CN103181999A - Solanum lytatum thunb for treating lupus erythematosus - Google Patents
Solanum lytatum thunb for treating lupus erythematosus Download PDFInfo
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- CN103181999A CN103181999A CN2013100657856A CN201310065785A CN103181999A CN 103181999 A CN103181999 A CN 103181999A CN 2013100657856 A CN2013100657856 A CN 2013100657856A CN 201310065785 A CN201310065785 A CN 201310065785A CN 103181999 A CN103181999 A CN 103181999A
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- lupus erythematosus
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- solani lyrati
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Abstract
The invention relates to an application of solanum lytatum thunb which is used for preparing a medicine for treating lupus erythematosus. The application is characterized in that the prepared medicine contains solanum lytatum thunb, and is prepared by single solanum lytatum thunb, solanum lytatum thunb extractives or addition of other traditional Chinese medicine raw materials. The solanum lytatum thunb has a remarkable curative effect on treatment of lupus erythematosus.
Description
Technical field
The present invention relates to medicine, particularly a kind of medicine for the treatment of the Herba Solani Lyrati preparation of lupus erythematosus belongs to medical technical field.
Background technology
Lupus erythematosus is a kind of agnogenic struvite connective tissue disease, mainly occurs in young women, but also involves the child.
Lupus erythematosus is a sick spectrality disease, and an end of sick spectrum is discoid lupus erythematosus, and pathological changes mainly is limited to skin, mucosa; The other end is systemic lupus erythematosus (sle), except skin, mucosa, often involve internal organs such as kidney, cardiac muscle, liver, lung and nervous system, often with General Symptomies such as heating, weak, arthralgia, and a lot of autoantibodys are arranged in blood, may be owing to the raising to the light-duty lupus erythematosus level of understanding, the cases reported number has the trend that day by day increases in the world wide in recent years.A multinational multicenter study shows that the lupus erythematosus sickness rate is between 12.5/10 ten thousand-39,/10 ten thousand at present, and the investigation of the portion of the U.S. shows that sickness rate is up to 3,72/,100,000 in the women more than 18 years old; Estimate annual neopathy number 1.8/10 ten thousand-7.6/10 ten thousand, wherein female patients be patient male 7-8 doubly.Lupus erythematosus has become commonly encountered diseases, and more and more is subjected to the handsome attention of each doctor of section.
Lupus erythematosus belongs to autoimmune, and its cause of disease is not clear so far, and a ship is thought many because of part.Heredodiathesis, gonadal hormone and environment go out mutual complicated effect such as element and cause the disorder of immunity of organism regulatory function, cause the generation of lupus erythematosus and continue, and make disease be difficult for alleviating.Though Western medicine can be controlled the movable and development of disease to a certain extent, many adverse effectes are obvious, and the state of an illness easily recurs after the drug withdrawal.
Herba Solani Lyrati (Solanum lyratum Thunb) is the herb of Solanaceae nightshade Herba Solani Lyrati, is commonly called as Herba Solani Lyrati, and nature and flavor are sweet, bitter, cold, return liver, gallbladder, kidney channel, have the effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be used for anemopyretic cold, heating, cough.Clinical normal and other drug compatibility is used for the treatment of multiple cancers such as pulmonary carcinoma, gastric cancer, hepatocarcinoma, also is used for the treatment of malaria, jaundice, edema, gonorrhea, rheumatic arthritis, leucorrhea etc.Modern pharmacology discovers, Herba Solani Lyrati has multiple effects such as antitumor, antiallergic, enhancing immunity, antioxidation, antibiotic, antiinflammatory, hepatoprotective, Mie Cheng spiral shell.
We find through long term studies, and Herba Solani Lyrati treatment lupus erythematosus has curative effect preferably.
Summary of the invention
The purpose of this invention is to provide with the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine.
The application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine, drug prepared contains Herba Solani Lyrati.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is that drug prepared is prepared by single flavor Herba Solani Lyrati.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is that Herba Solani Lyrati is directly pulverized, and makes powder and takes.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is that described medicine contains Herba Solani Lyrati extract.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is that described medicine is prepared by single flavor Herba Solani Lyrati extract.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature are further to add other raw material of Chinese medicine preparations according to actual needs.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is really to be feedstock production with Herba Solani Lyrati preferably.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature is really to be feedstock production with bright Herba Solani Lyrati or bright Herba Solani Lyrati preferably.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine, feature are really to be feedstock production with lyophilizing Herba Solani Lyrati or Herba Solani Lyrati or lyophilizing Herba Solani Lyrati preferably.
The application of Herba Solani Lyrati of the present invention in preparation treatment lupus erythematosus medicine is on the basis of existing technology, adopts the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful preparation.For example, Herba Solani Lyrati is pulverized, made powder and take after mixing it with water; By further extracting, extract adds adjuvant and makes tablet, capsule, granule, pill with Herba Solani Lyrati, but this does not limit protection scope of the present invention.
The above-mentioned extraction of the present invention can be passed through water heating extraction, extract at low temperature; Water, ethanol, methanol or their solution backflow, dipping, percolation extract.
So far finished the present invention, the medicine of Herba Solani Lyrati preparation of the present invention, the treatment lupus erythematosus is evident in efficacy, and beneficial effect of the present invention is further set forth in following clinical trial.
1, physical data: 34 routine lupus erythematosus patients, systemic lupus erythematosus (sle) 25 examples wherein, CDLE 9 examples; Women's 26 examples, male's 8 examples; Age is at 20-47 between year.
2, Therapeutic Method: get Herba Solani Lyrati, decoct with water twice, add 8 times of amounts of water for the first time, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, being concentrated into relative density is 1.10(60 ℃) time, add ethanol and make and contain the alcohol amount and reach 75%, precipitation, left standstill 36 hours, and drew supernatant, reclaim ethanol, concentrate, drying gets Herba Solani Lyrati extract.
Get Herba Solani Lyrati extract, add 5% carboxymethyl starch sodium, starch pastes grain in right amount, drying, and granulate, the adding Pulvis Talci is an amount of, mixing, tabletting.Every is equivalent to Herba Solani Lyrati 2g.The patient who is used for the treatment of lupus erythematosus, each 3, every day 3 times.3 months was 1 course for the treatment of.
3, observation item
3.1 the clinical symptoms change situation is seen 5 clinical symptoms change such as face red spot, oral ulcer, arthritis, heating, vasculitis, respectively before treatment and each observed and recorded for the treatment of back once.
3.2 lab index routine blood test: leukocyte, hemoglobin, platelet; Erythrocyte sedimentation rate; Antinuclear antibody; Amynologic index: immunoglobulin G (IgG); Complement C3, C4; Albuminuria index: 24h urine protein quantitation.Respectively before treatment and each observed and recorded for the treatment of back 1 time.
4, efficacy evaluation
Clinical remission: treatment back primary symptom disappears, and main laboratory indexes recovers normal; Produce effects: treatment back primary symptom takes a turn for the better, and main laboratory indexes is tending towards normal; Effectively: treatment back primary symptom makes moderate progress, and main laboratory indexes numerical value descends to some extent; Invalid: as not reach effective standard.
5, therapeutic outcome: treat 1-2 the course for the treatment of, clinical remission 24 examples in 34 examples, effective 6 examples, invalid 3 examples, total effective rate is 90.8%.Systemic lupus erythematosus (sle) 25 examples wherein, clinical remission 16 examples, effective 5 examples, invalid 4 examples, total effective rate is 84%; Chronic plate-like type lupus erythematosus 9 examples, clinical remission 8 examples, effective 1 example, invalid 0 example.Total effective rate is 100%.
The specific embodiment
Embodiment 1
Get Herba Solani Lyrati, pulverize, get powder, be packed as the 10g/ bag, the treatment lupus erythematosus, is divided clothes 2 times at 2 bags of every days.
Embodiment 2
Get Rhizoma Imperatae, each 3kg of Herba Taxilli, Zaocys 1kg, Radix Paeoniae Rubra 12kg; With water extraction 2 times, add 10 times of water gagings for the first time, extracted 1.5 hours, add 8 times of water gagings extractions 1 hour for the second time, merge extractive liquid, filters, and concentrates, drying adds water horn powder 3kg, Herba Solani Lyrati powder 30kg, mixing, starch slurry is granulated, drying, granulate, tabletting, the treatment lupus erythematosus, 12 of every days (every heavy 0.4g, contain Herba Solani Lyrati powder 0.3g), divide clothes 3 times, 3 months was 1 course for the treatment of.
Embodiment 3
Get extra dry white wine English 15kg, pulverize, cross 80 mesh sieves, add arabic gum 0.5kg, sorbic acid 0.5kg adds water to 100ml, and boiling sterilization gets the Herba Solani Lyrati suspensoid.Oral, each 30ml, every day 3 times.Be used for the treatment of the lupus erythematosus patient.
Embodiment 4
Get Herba Solani Lyrati 3kg, pulverize, with alcohol at normal temperature dipping 7 days, reclaim ethanol, drying is pulverized, and adds carboxymethyl starch sodium, starch is an amount of, and gelatinized corn starch is granulated, drying, granulate, the Capsules of packing into (every contains Herba Solani Lyrati 3g).Be used for 60 routine lupus erythematosus patients, each 2,3 times on the 1st, took effective percentage 93.3% 3 months.
Embodiment 5
Get Herba Solani Lyrati 3kg, use ethanol percolation, percolate reclaims ethanol, drying, with an amount of Icing Sugar, dextrin (Icing Sugar: abundant mixing dextrin=3: 1), granulate, drying, granulate gets 600 bags of granules.Lupus erythematosus patient, took 3 months effective percentage 96.6% every day 3 times by each 1 bag.
Embodiment 6
Get lyophilizing Herba Solani Lyrati 3kg, use ethanol percolation, percolate reclaims ethanol, adds 3kg lyophilizing Herba Solani Lyrati fruit powder, mixing, and drying with the abundant mixing of an amount of dextrin, is granulated, and drying gets 1200 bags of granules.Lupus erythematosus patient, each 1 bag was taken 3 months, all effectively every day each 1 time sooner or later.
Embodiment 7
Get extra dry white wine English 15kg, decoct with water twice, add the water of 10 times of amounts for the first time, decocted 1 hour, add the water of 8 times of amounts for the second time, decocted 1 hour, and merged medicinal liquid, medicinal liquid filters, and gets filtrate, being concentrated into relative density is 1.10(60 ℃) time, adding ethanol and make and contain the alcohol amount and reach 70%, precipitation left standstill 12 hours, draw supernatant, reclaim ethanol, concentrate drying, pulverize, the adding dextrin is an amount of, abundant mixing, wet granulation, drying gets granule 4kg, packing, every bag of 3g.Be used for the treatment of the lupus erythematosus patient, each 1 bag, every day each 1 time sooner or later, 3 months is a course for the treatment of, effective percentage 92.2%.
Embodiment 8
Get bright Herba Solani Lyrati 15kg, pulverize, flooded 7 days with alcohol at normal temperature, reclaim ethanol, vacuum drying is pulverized, and gets Herba Solani Lyrati extract.
Get Radix Paeoniae Alba 15kg, Radix Angelicae Pubescentis 10k, Fructus Ligustri Lucidi, Fructus Lycii, each 3kg of Fructus Mori, Radix Codonopsis, Herba Agrimoniae, each 12kg of Semen Persicae; With water extraction 2 times, add 8 times of water gagings for the first time, extracted 1.5 hours, add for the second time 6 times of water gagings and extracted 1 hour, merge extractive liquid, filters, being concentrated into relative density is 1.10(60 ℃) time, add ethanol and make and contain the alcohol amount and reach 70%, precipitation, left standstill 12 hours, and drew supernatant, reclaim ethanol, concentrate, drying is pulverized, and the powder medical material that gets dry extract gets extract;
With Herba Solani Lyrati extract and medicinal substances extract and the abundant mixing of 12kg dextrin, wet granulation, drying gets 2000 bags of granules.Be used for the treatment of the lupus erythematosus patient, each 1 bag, every day each 1 time sooner or later, 3 months is a course for the treatment of, effective percentage 89.6%.
Claims (7)
1. the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine.
2. according to the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine of claim 1, be characterised in that drug prepared contains Herba Solani Lyrati.
3. according to the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine of claim 1 or claim 2, be characterised in that drug prepared is prepared by single flavor Herba Solani Lyrati.
4. according to the application in preparation treatment lupus erythematosus medicine of the Herba Solani Lyrati of claim 1 or claim 2 or claim 3, be characterised in that Herba Solani Lyrati directly takes.
5. according to the application in preparation treatment lupus erythematosus medicine of the Herba Solani Lyrati of claim 1 or claim 2 or claim 3, be characterised in that Herba Solani Lyrati directly pulverizes, make powder and take.
6. according to the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine of claim 1 or claim 2, be characterised in that drug prepared contains Herba Solani Lyrati extract.
7. according to the application of Herba Solani Lyrati in preparation treatment lupus erythematosus medicine of claim 1 or claim 2 or claim 6, be characterised in that to add other raw material of Chinese medicine preparations.
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| CN2013100657856A CN103181999A (en) | 2013-03-03 | 2013-03-03 | Solanum lytatum thunb for treating lupus erythematosus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109851A (en) * | 2016-07-22 | 2016-11-16 | 陈洪晓 | A kind of Chinese medicine of systemic lupus erythematosus and its preparation method and application |
-
2013
- 2013-03-03 CN CN2013100657856A patent/CN103181999A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 杨毅: "真武茯苓汤治疗系统性红斑狼疮临床观察", 《中国医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109851A (en) * | 2016-07-22 | 2016-11-16 | 陈洪晓 | A kind of Chinese medicine of systemic lupus erythematosus and its preparation method and application |
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Application publication date: 20130703 |