JPH1180009A - Agent for improving brain function and agent for preventing lowering of brain function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject medicine almost free from fear of adverse effects or the like and having effective and wider general effect on brain function, especially in application to selfmedication by including saffron powder and extract of ginkgo leave or the like as active ingredients. SOLUTION: This medicine contains (A) (i) dried stamen powder of saffron or (ii) an extract extracted therefrom, (B) ginkgo extract containing flavonoid such as ginkolide extracted from ginkgo leaf, (C) yolk lecithin containing phosphatidylcholine, (D) vitamin B group such as vitamin B6 or vitamin B12 as active ingredients. The daily dose of the component A(i) or A(ii) is about 3-300 mg or about 0.3-30 mg/adult, respectively, and the daily doses of the components B, C and D are about 5-500 mg, about 5-500 mg and about 0.5-50 mg/adult, respectively. The medicine is provided in a form of a medicine or a food.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an agent for improving brain function and an agent for preventing its decline. More specifically, the present invention relates to an agent for improving brain function and a preventive agent for lowering brain function without side effects.

[0002]

2. Description of the Related Art In recent years, the average life expectancy of Japan has been steadily increasing, and a super-aging society is imminent. Along with this, senile dementia, which is increasing with aging, so-called blurring, is not only a medical problem but also a serious social problem.

[0003] Research on blurring has been actively conducted all over the world, but the disease causing the disease is diverse, and the symptoms are also diverse. Many causes of dementia such as Alzheimer's disease have yet to be solved for their causes or clear treatment methods. Further, in a clinical setting, it is extremely difficult to effectively treat an organic lesion once caused by an infarction or the like, and it is also extremely difficult to restore intellectual functions such as orientation, memorization and the like once affected. Therefore, blur,
For dementia, it is important to prevent recurrence and start treatment at an early stage, and to always strive to prevent it.

[0004] Most of the dementia diseases in the elderly are cerebrovascular dementia and Alzheimer-type dementia, or a mixture of both. Chronic cerebral circulation improvers or cerebral metabolic activators are used as therapeutic agents for these chronic phases, but their practical effects have not been proven. In particular, in the case of a synthetic drug or the like, the fact is that tachyphylaxis and various side effects due to long-term administration cannot be avoided.

[0005] From such a viewpoint, recently, a medicinal plant or a plant of natural origin, which has an effect of preventing or improving blurring, attracts attention and is being searched for and researched. These things are
Since there are few side effects, it is considered to have an important position especially in self-medication applications. In addition, the treatment in the clinic is determined by a specialist doctor based on advanced clinical tests and consultations,
Treatment is taking place. However, there are few hospitals that have specialized outpatient departments, and many patients often hesitate to visit such outpatient departments and spare their time and effort in going to the hospital to progress their illness.

[0006] Therefore, even in view of the above, it is important to take measures by simple self-medication. In the case of self-medication, drugs are selected based on their own subjective symptoms and the advice of a pharmacist, so that the drugs used for them are required to have sufficient safety and a wider comprehensive effect.

[0007] At present, there are many products on the market that are thought to improve or maintain the functions of the brain and nerves, and their effects are being proved. However, the methods of acting on brain nerves and brain functions are various. In addition, the structure and function of the brain are extremely complex and delicate, and are based on subtle balance (homeostasis) in the living body. Therefore, a biased action due to a large amount or continuous intake of some drugs and health foods may disturb the balance of the living body and adversely affect the activity and function of the brain.

[0008]

SUMMARY OF THE INVENTION An object of the present invention is to provide almost no concern about side effects and the like, and particularly to the application to self-medication, to have an effective and broader overall effect on brain functions. An object of the present invention is to provide an agent for improving brain function and a preventive agent for lowering the effect.

[0009]

SUMMARY OF THE INVENTION The object of the present invention is as follows.
It is achieved by an agent for improving and preventing brain function comprising saffron powder or extract, ginkgo biloba extract, egg yolk lecithin and vitamin B group as active ingredients.

