CN102961460A - Preparation method of compound bismuth aluminate tablet - Google Patents
Preparation method of compound bismuth aluminate tablet Download PDFInfo
- Publication number
- CN102961460A CN102961460A CN2012105281229A CN201210528122A CN102961460A CN 102961460 A CN102961460 A CN 102961460A CN 2012105281229 A CN2012105281229 A CN 2012105281229A CN 201210528122 A CN201210528122 A CN 201210528122A CN 102961460 A CN102961460 A CN 102961460A
- Authority
- CN
- China
- Prior art keywords
- bismuth aluminate
- preparation
- mixture
- compound bismuth
- mass percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a compound bismuth aluminate tablet. The preparation method comprises the steps of: weighing and mixing 100-300g of bismuth aluminate, 350-600g of heavy magnesium carbonate, 50-400g of sodium bicarbonate, 150-450g of licorice extract powders, 10-40g of buckthorn bark powders, 10-500g of filling diluent and 10-100g of disintegrating agent to obtain a mixture A; spraying 10-300g of adhesive in an atomization state and in a specific shape into the mixture A; pelletizing by a wet method; sifting with a sieve of 10-24 meshes; straightening particles; drying the particles till the water content is 1-7%; sifting with a sieve of 10-24 meshes; straightening particles to obtain particles A, wherein the specific shape of the adhesive in the atomization state is a sector of 0-180 degrees, a hollow cone, a solid cone or a solid square; uniformly mixing particles A, 1-30g of fennel powders and 5-25g of lubricants; tabletting; and packaging a product to obtain a finished product. According to the preparation method of the compound bismuth aluminate tablet, the safety is good, the productivity is high, the quality is stable and controllable and the effectiveness and the safety of the compound bismuth aluminate tablet can be guaranteed effectively.
Description
Technical field
What the present invention relates to is a kind of preparation method of pharmaceutical preparation, specifically a kind of preparation method of compound bismuth aluminate tablets.
Background technology
The main component of compound bismuth aluminate tablets is bismuth aluminate, Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum and Fructus Foeniculi powder etc., be mainly used in alleviating stomachache, heartburn sense (heartburn), the acid regurgitation that hyperchlorhydria causes, also can be used for chronic gastritis.Compound bismuth aluminate tablets is compound preparation; contained bismuth aluminate can form protecting film at stomach and Duodenal Mucosa; sodium bicarbonate, Heavy Magnesium Carbonate all have obvious antiacid effect; be made into compound recipe with Radix Glycyrrhizae extractum, FULANGSHULIPI, Fructus Foeniculi; can in and gastric acid, eliminate flatulence and constipation, strengthen stomach and Duodenal Mucosa barrier; make mucosa regeneration, promote the ulcer surface healing.Clinical application by for many years proves, this medicine all has definite good clinical efficacy aspect treatment gastric ulcer, duodenal ulcer, chronic gastric duodenitis and the intractable singultus, and this product is when possessing good clinical efficacy, product price is cheap, untoward reaction is few, take medicine conveniently, rapid-action, curative effect is lasting, recurrent is low characteristics, have suitable clinical value, for the problem that solves extensive patients " high cost of getting medical treatment " positive meaning is arranged.
But compound bismuth aluminate tablets is in actual production process, and its safety is relatively poor, the odd-numbered day production capacity is lower and the content fluctuation is larger.Main cause is: contain the larger Chinese medicine ingredients of toughness in the compound bismuth aluminate tablet recipe, this composition causes in the compound bismuth aluminate tablets production process as when adopting water or low-concentration ethanol solution to granulate as solvent, solvent is difficult to be dispersed in the material and then causes local material hydration rate too fast and lump, and finally causes damp production or production capacity extremely low.So in the compound bismuth aluminate tablets production process, will adopt the preparation technology of the alcoholic solution granulation of high concentration.In process of production, even full production line adopts antiknock device, but owing to used inflammable and explosive high concentration ethanol solution, and then greatly reduce the safety that compound bismuth aluminate tablets is produced, brought hidden danger for the safety in production of enterprise.Even yet the alcoholic solution preparation technology of employing high concentration, because its preparation technology's limitation, the defective of prepared granule causes compound bismuth aluminate tablets sheet when the high speed tabletting heavily to fluctuate large and then causes the finished product content fluctuation larger, thereby causes this product can't carry out the high speed tabletting.Therefore the odd-numbered day production capacity of the process for producing of compound bismuth aluminate tablets high concentration ethanol solution can't satisfy people to the demand of this medicine and can bring larger risk to the people's drug safety.
