CN103154024A - 新型n末端修饰的胰岛素衍生物 - Google Patents

新型n末端修饰的胰岛素衍生物 Download PDF

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Publication number
CN103154024A
CN103154024A CN2011800496891A CN201180049689A CN103154024A CN 103154024 A CN103154024 A CN 103154024A CN 2011800496891 A CN2011800496891 A CN 2011800496891A CN 201180049689 A CN201180049689 A CN 201180049689A CN 103154024 A CN103154024 A CN 103154024A
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CN
China
Prior art keywords
insulin
human insulin
desb30 human
gglu
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800496891A
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English (en)
Chinese (zh)
Inventor
P.马德森
P.巴尔施密特
S.哈夫伦
T.赫格-延森
T.B.克杰尔德森
C.H.菲恩博
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Novo Nordisk AS
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Novo Nordisk AS
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Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN103154024A publication Critical patent/CN103154024A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN2011800496891A 2010-10-15 2011-10-14 新型n末端修饰的胰岛素衍生物 Pending CN103154024A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10187706.6 2010-10-15
EP10187706 2010-10-15
US39409010P 2010-10-18 2010-10-18
US61/394,090 2010-10-18
PCT/EP2011/068019 WO2012049307A2 (en) 2010-10-15 2011-10-14 Novel n-terminally modified insulin derivatives

Publications (1)

Publication Number Publication Date
CN103154024A true CN103154024A (zh) 2013-06-12

Family

ID=43638785

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800496891A Pending CN103154024A (zh) 2010-10-15 2011-10-14 新型n末端修饰的胰岛素衍生物

Country Status (5)

Country Link
US (1) US20140315797A1 (https=)
EP (1) EP2627670A2 (https=)
JP (1) JP2013540771A (https=)
CN (1) CN103154024A (https=)
WO (1) WO2012049307A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646329A (zh) * 2019-03-29 2021-11-12 诺和诺德股份有限公司 葡萄糖敏感性胰岛素衍生物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
TN2017000178A1 (en) * 2014-11-21 2018-10-19 Merck Sharp & Dohme Insulin receptor partial agonists
ES2908373T3 (es) 2015-08-25 2022-04-28 Novo Nordisk As Nuevos derivados de insulina y los usos médicos de los mismos
US20190010206A1 (en) * 2015-08-25 2019-01-10 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
CN108368163A (zh) * 2015-08-25 2018-08-03 诺和诺德股份有限公司 新型胰岛素衍生物及其医学用途
CN109414408B (zh) * 2016-05-16 2022-03-29 得克萨斯州大学系统董事会 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质
PE20210857A1 (es) 2016-12-16 2021-05-18 Novo Nordisk As Composiciones farmaceuticas que contienen insulina
US10919949B2 (en) 2017-08-17 2021-02-16 Novo Nordisk A/S Acylated insulin analogues and uses thereof
KR20210102347A (ko) 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
DK4073097T3 (da) 2019-12-11 2024-08-19 Novo Nordisk As Nye insulinanaloger og anvendelser heraf

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145721A2 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S N-terminal modification of polypeptides for protection against degradation by aminopeptidases
WO2009022005A1 (en) * 2007-08-15 2009-02-19 Novo Nordisk A/S Insulin analogues with an acyl and alkylene glycol moiety

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132404A3 (en) * 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
CA2531988C (en) 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
US20080171695A1 (en) * 2005-02-02 2008-07-17 Novo Nordisk A/S Insulin Derivatives
US8097584B2 (en) 2005-05-25 2012-01-17 Novo Nordisk A/S Stabilized formulations of insulin that comprise ethylenediamine
RU2524150C2 (ru) 2006-09-22 2014-07-27 Ново Нордиск А/С Аналоги инсулина, устойчивые к протеазам
US20110144010A1 (en) 2007-06-01 2011-06-16 Novo Nordisk A/S Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
ES2561208T3 (es) * 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
EP2344200A2 (en) 2008-09-19 2011-07-20 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use
EP2370059A1 (en) 2008-11-28 2011-10-05 Novo Nordisk A/S Pharmaceutical compositions suitable for oral administration of derivatized insulin peptides
CA2786953A1 (en) 2010-01-12 2011-07-21 Florian Anders Foeger Pharmaceutical compositions for oral administration of insulin peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145721A2 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S N-terminal modification of polypeptides for protection against degradation by aminopeptidases
WO2009022005A1 (en) * 2007-08-15 2009-02-19 Novo Nordisk A/S Insulin analogues with an acyl and alkylene glycol moiety

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
WAYNE D.KOHN等: "pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity", 《PEPTIDES》 *
黄涛: "化学修饰胰岛素的制备、表征和生物活性", 《中国博士学位论文全文数据库工程科技I辑》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646329A (zh) * 2019-03-29 2021-11-12 诺和诺德股份有限公司 葡萄糖敏感性胰岛素衍生物
CN113646329B (zh) * 2019-03-29 2025-12-09 诺和诺德股份有限公司 葡萄糖敏感性胰岛素衍生物

Also Published As

Publication number Publication date
WO2012049307A3 (en) 2012-06-14
US20140315797A1 (en) 2014-10-23
JP2013540771A (ja) 2013-11-07
WO2012049307A2 (en) 2012-04-19
EP2627670A2 (en) 2013-08-21

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Application publication date: 20130612