CN103110667A - Industrial production method for traditional Chinese prescription medicine - Google Patents
Industrial production method for traditional Chinese prescription medicine Download PDFInfo
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- CN103110667A CN103110667A CN2013100442303A CN201310044230A CN103110667A CN 103110667 A CN103110667 A CN 103110667A CN 2013100442303 A CN2013100442303 A CN 2013100442303A CN 201310044230 A CN201310044230 A CN 201310044230A CN 103110667 A CN103110667 A CN 103110667A
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Abstract
The invention relates to an industrial production method for a traditional Chinese prescription medicine, relates to a preparation method of the traditional Chinese medicine and in particular relates to the industrial production method for the traditional Chinese prescription medicine by a water-decocting process. The industrial production method comprises the following steps of: adding water to quantitative single primarily-selected traditional Chinese medicines for decocting for three times, wherein the decocting time is determined according to the medicine properties; combining the decoction liquids, concentrating and drying the decoction liquid under environment, wherein the decocting temperature, concentrating temperature and drying temperature are controlled to 100 DEG C to 115 DEG C; crushing the medicines under vacuum environment after drying, and packaging the finished product powder under the vacuum environment; calculating the mass conversation rate of the primarily-selected traditional Chinese medicines to the finished product powder; determining the amount by measuring the mass of the finished product powder corresponding to each single primarily-selected traditional Chinese medicine, mixing the medicines with the powder, and brewing the mixture by boiling water to obtain prescription medicine decoction. The traditional Chinese prescription medicine produced by the industrial production method disclosed by the invention can be used for optimally bringing the pharmaceutical effects of all medicines; and moreover, the treatment method after syndrome differentiation in the traditional Chinese medicine is adopted for treating the patient, so that the patient can conveniently take the traditional Chinese prescription medicine.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine, particularly the decocting cooking method industrialized preparing process of tcm prescription medicine.
Background technology
The traditional Chinese medical science is the traditional medicine of China, the general efficacy of a drug of its medication is comparatively gentle, can be at once to the health injury, side effect perhaps appears, because toxicity occurs small, reaction is less comparatively speaking, therefore can play opsonic action to health integral body, has very large advantage for some chronic disease functional disease Chinese medicines.Treatment by Chinese herbs be individual symptom, therefore dialectical the treating of health that it is concrete according to everyone can be promoted human health level, disease preventing and treating, day by day is subject to the whole world and payes attention to.But the patient leaves prescription after the traditional Chinese medical science is seen a doctor diagnosis, through Chinese medicine pharmacy, according to dosage makes up a prescription, and claims to prepare the prescription prescription by medicine, then decocts, and decoction process is very loaded down with trivial details, brings very big inconvenience to the need patient who takes traditional Chinese medicine that registers the department of Chinese medicine; Press traditional decoction Chinese medicine method, the concentration of every pair of Chinese medicine can weaken gradually, can't keep each middle concentration, and is also just larger on the curative effect impact; Every kind of different medical material has its rational decocting time, and traditional method decocts all medical materials together, the drug effect of all medicines can not be performed to the best; The decocting time of Chinese medicine is longer, and is inconvenient to rescuing various critical patients.
In order to utilize well the Chinese herbal medicine of China, a lot of research departments and enterprise have taked research and the extraction (i.e. " Chinese medicine westernization ") to Chinese herbal medicine effective ingredients, although the therapeutic effect to part population is good, but still it is confined to doctor trained in Western medicine " point " treated, with strong points, can not be suitable for most of crowds.
The prescription drugs such as pill, tablet of a lot of Chinese medicines is also arranged on market, also all well and good to some its effects, but it only is suitable for some too, does not treat for concrete people is dialectical, so therapeutic effect is still undesirable.
Summary of the invention
The industrialized preparing process that the purpose of this invention is to provide a kind of tcm prescription medicine, the medicine that the method is produced can perform to the best with the drug effect of all medicines, and can keep the dialectical method that treats of Traditional Chinese Medicine that the patient is treated, patient's taking convenience.
Realize that the technical scheme that purpose of the present invention is taked is: quantitative various single primary election Chinese crude drugs are added respectively water, decoct 3 times, decocting time is decided according to the property of medicine, merge decoction liquor, vacuum concentration, vacuum drying decocts, concentrates and dry temperature is controlled at 100～115 ℃, dry final vacuum is pulverized, vacuum packaging finished product powder; Calculate the quality conversion ratio of primary election Chinese crude drug and finished product powder; Measuring and calculating by each finished product powder quality corresponding to various single primary election Chinese crude drug compatibility prescriptions is quantitative, mixes, and brews into the prescription drugs decoction with boiled water.
Require the first lower Chinese medicine that decocts for the traditional Chinese medical science, decocting time be 90～120 minutes once, temperature is controlled at 100～115 ℃, decocts altogether merging filtrate three times, entering triple effect falling liquid film continuous feed concentrator concentrates, temperature still is controlled at 100～115 ℃, then enters the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Fragrant volatility Chinese medicine under after require decocting for the traditional Chinese medical science, decocting time be 40～50 minutes once, temperature is controlled at 98～100 ℃, decoct altogether 3 times, merging filtrate enters Three-effect concentration device, adopt the evaporation mode of negative pressure external heating natural circulation type to concentrate, simmer down to
Body of paste, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Heat-sensitive substance Chinese medicine for the traditional Chinese medical science, decocting time is 30～35 minutes for the first time, 2nd, 3 decocting times are 38～45 minutes, temperature is controlled at 98～100 ℃, and merging filtrate carries out vacuum-concentrcted, then enter band-type vacuum drier and make the contact vacuum drying of continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
The Chinese medicine with pastel for the traditional Chinese medical science, adopt counter-current or circulation method to decoct during decoction, each decocting time is 55～65 minutes, decocts altogether 3 times, and temperature is controlled at 98～100 ℃, merging filtrate, enter vacuum concentrator, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Need the poisonous or hypertoxic Chinese medicine of special prescription for the traditional Chinese medical science, decoct and adopt Decocting pot to add boiling water, decoct altogether 2～3 times, decocted 3～3.5 hours at every turn, temperature is controlled at 100～115 ℃; Merging filtrate, filtrate concentrates, and then enters the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enters the vacuum pulverizer, is ground into
80～100 ordersFinished product powder.
Glue class Chinese medicine for the need molten of the traditional Chinese medical science directly enters with medical material the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, and when dry, temperature is controlled between 45～50 ℃, enters the vacuum pulverizer after drying, is ground into
80～100 ordersFinished product powder.
For the nourishing class precious Chinese medicine of the traditional Chinese medical science, the plant precious Chinese medicine is directly dried at 45～60 ℃, and the animal precious Chinese medicine is directly dried at 45～50 ℃, enters the vacuum pulverizer after drying, is ground into
80～100 ordersFinished product powder.
For above-mentioned various low aqueous solubility Chinese medicines, at first decoct with water 13～18 minutes with rice or red rice, filter and obtain rice water, through vacuum concentration, vacuum drying, vacuum is pulverized and is obtained dry diluent; Then Chinese medicine after the method for correspondence decocts, concentrates, the dry diluent that adds vacuum to pulverize in former the concentrated liquid of tradition Chinese medicine, then the drying pulverizing is
80～100 ordersFinished product powder; The dry diluent of rice is used for being added to Chinese medicine for oral administration liquid, and the dry diluent of red rice is used for being added to external application Chinese medicine liquid.
Useful technique effect of the present invention is: various single medical materials carry out preparation of industrialization according to the decocting method of Chinese medicine, the best that can better control accurately various medicines decocts and concentrates condition, make the drug effect of various medicines perform to the best, kept simultaneously the decoction method of Chinese medicine, drug effect has not been made a difference; Various single medical materials decoct makes powdery, by the concrete prescription of the traditional Chinese medical science, various medicines is brewed into medicinal liquid more at last, can keep the treatment marrow of China's traditional Chinese medical science---dialectical treating; The various Chinese medicines of powdery make patient's taking convenience, also are conducive to rescue various critical patients.
The specific embodiment
Embodiment 1: require the first lower Chinese medicinal preparation method that decocts for the traditional Chinese medical science.as: Concha Haliotidis, Concha Ostreae, Concha Meretricis Seu Cyclinae, Cornu Cervi, this class Chinese crude drug such as Magnetitum, its quality is hard, internal density is large, tightly, if decocting time is short, temperature is low, effective ingredient is difficult to fried, so its decocting time be 90～120 minutes once, temperature is controlled at 100～115 ℃, decoct altogether three times, merging filtrate, entering triple effect falling liquid film continuous feed concentrator concentrates, temperature still is controlled at 100～115 ℃, then enter band-type vacuum drier and do continuous feed, the contact vacuum drying of continuous discharge form, after drying, enter the vacuum pulverizer, be ground into 80～100 purpose finished product powders.
Embodiment 2: the fragrant volatility Chinese medicinal preparation method under after requiring to decoct for the traditional Chinese medical science.As: the medicines such as Herba Menthae, Bulbus Allii Fistulosi, Fructus Galangae, Fructus Amomi, Rhizoma Acori Graminei, long when decocting time, during excess Temperature, easily the effective ingredient volatilization is destroyed.So decocting time be 40～50 minutes once, temperature is controlled at 98～100 ℃, decocts altogether 3 times, merging filtrate enters Three-effect concentration device, adopts the evaporation mode of negative pressure external heating natural circulation type to concentrate, simmer down to
Body of paste, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Embodiment 3: for the heat-sensitive substance Chinese medicinal preparation method of the traditional Chinese medical science.As Ramulus Uncariae cum Uncis, Radix Et Rhizoma Rhei etc., being heated easily loses the effective ingredient material afterwards, when decocting, should be except controlling decocting time well, and also to correctly control the decoction temperature well.So decocting time is 30～35 minutes for the first time, 2nd, 3 decocting times are 38～45 minutes, temperature is controlled at 98～100 ℃, merging filtrate, carry out vacuum-concentrcted, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Embodiment 4: for the Chinese medicinal preparation method with pastel of the traditional Chinese medical science.All belong to this type of Chinese medicine as Flos Inulae, Folium Eriobotryae, Semen Plantaginis, Talcum, LIUYI SAN, Pollen Typhae etc., in decoction process, easily form " pastel " or " sticking thing ".Adopt counter-current or circulation method to decoct during decoction, each decocting time is 55～65 minutes, decoct altogether 3 times, temperature is controlled at 98～100 ℃, and merging filtrate enters vacuum concentrator, then enter band-type vacuum drier and make the contact vacuum drying of continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
Embodiment 5: the poisonous or hypertoxic Chinese medicinal preparation method that needs special prescription for the traditional Chinese medical science.Contain poisonous alkaloidal medicine as Radix Aconiti Lateralis Preparata, Flos Daturae, Semen Strychni etc., need long-time the decoction could reduce its toxicity.Adopt Decocting pot to add boiling water so decoct, decoct altogether 2～3 times, decocted 3～3.5 hours at every turn, temperature is controlled at 100～115 ℃; Merging filtrate, filtrate concentrates, and then enters the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enters the vacuum pulverizer, is ground into
80～100 ordersFinished product powder.
Embodiment 6: for the glue class Chinese medicinal preparation method of the need molten of the traditional Chinese medical science.As: Colla Corii Asini, Colla Plastri Testudinis, Colla carapax Trionycis, ERXIANJIAO etc., this class Chinese medicine major part is come as for animal, becomes glue class Animal Medicine through extraction, is used for various compatibilities prescription Chinese medicines and uses.So directly the medical material that cooks is entered the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, when dry, temperature is controlled between 45～50 ℃, enters the vacuum pulverizer after drying, is ground into
80～100 ordersFinished product powder.
Embodiment 7: for the nourishing class precious Chinese medicine preparation method of the traditional Chinese medical science.As Radix Notoginseng, Rhizoma Gastrodiae, Radix Ginseng, Radix Panacis Quinquefolii, Moschus, Cornu Cervi Pantotrichum etc., this class medicine should all be taken.So the plant precious Chinese medicine is directly dried at 45～60 ℃, the animal precious Chinese medicine is directly dried at 45～50 ℃, enters the vacuum pulverizer after drying, is ground into
80～100 ordersFinished product powder.
Embodiment 8: be low aqueous solubility Chinese medicine for part is arranged in above-described embodiment 1～5, as succinum, Carapax Eretmochelydis, Pumex, Haematitum, Calamina etc., the medicinal decocting of this class boils and also is difficult to see for a long time stripping material, but very important again in drug matching, need to just can carry out compatibility to human body without the carrier of property of medicine effect and use with a kind of.So at first decoct with water 13～18 minutes with rice or red rice, filter and obtain rice water, through vacuum concentration, vacuum drying, vacuum is pulverized and is obtained dry diluent; Then Chinese medicine after the method for correspondence decocts, concentrates, the dry diluent that adds vacuum to pulverize in former the concentrated liquid of tradition Chinese medicine, then the drying pulverizing is
80～100 ordersFinished product powder; The dry diluent of rice is used for being added to Chinese medicine for oral administration liquid, and the dry diluent of red rice is used for being added to external application Chinese medicine liquid.
Annotate: in the production process of above-described embodiment 1～7, produce extractum sugary and that starch is higher if run into, after about 60 ℃ difference dryings, mixture is pulverized, cross 40～60 mesh sieves and get final product; Part Chinese medicine is resinous, phlegmatic temperament is higher if run into, and can add 95% a small amount of ethanol, grinds altogether evenly rear drying with extractum to be.
Claims (9)
1. the industrialized preparing process of a tcm prescription medicine, it is characterized in that: quantitative various single primary election Chinese crude drugs are added respectively water, decoct 3 times, decocting time is decided according to the property of medicine, merges decoction liquor, vacuum concentration, vacuum drying, decoct, concentrated and dry temperature is controlled at 100～115 ℃, dry final vacuum is pulverized, vacuum packaging finished product powder; Calculate the quality conversion ratio of primary election Chinese crude drug and finished product powder; Measuring and calculating by each finished product powder quality corresponding to various single primary election Chinese crude drug compatibility prescriptions is quantitative, mixes, and brews into the prescription drugs decoction with boiled water.
2. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: require the first lower Chinese medicine that decocts for the traditional Chinese medical science, decocting time be 90～120 minutes once, temperature is controlled at 100～115 ℃, decoct altogether three times, merging filtrate enters triple effect falling liquid film continuous feed concentrator and concentrates, and temperature still is controlled at 100～115 ℃, then enter band-type vacuum drier and make the contact vacuum drying of continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
3. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: the fragrant volatility Chinese medicine under after requiring to decoct for the traditional Chinese medical science, decocting time be 40～50 minutes once, temperature is controlled at 98～100 ℃, decoct altogether 3 times, merging filtrate enters Three-effect concentration device, adopt the evaporation mode of negative pressure external heating natural circulation type to concentrate, simmer down to
Body of paste, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
4. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: for the heat-sensitive substance Chinese medicine of the traditional Chinese medical science, decocting time is 30～35 minutes for the first time, and the 2nd, 3 time decocting time is 38～45 minutes, and temperature is controlled at 98～100 ℃, merging filtrate, carry out vacuum-concentrcted, then enter the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
5. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: for the Chinese medicine with pastel of the traditional Chinese medical science, adopt counter-current or circulation method to decoct during decoction, each decocting time is 55～65 minutes, decoct altogether 3 times, temperature is controlled at 98～100 ℃, and merging filtrate enters vacuum concentrator, then enter band-type vacuum drier and make the contact vacuum drying of continuous feed, continuous discharge form, after drying, enter the vacuum pulverizer, be ground into
80～100 ordersFinished product powder.
6. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: for the poisonous or hypertoxic Chinese medicine that the traditional Chinese medical science need be write out a prescription, decoct and adopt Decocting pot to add boiling water, decoct altogether 2～3 times, the each decoction 3～3.5 hours, temperature is controlled at 100～115 ℃; Merging filtrate, filtrate concentrates, and then enters the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, after drying, enters the vacuum pulverizer, is ground into
80～100 ordersFinished product powder.
7. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: for the glue class Chinese medicine of the need molten of the traditional Chinese medical science, directly medical material is entered the contact vacuum drying that band-type vacuum drier is made continuous feed, continuous discharge form, when dry, temperature is controlled between 45～50 ℃, enter the vacuum pulverizer after drying, be ground into
80～100 ordersFinished product powder.
8. press the industrialized preparing process of tcm prescription medicine claimed in claim 1, it is characterized in that: for the nourishing class precious Chinese medicine of the traditional Chinese medical science, the plant precious Chinese medicine is directly dried at 45～60 ℃, and the animal precious Chinese medicine is directly dried at 45～50 ℃, enter the vacuum pulverizer after drying, be ground into
80～100 ordersFinished product powder.
9. by the industrialized preparing process of claim 2,3,4,5 or 6 described tcm prescription medicines, it is characterized in that: for low aqueous solubility Chinese medicine, at first decoct with water 13～18 minutes with rice or red rice, filtration obtains rice water, through vacuum concentration, vacuum drying, vacuum is pulverized and is obtained dry diluent; Then Chinese medicine after the method for correspondence decocts, concentrates, the dry diluent that adds vacuum to pulverize in former the concentrated liquid of tradition Chinese medicine, then the drying pulverizing is
80～100 ordersFinished product powder; The dry diluent of rice is used for being added to Chinese medicine for oral administration liquid, and the dry diluent of red rice is used for being added to external application Chinese medicine liquid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822697A (en) * | 2009-07-13 | 2010-09-08 | 湖南省中医药研究院 | Preparation method of traditional Chinese medicine ultrafine formula particles |
| CN102327302A (en) * | 2011-09-30 | 2012-01-25 | 江西省药物研究所 | Ilex pubescens formula granules and preparation method thereof |
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2013
- 2013-02-05 CN CN2013100442303A patent/CN103110667A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822697A (en) * | 2009-07-13 | 2010-09-08 | 湖南省中医药研究院 | Preparation method of traditional Chinese medicine ultrafine formula particles |
| CN102327302A (en) * | 2011-09-30 | 2012-01-25 | 江西省药物研究所 | Ilex pubescens formula granules and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘昕: "睛复明冲剂制备工艺研究", 《江西中医学院学报》 * |
| 谢若男: "中药特殊煎法改进初探", 《中药材》 * |
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Application publication date: 20130522 |