CN103181981B - Black nightshade for treating lupus erythematosus - Google Patents
Black nightshade for treating lupus erythematosus Download PDFInfo
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- CN103181981B CN103181981B CN201310065766.3A CN201310065766A CN103181981B CN 103181981 B CN103181981 B CN 103181981B CN 201310065766 A CN201310065766 A CN 201310065766A CN 103181981 B CN103181981 B CN 103181981B
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- solani nigri
- herba solani
- lupus erythematosus
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Abstract
The invention relates to an application of black nightshade which is used for preparing a medicine for treating lupus erythematosus. The application is characterized in that the prepared medicine contains black nightshade, and is prepared by single black nightshade, extractives or addition of other traditional Chinese medicine raw materials. The black nightshade has the remarkable curative effect on treatment of lupus erythematosus.
Description
Technical field
The present invention relates to medicine, the medicine that particularly prepared by a kind of Herba Solani Nigri for the treatment of lupus erythematosus, belongs to medical technical field.
Background technology
Herba Solani Nigri Solanum nigrumL. is Solanaceae (Solanaceace) Solanum annual herb plant.Another name Radix vitis romanetii, crow eyes grass, Herba Sonchi Oleracei, bitter certain herbaceous plants with big flowers.Herb of Herba Solani Nigri is used as medicine, and bitter in the mouth, cold in nature, micro-sweet, slightly poisonous, returns lung, stomach, urinary bladder channel, has the effect of heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema, eliminating phlegm and stopping cough.For sore and toxic, osteopatia sprain, chronic tracheitis, acute nephritis, skin eczema, dysuria, chronic senile tracheitis, leukorrhagia, prostatitis, the diseases such as dysentery.Herba Solani Nigri and compound preparation thereof are widely used in treating all kinds of tumors clinically, by Chinese medicine, are classified as one of ten large antitumor Chinese herbal medicine, and its antitumor action has caused the attention of research worker, and becomes the study hotspot of Chinese scholars.
Through long-term research, we find, Herba Solani Nigri treatment lupus erythematosus has good curative effect.
Summary of the invention
The object of this invention is to provide the application in preparation treatment lupus erythematosus medicine with Herba Solani Nigri.
The application of Herba Solani Nigri in preparation treatment lupus erythematosus medicine, prepared medicine contains Herba Solani Nigri.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is that prepared medicine is prepared by single taste Herba Solani Nigri.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is that Herba Solani Nigri is directly pulverized, and makes powder and takes.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is that described medicine contains Herba Solani Nigri extract.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is according to actual needs, further to add other raw material of Chinese medicine preparations.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is preferably to take Fructus Solani Nigri as raw material preparation.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is that preferably to take fresh Herba Solani Nigri or fresh Fructus Solani Nigri be raw material preparation.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, feature is that preferably to take lyophilizing Herba Solani Nigri or lyophilizing Fructus Solani Nigri be raw material preparation.
The application of Herba Solani Nigri of the present invention in preparation treatment lupus erythematosus medicine, is on the basis of existing technology, adopts Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful preparation.For example, Herba Solani Nigri is pulverized, make powder and take after mixing it with water; By Herba Solani Nigri, by further extracting, extract adds adjuvant to make tablet, capsule, granule, pill, but this does not limit the scope of the invention.
The above-mentioned extraction of the present invention can be extracted by heating water, extract at low temperature; Water, ethanol, methanol or their solution reflux, extract,, dipping, percolation.
So far completed the present invention, medicine prepared by Herba Solani Nigri of the present invention, treatment lupus erythematosus is evident in efficacy, and beneficial effect of the present invention is further set forth in following clinical trial.
1, physical data: 10 routine patients with SLEs, systemic lupus erythematosus (sle) 9 examples wherein, CDLE 1 example, is all women, the age is at 20-40 between year.