Summary of the invention
The object of the present invention is to provide a kind of safely, production capacity is large, the preparation method of the compound bismuth aluminate tablets that constant product quality is controlled.
The object of the present invention is achieved like this:
(1) get bismuth aluminate and cross the 120-150 eye mesh screen, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross the 100-150 eye mesh screen, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross the 80-120 eye mesh screen, for subsequent use.
(2) take by weighing by weight 100-300g bismuth aluminate, 350-600g Heavy Magnesium Carbonate, 50-400g sodium bicarbonate, 150-450g Radix Glycyrrhizae extractum powder, 10-40g buckthorn corium farinosum, 10-500g filling diluent, 10-100g disintegrating agent mix homogeneously and obtain mixture A;
(3) with the binding agent of 10-300g with spray pattern and be given shape and be injected to wet granulation among the mixture A, cross 10-24 order granulate, particle drying is crossed 10-24 order granulate and is obtained granule B to water content 1%-7%; Described binding agent spray pattern given shape is one or more combination of fan-shaped, open circles taper, solid conical or the solid squares of 0～180 degree.
(4) granule B and 1-30g Fructus Foeniculi powder, 5-25g mix lubricant is even, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Optimization prescription proportioning and the production technology of product are:
(1) get bismuth aluminate and cross the 120-140 eye mesh screen, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross the 100-120 eye mesh screen, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross the 80-100 eye mesh screen, for subsequent use.
(2) take by weighing by weight 150-280g bismuth aluminate, 350-450g Heavy Magnesium Carbonate, 150-350g sodium bicarbonate, 200-400g Radix Glycyrrhizae extractum powder, 20-30g buckthorn corium farinosum, 10-200g filling diluent, 10-90g disintegrating agent mix homogeneously and obtain mixture A;
(3) with the binding agent of 40-80g with spray pattern and be given shape and be injected to wet granulation among the mixture A, cross 10-24 order granulate, particle drying is crossed 10-24 order granulate and is obtained granule A to water content 1%-7%; Described binding agent spray pattern given shape is one or more combination of fan-shaped, the solid conical of 50～100 degree or solid squares.
(4) granule A and 5-20g Fructus Foeniculi powder, 5-20g mix lubricant is even, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product;
Adopt these its characteristics of optimization of C/C composites explained hereafter to be: when the high speed tabletting, it is less that sheet is heavily stablized tablet weight variation more, and when guaranteeing high security, high quality of production, production capacity amplification can reach more than 95%.
Described filling diluent is one or more the mixture in lactose, pregelatinized Starch, dextrin, sucrose Icing Sugar, white sugar Icing Sugar, microcrystalline Cellulose, inorganic salt, mannitol or the sorbitol.
Described disintegrating agent is one or more the mixture in carboxymethyl starch sodium, starch or the polyvinylpolypyrrolidone.
The mixture of one or more in the sodium alginate aqueous solution that the Aqueous Solutions of Polyethylene Glycol that described binding agent is water, mass percent are the cellulose derivative aqueous solution of 1%-15%, polyvidone aqueous solution that mass percent is 1%-15%, mass percent is 1%-15% aqueous gelatin solution, mass percent is 1%-15%, the aqueous sucrose solution that mass percent is 10%-70%, white sugar aqueous solution that mass percent is 10%-70% or mass percent are 1%-10%.Wherein, described cellulose derivative is one or more the mixture in methylcellulose, ethyl cellulose, hyprolose, hypromellose, sodium carboxymethyl cellulose or the carboxymethylcellulose calcium.
