CN103191064A - Animal-use enrofloxacin stomach-positioning pellets, and preparation method thereof - Google Patents
Animal-use enrofloxacin stomach-positioning pellets, and preparation method thereof Download PDFInfo
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- CN103191064A CN103191064A CN2012100022016A CN201210002201A CN103191064A CN 103191064 A CN103191064 A CN 103191064A CN 2012100022016 A CN2012100022016 A CN 2012100022016A CN 201210002201 A CN201210002201 A CN 201210002201A CN 103191064 A CN103191064 A CN 103191064A
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Abstract
The invention relates to animal-use enrofloxacin stomach-positioning pellets, and a preparation method thereof. The pellets are prepared through the steps that: a soft material is obtained by mixing enrofloxacin hydrochloride, microcrystalline cellulose, hydroxypropyl methyl cellulose, and saccharin; the soft material is prepared into micro-pellets by using a micro-pellet machine; a polymethacrylic resin latex solution is prepared into coatings; and granulation and drying are carried out, such that the stomach-positioning pellets are prepared. The pellets have good treatment effect against livestock and poultry influenza, and especially have substantial treatment effect in treating swine flu respiratory diseases. With the pellets, bitterness can be covered. When the pellets are mixed in to dry feedstuff, pig eating is not affected. A 2h accumulated dissolution rate of the pellets prepared after coating in gastric juice is 99.84%. The pellets are safe and reliable, and have the advantages of fast release, convenient application.
Description
Technical field: the present invention relates to a kind of stomach location piller of being made by enrofloxacin that is used for the treatment of the respiratory tract infection of swine flue secondary and pulmonary infection.
Background technology: bird flu produces enormous impact for livestock breeding industry in the world in recent years scope, and human health is also caused very big injury and threat.Swine flue is a kind of infectious disease that is caused by A type swine influenza virus, but the secondary pig hemophilus disease, and symptom is respiratory system infection, is a kind of acute, the height contagious disease of pig.Swine flue mainly shows as secondary respiratory tract infection and pulmonary infection, fatality rate 1%～4%, sickness rate can be up to 100%, to the raising of live pig, deliver for sale, increase heavy influence is bigger, even part is dead, influences the development of aquaculture.Live pig mainly contains powder, injection, oral liquid formulation with enrofloxacin on the at present domestic and international animal drugs market.Enrofloxacin is when being used for the treatment of the respiratory system disease that swine flue causes; need multiple dosing every day just can reach the treatment requirement; the enrofloxacin flavor is extremely bitter; oral powder and oral liquid encounter difficulties to the live pig administration; drug administration by injection to animal cause stress be big; need more manpower, bring inconvenience for the aquaculture of scale.
Summary of the invention: the objective of the invention is to overcome above-mentioned shortcoming, provide a kind of animal to locate piller and preparation method with the enrofloxacin stomach, it has mainly solved enrofloxacin taste hardship in treatment swine flue disease, and palatability is poor, is not suitable for problems such as oral administration.The object of the present invention is achieved like this; get Enrofloxacin HCL 67～75g; microcrystalline Cellulose 125～135g; hydroxypropyl emthylcellulose 10～15g; 0.5% glucide is with 105～114ml; with the mixed soft material that gets of above each composition; make micropill at the micropill machine; with latex liquid of polymethacrylic resin as coating; the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3; its preparation method is: by round as a ball comminutor pelletize; dry; taking by weighing the dried micropill of 200g is put in the coating machine; rotating speed 30Hz; weighing 150ml latex liquid of polymethacrylic resin carries out coating to it, and spray gun speed is 4.28r/min, 40 ℃ of coating indoor temperatures; coating time 2.5h; after coating finished, natural drying 24h made stomach location piller; the piller diameter is 0.2mm ± 0.1mm; the every 100g of piller contains enrofloxacin 35.57g, and it discharges in arriving Gaster Sus domestica, does not discharge medicine under live pig ph value of oral cavity condition.The present invention utilizes preparation that enrofloxacin is made animal stomach targeting piller, form orientation film with macromolecular material, tiny pill is evenly mixed in siccative, can cover the enrofloxacin bitterness, take smoothly when making live pig on the feed, can control piller again and under live pig ph value of oral cavity condition, not discharge medicine, abandon food to avoid the occurring bitterness live pig, guarantee to discharge in the enrofloxacin pellets preparation arrival Gaster Sus domestica, reach therapeutic purposes.Enrofloxacin has wide spectrum, efficient, advantage such as bioavailability is high, toxic and side effects is little, and antibacterial action is stronger, can satisfy the respiratory tract infection treatment that the pathogen of being everlasting such as large-scale pig farm cleaning antibacterial, mycoplasma cause swine flue fully.Microcrystalline Cellulose is a kind of pure native cellulose depolymerization product, is the crystalline powder of odorless, tasteless, is widely used in the excipient substance, does excipient in the present invention and uses.Hydroxypropyl emthylcellulose is a kind of non-ionic celluloses ether, has dimensional stability, good film property and characteristics such as anti-enzyme, dispersibility and caking property widely, does thickening agent and water-retaining