CN103157010B - 一种治疗慢性盆腔炎的中药灌肠剂 - Google Patents
一种治疗慢性盆腔炎的中药灌肠剂 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性盆腔炎的中药灌肠剂。祖国医学认为慢性盆腔炎病位在盆腔，其病因多由邪毒或湿热引起气血运行受阻，损害盆腔组织所致。为此，本发明选择具有活血化瘀、清热利湿的中药蛾药、胆木、山慈姑、广东金钱草、算盘子叶、蓝花扁竹、蝉翼藤、丹参、五灵脂、八月札、荔枝核，由我院制剂室制成灌肠剂，经临床试验，总有效率达到97.5％，明显优于对照组，具有较好的疗效。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗慢性盆腔炎的中药灌肠剂。
背景技术
慢性盆腔炎是妇科常见病、多发病，发病率30％～60％，且近年来其发病率有逐渐增高的趋势，因其病程长、病情顽固、复发率高而严重影响了妇女身心健康及生活质量。尚无特异疗法，目前多采用以抗生素为主的疗法，不但疗程长，而且易产生耐药性，扰乱机体内环境，导致在机体免疫功能下降时复发，甚至进行性加重。申请人经过多年的临床试验，利用中草药灌肠的方法治疗慢性盆腔炎，具有较好的疗效。
发明内容
本发明的目的是提供一种治疗慢性盆腔炎的中药灌肠剂。祖国医学认为，慢性盆腔炎病位在盆腔，其病因多由邪毒或湿热，经阴部上行而犯冲任、胞宫，以致邪气留注或瘀滞或虚损于该部，使气血运行受阻，损害盆腔组织，或病程日久，迁延不愈，粘连增生而成包块。故活血化瘀、清热利湿是治疗本病的首要法则。清热可解毒和利湿消炎，有利于祛邪解毒；化瘀可散瘀，通过降低炎性组织毛细血管的通透性，有利于炎症的吸收。
本发明的目的是通过以下技术方案实现的，该治疗慢性盆腔炎的中药灌肠剂由以下重量份的中药制成：蛾药40-45份、胆木15-20份、山慈姑10-15份、广东金钱草30-40份、算盘子叶16-18份、蓝花扁竹7-9份、蝉翼藤12-14份、丹参10-15份、五灵脂13-16份、八月札25-30份、荔枝核10-13份。
优选的，蛾药42份、胆木18份、山慈姑14份、广东金钱草38份、算盘子叶17份、蓝花扁竹8份、蝉翼藤13份、丹参14份、五灵脂15份、八月札27份、荔枝核12份。
制备方法：将以上中药加水浓煎至100mL～150mL。
方中：蛾药、胆木、山慈姑、丹参清热解毒、凉血祛瘀为全方主体；猫须草、广东金钱草、算盘子叶、蝉翼藤、五灵脂清热祛湿、消肿止痛；蓝花扁竹、八月札、荔枝核健脾和胃，疏肝理气，行气散结，散寒止痛，诸药合用，共奏清热利湿、解毒凉血、行气散结，化瘀消炎之功。
临床资料
1、一般资料2008年5月～2010年6月接收符合纳入标准的慢性盆腔炎患者160例。随机分为两组：治疗组80例，年龄22～53岁，平均32.5岁；病程6个月～8年，平均27.5个月；对照组80例，年龄21～54岁，平均31.5岁；病程7个月～9年，平均28个月。两组病例年龄、病程等经统计学处理，差异无显著性(P＞0.05)，具有可比性。
2、诊断标准均参照《中医临床病证诊断疗效标准》，(1)症状：自觉反复腰酸、下腹坠痛、白带增多，有异味，偶伴发热；(2)妇科检查：子宫体压痛，双侧附件区增厚，压痛明显；(3)B超提示：盆腔积液或炎性包块。
3、治疗方法治疗组采用本发明所述的灌肠剂，待药温保持在37℃～40℃，令患者睡前排空大小便，取左侧卧位，用导尿管插入肛门7cm～10cm左右，将药液缓慢注入直肠，保留到次日早晨，经期停止灌肠。对照组采用青霉素甲硝唑静点常规方案，青霉素800万U±生理盐水250ml日1次静点，甲硝唑注射液250ml日2次静点。同时忌生冷、刺激性食物，两组均10天为一个疗程。