Described lubricant is one or more the mixture in magnesium stearate, stearic acid, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, Polyethylene Glycol or the magnesium laurylsulfate.
The present invention adopts water or aqueous solution to carry out compound bismuth aluminate tablets production as binding agent fully, and by effectively controlling the hydration rate of the Chinese medicine ingredients that viscosity is larger in the prescription, and then reach the abundant moistening of all materials, solved the viscosity Chinese medicine ingredients and produced the problem that caking can't normally be produced because hydration rate is too fast, and evaded adopt the safety in production hidden danger brought of alcoholic solution preparation technology of inflammable and explosive high concentration fully.In addition, the present invention by effective control binding agent the atomized drop size so that effectively controlled the particle size distribution of prepared granule, the defective of evading the prepared granule of compound bismuth aluminate tablets high concentration ethanol solution preparation technology, the high production capacity preparation technology of compound bismuth aluminate tablets is achieved, and the finished product content fluctuation also significantly reduces.In the present invention in the related technique preparation process, general tablet manufacturing equipment can satisfy the requirement of each variety production, and has solved the fluctuate problem of large quality control difficulty of the low and product content of poor stability, the production capacity of traditional compound bismuth aluminate tablets production technology fully.
The specific embodiment
Embodiment 1
A kind of preparation method of compound bismuth aluminate tablets is comprised of following step:
(1) get bismuth aluminate and cross 120 eye mesh screens, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross 100 eye mesh screens, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross 100 eye mesh screens, for subsequent use.
(2) take by weighing by weight 200g bismuth aluminate, 400g Heavy Magnesium Carbonate, 200g sodium bicarbonate, 300g Radix Glycyrrhizae extractum powder, 25g buckthorn corium farinosum, 20g dextrin, 50g starch mix homogeneously obtains mixture A.
(3) with the purified water of 45g with spray pattern and be 65 degree and fan-shapedly be injected to wet granulation among the mixture A, cross 16 order granulate, particle drying is crossed 14 order granulate and is obtained granule A to water content 1%-7%.
(4) with granule A and 10g Fructus Foeniculi powder, 10g magnesium stearate mix homogeneously, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Among this embodiment, in actual production process, do not use inflammable and explosive organic solvent, avoided the potential safety hazard of bringing to production because of with an organic solvent fully.Using under the existing equipment prerequisite, when carrying out compound bismuth aluminate tablets production according to this production technology, hourly output can reach 105.42 ten thousand, and hourly output amplification reaches 97.34%.
Service property (quality) percentage ratio is that 1% or 5% hypromellose aqueous solution, mass percent are that 3% or 9% polyvidone aqueous solution, mass percent are that 3% or 9% polyvidone aqueous solution, mass percent are that 8% aqueous gelatin solution, mass percent are that the sodium alginate aqueous solution that 5% Aqueous Solutions of Polyethylene Glycol or mass percent are 1%-10% all can form new embodiment.
Embodiment 2
A kind of preparation method of compound bismuth aluminate tablets is comprised of following step:
(1) get bismuth aluminate and cross 120 eye mesh screens, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross 100 eye mesh screens, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross 100 eye mesh screens, for subsequent use.
(2) take by weighing by weight 200g bismuth aluminate, 420g Heavy Magnesium Carbonate, 280g sodium bicarbonate, 300g Radix Glycyrrhizae extractum powder, 28g buckthorn corium farinosum, 30g dextrin, the 80g lactose, 85g starch mix homogeneously obtains mixture A.
(3) with the purified water of 52g with spray pattern and be 61 degree solid conical, 73 degree and fan-shapedly be injected to wet granulation among the mixture A, cross 16 order granulate, particle drying is crossed 14 order granulate and is obtained granule A to water content 1%-7%.
(4) with granule A and 15g Fructus Foeniculi powder, 5g magnesium stearate, 5g micropowder silica gel mix homogeneously, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Among this embodiment, in actual production process, do not use inflammable and explosive organic solvent, avoided the potential safety hazard of bringing to production because of with an organic solvent fully.Using under the existing equipment prerequisite, when carrying out compound bismuth aluminate tablets production according to this production technology, hourly output can reach 105.22 ten thousand, and hourly output amplification reaches 96.97%.
Service property (quality) percentage ratio is that 3% hypromellose aqueous solution, mass percent are that 3% or 9% polyvidone aqueous solution, mass percent are that 3% or 9% polyvidone aqueous solution, mass percent are that 8% aqueous gelatin solution or mass percent are that 5% Aqueous Solutions of Polyethylene Glycol all can form new embodiment.
Embodiment 3
A kind of preparation method of compound bismuth aluminate tablets is comprised of following step:
(1) get bismuth aluminate and cross 120 eye mesh screens, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross 100 eye mesh screens, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross 100 eye mesh screens, for subsequent use.
(2) take by weighing by weight 150g bismuth aluminate, 370g Heavy Magnesium Carbonate, 180g sodium bicarbonate, 150g Radix Glycyrrhizae extractum powder, 35g buckthorn corium farinosum, 430g lactose, 40g polyvinylpolypyrrolidone mix homogeneously obtains mixture A.
(3) with the purified water of 100g with spray pattern and be 60 degree open circles tapers and be injected to wet granulation among the mixture A, cross 20 order granulate, particle drying is crossed 18 order granulate and is obtained granule A to water content 1%-7%.
(4) with granule A and 5g Fructus Foeniculi powder, 18g Pulvis Talci mix homogeneously, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Among this embodiment, in actual production process, do not use inflammable and explosive organic solvent, avoided the potential safety hazard of bringing to production because of with an organic solvent fully.Using under the existing equipment prerequisite, when carrying out compound bismuth aluminate tablets production according to this production technology, hourly output can reach 102.95 ten thousand, and hourly output amplification reaches 92.72%.
Service property (quality) percentage ratio is that 3% or 9% hypromellose aqueous solution, mass percent are that 8% aqueous gelatin solution, mass percent are that 5% Aqueous Solutions of Polyethylene Glycol all can form new embodiment.
Embodiment 4
A kind of preparation method of compound bismuth aluminate tablets is comprised of following step:
(1) get bismuth aluminate and cross 120 eye mesh screens, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross 100 eye mesh screens, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross 100 eye mesh screens, for subsequent use.
(2) take by weighing by weight 290g bismuth aluminate, 580g Heavy Magnesium Carbonate, 140g sodium bicarbonate, 440g Radix Glycyrrhizae extractum powder, 30g buckthorn corium farinosum, 20g dextrin, the 280g lactose, 25g polyvinylpolypyrrolidone mix homogeneously obtains mixture A.
(3) with the purified water of 63g with spray pattern and be 40 degree solid squares and be injected to wet granulation among the mixture A, cross 16 order granulate, particle drying is crossed 14 order granulate and is obtained granule A to water content 1%-7%.
(4) with granule A and 15g Fructus Foeniculi powder, 12g micropowder silica gel mix homogeneously, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Among this embodiment, in actual production process, do not use inflammable and explosive organic solvent, avoided the potential safety hazard of bringing to production because of with an organic solvent fully.Using under the existing equipment prerequisite, when carrying out compound bismuth aluminate tablets production according to this production technology, hourly output can reach 103.33 ten thousand, and hourly output amplification reaches 94.43%.
Service property (quality) percentage ratio is that 9% hypromellose water-alcohol solution or 3% aqueous gelatin solution all can form new embodiment.
