CN103127182A - Preparation method of tablet of cordyceps sinensis fungus hirsutella hepialid mycelia ultrafine powder - Google Patents
Preparation method of tablet of cordyceps sinensis fungus hirsutella hepialid mycelia ultrafine powder Download PDFInfo
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- CN103127182A CN103127182A CN2013100753340A CN201310075334A CN103127182A CN 103127182 A CN103127182 A CN 103127182A CN 2013100753340 A CN2013100753340 A CN 2013100753340A CN 201310075334 A CN201310075334 A CN 201310075334A CN 103127182 A CN103127182 A CN 103127182A
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- 241000143459 Hirsutella Species 0.000 title claims abstract description 33
- 239000000843 powder Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 241001248610 Ophiocordyceps sinensis Species 0.000 title abstract 2
- 238000002156 mixing Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- 239000002002 slurry Substances 0.000 claims abstract description 4
- 241000190633 Cordyceps Species 0.000 claims description 12
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000000314 lubricant Substances 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 238000000889 atomisation Methods 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 4
- -1 hydroxypropyl Chemical group 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 238000013467 fragmentation Methods 0.000 claims description 3
- 238000006062 fragmentation reaction Methods 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 claims description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 2
- 229940037627 magnesium lauryl sulfate Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 6
- 239000002245 particle Substances 0.000 abstract description 3
- 238000000465 moulding Methods 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 235000019580 granularity Nutrition 0.000 description 12
- 238000000748 compression moulding Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a preparation method of a tablet of hirsutella hepialid mycelia ultrafine powder. The preparation method mainly comprises the following steps of 1, crushing the cordyceps sinensis fungus hirsutella hepialid mycelia into 300 meshes of ultra-fine powder; 2, evenly mixing 300 meshes of powder with water to prepare slurry; 3, atomizing and drying the slurry into particles; 4, pelletizing; and 5, pressing into tablets. The technical problem of poor tabletting and molding effects caused by over-small particle size of ultrafine powder in the preparation process of the hirsutella hepialid mycelia ultrafine powder tablet is solved by chance by applying a common spray drying method in a traditional Chinese medicine processing process into the preparation of the hirsutella hepialid mycelia ultrafine powder tablet; and the unexpected technical effect is obtained.
Description
Technical field
The present invention relates to a kind of preparation method of Cordyceps class health product, especially a kind of preparation method that contains Hirsutella hepiali Chen et Shen silk powder tablet.
Background technology
Chinese invention patent application CN101095701A has disclosed a kind of lamellar medicine that contains Hirsutella hepiali Chen et Shen-fermented Cordyceps powder and preparation method thereof, this preparation method is: get the Hirsutella hepiali Chen et Shen silk, be ground into micropowder (more than further being disclosed as granularity 150 orders in description), get micropowder 333g, add wetting agent and/or binding agent 30-40g, disintegrating agent 20-30g, mix homogeneously, add the binder solution of concentration 10-15% to be in harmonious proportion, granulate, dry below 80 ℃, granulate, add disintegrating agent 25-35g, lubricant 10-20g, mixing, be pressed into 1000, packing, and get final product.Although the document has disclosed above these ins and outs of granularity 150 orders, in fact its granularity that adopts is specially about 150 orders, because adopt the method to prepare lamellar medicine compression molding poor effect for surpassing the thinner granularity of 200 purposes.
Chinese invention patent application CN102670666A has disclosed the preparation method of the fine powder of a kind of Chinese medicine, traditional Chinese medicine powder after concocting can be broken to the 400-1200 order, therefore the effective ingredient that is conducive to Chinese crude drug is separated out to greatest extent on the cells in vitro surface, is conducive to active substance and is absorbed rapidly.
A kind of compression molding is respond well, the preparation method of the tablet (being the lamellar medicine) of Hirsutella hepiali Chen et Shen silk micropowder that surpass 200 order granularities if can successfully develop, and can greatly promote the health-care effect of Hirsutella hepiali Chen et Shen silk powder tablet.
Summary of the invention
Given this, the inventor successfully develops a kind of preparation method of tablet of Hirsutella hepiali Chen et Shen silk micropowder through studying intensively with great concentration, has greatly promoted the health-care effect of Hirsutella hepiali Chen et Shen silk powder tablet product.
In order to realize this purpose, technical scheme of the present invention is:
A kind of preparation method of tablet of Hirsutella hepiali Chen et Shen silk micropowder comprises following steps:
The first step: get Cordyceps fungus Hirsutella hepiali Chen et Shen mycelium, adopt the superfine powder fragmentation to be ground into ultra-fine 300 order granularity powder;
Second step: this 300 order granularity powder and water are prepared into serosity according to mass ratio 1:1 mixing;
The 3rd step: this serosity is pumped into the spraying pressurized nozzles and is sprayed to carry out atomization drying below 65 ℃ in spray drying tower and become graininess;
The 4th step: get this graininess mycelium powder 330g, add 30-40g wetting agent and/or binding agent, disintegrating agent 10-20g, mix homogeneously adds the binder solution of concentration 10-15% to be in harmonious proportion, and granulates;
The 5th step: through dry below 65 ℃, granulate adds disintegrating agent 25-35g, lubricant 10-20g, mixing, according to the compacting of 0.5g/ sheet weight specification in flakes.