[0010]

DETAILED DESCRIPTION OF THE INVENTION Saffron (Crocus sativus L.)
Is a crude drug that has been used in traditional Chinese medicine for women's diseases such as menstrual cramps and menstrual irregularities. Saffron has an effect of improving the suppression of memory learning ability decline and suppression of hippocampal long-term potentiation by alcohol (Japanese Patent Laid-Open No. 7-69908),
It has been shown to directly stimulate the memory centers of the brain. In the present invention, a powder of a dried pistil of saffron or an extract extracted therefrom using water, alcohol, another organic solvent or a mixed solvent thereof under a room temperature condition or a heating condition is used.

Ginkgo biloba extract is known to have a function of improving blood circulation in the brain, and has already been used in Western Europe for preventing blurring of the elderly or improving blood circulation. Ginkgo biloba extract contains a lot of more than 20 types of flavonoids, among which flavonoids such as ginkgolide and bilobalide are used to suppress active oxygen and platelet activating factor, and to prevent various diseases such as cerebral blood flow disorder and heart disease. A great pharmacological effect and function are expected. In the present invention, water, alcohol, other organic solvent or a mixed solvent thereof from ginkgo biloba is subjected to extraction or solvent treatment or the like extracted at room temperature or under heating conditions, and the concentration of the flavonoid as an active ingredient. Purified to a certain concentration is used.

[0012] Egg yolk lecithin contains a large amount of a substance called phosphatidylcholine. This phosphatidylcholine is indispensable as a membrane component of human cells and is also a raw material of acetylcholine, a neurotransmitter. The cause of Alzheimer's senile dementia is thought to be due to the drastic decrease of acetylcholine, and ingestion of egg yolk lecithin is expected to lead to its prevention.

[0013] The vitamin B group is called a nerve vitamin. In particular, vitamin B ₆ and vitamin B ₁₂
It has been reported that it has a function of repairing nerve cells and a function of maintaining survival, and it has also been reported that it has an effect of promoting the synthesis of neurotransmitters, and is expected to have an effect of improving the function of the brain.

In addition to the above four components, it is also effective to further add at least one of docosahexaenoic acid, grape seed extract, bone marrow extract and vitamin E.

Docosahexaenoic acid (DHA) is a highly unsaturated ω-3 fatty acid contained in fats of fish such as bonito and tuna, and the reason why children who eat a lot of fish containing DHA have a high intelligence index. Is a healthy brain component that has recently attracted attention, and its effects have been confirmed in clinical trials for Alzheimer-type dementia and cerebrovascular dementia.

It has been reported that grape seed extract contains a large amount of flavonoids called proanthocyanidins and has strong antioxidant activity. And its antioxidant power is
It is reported that it is stronger than vitamin C, vitamin E, β-carotene, etc. In the present invention, from grape seeds, using water, alcohol, other organic solvent or a mixed solvent thereof, extract or solvent treatment or the like extracted under room temperature conditions or under heating conditions, the flavonoid of the active ingredient Purified to a certain concentration is used.

The bone marrow extract contains a large amount of phospholipid, which is a cell membrane component of the brain. Since the metabolism of the cranial nerves is actively performed, ingesting a component that can be the raw material activates the brain. In addition, it is good for health because it is rich in minerals and vitamins. In the present invention, a bone marrow part mechanically extruded from mammalian bone or an extract extracted therefrom using water, alcohol, another organic solvent or a mixed solvent thereof at room temperature or under heating is used. .

Furthermore, it has been found that vitamin E has the same action as grape seed extract. Active oxygen is said to have a deep connection with arteriosclerosis and aging phenomenon,
It is expected that suppressing this will be effective in preventing cerebrovascular disorders.

Docosahexaenoic acid, bone marrow extract,
Vitamin E has the function of dissolving other fat-soluble vitamins and components well and increasing its absorption efficiency.

Each of the above components is expected to directly or indirectly have a function of improving brain function or a function of preventing function decline by a different mechanism of action. Typical effects are:
Acts directly on the brain and nerve cells to activate them, improves blood flow in the brain and reaching the brain, activates the metabolism of the whole brain or brain nerve cells, damages brain nerve cells and blood vessels It is thought to have the effect of removing factors and maintaining the survival of nerve cells. Therefore, to improve or prevent brain function overall, saffron powder or extract, ginkgo extract, egg yolk lecithin and vitamin B group, respectively (Especially vitamin B ₆ ) must be used in combination.