2, Therapeutic Method: get Herba Solani Nigri, decoct with water twice, add for the first time 8 times of amounts of water, decoct 2 hours, add for the second time 8 times of amounts of water, decoct 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, being concentrated into relative density is 1.10(60 ℃) time, add ethanol to make to reach 75% containing alcohol amount, precipitation, standing 36 hours, draw supernatant, reclaim ethanol, concentrated, dry, pulverize; Obtain Herba Solani Nigri extract.
Get Herba Solani Nigri extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, dry, arranges, and adds Pulvis Talci appropriate, mixes tabletting.Every is equivalent to Herba Solani Nigri 2g.The patient who is used for the treatment of lupus erythematosus, each 3, every day 3 times.It within 3 months, was 1 course for the treatment of.
3, observation item
3.1 clinical symptoms change situations are seen 5 clinical symptoms change such as face red spots, oral ulcer, arthritis, heating, vasculitis, and before treatment and after treatment, each observed and recorded is once respectively.
3.2 lab index routine blood tests: leukocyte, hemoglobin, platelet; Erythrocyte sedimentation rate; Antinuclear antibody; Amynologic index: immunoglobulin G (IgG); Complement C3, C4; Albuminuria index: 24h urine protein quantitation.Each observed and recorded 1 time before treatment and after treatment respectively.
4, efficacy evaluation
Clinical remission: after treatment, primary symptom disappears, main laboratory indexes recovers normal; Effective: after treatment, primary symptom takes a turn for the better, main laboratory indexes is tending towards normal; Effective: after treatment, primary symptom makes moderate progress, main laboratory indexes numerical value declines to some extent; Invalid: not reach effective standard.
5, therapeutic outcome: treat 1-2 the course for the treatment of, all clinical remission.
The specific embodiment
Embodiment 1
Get Herba Solani Nigri, pulverize, obtain powder, be packed as 10g/ bag, treatment lupus erythematosus, 2 bags of every days, minute 2 clothes.
Embodiment 2
Get Rhizoma Imperatae, each 3kg of Herba Taxilli, Zaocys 1kg, Radix Paeoniae Rubra 12kg; With water extraction 2 times, add for the first time 10 times of water gagings, extract 1.5 hours, add for the second time 8 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, add Cornu Bubali powder 3kg and Herba Solani Nigri powder 30kg, mix, starch slurry is granulated, dry, granulate, add Pulvis Talci appropriate, tabletting, treatment lupus erythematosus, 12 of every days (containing Herba Solani Nigri powder 4g), minute 3 clothes, 3 months were 1 course for the treatment of.
Embodiment 3
Get dry Herba Solani Nigri 15kg, pulverize, cross 200 mesh sieves, add arabic gum 0.5kg, sorbic acid 0.3kg, adds water to 100kg, obtains Herba Solani Nigri suspensoid.Oral, each 20ml, every day 3 times.Be used for the treatment of patients with SLE.
Embodiment 4
Get Herba Solani Nigri 3kg, pulverize, with alcohol at normal temperature, flood 7 days, reclaim ethanol, dry, pulverize, add starch appropriate, gelatinized corn starch is granulated, and dry, granulate, adds Pulvis Talci appropriate, mixes, and packs Capsules into.For 60 routine patients with SLEs, take effective percentage 93.8% 3 months.
Embodiment 5
Get Herba Solani Nigri 3kg, with ethanol percolation, percolate reclaims ethanol, dry, fully mixes with appropriate dextrin, granulates, dry, obtains 600 bags of granules.Patients with SLE, each 1 bag, every day each 1 time sooner or later, takes effective percentage 96.6% 3 months.
Embodiment 6
Get lyophilizing Herba Solani Nigri 3kg, with ethanol percolation, percolate reclaims ethanol, adds 3kg lyophilizing Fructus Solani Nigri powder, dry, fully mixes with appropriate dextrin, granulates, dry, obtains 1200 bags of granules.Patients with SLE, each 1 bag, every day each 1 time sooner or later, takes 3 months, all effective.