Further, described wetting agent and/or binding agent are one or more in polyvinylpolypyrrolidone, hydroxypropyl emthylcellulose, dextrin, microcrystalline Cellulose, distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, gelatin, sucrose, polyvinylpyrrolidone; Described disintegrating agent is one or more in carboxymethyl starch sodium, dried starch, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose; Lubricant is one or more in micropowder silica gel, magnesium stearate, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols, magnesium laurylsulfate.
after the Hirsutella hepiali Chen et Shen silk is made into 300 order micropowders, too little so that the powder integral compressible is poor because of granularity, compression molding poor effect after directly granulating, and this micropowder first is mixed and made into serosity and by spray drying technology, it first is prepared into graininess with water, and then again this graininess mycelia powder is granulated, thereby when compression molding, in fact mycelia powder grain group forms " grain group-graininess-300 order granularity micropowder " detail analysis structure, greatly improved the compressibility that after granulating, grain is rolled into a ball, thereby prepare the effective Hirsutella hepiali Chen et Shen silk superfine powder tablets of compression molding.
The present invention applies in the preparation of Hirsutella hepiali Chen et Shen silk powder tablet by the spray drying process that will commonly use in the Chinese medicine course of processing, unexpectedly solve the technical problem of the compression molding poor effect that causes because the micropowder granularity is meticulous in the preparation process of Hirsutella hepiali Chen et Shen silk superfine powder tablets, obtained unforeseeable technique effect.
For the Hirsutella hepiali Chen et Shen silk, the cell wall breaking rate under 300 order fineness conditions is greater than 95 %, and cell intracellular effective ingredient after breaking cellular wall fully comes out, rate of release and the burst size of medicine can significantly improve.The medical material particle is after the cell grade micronizing, and aobvious proud Microscopic observation only has the minute quantity intact cell to exist.
Utilize the Hirsutella hepiali Chen et Shen silk superfine powder tablets of preparation method preparation of the present invention to mainly contain following advantage:
1. improve the dissolution of Cordyceps fungus Hirsutella hepiali Chen et Shen filament;
2. improve the bioavailability of Cordyceps fungus Hirsutella hepiali Chen et Shen filament;
3. strengthen the drug effect of Cordyceps fungus Hirsutella hepiali Chen et Shen filament;
4. minimizing dosage, conservation is raised the efficiency, and reduces costs;
" solid emulsifying " make each effective ingredient homogenization such as adenosine, cordycepin, Cordyceps polysaccharide, mannitol of Hirsutella hepiali Chen et Shen filament;
6. be conducive to keep Hirsutella hepiali Chen et Shen filament bioactive ingredients;
7. improve tabletting and the granulation performance of Hirsutella hepiali Chen et Shen, take mouthfeel good, be convenient to absorb and use.
The specific embodiment
In order further to explain technical scheme of the present invention, the present invention will be described in detail below by specific embodiment.
A kind of preparation method of tablet of Hirsutella hepiali Chen et Shen silk micropowder comprises following steps:
The first step: get Cordyceps fungus Hirsutella hepiali Chen et Shen mycelium, adopt the superfine powder fragmentation to be ground into ultra-fine 300 order granularity powder;
Second step: this 300 order granularity powder and water are prepared into serosity according to mass ratio 1:1 mixing;
The 3rd step: this serosity is pumped into the spraying pressurized nozzles and is sprayed to carry out 60 ℃ of atomization dryings in spray drying tower and become graininess; Usually 4.0 * 10
6Pa to 1.0 * 10
7The spraying of Pa pressure limit adopts 4.0 * 10 in the present embodiment
6The Pa press atomization;
The 4th step: get this graininess mycelium powder 330g, add 40g polyvinylpolypyrrolidone, hydroxypropyl emthylcellulose, dextrin, microcrystalline cellulose mixt, carboxymethyl starch sodium 20g, mix homogeneously adds the sucrose solution of concentration 15% to be in harmonious proportion, and granulates;
The 5th step: through 60 ℃ of dryings, granulate adds carboxymethyl starch sodium 35g, micropowder silica gel 20g, mixing, according to the compacting of 0.5g/ sheet weight specification in flakes.
The Cordyceps fungus Hirsutella hepiali Chen et Shen mycelium of this specific embodiment adopts the patent No. to make for the Chinese invention patent " method of the pure Cordyceps fungus of a kind of raising-Hirsutella hepiali Chen et Shen filament Biomass " of " 201110154398.0 ".
