CN103110810A - Traditional Chinese medicine preparation for treating dry eye diseases - Google Patents
Traditional Chinese medicine preparation for treating dry eye diseases Download PDFInfo
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- CN103110810A CN103110810A CN2013100713979A CN201310071397A CN103110810A CN 103110810 A CN103110810 A CN 103110810A CN 2013100713979 A CN2013100713979 A CN 2013100713979A CN 201310071397 A CN201310071397 A CN 201310071397A CN 103110810 A CN103110810 A CN 103110810A
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Abstract
The invention provides a traditional Chinese medicine preparation for treating dry eye diseases, which is prepared from the following raw materials in parts by weight: 6-10 parts of liquorice, 25-35 parts of Chinese wolfberry, 10-20 parts of chrysanthemum, 10-20 parts of radix scrophulariae, 8-15 parts of cassia seeds, 10-30 parts of prepared rhizome of rehmannia, 25-35 parts of radix ophiopogonis, 25-35 parts of astragalus membranaceus, and 25-35 parts of bidens pilosa. The traditional Chinese medicine preparation for treating dry eye diseases can be prepared into any dosage forms by using a pharmaceutically conventional preparation method. The raw materials used in the invention are all pure natural Chinese herbal medicines, therefore, the material taking is convenient and economic, and the preparation method is simple; the curative effect can be improved, especially, and the lacrimal secretion can be increased, thereby relieving the subjective symptoms of patients, and easing the pain; and no toxic or side effect is caused after the preparation is taken for a long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation for the treatment of xerophthalmia.
Background technology
Xerophthalmia refers to tear matter that any reason causes or amount is abnormal or kinetics is abnormal, causes tear film stability decline, and with ophthalmic uncomfortable and (or) general name of the various diseases of eye table organization characteristics of lesion, be the common a kind of chronic disease of ophthalmology.Investigation confirms, in the people more than 3 hours of working before computer every day, 90% people suffers from xerophthalmia in various degree, and in the five-year, the dry eye patients number also will be with annual speed rising more than 10%.Common sympton comprises that eyes are dry and astringent, and is easily tired, and sleepy can be itched, and foreign body sensation is arranged, the pain burning sensation, eyelid is tight heavy, the secretions thickness, aversion to wind, photophobia, stimulate to external world very sensitive, temporary blurred vision; Sometimes eyes are too dried, and basic oligodacrya stimulates on the contrary the reflexive lacrimal secretion and causes the symptom that usually drops tears; The more severe case eyes can be red and swollen, hyperemia, and keratinization, corneal epithelium broken skin and have filament to adhere to, long-term injury can cause the angle conjunctive disorder, and can affect one's power of vision.Xerophthalmia also can't be effected a radical cure at present, mostly adopts clinically artificial tears's relief of symptoms, if but surpassed more than 6 times in one day, will wash away normal tear film, thereby increase the weight of symptom, in case stop using, symptom often can recur again, and the artificial tears has little effect for the dry eye patients of severe.Take the puncta Embolization for severe patient, the operative treatments such as Autotransplantation of submandibular gland, the puncta Embolization can also can reduce artificial tears's consumption by mitigation symptoms, and taking a turn for the better appears in the sings and symptoms that improves the patient, patient for the severe xerophthalmia may need the long period to improve, and somewhat expensive has increased patient's misery, and common patient is difficult to accept.In recent years, the Chinese medicine preparation of many treatment xerophthalmia is arranged also, the profit order spirit of particularly adopting Radix Glycyrrhizae, Fructus Lycii, Flos Chrysanthemi, Radix Scrophulariae, Semen Cassiae, Herba Bidentis Bipinnatae to make obtained sure curative effect on the treatment xerophthalmia, but effect is still not ideal enough.
Summary of the invention
For the deficiencies in the prior art the invention provides a kind of cheap, can increase lacrimal secretion, curative effect treats the Chinese medicine preparation of xerophthalmia reliably.
Raw material composition and the weight proportion of making this Chinese medicine preparation effective ingredient are: Radix Glycyrrhizae 6～10 Fructus Lycii 25～35 Flos Chrysanthemi 10～20 Radix Scrophulariae 10～20 Semen Cassiae 8～15 Radix Rehmanniae Preparata Radix Astragali 25～35 Herba Bidentis Bipinnatae 25～35 10～30 Radix Ophiopogonis 25～35.
