CN103110108B - Health-care food with effects of improving eyesight and reinforcing intelligence - Google Patents
Health-care food with effects of improving eyesight and reinforcing intelligence Download PDFInfo
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- CN103110108B CN103110108B CN201310071534.9A CN201310071534A CN103110108B CN 103110108 B CN103110108 B CN 103110108B CN 201310071534 A CN201310071534 A CN 201310071534A CN 103110108 B CN103110108 B CN 103110108B
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Abstract
The invention discloses a health-care food with effects of improving eyesight and reinforcing intelligence, and belongs to the technical field of health-care foods. The health-care food comprises the following raw materials in parts by weight: 100-600 parts of a needle mushroom extract, 150-500 parts of a Europe blueberry extract, 80-260 parts of a ginkgo leaf extract, 100-400 parts of soyabean lecithin, 50-200 parts of taurine, 80-400 parts of DHA, 0.5-5 parts of VB1, 0.5-5 parts of VB2, 5-20 parts of VB3, 0.25-0.8 part of VA and 5-80 parts of VE. The raw materials are organically combined, so that various different effect components are fused into a product, and the components are matched and coordinated; nutrition is complemented and organisms are conditioned in a systematical and comprehensive manner; and the health-care effects of realizing two functions of improving the memory and relieving the eyesight fatigue are achieved.
Description
Technical field
The present invention relates to a kind of health food with eyesight-improving intelligence-developing effect, belong to health food technology field.
Background technology
1, being losing one's memory of the elderly: cerebral function decline is the principal element of middle-aged and old failure of memorys: people enters person in middle and old age after the stage, often there are cerebral arteriovenous malformation in various degree, the phenomenon that lumen of vessels narrows down, and with advancing age, lipid components content in blood increases gradually, blood viscosity increases, all make VPV slow down, the corresponding minimizing of CBF, cause and remember relevant position blood and oxygen long run supply deficiency, thereby impel nerve cell shrinkage, sex change, cause failure of memory; Simultaneously along with the increase at age, DHA(DHA in brain) content declines gradually, and the quantity of brain cell number and nerve synapse constantly reduces, and speed and Quality Down that between nerve, information is transmitted, also caused going down of memory.
2, adolescent student decrease of memory: main task of adolescence is learnt exactly.Student's learning tasks are heavy, and good memory seems that to them particular importance, some students envy that others has good memory, and for own poor memory produces worry, is even absorbed in and feels oneself inferior simultaneously very much.The power of memory is not born in fact, although have certain relation with heredity, this is not far a crucial factor, and crucial or some self factor has caused some shortcoming of memory, for example, and psychological regulation scarce capacity, subalimentation etc.
3, eye fatigue: advanced information society, healthy eyes are more and more important for people.Because most information all will be obtained by eyes, but meanwhile, watch for a long time computer, TV attentively, ignore the bad habits such as eye hygiene, all easily cause visual fatigue and visual impairment, make near-sighted number constantly increase, the generation age of presbyopic is rejuvenation trend.Asthenopic common manifestation is that eye is tired, occurs that eyes are scorching hot, itches, is dried, the discomfort such as distending pain, blurred vision.If asthenopic situation is frequent, can make the blurring of image, eyes premature aging.The modern life, information huge explosion brings white elephant to eyes.All eye problems such as visual fatigue, visual impairment, for people's good life has been coverd with one deck haze.
For above-mentioned two class body health problems, at present, on market, product mostly can only be in two health problems plays a role aspect single.For improving memory, mostly select that to be rich in the fish oil of DHA or to have the rhodiola root that improves body hypoxia-bearing and antifatigue effect be raw material; And for asthenopic recovery, the nutraceutical that improves visual function is used the raw materials such as Bilberry fruit P.E, lutein mostly.
The present invention overcomes prior art deficiency, by nutraceutical and vitamin, combines, and provides a kind of eyesight-improving intelligence-developing effect that has, i.e. the health food of auxiliary improvement of memory and the difunctional effect of remitting vision fatigue.
Summary of the invention
The invention provides a kind of health food with eyesight-improving intelligence-developing effect, there is the difunctional effect of auxiliary improvement of memory and remitting vision fatigue.According to the relation between body health and nutrition,, physiology of science in conjunction with modern disease and pharmacological research, combine together mutually, unique formula Design being undertaken by supporting, adjust, treat the mechanism of action that combines together of setting up.
Described a kind of health food with eyesight-improving intelligence-developing effect, the raw material that contains following weight proportion:
Gold needle mushroom extract 100-600 part, European blueberry extract 150-500 part, ginkgo biloba p.e 80-260 part, soybean lecithin 100-400 part, taurine 50-200 part, DHA80-400 part, VB
10.5-5 part, VB
20.5-5 part, VB
35-20 part, VA0.25-0.8 part, VE5-80 part.
Described health food preferably contains the raw material of following weight proportion:
Gold needle mushroom extract 200-500 part, European blueberry extract 250-400 part, ginkgo biloba p.e 140-240 part, soybean lecithin 150-300 part, taurine 70-150 part, DHA180-300 part, VB
11-4 part, VB
21-4 part, VB
37-18 part, VA0.3-0.8 part, VE20-50 part;
Described health food further preferably contains the raw material of following weight proportion:
Gold needle mushroom extract 250-400 part, European blueberry extract 275-350 part, ginkgo biloba p.e 160-220 part, soybean lecithin 175-250 part, taurine 90-120 part, DHA200-260 part, VB
11-3 part, VB
21-3 part, VB
310-15 part, VA0.3-0.8 part, VE15-30 part.
Described DHA is preferably Ω-3DHA microcapsules freeze-dried powder of content 10%.
Described health food can add appropriate dolomol, pre-gelatinized starch if desired; As dolomol 3-8 part, pre-gelatinized starch 100-500 part.
Described part is the unit of weights such as g, kg, ton.
Health food of the present invention can adopt present routine techniques to make tablet, pulvis, capsule, granule or oral liquid etc.
" gold needle mushroom extract, European blueberry extract, ginkgo biloba p.e, can outsourcing finished product, also can prepare voluntarily for described raw material.
Preparation method is voluntarily, and take respectively asparagus, European blueberry and ginkgo leaf is raw material, adopts the method for water extract-alcohol precipitation to extract its contained effective ingredient, is prepared into corresponding extract; Concrete technology is as follows:
Raw material → raw material screening (removing external foreign matter and impurity) → raw material is pulverized collect → screening of be dried → dry powder of concentrated (the Vacuum Concentration) → ethanol precipitation of (10 order) → extraction with aqueous solution (decocting boils, material-water ratio example 1 ﹕ 3) → centrifugal filtration → filtered fluid (75% ethanol) → centrifugal filtration (ethanol recovery) → medicinal extract → hot water dissolving (80 ℃) → resin adsorption (removal heavy metal) → spraying (40 order) → extract.
Gold needle mushroom extract
Asparagus formal name used at school hair handle money bacterium, claims again the little fiery mushroom of hair handle, plain mushroom, golden mushroom, intelligence mushroom etc.Zinc content is higher, has the effect that promotes children ' s intelligence development and brain tonic.
1, asparagus contains more full essential amino acid composition, and wherein lysine and arginine content are especially abundant, and zinc content is higher, to increasing intelligence, especially children's height and intelligence development is had to good effect, and person " increases intelligence mushroom ";
2, in asparagus, also contain a kind of material that is Flammulin, have and strengthen the resist ability of body to cancer cell, often eating asparagus can also norcholesterol, and prevention of liver disease and intestines and stomach ulcer, strengthen body healthy tendency, illness prevention and fitness;
3, asparagus can strengthen the biologically active of body effectively, promotes body intracellular metabolic, is conducive to absorption and the utilization of various nutrients in food, also benefits, thereby have the laudatory title of " increasing intelligence mushroom ", " stops mushroom " to growing;
4, asparagus can suppress blood fat rising, reduces cholesterol, control cardiovascular and cerebrovascular disease;
5, edible asparagus has resisting fatigue, anti-inflammation, removing heavy metal salt material, antineoplastic action.
Europe blueberry extract
Blueberry contains a large amount of anthocyanidin, and abundant VitAVitE, carotenoid, dietary fiber, potassium and zinc.In 40 kinds of vegetables and fruit with anti-oxidant effect, the anthocyanidin content of blueberry ranks the first, and, the special dietary compositions such as the contained anthocyanidin of blueberry, organic germanium, Organic Selenium, Arbutin, amino acid, tartaric acid are that any plant is all incomparable, especially the anthocyanidin being comprised of 16 kinds of bioflavonoids, has the physiologically active more superior than general Anthocyanin.According to the U.S., Japan, the scholar of European Section research, often edible blueberry goods, can strengthen eyesight significantly, anti-eye strain, and skin nutrition, delays cranial nerve aging.
1, protection eyes, strengthen eyesight.Anthocyanidin in blueberry can promote the regeneration of visual purple in retina cell, can prevent laser high myopia and detached retina, and can promote eyesight.
2, strengthen autoimmunity, slow down the mankind's aging.Free radical can produce in many environment, and worsens in human body, causes various associated diseases, and blueberry anthocyanin is the most effective antioxidant, can resist and eliminate free radical.By removing free radical, reduce the infringement of oxygen radical cell membrane, DNA and other cell component, dysfunction in prevention body, strengthens people's self immune disease-resistance ability, delays the aging of body.
3, strengthen memory.Blueberry has high antioxidant in all vegetables and fruits can be promoted mental and reduce Alzheimer degenerative brain disorder etc., the dietary requirement anthocyanidin of science, and this contributes to delay senility, if select anthocyanidin, blueberry is important selection.It has the functional disturbance of preventing, improve short-term memory, improve the effects such as the elderly's balance and harmony.
Ginkgo biloba p.e
Total Ginkgo Flavone-Glycoides content >=24.0% in ginkgo biloba p.e; GINKGO BILOBA EXTRACT has powerful anti-oxidant and free radical ability; there is the cerebrovascular of increasing flow, reduce cerebral vascular resistance, improve cerebrovascular circulatory function; protection brain cell; avoid ischemic damage, coronary artery dilator, prevents angina pectoris and miocardial infarction; suppress platelet aggregation, prevent the functions such as thrombosis.
1, promote circulation: ginkgo biloba p.e can promote the circulation of brain and health limbs simultaneously.
2, antioxidation: ginkgo biloba p.e can be at brain, can bring into play anti-oxidation characteristics in eyeball retina and cardiovascular system.Its antioxidation in brain and central nervous system may contribute to prevent that the cerebral function causing because of the age from declining.
3, anti-senescence function: ginkgo biloba p.e can promote cerebral blood flow and nervous system is had to fabulous tonic effect.The effect that hundreds of scientific researches that comprise patients up to ten thousand have confirmed ginkgo biloba p.e is to comprising the effect of problems of the not enough and gerontal patient's of brain blood flow intelelectual deterioration.
4, prevent retinal damage: the flavonoids in ginkgo can stop or alleviating some PVR.
Soybean lecithin
Phosphatide is the basis of human body cell (cell membrane, nuclear membrane, plastid film), and the merits such as nerve, reproduction, hormone are had to important relationship, has very high nutritive value and medical value.
1, deferring senility: the cell membrane of human body cell mainly consists of lecithin, human body supplements lecithin can repair the cell membrane being damaged, and increases the degree of unsaturation of the aliphatic acid of cell membrane, improves the function of film, makes its softening and rejuvenation; So just improved the metabolic capability of human body, the power of regeneration of self-healing ability and body tissue, thereby strengthen the vitality of human body integral, the fundamentally aging of delaying human body, the diseases such as exercise not harmony that human senility is caused have the improvement of suitable high level, the health, youth and the vigor that keep the mankind.
2, regulate blood fat, reduce cholesterol: causing that arteriosclerotic cholesterol is the waxy substance of fatty, if the too high richness of cholesterol level is amassed on arterial wall, will have a strong impact on blood circulation, is the main cause that causes the heart, cerebrovascular disease; Lecithin has the effect of remarkable reduction cholesterol, triglycerides, low-density lipoprotein, and this is mainly because the emulsification of lecithin has affected cholesterol and fatty transportation and deposition, and can remove superfluous triglycerides.Therefore, soybean lecithin can effectively reduce too high blood fat and cholesterol, and then control is because of its cardiovascular and cerebrovascular disease causing.
3, strengthening brain function, strengthen memory: to account for the 17%-20% " acetylcholine " of its quality be IC a kind of Information Conduction material to the content of lecithin in cranial nerve cell, " choline " is the basis of soybean lecithin, the ample supply of lecithin synthesizes " acetylcholine " by " acetyl " that ensures in sufficient choline and human body, thereby for human brain provides sufficient Information Conduction material, and then the activate degree of raising brain cell, improve memory and intellectual level.Phosphatide has the eugonic effect of the nerve cell of making internal structure simultaneously.
Taurine
Taurine, as a kind of nutrient of high-quality, has several functions to health.Wherein, related to the present invention acting as
1, improve the function of memory: taurine is one of free amino acid that in nervous system, content is maximum, quite abundant at the content of the region taurines such as animal brain cortex, cerebellum and olfactory bulb.It can obviously promote neural growing and cell proliferation, differentiation, and is dose dependent, in cranial nerve cell growth course, plays an important role.In the animal experiment study of taurine and brain growth relation, find, taurine can promote the learning and m emaory of big white mouse.Supplement appropriate taurine and not only can improve learning and memory speed, but also can improve the accuracy of learning and memory, and to the neural anti-ageing certain effect that also has.
2, improve nerve conduction and visual function: taurine is the highest amino acid of content in retina, safeguarding on amphiblestroid 26S Proteasome Structure and Function to there is important function.While lacking taurine in retina, can cause photoreceptor structural damage, cause serious dysopia.The reports such as Hayes in 1975, if lack taurine in the feed of cat, can cause its retinosis, and long-term lacking, eventually to blind.Why cat and night flight or navigation cat owl will prey on mouse, and its main cause is that mouse body contains abundant taurine, and many foods can keep its sharp keen vision.If infant lacks taurine, can there is retinal function disorder.The patient of long-term PN solution, if there is no taurine in transfusion, can make patient's retina map of current change, and only has heavy dose of taurine of supplementing could correct this variation.
DHA
DHA, DHA, is commonly called as docosapentaenoic acid, is a kind of to the very important polyunsaturated fatty acid of human body, belongs to the important member in Omega-3 unrighted acid family.DHA is a kind of essential element that nervous system cell is grown and maintained, and is brain and amphiblestroid important composition composition, and in human brain cortex, content is up to 20%, and in eye retina, proportion is maximum, accounts for 50%.
Man memory, thinking ability depend on the function of the nerve fibers such as brain cell that control information transmits, cynapse, i.e. transmission scope, direction and the effect of information in nervous system.DHA accounts for 25% of its fat content in nerve fiber, and cynapse is the key position that control information is transmitted, and synaptic membrane and gap, consists of, and DHA contributes to its structural integrity, Function.
1, promote the growth of brain cell: in cerebral cortex, DHA is the Main Ingredients and Appearance of nerve conduction cell, also be the film formed Main Ingredients and Appearance of cell, most DHA can not digested by gastric juice, and directly enter blood, by organs such as liver or brains, absorbed, and EPA and linolenic acid are not absorbed, main cause is because DHA can enter brain cell via blood-brain barrier, and be both the EPA and the linolenic acid that belong to unrighted acid, cannot by brain, be absorbed by blood-brain barrier.
2, improve old man's dementia: due to advancing age, the DHA in brain will reduce gradually, that is to say the degeneration that easily causes brain function.In fact, brain cell can constantly be grown up before two to three years old, after growing to manhood, can reduce gradually, according to investigation, in the time of 20 to 30 years old, brain cell can reduce gradually with the ratio of 100,000, even so, DHA still has the strength that makes remaining brain cell activate, improves fully memory and learning ability.
3, promote the maturation of retina light sensation cell: DHA not only has material impact to brain development, and the maturation of retina light sensation cell is played an important role.
B family vitamin
B family vitamin is push body intracellular metabolite, indispensable material when sugar, fat, protein etc. are changed into heat.If lack Cobastab, cell function reduces at once, causes dysbolism, and at this moment human body there will be idle stagnant and poor appetite.
1, Cobastab
1: VB
1, be called as psychogenic vitamin, be that sugar decomposition is converted into the indispensable vitamin of heat energy.Be the important substance that maintains and participate in the cell functions such as optic nerve and metabolism, thereby can cause optic nerve during shortage and eyeball is dry and astringent affects one's power of vision.
2, Cobastab
2: VB
2, participate in biological oxidation and energetic supersession in body, relevant with the metabolism of carbohydrate, protein, nucleic acid and fat, can improve the utilization rate of human body to protein, enhancing development, safeguards the integrality of skin and cell membrane.The growth metabolism that participates in cell is the necessary nutrient of injected organism tissue metabolism and reparation.Be the important substance of protection eyelid, conjunctive bulbi and cornea, during shortage, can cause eye-blurred, photophobia, conjunctival congestion, eyelid inflammation etc.
3, Cobastab
3: VB
3, also referred to as nicotinic acid or nicotinic acid.The normal function that can maintain skin and digestive system, stimulates circulation, and can also make human body utilize fully food to increase energy.These product have stronger expansion peripheral vessels effect, clinical headache, antimigraine, tinnitus, the auditory vertigo etc. of being used for the treatment of.Nicotinic acid deficiency can cause bark favus, occurs losing weight, tired weak, the symptoms such as poor memory, insomnia.
Vitamin A (VA)
Vitamin A is general cellular metabolism and the requisite important component of subcellular structure, has enhancing development, safeguards bone, the effect of dental health and normal sense of smell.Protecting all part tissue of eye (eye has a lot of epithelial tissues), is the raw material that forms photoactive substance in cellula visualis.Main Function in the present invention is
1, maintain normal vision function: the photoreceptor of eye is rhabdocyte and the cone cell in retina.These two kinds of cells all have photopigment, feel the rhodopsin of the low light level and the visual violet of sense high light.Rhodopsin and visual violet are all to consist of opsin and retinene.Vitamin A claims again retinol (its aldehyde derivatives retinene), is to form the constituent of experiencing the rhodopsin of the low light level in cellula visualis.
2, safeguard the synthetic of the health of Epithelial cell and Promote immunity globulin: what vitamin A can involved in sugar albumen is synthetic, this normal formation for epithelium, grow and remain very important.Immunoglobulin (Ig) is a kind of glycoprotein, so vitamin A can promote the synthetic of this albumen, for body's immunity, has material impact, and during shortage, cellular immunity presents decline.
3, vitamin A can strengthen the judgment of brain.
Vitamin E (VE)
Vitamin E is a kind of liposoluble vitamin, claims again tocopherol, is one of topmost antioxidant.Main Function in the present invention is
1, vitamin E can suppress the lipid peroxidation reaction in eye lens, makes slightly blood vessel dilatation of end, improves blood circulation, and pre-myopia prevention occurs and development.
2. vitamin E can suppress decline and the necrosis of aliphatic acid cell in brain effectively, and protection brain makes it avoid free radical and attacks, and prevents that radical pair is in neuronic damage.
Advantage of the present invention
1, guarantee human body energy supply, reduce and eliminate the fatigue of brain and eyes.B family vitamin can promote glycometabolism, fat metabolism and protein metabolism, to guarantee the Power supply of brain and eyes, is conducive to eliminate burnout, fatigue, accelerate brain reaction, maintain nerve information transmission.
2, reduce cellular oxidation, maintain the vigor of brain and eyes.Europe blueberry is rich in anthocyanidin, and anthocyanidin can effectively suppress decline and the necrosis of aliphatic acid cell in brain with mutually auxiliary the multiplying each other of vitamin E, reduces or elimination radical pair optic cell and amphiblestroid damage.
3, provide for nutrition, promote the recovery of damaging cells.
(1) in soybean lecithin, be rich in lecithin, in cranial nerve cell, the content of lecithin accounts for 17%～20% of its quality, " choline " is the basis of soybean lecithin, the ample supply of lecithin guarantees that " acetyl " in sufficient " choline " and human body synthesizes " acetylcholine ", " acetylcholine " is IC a kind of Information Conduction material, thereby improve the activate degree of brain cell, improve memory and intellectual level.
(2) DHA is brain and amphiblestroid important composition composition, and in human brain cortex, content is up to 20%, and in eye retina, proportion is maximum, accounts for 50%.
(3) in asparagus, be rich in zinc, zinc is the synthetic essential material of Brain protein SYNUCLEINS and nucleic acid, is the constituent of retinol reductase in retinal tissue cell.
(4) taurine is one of free amino acid that in nervous system, content is maximum, and it can obviously promote neural growing and cell proliferation, differentiation, and is dose dependent, in cranial nerve cell growth course, plays an important role; Taurine is also the highest amino acid of content in retina, is safeguarding on amphiblestroid 26S Proteasome Structure and Function to have important function.
4, the present invention is by organically combining above raw material, multiple different efficacies composition is incorporated in product, these compositions cooperatively interact, synergy, system is nutrition cerebral nerve and optic cell, conditioning engine body function all sidedly, promote functional rehabilitation tired or damage organ, reach the health-care effect of auxiliary improvement of memory and remitting vision fatigue dual-use function.
The specific embodiment
Embodiment 1
The health food with eyesight-improving intelligence-developing effect, selects 100 parts of gold needle mushroom extracts, 150 parts of European blueberry extracts, 80 parts of ginkgo biloba p.es, 400 parts of soybean lecithins, 200 parts of taurines, DHA80 part, VB
10.5 part, VB
20.5 part, VB
37 parts, VA0.3 part, VE80 part.
Can add appropriate dolomol, pre-gelatinized starch if desired; As 7 parts of dolomols, 294.7 parts of pre-gelatinized starches.
Adopt conventional method to make tablet, capsule, granule or oral liquid goods.The specification of tablet or capsule is 0.35 gram/, and take 2-3 every day, each 2-3 grain.
Embodiment 2
The health food with eyesight-improving intelligence-developing effect, selects 350 parts of gold needle mushroom extracts, 325 parts of European blueberry extracts, 170 parts of ginkgo biloba p.es, 250 parts of soybean lecithins, 125 parts of taurines, DHA240 part, VB
12 parts, VB
22 parts, VB
312.5 parts, VA0.5 part, VE40 part.
Can add appropriate dolomol, pre-gelatinized starch if desired; As 5 parts of dolomols, 228 parts of pre-gelatinized starches.
Adopt conventional method to make tablet, capsule, granule or oral liquid goods.The specification of tablet or capsule is 0.35 gram/, and take 2-3 every day, each 2-3 grain.
Embodiment 3
The health food with eyesight-improving intelligence-developing effect, selects 600 parts of gold needle mushroom extracts, 500 parts of European blueberry extracts, 260 parts of ginkgo biloba p.es, 100 parts of soybean lecithins, 50 parts of taurines, DHA400 part, VB
14 parts, VB
24 parts, VB
320 parts, VA0.8 part, VE5 part.