agent in the present invention and uses.The enrofloxacin flavor is extremely bitter, adds glucide, covers bitter taste of drug, increases animal feed effect.Latex liquid of polymethacrylic resin is the liquid pharmaceutic adjuvant of gastric disintegrable type, is the water dispersant coating material, behind the piller coating, makes stomach location piller.Animal comprises palatability and drug efficacy study to pig with the clinical experimental study of enrofloxacin piller.The land-reclaimable ocean breed company limited of containing carries out in Bao Quan mountain range, Heilongjiang Province in the palatability experiment, respectively health pig and morbidity pig is tested.Health pig is divided into healthy growing and fattening pigs and two groups of tests of healthy sow, and every group of test is divided into test group and matched group, and with 0.1% concentration spice, the whole day spice is used in conjunction 5 days to test group with 10% enrofloxacin piller.Not medication of matched group.After the medication 5 days, the average feed intake 2.71kg/ head of healthy growing and fattening pigs test group/sky, the average feed intake 2.69kg/ head of matched group/sky, the refusing to eat phenomenon does not appear in test group feed intake and matched group no significant difference, has no side effect; The average feed intake 3.45kg/ head of healthy sow test group/sky, the average feed intake 3.46kg/ head of matched group/sky, the refusing to eat phenomenon does not appear in test group feed intake and matched group no significant difference, has no side effect.Result of the test shows that the enrofloxacin piller is the feed intake of unhealthful pig not, good palatability.The morbidity pig is divided into the morbidity growing and fattening pigs and the morbidity sow is tested for two groups.The morbidity pig is established test group and matched group, and with 0.1% concentration spice, the whole day spice is used in conjunction 5 days to test group, not medication of matched group with 10% enrofloxacin piller.After the medication 5 days, the average feed intake 2.24kg/ head of morbidity growing and fattening pigs test group/sky, the average feed intake 2.05kg/ head of matched group/sky, the test group feed intake increases to some extent, and the mental status takes a turn for the better to some extent; The average feed intake 3.83kg/ head of morbidity sow test group/sky, the average feed intake 3.61kg/ head of matched group/sky, the test group feed intake increases to some extent, the appearance that has no side effect, the mental status takes a turn for the better to some extent.The matched group feed intake descends, and illustrates that disease influences to some extent to feed intake.The test group feed intake increases, and disease is constantly recovered, and illustrates that enrofloxacin piller bag by success, can cover bitterness, does not influence the feed intake of pig, good palatability, and also having confirmed the enrofloxacin piller has good therapeutic effect to swine flue.The enrofloxacin piller is contained plant to the test of pesticide effectiveness of morbidity growing and fattening pigs in Zhaoyuan County Gu Qia township man and is carried out.Test is divided into test group and matched group, and with 0.1% concentration spice, the whole day spice is used in conjunction 5 days to test group, not medication of matched group with 10% enrofloxacin piller.After the medication 5 days, the sick pig of test group does not have death, and feed intake constantly increases, and gradually recovers one's health; Matched group and test group significant difference, dead 6, remain sxs such as the heating of disease pig, cough, dyspnea, feed intake constantly descends, and the state of an illness increases the weight of.Result of the test shows, the enrofloxacin piller has good curative effect to treatment swine flue secondary respiratory tract infection and pulmonary infection, the micropill of making after coated is accumulation stripping 99.84% in 2 hours in gastric juice, release fast, easy to use, safe and reliable, effective percentage 100%, cure rate 98% is a kind of medicine of very promising treatment swine flue.
The specific embodiment:
Embodiment 1:
Get Enrofloxacin HCL 67g, microcrystalline Cellulose 125g, hydroxypropyl emthylcellulose 10g, 0.5% glucide 105ml, with the mixed soft material that gets of above each composition, make micropill at the micropill machine, as coating, the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3 with latex liquid of polymethacrylic resin.
Embodiment 2:
Get Enrofloxacin HCL 70g, microcrystalline Cellulose 130g, hydroxypropyl emthylcellulose 12g, 0.5% glucide 110ml, with the mixed soft material that gets of above each composition, make micropill at the micropill machine, as coating, the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3 with latex liquid of polymethacrylic resin.
Embodiment 3:
Get Enrofloxacin HCL 75g, microcrystalline Cellulose 135g, hydroxypropyl emthylcellulose 15g, 0.5% glucide 114ml, with the mixed soft material that gets of above each composition, make micropill at the micropill machine, as coating, the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3 with latex liquid of polymethacrylic resin.
More than the preparation method of three embodiment be: by round as a ball comminutor pelletize, drying, take by weighing the dried micropill of 200g; be put in the coating machine; rotating speed 30Hz; weighing 150ml latex liquid of polymethacrylic resin carries out coating to it; spray gun speed is 4.28r/min; 40 ℃ of coating indoor temperatures; coating time 2.5h; after coating finished, natural drying 24h made stomach location piller; the piller diameter is 0.2mm ± 0.1mm; the every 100g of piller contains enrofloxacin 35.57g, and it discharges in arriving Gaster Sus domestica, does not discharge medicine under live pig ph value of oral cavity condition.