The raw material of making this Chinese medicine preparation effective ingredient form and weight proportion preferably: Radix Glycyrrhizae 7～10 Fructus Lycii 28～32 Flos Chrysanthemi 12～16 Radix Scrophulariae 12～18 Semen Cassiae 10～14 Radix Rehmanniae Preparata Radix Astragali 26～33 Herba Bidentis Bipinnatae 27～34 15～28 Radix Ophiopogonis 26～32.
The raw material of making this Chinese medicine preparation effective ingredient form and weight proportion preferably: the Radix Glycyrrhizae 8 Fructus Lycii 30 Flos Chrysanthemi 15 Radix Scrophulariae 15 Semen Cassiae 12 Radix Rehmanniae Preparata Radix Astragali 30 Herba Bidentis Bipinnatae 30 20 Radix Ophiopogonis 30.
Various natural Chinese medicinal herb of the present invention all can be buied on market, adopts the routine techniques of this field pharmacy to make said dosage form on pharmaceutics according to described component and weight proportion, as capsule, granule, tablet, pill, powder etc.
The present invention is directed to the various diseases of xerophthalmia, treat from the angle of the traditional Chinese medical science is dialectical, with nourishing the liver and kidney, promote the production of body fluid and moisturize, Yin-nourishing and body fluid promoting is main.Wherein Radix Glycyrrhizae can invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing; Fructus Lycii energy the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst can be used for treating hepatic and renal YIN deficiency; Flos Chrysanthemi can fall apart wind heat clearing away, liver heat removing and eyesight improving, detoxicating, relieving inflammation; The Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing; Semen Cassiae possesses the clearing away heat to improve acuity of vision effect; The Radix Rehmanniae Preparata YIN nourishing of enriching blood again can vital essence replenishing and marrow benifiting, is specially adapted to the disease that deficiency of kidney yin causes; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire; The Radix Astragali has invigorating the spleen and replenishing QI, the effect of tonifying the lung consolidating superficial resistance, Herba Bidentis Bipinnatae expelling wind and removing dampness, heat-clearing and toxic substances removing, promoting blood circulation and detumescence.
Fructus Lycii, Radix Rehmanniae Preparata, Radix Ophiopogonis, the Radix Astragali, Herba Bidentis Bipinnatae are principal agent of the present invention, clinical research shows that most xerophthalmia belong to tear and generate not enough, from the angle of the traditional Chinese medical science dialectically mostly be deficiency of the liver and kindey, stagnated fire is attacked or the vim and vigour stasis blocking, the present invention bases oneself upon with the clearing away heat and nourishing YIN nourishing the liver and kidney that promotes the production of body fluid, Radix Rehmanniae Preparata, Radix Ophiopogonis, the Radix Astragali of certain proportioning have been increased especially on the basis of existing technology, be equipped with again Radix Glycyrrhizae, Flos Chrysanthemi, Radix Scrophulariae, can improve curative effect, particularly can increase lacrimal secretion, effectively the subjective symptom of reduction of patient.
Various raw materials by described formula make the said dosage form of any pharmaceutics all can, comparatively simple with powder preparation.
The invention has the beneficial effects as follows: the raw materials used Chinese herbal medicine that is pure natural, to draw materials convenient economical, preparation method is simple, can improve curative effect, increases lacrimal secretion, and the subjective symptom of reduction of patient palliates the agonizing sufferings, and long-term taking is without any side effects.
For proving curative effect of the present invention, use this invention to carry out clinical practice, its method and result are as follows:
1, screening case
Diagnosis about xerophthalmia there is no unified standard at present, and the applicant drafts with reference to the diagnostic criteria of Liu Zuguo " eye surface diseases " xerophthalmia: (1) subjective symptom (essential): dry sensation, foreign body sensation, feeling of fatigue, photophobia, pain, shed tears, blurred vision, furious.(2) tear film unstable (essential): breakup time of tear film (BUT).(3) lacrimal secretion reduces: lacrimal secretion experiment (Schirmer I Test)≤10mm/5min..(4) ocular surface injury (strengthening diagnosis): fluorescent staining 〉=3 are or/and brave red colouring 〉=3.In above-mentioned several, get rid of (1)+(2) after other reasons (BUT≤5s) or 1+2(BUT≤10s)+3 or 4 diagnosis xerophthalmia.
Totally 70 examples that meet this standard, male's 32 examples wherein, 58, age is at 18～67 years old, women's 38 examples, and the age was at 21～72 years old, 72, totally 130 of men and women with two groups of 130 random average marks (same patient's right and left eyes should at same group), be namely moistened order spirit group eye (65) and an of the present invention group of eye (65).Before and after treatment respectively to two groups of subjective symptoms mark, breakup time of tear film (BUT), lacrimal secretion experiment (Schirmer I Test) quantizes record.
2, Therapeutic Method
Of the present invention group: press described component and weight proportion relation according to the agent of preparation method granulation, capsule, tablet, pill conventional on pharmaceutics, each patient chooses a kind of dosage form at random, and taking continuously for 8 weeks is a course for the treatment of.
Profit order spirit group: oral profit order spirit, every day 2 times, is equivalent to extracting liquorice 3 Fructus Lycii 10 Flos Chrysanthemi 6 Herba Bidentis Bipinnatae 30(units: gram) make instant granular through the decocting in water spray drying, took continuously for 8 weeks by each one bag.Two groups cut out other related drugs and artificial tears during treating.
3, therapeutic evaluation
Treatment is tested (Schirmer I Test), is carried out cross-reference two groups of subjective symptoms, breakup time of tear film (BUT), lacrimal secretion after 8 weeks.
Evaluation to subjective symptom: observe dried the scoring of eye and formulate with reference to " new Chinese medicine clinical guidance principle ": 0 minute, without uncomfortable; 2 minutes, occasionally have dry and astringent; 4 minutes, often have dry and astringent not well; 6 minutes, unbearable sensation of dryness of the eye was not stopped paying out work.
BUT measures: drip 2% fluorescein in lower, the time used when occurring to first bitot's patches speckle of twinkling is for the last time recorded in observation under the slit lamp cobalt blue filters, and totally 3 times, averages.
Lacrimal secretion experiment (Schirmer I Test): use commercially available fluorescent test paper strip, folding outer 1/3 conjunctival sac of lower eyelid of putting in end 5mm place, eyes Natural closure 5 minutes is measured its wetted length from burst.
4, result
(1) " the disease of tcm Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine.Clinical recovery: after medication 1 course for the treatment of, sings and symptoms substantially disappear (Liao effect Zhi Shuo＞=90%).Produce effects: after medication 1 course for the treatment of, sings and symptoms obviously improves (90%〉therapeutic index 〉=60%).Effectively: after medication course for the treatment of, sings and symptoms is improved (60〉Liao effect Zhi Shuo＞=30%).Invalid: after medication 1 course for the treatment of, sings and symptoms is without obviously improving (therapeutic index＜30%).
Treatment effectiveness evaluation sees Table 1
Table 1
As can be seen from Table 1: of the present invention group all moistens the obviously raising of order spirit group on obvious effective rate, effective percentage, and inefficiency is starkly lower than profit order spirit group.
(2) after the treatment, the cross-reference of various indexs sees Table 2
Table 2
Table 2 result shows: the secretion of of the present invention group for the treatment of tears, breakup time of tear film and xerophthalmia shape moisten order spirit group all has in various degree improvement, particularly lacrimal secretion to improve especially obvious.Learn by statistics check, before and after two groups of treatments, comparing difference has statistical significance.
Specific embodiment (totally 21 examples)
Embodiment 1～19
Press weight proportion listed in table 3, according to conventional preparation method on pharmaceutics, embodiment 1～4 makes granule, and embodiment 5～9 makes tablet, and embodiment 10～13 makes pill, and embodiment 14～16 makes powder, and embodiment 17～19 makes capsule.
The unit of weight of each raw material in table 3 table: kilogram
Embodiment 20
Patient Li Feng, the women, 34 years old, be engaged in for a long time computer work, according to the diagnostic criteria of described xerophthalmia, get rid of other systemic diseases more than 8 hours every day, is diagnosed as xerophthalmia (left side).
After taking a course for the treatment of of the prepared tablet in treatment of the embodiment of the present invention 5 (8 week), all symptom and signs disappear substantially, the results are shown in following table 4 before and after treatment:
Table 4
Embodiment 21
Patient Wu Qinghong, the male, 45 years old, according to the diagnostic criteria of described xerophthalmia, get rid of other systemic diseases, be diagnosed as the bilateral xerophthalmia, cisco unity malfunction and life before patient treatment, dry and astringent, pain, do not stop paying out and do to be difficult to stand, the temper dysphoria that becomes scrapes the bottom of the barrel; The powder that the oral embodiment of the present invention 14 makes is treated after a course for the treatment of (8 week) symptom and is obviously alleviated, although dry and astringent symptom is often arranged, can alleviate and can stand by having a rest, and does not affect general life and mood.