Can add appropriate dolomol, pre-gelatinized starch if desired; As 3 parts of dolomols, 153.2 parts of pre-gelatinized starches.
Adopt conventional method to make tablet, capsule, granule or oral liquid goods.The specification of tablet or capsule is 0.35 gram/, and take 2-3 every day, each 2-3 grain.
Embodiment 4
The health food with eyesight-improving intelligence-developing effect, selects 200 parts of gold needle mushroom extracts, 250 parts of European blueberry extracts, 140 parts of ginkgo biloba p.es, 300 parts of soybean lecithins, 150 parts of taurines, DHA180 part, VB
11 part, VB
21 part, VB
310 parts, VA0.3 part, VE50 part.
Can add appropriate dolomol, pre-gelatinized starch if desired, adopt conventional method to make tablet, capsule, granule or oral liquid goods.As add 217.7 parts of pre-gelatinized starches, be prepared into granule product; The specification of granule product is 1.5 grams/bag, and take 1-2 every day, each 1-2 bag.
Embodiment 5
The health food with eyesight-improving intelligence-developing effect, selects 250 parts of gold needle mushroom extracts, 275 parts of European blueberry extracts, 160 parts of ginkgo biloba p.es, 250 parts of soybean lecithins, 120 parts of taurines, DHA200 part, VB
11.5 parts, VB
21.5 parts, VB
310 parts, VA0.5 part, VE30 part.
Can add appropriate dolomol, pre-gelatinized starch if desired, adopt conventional method to make tablet, capsule, granule or oral liquid goods.As add 201.5 parts of pre-gelatinized starches, be prepared into granule product; The specification of granule product is 1.5 grams/bag, and take 1-2 every day, each 1-2 bag.
Embodiment 6
The health food with eyesight-improving intelligence-developing effect, selects 400 parts of gold needle mushroom extracts, 350 parts of European blueberry extracts, 225 parts of ginkgo biloba p.es, 185 parts of soybean lecithins, 90 parts of taurines, DHA260 part, VB
13 parts, VB
23 parts, VB
315 parts, VA0.6 part, VE20 part.
Can add appropriate dolomol, pre-gelatinized starch if desired, adopt conventional method to make tablet, capsule, granule or oral liquid goods.As add 453.4 parts of pre-gelatinized starches, be prepared into oral liquid product; The specification of oral liquid product is 20 milliliters/bottle, and take 1-2 every day, each 1-2 bottle.
Product health care human feeding trial of the present invention
Eyesight-improving intelligence-developing capsule auxiliary improving memory function human feeding trial
1. the method for material
1.1 sample
Test specimen capsule No.1, No. 2, the two is basically identical in packing, outward appearance, color and luster and mouthfeel.Wherein No. 1 sample is the prepared capsule product of example 2 of the present invention, and No. 2 samples are placebo.Human oral RD every day 2 times, each 2.
1.2 experimenters select
1.2.1 inclusive criteria: experimenter is from middle school, Hengnan County, Hengyang City, healthy, without dysnoesia, informed consent, be ready to give one's cooperation, the healthy students of age between 10 to 14 years old, did not accept similarly test (memory quotient, IQ test), in 1 year, did not take medicine or the health food relevant with improving memory.
1.2.2 exclusion standard: there is obvious impediment person, influential hearing, language performance and amentia, have the abnormal and cooperation gastrointestinal disease patient of obvious spirit, sleep and life style; Take in a short time the article relevant with tested function, have influence on result judgement person; Do not meet inclusive criteria, credit given the test agent in accordance with regulations not, cannot judge effect or data umbra ring effect can security judgement person.
1.3 experimental designs and grouping
Adopt contrast, double blinding, random method for designing.Method by random cluster extracts two classes of the same grade from elementary middle school, and the colony that living environment is got along tests before taking sample for the first time, by memory quotient, just queue up,, even number strange by sequence divides two groups, then to randomly draw one group be test-meal group, and another group is control group.
1.4 test method
By meeting inclusive criteria and guaranteeing the volunteer of compatibility test, be divided at random test-meal group and control group.Test-meal group and control group are taken eyesight-improving intelligence-developing capsule or placebo by RD, take continuously 30 days.Duration of test does not change original eating habit, normal diet.
The environment of 1.5 main equipment and method of testing:
1.5.1 test equipment: record has the tape of stimulus of the instruction of the memory pointed to and associative learning; Picture material, free recall each 15, two groups, image picture of image, totally 30 (minute first, second two covers); Random shape is re-recognized picture, and standby presenting for the first time with 20, goal stimulus picture, standby presenting with sneaking into of goal stimulus while re-recognizing for the second time stimulates each 20, picture, totally 40, adds up to 60 pictures (minute first, second two is overlapped); Picture is recalled in the contact of portrait feature, for being used black and white for the first time, delineates 6 of people's image surfaces, 6 of the people's image surfaces presenting during standby memory, and both contents are identical, and order is different, 12 altogether; There are the features (minute first, second two covers) such as the surname, occupation, hobby of this portrait at every portrait picture back side.Recorder, stopwatch, record-paper.
1.5.2 method of testing and environment:
1.5.2.1 method of testing: forward and backward twice test of each experimenter, by same main examiner's testing, reduces systematic error.Test time point: forward and backward twice test of each experimenter wants same time point to carry out, and avoids the impact of biological rhythm.While testing for the second time, main examiner does not see grouping list, blind method test.
Environmental condition while 1.5.2.2 testing: tested by specially trained personnel; Testing location is selected in a quiet room and carries out.Except experimenter and main examiner, avoided other people on the scene as far as possible; In this scale, have the relevant subtest of vision of three, indoor light can guarantee to see clearly Chu stimulates picture; Get rid of as far as possible and affect Memory result because of hearing or dysphotia; During test, keep a close eye on the state of mind of experimenter when tested, test need be normal in experimenter's mood, do not oppose to carry out in the more concentrated situation of acceptance test, notice; Whether whether whether experimenter is tired, and whether notice is concentrated, coordinate, nervous to test, and whether confident grade is all recorded in the homepage of record-paper; Same experimenter's test is once finished; With age scale, dividing while relatively dividing test result, noting what whether test in different minutes was carried out under the identical state of mind.After check in original minute of every minute test result is errorless, insert in original subitem.