Embodiment 5
A kind of preparation method of compound bismuth aluminate tablets is comprised of following step:
(1) get bismuth aluminate and cross 120 eye mesh screens, for subsequent use; Get Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum, Fructus Foeniculi powder and cross 100 eye mesh screens, for subsequent use; Get filling diluent, disintegrating agent and lubricant and cross 100 eye mesh screens, for subsequent use.
(2) take by weighing by weight 245g bismuth aluminate, 500g Heavy Magnesium Carbonate, 370g sodium bicarbonate, 280g Radix Glycyrrhizae extractum powder, 20g buckthorn corium farinosum, 390g microcrystalline Cellulose, 20g starch, 35g carboxymethyl starch sodium mix homogeneously obtain mixture A.
(3) with the purified water of 142g with spray pattern and be 102 degree solid squares and be injected to wet granulation among the mixture A, cross 16 order granulate, particle drying is crossed 14 order granulate and is obtained granule A to water content 1%-7%.
(4) with granule A and 25g Fructus Foeniculi powder, 17g micropowder silica gel mix homogeneously, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
Among this embodiment, in actual production process, do not use inflammable and explosive organic solvent, avoided the potential safety hazard of bringing to production because of with an organic solvent fully.Using under the existing equipment prerequisite, when carrying out compound bismuth aluminate tablets production according to this production technology, hourly output can reach 103.58 ten thousand, and hourly output amplification reaches 93.90%.
Service property (quality) percentage ratio is that 3% polyvidone aqueous solution, mass percent are that 3% aqueous gelatin solution or mass percent are that 5% Aqueous Solutions of Polyethylene Glycol all can form new embodiment.
In addition, when adopting the product preparation process production compound bismuth aluminate tablets among the present invention, because adopting is effective material aquation rate control techniques and particle size distribution control technology, so that the prepared Particle Phase of the final product particle that obtains and former technique is than having splendid flowability and compressibility, and then reduced the sheet of product when the high speed tabletting and heavily fluctuate, and then guaranteed product yield and finished product content, guaranteed the effectiveness of medicine and the safety of people's medication.Comparing result sees Table 1.
Table 1 compound bismuth aluminate tablets comparing result
Claims (7)
1. the preparation method of a compound bismuth aluminate tablets is characterized in that:
(1) bismuth aluminate is crossed the 120-150 eye mesh screen, and Heavy Magnesium Carbonate, sodium bicarbonate, Radix Glycyrrhizae extractum powder, buckthorn corium farinosum and Fructus Foeniculi powder are crossed the 100-150 eye mesh screen, and filling diluent, disintegrating agent and lubricant are crossed the 80-120 eye mesh screen;
(2) take by weighing by weight 100-300g bismuth aluminate, 350-600g Heavy Magnesium Carbonate, 50-400g sodium bicarbonate, 150-450g Radix Glycyrrhizae extractum powder, 10-40g buckthorn corium farinosum, 10-500g filling diluent and 10-100g disintegrating agent mix homogeneously and obtain mixture A;
(3) with the binding agent of 10-300g with spray pattern and be given shape and be injected to wet granulation among the mixture A, cross 10-24 order granulate, particle drying is crossed 10-24 order granulate and is obtained granule B to water content 1%-7%;
(4) granule B and 1-30g Fructus Foeniculi powder, 5-25g mix lubricant is even, suppress the laggard row packing of product in blocks and obtain the compound bismuth aluminate tablets finished product.
2. the preparation method of a kind of compound bismuth aluminate tablets according to claim 1 is characterized in that: described binding agent spray pattern given shape is one or more combination of fan-shaped, open circles taper, solid conical or the solid squares of 0～180 degree.
3. the preparation method of a kind of compound bismuth aluminate tablets according to claim 2 is characterized in that: described filling diluent is one or more the mixture in lactose, pregelatinized Starch, dextrin, sucrose Icing Sugar, white sugar Icing Sugar, microcrystalline Cellulose, inorganic salt, mannitol or the sorbitol.
4. the preparation method of a kind of compound bismuth aluminate tablets according to claim 3 is characterized in that: described disintegrating agent is one or more the mixture in carboxymethyl starch sodium, starch or the polyvinylpolypyrrolidone.
5. the preparation method of a kind of compound bismuth aluminate tablets according to claim 4 is characterized in that: the mixture of one or more in the sodium alginate aqueous solution that the Aqueous Solutions of Polyethylene Glycol that described binding agent is water, mass percent are the cellulose derivative aqueous solution of 1%-15%, polyvidone aqueous solution that mass percent is 1%-15%, mass percent is 1%-15% aqueous gelatin solution, mass percent is 1%-15%, the aqueous sucrose solution that mass percent is 10%-70%, white sugar aqueous solution that mass percent is 10%-70% or mass percent are 1%-10%.
6. the preparation method of a kind of compound bismuth aluminate tablets according to claim 5 is characterized in that: described cellulose derivative is one or more the mixture in methylcellulose, ethyl cellulose, hyprolose, hypromellose, sodium carboxymethyl cellulose or the carboxymethylcellulose calcium.
7. the preparation method of a kind of compound bismuth aluminate tablets according to claim 6 is characterized in that: described lubricant is one or more the mixture in magnesium stearate, stearic acid, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, Polyethylene Glycol or the magnesium laurylsulfate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105281229A CN102961460A (en) | 2012-12-10 | 2012-12-10 | Preparation method of compound bismuth aluminate tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105281229A CN102961460A (en) | 2012-12-10 | 2012-12-10 | Preparation method of compound bismuth aluminate tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102961460A true CN102961460A (en) | 2013-03-13 |
Family
ID=47792079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012105281229A Pending CN102961460A (en) | 2012-12-10 | 2012-12-10 | Preparation method of compound bismuth aluminate tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102961460A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104337854A (en) * | 2013-07-25 | 2015-02-11 | 哈药集团三精制药股份有限公司 | Naoan tablet preparation method |
| CN107854500A (en) * | 2017-12-28 | 2018-03-30 | 广东伊茗药业有限公司 | A kind of pharmaceutical preparation for treating stomach trouble |
| CN115531448A (en) * | 2022-11-24 | 2022-12-30 | 弘美制药（中国）有限公司 | Francisella bark extract powder, preparation thereof and application thereof in stomach bismuth magnesium particles |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577533A (en) * | 1968-02-21 | 1971-05-04 | Joseph Alfred Rider | Antacid compositions containing bismuth aluminate and coprecipitated aluminum hydroxide and magnesium carbonate |
| CN1150024A (en) * | 1995-11-13 | 1997-05-21 | 营口市第二制药厂 | Prescription and technique of compound bismuth aluminate granule |
| CN1579473A (en) * | 2003-09-24 | 2005-02-16 | 太平洋医药（通化）有限公司 | Medicine composition for treating stomach disease, its preparation method and use |
| CN1824131A (en) * | 2005-12-20 | 2006-08-30 | 诺氏制药（吉林）有限公司 | Weibimei medicical composition for treating stomach disease and its preparation method |
| WO2009095210A1 (en) * | 2008-01-31 | 2009-08-06 | Bayer Consumer Care Ag | Composition comprising an antacid and a h2-antagonists |
| CN102058554A (en) * | 2010-12-28 | 2011-05-18 | 哈药集团三精制药股份有限公司 | Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states |
| WO2011099998A2 (en) * | 2010-02-09 | 2011-08-18 | Sanford Siegal | Edible compositions |
-
2012
- 2012-12-10 CN CN2012105281229A patent/CN102961460A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577533A (en) * | 1968-02-21 | 1971-05-04 | Joseph Alfred Rider | Antacid compositions containing bismuth aluminate and coprecipitated aluminum hydroxide and magnesium carbonate |