4、疗效标准(1)痊愈：腰痛、腹胀痛明显减轻，白带明显减少，经期缩短或月经正常，附件压痛消失，炎性包块消失，评分为0分；(2)显效：腰痛、腹胀痛明显减轻，白带减少，附件压痛明显好转，子宫活动有所好转，炎性包块缩小，治疗后积分比治疗前降低2/3以下；(3)好转：白带减少，腰痛、腹胀痛减轻，附件压痛减轻，炎性包块缩小不明显，治疗后积分比治疗前降低1/3以下；(4)无效：自觉症状及体征无改变。
5、治疗结果(1)治疗后两组患者主要临床症状及体征的改善情况，见表1。
表1两组症状及体征的改善情况
X2检验，P＜0.05，两组间有显著性差异
(2)治疗后两组盆腔炎性包块的吸收情况，见表2。
见表2治疗后两组盆腔炎性包块的吸收情况
治疗后两组包块的吸收有显著性差异，治疗组优于对照组(P＜0.05)。
(3)两组治疗两个疗程后统计疗效比较，见表3。
表3两组治疗一个疗程后统计疗效比较
两组间疗效有显著性差异，治疗组优于对照组(P＜0.01)
具体实施方式
实施例一：称取蛾药42g、胆木18g、山慈姑14g、广东金钱草38g、算盘子叶17g、蓝花扁竹8g、蝉翼藤13g、丹参14g、五灵脂15g、八月札27g、荔枝核12g。将以上中药浓煎至100mL～150mL备用。
实施例二：称取蛾药40g、胆木15g、山慈姑10g、广东金钱草30g、算盘子叶16g、蓝花扁竹7g、蝉翼藤12g、丹参10g、五灵脂13g、八月札25g、荔枝核10g。同上。
实施例三：称取蛾药45g、胆木20g、山慈姑15g、广东金钱草40g、算盘子叶18g、蓝花扁竹9g、蝉翼藤14g、丹参15g、五灵脂16g、八月札30g、荔枝核13g。同上。
Claims (2)
1.一种治疗慢性盆腔炎的中药灌肠剂，其特征在于该中药灌肠剂由以下重量份的中药制成：蛾药40-45份、胆木15-20份、山慈菇10-15份、广东金钱草30-40份、算盘子叶16-18份、蓝花扁竹7-9份、蝉翼藤12-14份、丹参10-15份、五灵脂13-16份、八月札25-30份、荔枝核10-13份。
2.根据权利要求1所述的一种治疗慢性盆腔炎的中药灌肠剂，其特征在于该中药灌肠剂由以下重量份的中药制成：蛾药42份、胆木18份、山慈菇14份、广东金钱草38份、算盘子叶17份、蓝花扁竹8份、蝉翼藤13份、丹参14份、五灵脂15份、八月札27份、荔枝核12份。
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| CN101391077A (zh) * | 2008-10-27 | 2009-03-25 | 张祥峰 | 一种治疗慢性盆腔炎的中药制备方法 |
| CN102743471A (zh) * | 2012-07-24 | 2012-10-24 | 广州海博特医药科技有限公司 | 胆木提取物及其对盆腔炎的治疗应用 |
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| CN101391077A (zh) * | 2008-10-27 | 2009-03-25 | 张祥峰 | 一种治疗慢性盆腔炎的中药制备方法 |
| CN102743471A (zh) * | 2012-07-24 | 2012-10-24 | 广州海博特医药科技有限公司 | 胆木提取物及其对盆腔炎的治疗应用 |
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