1.5.2.3 data processing method: will record minute (original a minute) and be converted into scale score, the scale score of every subtest before comparing two groups, calculate total scale score, check in after memory quotient the relatively difference between two groups, between employing own control and group, contrast two kinds of modes and carry out statistical analysis, eliminate the impact of transfer learning.
2 observation index
When test-meal on-test and end, each measures once every observation index.
2.1 safety indexes
2.1.1 ordinary circumstance: inquiry experimenter health status in detail before test, understand experimenter's situations such as spirit, sleep, diet, stool and urine.Carry out heart and lung auscultation, liver palpation of spleen, and measure body weight, blood pressure, heart rate.
2.1.2 routine blood test: red blood cell count(RBC), white blood cell count(WBC), content of hemoglobin mensuration etc.
2.1.3 routine urinalysis: pH value, leucocyte etc.
2.1.4 stool for routine: worm's ovum inspection etc.
2.1.5 bad reaction is observed
2.2 effect indexs: use the test of Clinical Memory scale, look into scale score for original minute with the test in each minute after test: sensing memory, associative learning, image are freed recall, random shape is re-recognized, the contact of portrait feature is recalled.Each minute test scale divides to be added and to obtain total scale score, with total scale score, looks into memory quotient.
3 data statistics: this test data is measurement data, can analyze with t check two groups of each subtest scale scores and memory quotient.Own control can adopt paired t-test, the parallel check that relatively adopts two sample averages between group, the latter need carry out homogeneity test of variance, and the data of Non-Gaussian Distribution or heterogeneity of variance are carried out to suitable variable conversion, wait meet normal state or variance neat after, by the data of changing, carry out t check; If translation data still can not meet the neat requirement of normal state variance, use t check or rank test instead; But the coefficient of variation is the data application rank test of large (as CV>50%) too.With SPSS, INSTST statistical software, add up.
4 results are judged: before test under the prerequisite of two groups of memory quotient equilibriums, after test-meal, the memory quotient of test-meal group is higher than control group, and difference has conspicuousness, memory quotient before memory quotient after the test of the group of test-meal is simultaneously tested higher than it, and difference has conspicuousness, can judge that this given the test agent has the effect of auxiliary improving memory function.
5 results
Double-blind study is observed and is finished to make known: take No. 1 sample (example 2 products of the present invention) person for test-meal group, taking No. 2 sample persons is control group (placebo).
5.1 test groupings: initial trial crowd's test-meal group 52 examples, control group 52 examples, 12.81 ± 0.63 years old control group age, 12.65 ± 0.62 years old test-meal group age; Control group male/female is 31/21, and test-meal group male/female is 30/22.The Zhuo Non Apparent Abnormalities such as test front and back experimenter's mental status, diet situation, sleep quality and mental activity.
5.2 result of the tests:
Double-blind study is observed and is finished to make known: take No. 1 sample (example 2 products of the present invention) person for test-meal group, taking No. 2 sample persons is control group (placebo).
5.1 ordinary circumstances: initial trial crowd's test-meal group 52 examples, control group 52 examples, 12.81 ± 0.63 years old control group age, 12.65 ± 0.62 years old test-meal group age; Control group male/female is 31/21, and test-meal group male/female is 30/22.The Zhuo Non Apparent Abnormalities such as test front and back experimenter's mental status, diet situation, sleep quality and mental activity.
The impact of 5.2 eyesight-improving intelligence-developing capsules on human body memory effect index
Take sensing memory scale score and the control group comparison of the front test-meal group of sample, no significant difference (P>0.05); The sensing memory scale score that takes test-meal group after sample with self take comparison before sample, difference has conspicuousness (P<0.05); With take control group comparison after sample, no significant difference (P>0.05).The results are shown in Table 1.
Table 1 eyesight-improving intelligence-developing capsule is on pointing to the impact (x ± s) of memory scale score
Note: own control * P<0.05
Take associative learning scale score and the control group comparison of the front test-meal group of sample, no significant difference (P>0.05); Before taking the associative learning scale score of test-meal group after sample and self taking sample and take control group comparison after sample, difference all has conspicuousness (P<0.05).The results are shown in Table 2.
The impact (x ± s) that table 2 eyesight-improving intelligence-developing capsule divides association's quantity of study table
Note: between own control * P<0.05 group, contrast #P<0.05
Take before sample the image of test-meal group free recall scale score and control group comparison, no significant difference (P>0.05); Take after sample the image of test-meal group free recall scale score and self take sample before and take control group comparison after sample, difference is all without conspicuousness (P>0.05).The results are shown in Table 3.
Table 3 eyesight-improving intelligence-developing capsule is on the free recall impact (x ± s) of scale score of image
The random shape that takes the front test-meal group of sample is re-recognized scale score and control group comparison, no significant difference (P>0.05); Take after sample before the random shape of test-meal group is re-recognized scale score and self taken sample and take sample after control group comparison, difference is all without conspicuousness (P>0.05).The results are shown in Table 4.
Table 4 eyesight-improving intelligence-developing capsule is re-recognized the impact (x ± s) of scale score on random shape
Scale score and control group comparison, no significant difference (P>0.05) are recalled in the portrait feature contact that takes the front test-meal group of sample; The portrait feature contact that takes test-meal group after sample is recalled scale score and is taken control group comparison after sample with self taking before sample expansion, and difference all has conspicuousness (P<0.05).The results are shown in Table 5.
The impact (x ± s) of table 5 eyesight-improving intelligence-developing capsule on portrait feature contact memory scale score
Note: between own control * P<0.05 group, contrast #P<0.05
Take memory quotient and the control group comparison of the front test-meal group of sample, no significant difference (P>0.05); Take the memory quotient of test-meal group after sample and be significantly higher than control group (P<0.05); Test-meal group takes memory quotient after sample and is significantly higher than and takes (P<0.05) before sample.The results are shown in Table 6.
Table 6 eyesight-improving intelligence-developing capsule is on memory quotient impact (x ± s)
Note: between own control * P<0.05 group, contrast #P<0.05
5.3 de-mistake rates
After test in 30 days, control group has 1 routine experimenter cannot be screened out by determine effect by test product because being interrupted to take; Test-meal group has 1 routine experimenter cannot be screened out by determine effect by test product because being interrupted to take.Last efficiency test crowd control group 51 examples, test-meal group 51 examples.In Table 7.
Above-mentioned human feeding trial result shows, experimenter takes after 30 days continuously, and the associative learning of test-meal group, the contact of portrait feature are recalled scale score and memory quotient all higher than before test and take control group after sample, and difference has conspicuousness (P<0.05); According to the check of < < health food and assessment technique standard > > (version in 2003) evaluation criterion, show that eyesight-improving intelligence-developing capsule of the present invention has the auxiliary effect that improves human body memory function.
Eyesight-improving intelligence-developing capsule asthenopia releasing function human feeding trial
1. materials and methods
1.1 samples and placebo: test specimen capsule No.1, No. 2, the two is basically identical in packing, outward appearance, color and luster and mouthfeel, and No. 1 sample is the prepared capsule product of example 2 of the present invention, and No. 2 samples are placebo.Human oral RD every day 2 times, each 2.
1.2 experimenter's mass selections are selected:
1.2.1 inclusive criteria: select long-term with eye, eyesight fatiguability person, the age is the teenager between 10-14 year.Allly meet above-mentioned condition and voluntary participation guarantee that cooperation person all can include test in.
1.2.2 exclusion standard:
1.2.2.1 do not meet the experimenter who includes age criterion in; To health food allergy sufferers.
1.2.2.2 suffers from infectious eye disease person, the inside and outside eye disease patient such as nebula, keratoconus.
1.2.2.3 suffer from fundus oculi disease or be associated with the diseases such as cardiovascular, the cerebrovascular, liver, kidney, hematopoiesis function.
1.2..2.4 take in a short time the relevant article of tested function, have influence on result is had to judgement person.
1.2.2.5 medicine of other relevant treatment eyesight of long-term taking or use other methods for the treatment of, fails terminator.
1.2.2.6 method is not taken in accordance with regulations, or data is not congruent affects effect or the security person of sentencing.
1.3 test methods: adopt two kinds of control design between self and group, according to requirement random, double blinding, by meeting inclusive criteria and guaranteeing the volunteer of compatibility test, according to symptom, eye test situation, consider that the factors such as age, sex are divided into test-meal group and control group simultaneously.Test-meal group and control group are taken sample or placebo by RD, continuous 45 days.Duration of test does not change original eating habit, normal diet.
2. observation index:
When test-meal on-test and end, each measures once every observation index.
2.1 safety indexes
2.1.1 general physical examination: inquire and understand in detail experimenter's health before test, experimenter is carried out to conventional physical examination and necessary laboratory examination.
2.1.2 routine blood test: red blood cell count(RBC), white blood cell count(WBC), content of hemoglobin mensuration etc.
2.1.3 routine urinalysis: pH value, leucocyte etc.
2.1.4 stool routine examination: worm's ovum inspection etc.
2.1.5 bad reaction is observed.
2.2 efficiency index
2.2.1 Symptom Observation: inquire in detail visual fatigue situation, the symptom such as observe ophthalmodynia, eye is swollen, photophobia, blurred vision, eye are dry and astringent, by mild symptoms multiple integral (severe 3 minutes, middle disease 2 minutes, light disease 1 minute) statistics integrated value before and after test-meal, and improve (each symptom is improved l and divided above for improving) situation with regard to its symptom, improvement rate observes the symptoms.
2.2.2 visuognosis persistence test.
2.2.3 distant vision is measured.
3. experimental data is added up: data result represents by mean ± standard deviation, self paired data adopts paired t-test, between observation group and control group under the prerequisite of homogeneity of variance, mean relatively adopts t check in groups, otherwise adopt t check after carrying out meeting homogeneity of variance after variable conversion, if variance is still uneven, adopting rank test. improvement rate is enumeration data, can use x
2check, the total number of cases of four fold table is less than 40, or total number of cases is equal to or greater than 40 but occur that theoretical value is equal to or less than at 1 o'clock, uses definite probabilistic method instead.
4. result criterion:
4.1 symptoms are improved: ophthalmodynia, eye is swollen, photophobia, blurred vision, the dry and astringent arbitrary symptom of eye improves 1 minute and l divides the above improvement that is, and 5 kinds of arbitrary improvement of symptom and other symptoms judge that without worsening symptom improves.
Before and after 4.2 symptoms improvement and duration of photopic vision, differs by more than and equal 0.1, and comparing difference there is conspicuousness by statistics.
4.3 is invalid: do not reach effective standard.
4.4 reference indexs: eyesight improving rate.To improve two behaviors before test after test-meal test, improve, add up two groups and take eyesight improving rate after tested material as with reference to index, reference index is not as to whether effectively criterion of asthenopia releasing function.
5. result
Double-blind study is observed and is finished to make known: take No. 1 sample (example 2 products of the present invention) person for test-meal group, taking No. 2 sample persons is control group (placebo).
5.1 ordinary circumstances: initial trial crowd's test-meal group 52 examples, control group 52 examples, control group: male/female is 32/20, the age is 11.35 ± 0.59 years old; Test-meal group: male/female is 31/21, the age is 11.40 ± 0.57 years old.Experimenter spirit during test-meal, sleep,
Diet, stool and urine are all normal.
5.2 result of the tests:
5.2.1 clinicing symptom observation
In Table 1,2. test-meal group ophthalmodynia after test, eye is swollen, photophobia, blurred vision, eye are dry and astringent etc., and clinical symptoms are improved, the front obvious reduction of its symptom integral and test-meal, difference has conspicuousness (P<0.05); With control group comparison, difference is conspicuousness (P<0.05) also.
Table 1 clinical symptoms integration statistics
* with control group comparison, P<0.05# and self relatively, P<0.05.
Table 2 clinical symptoms are improved situation
5.2.2 observation of curative effect
From table 3, take tested material after 45 days, test-meal group clinical observation total effective rate is 78.43%, has conspicuousness (P<0.05) with control group (23.53%) comparing difference
The comparison of table 3 clinical observation effect
* with control group comparison, P<0.05.
5.2.3 the impact on duration of photopic vision
As seen from Table 4, it is front 0.12 that after test, test-meal group duration of photopic vision is tested prerequisite, and the increase rate of duration of photopic vision and control group is obvious increases, and difference has conspicuousness (P<0.05).Illustrate that eyesight-improving intelligence-developing capsule is improved the effect of duration of photopic vision.
The variation of table 4 duration of photopic vision
* with control group comparison, P<0.05# and self relatively, P<0.05.
5.2.4 the impact on eyesight
From table 5, test-meal group tests backsight force level and test-meal is front and control group comparison, and difference is without remarkable (P>0.05).Test-meal group eyesight increase rate and improvement rate and control group comparing difference are without conspicuousness (P>0.05).
Eyesight situation (x ± s) before and after the test-meal of table 5 eyesight-improving intelligence-developing capsule
The improvement situation of eyesight before and after table 6 test
5.2.5 de-mistake rate
After test in 45 days, control group has 1 routine experimenter cannot be screened out by determine effect by test product because being interrupted to take; Test-meal group has 1 routine experimenter cannot be screened out by determine effect by test product because being interrupted to take.Finally there are test crowd control group 51 examples, test-meal group 51 examples.In Table 7.
The de-mistake rate of table 7 test
Above-mentioned experiment results proved, test-meal group ophthalmodynia, swollen, the photophobia of eye, depending on optical mode stick with paste, eye is dry and astringent etc., and clinical symptoms have clear improvement, the front and control group comparing difference of symptom integral and test-meal has conspicuousness (P<0.05); Test-meal group clinical observation total effective rate is 78.43%, has conspicuousness (P<0.05) with control group (23.53%) comparing difference; After test, test-meal group duration of photopic vision is tested front raising 0.12, and the increase rate of duration of photopic vision and control group is obvious increases, and difference has conspicuousness (P<0.05); After test-meal, test-meal group eyesight increase rate and improvement rate and control group comparing difference are without conspicuousness (P>0.05).Judgment criteria according to the check of < < health food with the middle regulation of assessment technique standard > > (2003 editions), shows that eyesight-improving intelligence-developing capsule of the present invention has the effect of asthenopia releasing function.
Claims (6)
1. a health food with eyesight-improving intelligence-developing effect, is characterized in that the raw material that contains following weight proportion:
Gold needle mushroom extract 100-600 part, European blueberry extract 150-500 part, ginkgo biloba p.e 80-260 part, soybean lecithin 100-400 part, taurine 50-200 part, DHA80-400 part, VB
10.5-5 part, VB
20.5-5 part, VB
35-20 part, VA0.25-0.8 part, VE5-80 part.
2. health food according to claim 1, is characterized in that preferably containing the raw material of following weight proportion:
Gold needle mushroom extract 200-500 part, European blueberry extract 250-400 part, ginkgo biloba p.e 140-240 part, soybean lecithin 150-300 part, taurine 70-150 part, DHA180-300 part, VB
11-4 part, VB
21-4 part, VB
37-18 part, VA0.3-0.8 part, VE20-50 part.
3. health food according to claim 1, is characterized in that further preferably containing the raw material of following weight proportion:
Gold needle mushroom extract 250-400 part, European blueberry extract 275-350 part, ginkgo biloba p.e 160-220 part, soybean lecithin 175-250 part, taurine 90-120 part, DHA200-260 part, VB
11-3 part, VB
21-3 part, VB
310-15 part, VA0.3-0.8 part, VE15-30 part.
4. according to the arbitrary described health food of claim 1-3, it is characterized in that described DHA is preferably Ω-3DHA microcapsules freeze-dried powder of content 10%.
5. according to the arbitrary described health food of claim 1-3, it is characterized in that also containing appropriate dolomol, pre-gelatinized starch.
6. health food according to claim 5, is characterized in that containing dolomol 3-8 part, pre-gelatinized starch 100-500 part.
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| JP6779546B2 (en) * | 2016-11-06 | 2020-11-04 | ナノスコープ テクノロジーズ エルエルシーＮａｎｏｓｃｏｐｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | Optogenetic regulation with multi-characteristic opsin for visual acuity restoration and other uses |
| CN107822011A (en) * | 2017-09-28 | 2018-03-23 | 黑龙江绿知都生物科技开发有限公司 | A kind of children's intelligence development blueberry composite chewable tablet |
| CN107714737A (en) * | 2017-10-11 | 2018-02-23 | 澳诺（中国）制药有限公司 | A kind of pharmaceutical composition for promoting brain development |
| CN109123609A (en) * | 2018-08-24 | 2019-01-04 | 广州加原医药科技有限公司 | A kind of improvement memory pre-gelatinized Tetramune and preparation method thereof |
| CN111493315A (en) * | 2020-05-26 | 2020-08-07 | 广东时代食品与生命健康研究有限公司 | Memory-improving antioxidant composition and application thereof |
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| CN102048201A (en) * | 2009-11-09 | 2011-05-11 | 樊宝顺 | Novel fruit and vegetable beverage |
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