| CN1150024A (en) * | 1995-11-13 | 1997-05-21 | 营口市第二制药厂 | Prescription and technique of compound bismuth aluminate granule |
| CN1579473A (en) * | 2003-09-24 | 2005-02-16 | 太平洋医药（通化）有限公司 | Medicine composition for treating stomach disease, its preparation method and use |
| CN1824131A (en) * | 2005-12-20 | 2006-08-30 | 诺氏制药（吉林）有限公司 | Weibimei medicical composition for treating stomach disease and its preparation method |
| WO2009095210A1 (en) * | 2008-01-31 | 2009-08-06 | Bayer Consumer Care Ag | Composition comprising an antacid and a h2-antagonists |
| WO2011099998A2 (en) * | 2010-02-09 | 2011-08-18 | Sanford Siegal | Edible compositions |
| CN102058554A (en) * | 2010-12-28 | 2011-05-18 | 哈药集团三精制药股份有限公司 | Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104337854A (en) * | 2013-07-25 | 2015-02-11 | 哈药集团三精制药股份有限公司 | Naoan tablet preparation method |
| CN107854500A (en) * | 2017-12-28 | 2018-03-30 | 广东伊茗药业有限公司 | A kind of pharmaceutical preparation for treating stomach trouble |
| CN115531448A (en) * | 2022-11-24 | 2022-12-30 | 弘美制药（中国）有限公司 | Francisella bark extract powder, preparation thereof and application thereof in stomach bismuth magnesium particles |
| CN115531448B (en) * | 2022-11-24 | 2023-03-10 | 弘美制药（中国）有限公司 | Francisella fern bark extract powder, preparation thereof and application thereof in stomach bismuth magnesium granules |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102058554B (en) | Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states | |
| CN102058480B (en) | Oral effervescent tablet and preparation method thereof | |
| KR102064242B1 (en) | Natural material based tablet composition, tablet and method for preparation using the same | |
| EP3661508B1 (en) | Manufacturing method of oral dosage form containing berberine, oral dosage form containing berberine and use thereof | |
| CN102961460A (en) | Preparation method of compound bismuth aluminate tablet | |
| CN101007071A (en) | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology | |
| CN100546571C (en) | Sangju effervescent tablet for treating common cold | |
| CN110585437A (en) | Sugar fine particles and preparation method, equipment and application thereof | |
| TWI549700B (en) | Panax notoginseng broken wall preparation | |
| CN103127182B (en) | Preparation method of tablet of cordyceps sinensis fungus hirsutella hepialid mycelia ultrafine powder | |
| CN110575442B (en) | Fermented cordyceps sinensis powder tablet | |
| CN105663073A (en) | Method for preparing traditional Chinese medicine tablet granulated by adhesive foam state | |
| CN1785336A (en) | Tongyou dryness moistening fast dispersion solid preparation and its preparation method | |
| CN101745025A (en) | Method for preparing brain-nourishing capsule oral solid preparation | |
| TW201436818A (en) | Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form | |
| KR20210087627A (en) | Natural material based tablet composition and tablet | |
| CN101732555A (en) | Medicament for treating cold cough and chronic bronchitis | |
| CN100384404C (en) | Jinsuo emission-arresting fast dispersing solid preparation and its preparation method | |
| CN100364502C (en) | Anemarrhena, phello dendron and rehmannia fast dispersion solid medicinal preparation and its manufacturing method | |
| CN100428929C (en) | Kunshun fast dispersion solid preparation and its preparation method | |
| CN102038715B (en) | Traditional Chinese medicine dispersible tablet and preparation method thereof | |
| CN1698701A (en) | Gout relaxing tablet and preparation method thereof | |
| CN100515411C (en) | Fast dispersion solid preparation for Child and its preparation method | |
| CN101181306B (en) | Nano-scale compound pearl dimension C lozenge and preparation method thereof | |
| CN100486564C (en) | Jinkui kidney qi fast dispersion solid preparation and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130313 |