The results are shown in following table 5 before and after treatment:
Table 5
Claims (3)
1. a Chinese medicine preparation for the treatment of xerophthalmia, is characterized in that raw material composition and the weight proportion of wherein making effective ingredient are: Radix Glycyrrhizae 6～10 Fructus Lycii 25～35 Flos Chrysanthemi 10～20 Radix Scrophulariae 10～20 Semen Cassiae 8～15 Radix Rehmanniae Preparata Radix Astragali 25～35 Herba Bidentis Bipinnatae 25～35 10～30 Radix Ophiopogonis 25～35.
2. a Chinese medicine preparation for the treatment of xerophthalmia, is characterized in that raw material composition and the weight proportion of wherein making effective ingredient are: Radix Glycyrrhizae 7～10 Fructus Lycii 28～32 Flos Chrysanthemi 12～16 Radix Scrophulariae 12～18 Semen Cassiae 10～14 Radix Rehmanniae Preparata Radix Astragali 26～33 Herba Bidentis Bipinnatae 27～34 15～28 Radix Ophiopogonis 26～32.
3. the Chinese medicine preparation for the treatment of xerophthalmia as claimed in claim 1, is characterized in that raw material composition and the weight proportion of wherein making effective ingredient are: the Radix Glycyrrhizae 8 Fructus Lycii 30 Flos Chrysanthemi 15 Radix Scrophulariae 15 Semen Cassiae 12 Radix Rehmanniae Preparata Radix Astragali 30 Herba Bidentis Bipinnatae 30 20 Radix Ophiopogonis 30.
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| CN2013100713979A CN103110810A (en) | 2013-03-06 | 2013-03-06 | Traditional Chinese medicine preparation for treating dry eye diseases |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027564A (en) * | 2014-06-03 | 2014-09-10 | 陈凯 | Traditional Chinese medicine composition eye drops for treating xerophthalmia |
| CN104324222A (en) * | 2014-11-27 | 2015-02-04 | 崔合芳 | Traditional Chinese medicine preparation for treating Qi and Yin deficiency type dry eye syndromes |
| CN104522227A (en) * | 2014-12-11 | 2015-04-22 | 青岛佰众化工技术有限公司 | Health tea and preparation method thereof |
| CN104906346A (en) * | 2015-06-05 | 2015-09-16 | 方淑芬 | Fixed external-use medicament for ophthalmology |
| CN104971304A (en) * | 2015-06-18 | 2015-10-14 | 钟海林 | Xerophthalmia treatment medicine |
| CN105055947A (en) * | 2015-08-04 | 2015-11-18 | 庄迎春 | Medicine for treating eye dryness |
| CN105194279A (en) * | 2014-06-26 | 2015-12-30 | 梁军 | Drug for treating dry eye syndrome |
| CN109620909A (en) * | 2018-10-08 | 2019-04-16 | 车丽萍 | Chinese medicine composition, Chinese medicine eye mask and its preparation and application |
-
2013
- 2013-03-06 CN CN2013100713979A patent/CN103110810A/en active Pending
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| 韦东 等: "润目舒口服液治疗绝经后期妇女干眼症疗效观察", 《中国中西医结合杂志》 * |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027564A (en) * | 2014-06-03 | 2014-09-10 | 陈凯 | Traditional Chinese medicine composition eye drops for treating xerophthalmia |
| CN105194279A (en) * | 2014-06-26 | 2015-12-30 | 梁军 | Drug for treating dry eye syndrome |
| CN104324222A (en) * | 2014-11-27 | 2015-02-04 | 崔合芳 | Traditional Chinese medicine preparation for treating Qi and Yin deficiency type dry eye syndromes |
| CN104522227A (en) * | 2014-12-11 | 2015-04-22 | 青岛佰众化工技术有限公司 | Health tea and preparation method thereof |
| CN104906346A (en) * | 2015-06-05 | 2015-09-16 | 方淑芬 | Fixed external-use medicament for ophthalmology |
| CN104971304A (en) * | 2015-06-18 | 2015-10-14 | 钟海林 | Xerophthalmia treatment medicine |
| CN105055947A (en) * | 2015-08-04 | 2015-11-18 | 庄迎春 | Medicine for treating eye dryness |
| CN109620909A (en) * | 2018-10-08 | 2019-04-16 | 车丽萍 | Chinese medicine composition, Chinese medicine eye mask and its preparation and application |
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Application publication date: 20130522 |