Embodiment 7
Get dry Herba Solani Nigri 15kg, decoct with water twice, add for the first time the water of 10 times of amounts, decoct 1 hour, the water that adds for the second time 8 times of amounts, decocts 1 hour, merges medicinal liquid, and medicinal liquid filters, get filtrate, being concentrated into relative density is 1.10(60 ℃) time, add ethanol to make to reach 70% containing alcohol amount, precipitation, standing 12 hours, draw supernatant, reclaim ethanol, concentrated, dry, pulverize, add dextrin appropriate, fully mix, wet granulation, dry, obtain 1500 bags of granules.Be used for the treatment of patients with SLE, each 1 bag every day each 1 time sooner or later, 3 months is a course for the treatment of.
Embodiment 8
Get fresh Herba Solani Nigri 15kg, pulverize, with alcohol at normal temperature, flood 7 days, reclaim ethanol, vacuum drying, pulverizes, and obtains Herba Solani Nigri extract.
Get Radix Paeoniae Alba 15kg, Radix Angelicae Pubescentis 10k, Fructus Ligustri Lucidi, Fructus Lycii, each 3kg of Fructus Mori, Radix Codonopsis, Herba Agrimoniae, each 12kg of Semen Persicae; With water extraction 2 times, add for the first time 8 times of water gagings, extract 1.5 hours, add for the second time 6 times of water gagings and extract 1 hour, merge extractive liquid,, filters, being concentrated into relative density is 1.10(60 ℃) time, add ethanol to make to reach 70% containing alcohol amount, precipitation, standing 12 hours, draw supernatant, reclaim ethanol, concentrated, dry, pulverize, obtain medicinal substances extract;
Get Herba Solani Nigri extract and medicinal substances extract and 0.3kg dextrin fully mixes in right amount, wet granulation, dry, obtain granule.Be used for the treatment of patients with SLE, each 1 bag every day each 1 time sooner or later, 3 months is a course for the treatment of.
Claims (1)
1. the application of Herba Solani Nigri in preparation treatment lupus erythematosus medicine, is characterized in that prepared medicine prepared by single taste Herba Solani Nigri.
2. the application in preparation treatment lupus erythematosus medicine according to the Herba Solani Nigri of claim 1, is characterized in that Herba Solani Nigri directly pulverizes, and makes powder and takes.
3. the application in preparation treatment lupus erythematosus medicine according to the Herba Solani Nigri of claim 1, is characterized in that prepared medicine prepared by single taste Herba Solani Nigri extract.
4. the application in preparation treatment lupus erythematosus medicine according to the Herba Solani Nigri of claim 1, is characterized in that by single delicious Herba Solani Nigri being prepared by raw material.
5. the application in preparation treatment lupus erythematosus medicine according to the Herba Solani Nigri of claim 1 or claim 2, is characterized in that take that single taste lyophilizing Herba Solani Nigri is as raw material preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310065766.3A CN103181981B (en) | 2013-03-03 | 2013-03-03 | Black nightshade for treating lupus erythematosus |
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| CN201310065766.3A CN103181981B (en) | 2013-03-03 | 2013-03-03 | Black nightshade for treating lupus erythematosus |
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| CN103181981A CN103181981A (en) | 2013-07-03 |
| CN103181981B true CN103181981B (en) | 2014-02-26 |
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Owner name: JI NAN SUNNYPHARMACY CO., LTD. Free format text: FORMER OWNER: JINAN KANGZHONG MEDICIN SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20150508 |
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Effective date of registration: 20150508 Address after: 250200 Shandong Province, Zhangqiu City Industrial Economic Development Zone Mingshui Road Northwest Section Patentee after: Jinan Sunnypharmacy Co., Ltd. Address before: Lixia District Hospital in Shandong province Ji'nan City Road 250014 No. 19 No. 4 West of Shandong Academy of Sciences Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |