CN103191205B - Externally-used medicine for treating grease-heel of equus animals and preparation method thereof - Google Patents

Abstract

The invention discloses an externally-used medicine for treating grease-heel of equus animals; the externally-used medicine comprises the components in parts by weight: 6-10 parts of salicylic acid powder, 1-3 parts of iodoform, 3-7 parts of sulfanilamide powder, 2-6 parts of dried alum, 2-6 parts of calcined gypsum, 8-12 parts of rheum officinale, 8-12 parts of olibanum, 8-12 parts of myrrh and 15-25 parts of 10% of ichthammol ointment; and the externally-used medicine is prepared by extracting the rheum officinale, the olibanum and the myrrh by alcohol, removing the alcohol and concentrating, and mixing the obtained matter with other medicines to obtain an ointment extract. The externally-used medicine is organically combined, is dialectical in compatibility of medicines and enables the medicines to supplement one another, and the effects of preventing corrosion, absorbing moisture, regenerating tissue to heal wounds, sterilizing and itching reliving are improved, so that the aim of curing can be achieved. The externally-used medicine for treating the grease-heel of the equus animals is low in cost, easy to prepare, free from toxic and side effects and remarkable in treatment effect. A feasible new medicine is provided for clinic treatment. The clinical practice proves that the cure rate by using the externally-used medicine is 94.44%, and the effective rate of the externally-used medicine is 100%.

Description

A kind of external used medicine for the treatment of equus grease-heel and preparation method thereof

Technical field

The invention belongs to animal field of medicaments, particularly a kind of external used medicine that is specifically designed to treatment equus grease-heel and preparation method thereof.

Background technology

Grease-heel has another name called pastern chaps, and is the common limb hoof dermatosis of mule, the lighter is local occur heat, bitterly, the symptom of itching, the serious malfunction that also occurs, affect the working capacity of mule, endangers larger to horse keeping industry.

This pathogenetic reason is a lot, is mostly the grooming of pastern skin unclean, when mew is long, do not sweep, and dirty humidity, pastern is subject to the stimulation of earth, excrement, urine; Or herd in rainy season and low humidity swampy area, pastern is subject to clammy stimulation for a long time; Herd and when the horses of Baoding, pastern skin is subject to twining of rope and ties up and excessive compressing; Pastern is subject to various mechanical injuries, as traumatic injury, contusion and stab etc.; And the stimulation of acids, bases, Calx, zest ointment etc.In addition, shoeing is inappropriate, and it is recess pleat that the hoof of being on tiptoe causes, and causes adhering to of filth etc., all can cause morbidity.

Primary disease clinically the initial stage taking erubescence and have the swelling of slight band pain property as feature, general not obvious and be often left in the basket on the skin that has pigment.But, as long as the performance that has epithelium to strip off can judge primary disease once occurred.Particularly some external kinds poor horses as soft in skins such as English pure blood, Arab easily fall ill.Along with further developing of the state of an illness, there is lesser tubercle in pastern skin surface, and increases serous effusion gradually, makes the horny layer of epithelium peel off and form vesicle.After vesicle is broken, expose red corium, form wet rotten, the sensitivity of touching, particularly when exudate with sticked together by hair, become dry and form after crust, there is pain because pastern skin is nervous, therefore present slight limping when fortune walks.Crust strips off generally can cure afterwards, but due to the existing of the cause of disease, or treats inappropriately and not in time, and skin becomes plumpness gradually, forms gauffer and be full of cracks.If infection suppurates, is everlasting and wherein amasss and have pus.The state of an illness further develops again, and subcutaneous tissue is fibroid plumpness and sclerosis.How, from being recess skin, spread to gradually coronet, bulb and the sole of the foot (palm) portion etc.There is excipuliform type pastern dermatitis.Performance is that recess pachyderma, volume increase, hypocinesia, and quilt hair is fluffy and disorderly to come off with part.On skin, there is the wart-like lump differing in size, how much indefinite, color is different.Large is that the grain of rice is large or beans is large; Larger forms cauliflower-like vegetation because wart-like lump merges mutually.The normal attached cacodorous dirty Lycoperdon polymorphum Vitt secretions that wart-like lump surface has, what have is pale red, easily hemorrhage when stimulation.Between skinfold, easily accumulate purulent secretion, the phenomenon of conventionally not walking lamely.Course of disease person of a specified duration, often forms elephantiasis.