Claims (4)
1. an animal is located piller with the enrofloxacin stomach, it is characterized in that: get Enrofloxacin HCL 67～75g, microcrystalline Cellulose 125～135g, hydroxypropyl emthylcellulose 10～15g, 0.5% glucide with 105～114ml, with the mixed soft material that gets of above each composition, make micropill at the micropill machine, as coating, the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3 with latex liquid of polymethacrylic resin.
2. the described animal of claim 1 is located piller with the enrofloxacin stomach, it is characterized in that: get Enrofloxacin HCL 70g, microcrystalline Cellulose 130g, hydroxypropyl emthylcellulose 12g, 0.5% glucide 110ml, with the mixed soft material that gets of above each composition, make micropill at the micropill machine, as coating, the proportioning of micropill and latex liquid of polymethacrylic resin is 4: 3 with latex liquid of polymethacrylic resin.
3. the described animal of claim 1 is located piller with the enrofloxacin stomach, it is characterized in that: enrofloxacin stomach location piller discharges in arriving Gaster Sus domestica, does not discharge medicine under live pig ph value of oral cavity condition.
4. claim 1 or 2 described preparation methoies; it is characterized in that: by round as a ball comminutor pelletize, drying, take by weighing the dried micropill of 200g and be put in the coating machine, rotating speed 30Hz, weighing 150ml latex liquid of polymethacrylic resin carries out coating to it; spray gun speed is 4.28r/min; 40 ℃ of coating indoor temperatures, coating time 2.5h is after coating finishes; natural drying 24h; make stomach location piller, the piller diameter is 0.2mm ± 0.1mm, and the every 100g of piller contains enrofloxacin 35.57g.
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| CN2012100022016A CN103191064A (en) | 2012-01-05 | 2012-01-05 | Animal-use enrofloxacin stomach-positioning pellets, and preparation method thereof |
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| CN2012100022016A CN103191064A (en) | 2012-01-05 | 2012-01-05 | Animal-use enrofloxacin stomach-positioning pellets, and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103524448A (en) * | 2013-10-18 | 2014-01-22 | 河南碧云天动物药业有限公司 | Enrofloxacin-saccharin compound |
| CN105106175A (en) * | 2015-09-22 | 2015-12-02 | 四川省川龙动科药业有限公司 | Rumen-protected coated enrofloxacin mini-pill and preparation method thereof |
| CN105106164A (en) * | 2015-09-22 | 2015-12-02 | 四川省川龙动科药业有限公司 | Coated enrofloxacin micropills for freshwater fish and preparation method of coated enrofloxacin micropills |
| CN110075082A (en) * | 2019-04-12 | 2019-08-02 | 瑞普（天津）生物药业有限公司 | A kind of Enrofloxacin fast release micropill and preparation method thereof |
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| CN1969851A (en) * | 2005-11-25 | 2007-05-30 | 天津市润拓生物技术有限公司 | Method for preparing colon targeted pill of enrofloxacin used for poultry and livestock |
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- 2012-01-05 CN CN2012100022016A patent/CN103191064A/en active Pending
Patent Citations (1)
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| CN1969851A (en) * | 2005-11-25 | 2007-05-30 | 天津市润拓生物技术有限公司 | Method for preparing colon targeted pill of enrofloxacin used for poultry and livestock |
Non-Patent Citations (3)
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| 玉莲等: "恩诺沙星微丸质量考察和稳定性研究", 《黑龙江医药科学》 * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103524448A (en) * | 2013-10-18 | 2014-01-22 | 河南碧云天动物药业有限公司 | Enrofloxacin-saccharin compound |
| CN105106175A (en) * | 2015-09-22 | 2015-12-02 | 四川省川龙动科药业有限公司 | Rumen-protected coated enrofloxacin mini-pill and preparation method thereof |
| CN105106164A (en) * | 2015-09-22 | 2015-12-02 | 四川省川龙动科药业有限公司 | Coated enrofloxacin micropills for freshwater fish and preparation method of coated enrofloxacin micropills |
| CN105106164B (en) * | 2015-09-22 | 2017-12-12 | 四川省川龙动科药业有限公司 | A kind of fresh-water fishes coating Enrofloxacin micropill and preparation method thereof |
| CN105106175B (en) * | 2015-09-22 | 2018-06-26 | 四川省川龙动科药业有限公司 | A kind of rumen bypass coating Enrofloxacin pellet and preparation method thereof |
| CN110075082A (en) * | 2019-04-12 | 2019-08-02 | 瑞普（天津）生物药业有限公司 | A kind of Enrofloxacin fast release micropill and preparation method thereof |
| CN110075082B (en) * | 2019-04-12 | 2021-05-18 | 瑞普（天津）生物药业有限公司 | Enrofloxacin quick-release pellet and preparation method thereof |
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Application publication date: 20130710 |