Above-described embodiment and non-limiting preparation method of the present invention, any person of an ordinary skill in the technical field all should be considered as not breaking away from patent category of the present invention to its suitable variation or modification of doing.
Claims (2)
1. the preparation method of the tablet of a Hirsutella hepiali Chen et Shen silk micropowder is characterized in that comprising following steps:
The first step: get Cordyceps fungus Hirsutella hepiali Chen et Shen mycelium, adopt the superfine powder fragmentation to be ground into ultra-fine 300 order granularity powder;
Second step: this 300 order granularity powder and water are prepared into serosity according to mass ratio 1:1 mixing;
The 3rd step: this serosity is pumped into the spraying pressurized nozzles and is sprayed to carry out atomization drying below 65 ℃ in spray drying tower and become graininess;
The 4th step: get this graininess mycelium powder 330g, add 30-40g wetting agent and/or binding agent, disintegrating agent 10-20g, mix homogeneously adds the binder solution of concentration 10-15% to be in harmonious proportion, and granulates;
The 5th step: through dry below 65 ℃, granulate adds disintegrating agent 25-35g, lubricant 10-20g, mixing, according to the compacting of 0.5g/ sheet weight specification in flakes.
2. the preparation method of the tablet of a kind of Hirsutella hepiali Chen et Shen silk micropowder as claimed in claim 1 is characterized in that:
Described wetting agent and/or binding agent are one or more in polyvinylpolypyrrolidone, hydroxypropyl emthylcellulose, dextrin, microcrystalline Cellulose, distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, gelatin, sucrose, polyvinylpyrrolidone; Described disintegrating agent is one or more in carboxymethyl starch sodium, dried starch, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose; Lubricant is one or more in micropowder silica gel, magnesium stearate, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols, magnesium laurylsulfate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310075334.0A CN103127182B (en) | 2013-03-11 | 2013-03-11 | Preparation method of tablet of cordyceps sinensis fungus hirsutella hepialid mycelia ultrafine powder |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310075334.0A CN103127182B (en) | 2013-03-11 | 2013-03-11 | Preparation method of tablet of cordyceps sinensis fungus hirsutella hepialid mycelia ultrafine powder |
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| CN103127182A true CN103127182A (en) | 2013-06-05 |
| CN103127182B CN103127182B (en) | 2014-05-28 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642688A (en) * | 2015-02-13 | 2015-05-27 | 佛山市宝资林生物科技有限公司 | Preparation method of cordyceps militaris link tableted candy |
| CN106668080A (en) * | 2017-03-07 | 2017-05-17 | 庞会心 | Pure powdered tablet with pure cordyceps sinensis mycelia and preparation method thereof |
| CN110496141A (en) * | 2019-09-10 | 2019-11-26 | 杭州华东医药集团新药研究院有限公司 | A kind of pharmaceutical composition containing cordyceps sinensis |
| CN110772545A (en) * | 2019-11-08 | 2020-02-11 | 西藏藏草宜生生物科技有限公司 | Preparation method of tablet of hirsutella hepiali mycelia ultrafine powder |
| CN112617187A (en) * | 2020-12-30 | 2021-04-09 | 广东粤微食用菌技术有限公司 | A capsule prepared from cell wall-broken hirsutella hepiali Chen et Shen mycelia with immunity enhancing effect, and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095701A (en) * | 2007-07-15 | 2008-01-02 | 樊立 | Flaky medicine containing hirsutella.hepia - cordyceps fungus powder and method for preparing the same |
-
2013
- 2013-03-11 CN CN201310075334.0A patent/CN103127182B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095701A (en) * | 2007-07-15 | 2008-01-02 | 樊立 | Flaky medicine containing hirsutella.hepia - cordyceps fungus powder and method for preparing the same |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642688A (en) * | 2015-02-13 | 2015-05-27 | 佛山市宝资林生物科技有限公司 | Preparation method of cordyceps militaris link tableted candy |
| CN106668080A (en) * | 2017-03-07 | 2017-05-17 | 庞会心 | Pure powdered tablet with pure cordyceps sinensis mycelia and preparation method thereof |
| CN110496141A (en) * | 2019-09-10 | 2019-11-26 | 杭州华东医药集团新药研究院有限公司 | A kind of pharmaceutical composition containing cordyceps sinensis |
| CN110496141B (en) * | 2019-09-10 | 2022-02-25 | 杭州华东医药集团新药研究院有限公司 | A pharmaceutical composition containing Cordyceps |
| CN110772545A (en) * | 2019-11-08 | 2020-02-11 | 西藏藏草宜生生物科技有限公司 | Preparation method of tablet of hirsutella hepiali mycelia ultrafine powder |
| CN112617187A (en) * | 2020-12-30 | 2021-04-09 | 广东粤微食用菌技术有限公司 | A capsule prepared from cell wall-broken hirsutella hepiali Chen et Shen mycelia with immunity enhancing effect, and its preparation method and application |
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| CN103127182B (en) | 2014-05-28 |
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