This disease almost spreads all over the country of all raising equus in the world, is widely distributed.This disease at present conventional medicine is mainly that the medicines such as iodine tincture, Gentian Violet and spreading sulfa powder are embrocated in part, but curative effect imprecise.Therefore researching and developing a kind of efficient medicine for the treatment of equus grease-heel is one of new problem urgently to be resolved hurrily.

summary of the invention:

The object of the invention is to overcome the weak point in treatment equus grease-heel at present, provide one draw materials easy, easy to prepare, reduce drug residue and toxic and side effects, and the external used medicine of the higher treatment equus grease-heel of cheap curative effect.

Treat an external used medicine for equus grease-heel, its composition by weight is: salicylic acid powder 6-10 part, iodoform 1-3 part, sulfa powder 3-7 part, dried Alumen 2-6 part, Gypsum Fibrosum Preparatum 2-6 part, Radix Et Rhizoma Rhei 8-12 part, Olibanum 8-12 part, Myrrha 8-12 part, 10% YUSHIZHI RUANGAO 15-25 part; Described Radix Et Rhizoma Rhei, Olibanum and Myrrha alcohol extraction, extract goes ethanol concentrated, then mixes with other medicines;

Preferred composition by weight is:

10 parts of salicylic acid powder, 3 parts of iodoform, 3 parts of sulfa powders, 6 parts of dried Alumens, 6 parts of Gypsum Fibrosum Preparatum, 8 parts of Radix Et Rhizoma Rhei, 12 parts of Olibanums, 12 parts of Myrrhas, 25 parts of 10% YUSHIZHI RUANGAO;

Or be:

6 parts of salicylic acid powder, 1 part of iodoform, 7 parts of sulfa powders, 2 parts of dried Alumens, 2 parts of Gypsum Fibrosum Preparatum, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Olibanums, 8 parts of Myrrhas, 15 parts of 10% YUSHIZHI RUANGAO;

Or be:

8 parts of salicylic acid powder, 2 parts of iodoform, 5 parts of sulfa powders, 4 parts of dried Alumens, 4 parts of Gypsum Fibrosum Preparatum, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of 10% YUSHIZHI RUANGAO;

Another object of the present invention is to provide a kind of preparation method of external used medicine for the treatment of equus grease-heel, and it comprises:

1) component takes by weight: salicylic acid powder 6-10 part, iodoform 1-3 part, sulfa powder 3-7 part, dried Alumen 2-6 part, Gypsum Fibrosum Preparatum 2-6 part, Radix Et Rhizoma Rhei 8-12 part, Olibanum 8-12 part, Myrrha 8-12 part, 10% YUSHIZHI RUANGAO 15-25 part;

2) Radix Et Rhizoma Rhei, Olibanum, Myrrha are ground into after coarse powder, adopt the ethanol merceration of 50-70%, leachate concentrates and removes ethanol, obtain thick liquid, be cooled to 40 DEG C, add salicylic acid powder, iodoform, sulfa powder, dried Alumen, Gypsum Fibrosum Preparatum after pulverizing, after stirring, add 10% YUSHIZHI RUANGAO, again stir.

Treat an external used medicine for equus grease-heel, in side, salicylic acid is the disinfection preservative that purposes is extremely wide, has the ability of good exfoliation, unclogging, and has good antifungic action.In finite concentration, safe, less to the zest of skin; Sulfa powder has good antibacterial and anti-inflammation functions to skin.Iodoform is the disinfection preservative that surgery is conventional, has slowly lasting disinfective action, and has special abnormal smells from the patient, can prevent biting of mosquitos and flies; Dried Alumen has another name called calcined Alumen, cold in nature, sour-puckery flavor, and external has good removing dampness itching-relieving action, is used for carbuncle sore tumefacting virus, has antipruritic, dampness, antibacterial action in we; Gypsum Fibrosum Preparatum is sweet, pungent, puckery, cold.Attach to the lung and stomach meridians.There is removing dampness, granulation promoting, sore, the merit of hemostasis, grinds external into powder and is used for treating surgery diseases.Radix Et Rhizoma Rhei nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.The key medicine of capturing for bitter cold.Under can rushing down, expel the heat-evil, again can blood circulation promoting and blood stasis dispelling, be again the application compress for the treatment of simply pathopyretic ulcer, with heat-clearing and toxic substances removing; Olibanum nature and flavor are arduous, temperature.Enter the heart, liver, spleen channel.There is promoting blood circulation and stopping pain, the merit of granulation promoting.By stomachache, traumatic injury and the carbuncle pain etc. controlled due to stagnation of QI-blood, external can be ground into powder and wither depositedly, has effect of granulation promoting.Myrrha nature and flavor hardship, flat.Enter Liver Channel.Have blood circulation promoting and blood stasis dispelling, the merit of pain relieving granulation promoting, share and can increase curative effect with Olibanum.YUSHIZHI RUANGAO is also conventional Cidex-7, has gentle zest and antiinflammatory, anticorrosion and detumescence effect.Anticorrosion moisture absorption is played, promoting tissue regeneration and ulcer healing, the merit of sterilizing and itch-relieving altogether by full side.

The invention provides a kind of external used medicine for the treatment of equus grease-heel, it is to be with composition by weight: salicylic acid powder 6-10 part, iodoform 1-3 part, sulfa powder 3-7 part, dried Alumen 2-6 part, Gypsum Fibrosum Preparatum 2-6 part, Radix Et Rhizoma Rhei 8-12 part, Olibanum 8-12 part, Myrrha 8-12 part, 10% YUSHIZHI RUANGAO 15-25 part, Radix Et Rhizoma Rhei, Olibanum and Myrrha alcohol extraction, go ethanol concentrated, then the unguentum being mixed with other medicines; Facts have proved, medicine of the present invention is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country has strengthened the anticorrosion moisture absorption of the party, promoting tissue regeneration and ulcer healing, and the merit of sterilizing and itch-relieving, thus reach the object of healing.Have that cost is low, preparation easily, have no side effect and evident in efficacy.For this disease of clinical treatment provides a kind of practicable new drug.Clinical practice proves, the cure rate 94.44% of this medicine, effective percentage 100%.

Detailed description of the invention

embodiment 1

Composition by weight: 10 parts of salicylic acid powder, 3 parts of iodoform, 3 parts of sulfa powders, 6 parts of dried Alumens, 6 parts of Gypsum Fibrosum Preparatum, 8 parts of Radix Et Rhizoma Rhei, 12 parts of Olibanums, 12 parts of Myrrhas, 25 parts of 10% YUSHIZHI RUANGAO (ichthyol 10%, vaseline 90%).

embodiment 2

Composition by weight: 6 parts of salicylic acid powder, 1 part of iodoform, 7 parts of sulfa powders, 2 parts of dried Alumens, 2 parts of Gypsum Fibrosum Preparatum, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Olibanums, 8 parts of Myrrhas, 15 parts of 10% YUSHIZHI RUANGAO.

embodiment 3

Composition by weight: 8 parts of salicylic acid powder, 2 parts of iodoform, 5 parts of sulfa powders, 4 parts of dried Alumens, 4 parts of Gypsum Fibrosum Preparatum, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of 10% YUSHIZHI RUANGAO.

embodiment 4

Press embodiment 1,2 or 3, a kind of proportioning raw materials of external used medicine for the treatment of equus grease-heel takes each component, and Radix Et Rhizoma Rhei wherein, Olibanum, Myrrha are ground into after coarse powder, adopts the mode of cold-maceration.First the medical material of pulverizing is put into macerator and add 60% ethanol, after submergence, exceed 3 centimetres again, build lid, flood 72 hours, in dipping process, often jolting or stirring, to accelerate leaching.Then take out impregnation liquid, filter, and squeeze medicinal residues, the pressed liquor of gained and leachate are merged.Medicinal residues are put into macerator again, then add 60% ethanol, after submergence, exceed again 3 centimetres, again flood 72 hours; Again squeeze medicinal residues, the pressed liquor of gained and leachate are merged.Twice soak mixed, again filter to obtain immersion, concentrate and remove ethanol, obtain thick liquid, be Chinese medicine extract.Then natural cooling, during to 40 DEG C, add salicylic acid powder, iodoform, sulfa powder, dried Alumen, Gypsum Fibrosum Preparatum after pulverizing, in the process adding, constantly stir, it is fully dissolved, after stirring, add 10% YUSHIZHI RUANGAO, again stir, obtain a kind of external used medicine for the treatment of equus grease-heel.Described umber is weight portion.

experimental example

1. method: publish two, stud-farm and the out-patient treatment case of raw equus grease-heel, select altogether 76 of the ill equus of equus grease-heel, wherein 71 of horses, 5 of mules, age 5-14 year.Trouble poultry is divided into three groups, is respectively of the present invention group, BINGPENG SAN group, eczema Realgar cream group, Shi Zhen loose group, male vitriol ointment group and matched group.

1) first will suffer from horse and properly in two post hurdles, for the ease of operation, can sling suffering from poultry one limb Baoding rope in Baoding, to the trouble horse that is in a tumult uneasy, can apply rather calmness of Baoding.

2) suffering limb pastern is conscientiously cleaned to rear cropping, then with 0.1% potassium permanganate water cleaning, remove crust and dirt, absorbent cotton is dried, and ointment is applied in and suffers from horse pastern, examine, and does not have the place of omission.Bandaging or open, change dressings every day once, 5 days is a course for the treatment of.Heal a course for the treatment of for light disease, as course for the treatment of of medication more not.

3) for there is the excrescent trouble of wart-like lump or cauliflower-like horse, can first adopt the method excision of operation, and then coating ointment, bandage for dressing.

Of the present invention group is by the external used medicine liniment of the prepared treatment equus of embodiment 4 grease-heel.

BINGPENG SAN group medicine used is made up of 10 parts of 3 parts of Borneolum Syntheticums, 15 parts of boric acid, withered Gong, is ground into superfine end, and mix homogeneously is made into.

The medicine of eczema Realgar cream group is by 25 parts of Realgars, 25 parts of dried Alumens, and 25 parts, catechu, 50 parts of Fructus Gardeniaes, 50 parts of Radix Et Rhizoma Rhei, are ground into superfine end, and mix homogeneously adds 250 parts of medical ventolins, is modulated into unguentum.

The ingredients of the loose group of Shi Zhen is made up of each 3 parts of 4 parts of plaster of paris, Indigo Naturalis and Cortex Phellodendri, is ground into smalls, mix homogeneously.

The medicine of male vitriol ointment group is made up of 40 parts of 10 parts of Realgars, 40 parts, Alumen, sodium chloride, is ground into smalls, and mix homogeneously, stirs in the YUSHIZHI RUANGAO of 500 part 10%, is modulated into unguentum.

Matched group does not use any medicine.

Treatment time is two courses for the treatment of, and be 5 days each course for the treatment of, every day coating once.

Table 1 is suffered from poultry grouping and primary treatment method

------------------2. efficacy determination:

Criterion of therapeutical effect: a kind of external medication equus grease-heel for the treatment of equus grease-heel, whether efficacy determination Main Basis grease-heel symptom disappears.Taking medicine 5 days is a course for the treatment of, after two courses for the treatment of, judges curative effect.Concrete curative effect is divided into three grades:

Cure: equus grease-heel symptom all disappears;

Take a turn for the better: equus grease-heel symptom part disappears;

Invalid: equus grease-heel symptom is not improved.

3. result: suffer from poultry by different dosage regimens for 76, after the treatment of two courses for the treatment of, the therapeutic effect of each group is in table 2.

Poultry effect is suffered from the various therapeutic scheme treatments of table 2

From table 2; five groups of medicines have different therapeutic effect to equus grease-heel, and wherein best with of the present invention group of therapeutic effect, cure rate reaches 94.44%; total effective rate 100.00%, the utmost point is significantly higher than other four groups (P< 0.01); Other four group differences are remarkable (P>0.05) not, and matched group does not have therapeutical effect.Statistical result shows, of the present invention group with other four treatment groups, other four treatment groups and contrast extremely significantly (P< 0. 01) of group difference.

Medicine of the present invention is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country has strengthened the anticorrosion moisture absorption of the party, promoting tissue regeneration and ulcer healing, and the merit of sterilizing and itch-relieving, has good curative effect for equus grease-heel.Thereby reach the object of healing.Adopt that the external used medicine of the treatment equus grease-heel that the preparation method of the present invention a kind of external used medicine for the treatment of equus grease-heel makes has that cost is low, preparation easily, have no side effect and evident in efficacy.For this disease of clinical treatment provides a kind of practicable new drug.Clinical practice proves, the cure rate 94.44% of this medicine, effective percentage 100%.

The above-mentioned detailed description that external used medicine to this treatment equus grease-heel and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (5)

1. treat an external used medicine for equus grease-heel, its composition by weight is: salicylic acid powder 6-10 part, iodoform 1-3 part, sulfa powder 3-7 part, dried Alumen 2-6 part, Gypsum Fibrosum Preparatum 2-6 part, Radix Et Rhizoma Rhei 8-12 part, Olibanum 8-12 part, Myrrha 8-12 part, 10% YUSHIZHI RUANGAO 15-25 part; Described Radix Et Rhizoma Rhei, Olibanum and Myrrha alcohol extraction, extract goes ethanol concentrated, then mixes with other medicines.

2. a kind of external used medicine for the treatment of equus grease-heel according to claim 1, is characterized in that: 10 parts of salicylic acid powder, 3 parts of iodoform, 3 parts of sulfa powders, 6 parts of dried Alumens, 6 parts of Gypsum Fibrosum Preparatum, 8 parts of Radix Et Rhizoma Rhei, 12 parts of Olibanums, 12 parts of Myrrhas, 25 parts of 10% YUSHIZHI RUANGAO.

3. a kind of external used medicine for the treatment of equus grease-heel according to claim 1, is characterized in that: 6 parts of salicylic acid powder, 1 part of iodoform, 7 parts of sulfa powders, 2 parts of dried Alumens, 2 parts of Gypsum Fibrosum Preparatum, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Olibanums, 8 parts of Myrrhas, 15 parts of 10% YUSHIZHI RUANGAO.

4. a kind of external used medicine for the treatment of equus grease-heel according to claim 1, is characterized in that: 8 parts of salicylic acid powder, 2 parts of iodoform, 5 parts of sulfa powders, 4 parts of dried Alumens, 4 parts of Gypsum Fibrosum Preparatum, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of 10% YUSHIZHI RUANGAO.

5. a preparation method for the treatment of the external used medicine of equus grease-heel, it comprises:

1) component takes by weight: salicylic acid powder 6-10 part, iodoform 1-3 part, sulfa powder 3-7 part, dried Alumen 2-6 part, Gypsum Fibrosum Preparatum 2-6 part, Radix Et Rhizoma Rhei 8-12 part, Olibanum 8-12 part, Myrrha 8-12 part, 10% YUSHIZHI RUANGAO 15-25 part;

2) Radix Et Rhizoma Rhei, Olibanum, Myrrha are ground into after coarse powder, adopt the ethanol merceration of 50-70%, leachate concentrates and removes ethanol, obtains thick liquid, is cooled to 40 ⁰c, adds salicylic acid powder, iodoform, sulfa powder, dried Alumen, Gypsum Fibrosum Preparatum after pulverizing, after stirring, adds 10% YUSHIZHI RUANGAO, again stirs.