998-06-04 | Ludwig Institute For Cancer Research | Cellular adjuvant |
| US6498034B1 (en) * | 1996-08-14 | 2002-12-24 | Novartis Ag | Method of producing dendritic cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005515192A (ja) * | 2001-11-29 | 2005-05-26 | ダンドリット バイオテック アクティーゼルスカブ | ヒト又は動物において免疫応答を誘導するための医薬組成物 |
| US20060216269A1 (en) * | 2004-09-17 | 2006-09-28 | Kenichiro Hasumi | Dendritic cell tumor injection (DCTI) therapy |
| GB0700058D0 (en) | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
| JP5279063B2 (ja) | 2007-05-25 | 2013-09-04 | 国立大学法人愛媛大学 | Hla−a2拘束性抗原ペプチドおよびその用途 |
| JP2009013166A (ja) | 2007-06-04 | 2009-01-22 | Osaka Prefecture Univ | 腫瘍治療用組成物およびその応用 |
-
2010
- 2010-08-11 GB GBGB1013443.5A patent/GB201013443D0/en not_active Ceased
-
2011
- 2011-08-11 EP EP11749387.4A patent/EP2603582B1/en not_active Not-in-force
- 2011-08-11 CA CA2807892A patent/CA2807892A1/en not_active Abandoned
- 2011-08-11 CN CN201180046061.6A patent/CN103201378B/zh not_active Expired - Fee Related
- 2011-08-11 EA EA201390215A patent/EA201390215A1/ru unknown
- 2011-08-11 AU AU2011288416A patent/AU2011288416B2/en not_active Ceased
- 2011-08-11 BR BR112013003385A patent/BR112013003385A2/pt not_active IP Right Cessation
- 2011-08-11 SG SG2013010855A patent/SG187839A1/en unknown
- 2011-08-11 WO PCT/EP2011/063867 patent/WO2012020100A2/en not_active Ceased
- 2011-08-11 KR KR1020137004865A patent/KR20130103492A/ko not_active Ceased
- 2011-08-11 US US13/816,359 patent/US9567567B2/en not_active Expired - Fee Related
- 2011-08-11 JP JP2013523627A patent/JP6060077B2/ja not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006826A1 (en) * | 1996-08-14 | 1998-02-19 | Nexell Therapeutics Inc. | Dendritic cells produced in serum-free culture |
| US6498034B1 (en) * | 1996-08-14 | 2002-12-24 | Novartis Ag | Method of producing dendritic cells |
| WO1998023728A1 (en) * | 1996-11-27 | 1998-06-04 | Ludwig Institute For Cancer Research | Cellular adjuvant |
Non-Patent Citations (5)
| Title |
|---|
| Coating-techniques to improve the hemocompatibility of arti®cial devices used for extracorporeal circulation;Hans Peter Wendel 等;《European Journal of Cardio-thoracic Surgery》;19990930;第16卷;第342页摘要 * |
| Functional characterization of monocyte-derived dendritic cells generated under serumfree culture conditions;Manfred Lehner 等;《Immunology Letters》;20050715;210页左栏的2段,第211页左栏第2段,第215页左栏第3-5段以及第210页摘要 * |
| Functional monocyte-derived dendritic cells can be generated in chronic lymphocytic leukaemia;FrancËoise Vuillier 等;《British Journal of Haematology》;20011201;第1131页摘要 * |
| Heparin Induces Differentiation of CD1a Dendritic Cells from Monocytes: Phenotypic and Functional Characterization;Chang-Qing Xia 等;《anticancer research》;20080531;1131-1139 * |
| IFN-γ Enhances TH1 Polarisation of Monocyte-derived Dendritic Cells Matured with Clinical-grade Cytokines Using Serum-free Conditions;BERND HILDENBRAND 等;《ANTICANCER RESEARCH》;20080530;1467-1476 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012020100A3 (en) | 2013-01-17 |
| SG187839A1 (en) | 2013-03-28 |
| BR112013003385A2 (pt) | 2019-09-24 |
| AU2011288416A1 (en) | 2013-03-07 |
| EA201390215A1 (ru) | 2013-07-30 |
| EP2603582A2 (en) | 2013-06-19 |
| US20130216584A1 (en) | 2013-08-22 |
| WO2012020100A2 (en) | 2012-02-16 |
| KR20130103492A (ko) | 2013-09-23 |
| GB201013443D0 (en) | 2010-09-22 |
| CN103201378A (zh) | 2013-07-10 |
| US9567567B2 (en) | 2017-02-14 |
| EP2603582B1 (en) | 2018-01-10 |
| JP6060077B2 (ja) | 2017-01-11 |
| CA2807892A1 (en) | 2012-02-16 |
| AU2011288416B2 (en) | 2015-06-18 |
| JP2013535218A (ja) | 2013-09-12 |
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