These are provided in the form of pharmaceuticals or foods. When used as pharmaceuticals, they are provided in the form of powders, granules, tablets, dragees, capsules, liquids, etc., and when used as foods, they are provided in the form of gums, candies, jellies, tablet confections, beverages, etc. You.

The dose or compounding amount is appropriately determined in consideration of the age, sex, body weight, symptom of the target patient or whether it is used as an improving agent or a prophylactic agent. About 3-30 with saffron powder
0mg, about 0.3-30mg in extract, about 5-5 in ginkgo extract
00mg, about 5-500mg with egg yolk lecithin, about 0.5 with vitamin B group
5050 mg. Furthermore, when other components are blended,
Docosahexaenoic acid about 20-2000mg, grape seed extract about 3-300mg, bone marrow extract about 20-2000mg, vitamin E
Is taken about 20-2000 mg.

[Clinical test example] Saffron pistil powder 10 weight
%, Ginkgo biloba extract 5% by weight, egg yolk lecithin 1% by weight, vitamin
B₆0.15% by weight, vitamin E 15% by weight and bulking agent (shiso
(Oil, dense wax) 68.85% by weight, the content per grain is 20
6 capsules of gelatin-coated soft capsules with 0 mg (per day)
Was the recommended intake. (Target patients) Healthy subjects who have no abnormalities in the health examination,
Select a person who complained of extremely mild blurring (dose, dosage, administration period)
Administer 2 capsules once every meal for 3 months (follow-up observation and efficacy evaluation)
Create a questionnaire and evaluate the answers by scoring them. Contents of question   Answer score 1) feel anxiety (anxiety) 2) get irritated or irritated (feeling sensation) 3) feel uncomfortablely depressed (depression) 4) can't express joy and sadness well (emotional side) 5) meet people 6) I get angry or cry with a small incident (disturbance / excitation) 7) I sometimes go out without knowing at night (wandering at night) 8 ) Become panicking or suspicious by trivial things (delirium) 9) I sometimes see hallucinations (hallucinations) 10) Think about things badly (delusions) 11) I can't sleep well (sleep disorders) 12) I fall asleep (Sleep disorder) 13) Difficulty performing simple calculations (calculation impairment) 14) Headache or headache (subjective symptoms) 15) Dizziness (subjective symptoms) 16) Numbness (Subjective symptoms) 17) Stuck in words (Words do not come out) (Evaluation of daily life function) 18) Difficulty hearing (Evaluation of daily life functions) 19) Feel impaired vision (Evaluation of daily life functions) 20) Insatiable and unable to concentrate on things (Evaluation of daily life functions) 21) The body does not move or it is difficult to move even if it is urgent (daily life) (Life function evaluation) 22) Restless and unable to stay still (Everyday function evaluation) 23) Eating with chopsticks spills (Everyday function evaluation) 24) I can't remember the name of the other party to call (Memory impairment) 25) Sometimes you can't remember the name of a close person (memory impairment) 26) You forget recent events and important promises (memory impairment) 27) You can't remember the names of old friends and teachers (memory impairment) 28) Sometimes I don't know where I am (orientation disorder) 29) I get drunk immediately after drinking (alcohol disorder) 30) I get drunk (alcohol disorder)31) I lose my memory when I drink (Alcohol disorder)  Total points If the total number of answer points decreases by 10 or more, "valid", 5-9 reduction
Evaluate a little lower as "Slightly effective"

(Case) Case 1: A 42-year-old man who did not hinder his normal life, but he forgot more than a few years ago.
In particular, they often forget completely about a few promises or appointments. Also, you may not be able to remember things you know well, such as names of people or places.

The results before administration and three months after administration are shown in Table 2 below. The total number of response points decreased from 52 points to 44 points by 8 points, and was evaluated as somewhat effective. Mainly, daily life functions were improved.

Case 2: A 55-year-old man who has forgotten the name of the person in charge of a business partner many times, or who has never been there before, has spoken and is stuck in words, and cannot explain well.

The results before administration and 3 months after administration are shown in Table 2 below. The total number of response points decreased from 46 points to 37 points by 9 points, and was evaluated as somewhat effective. Mainly, sleep disorders and daily living functions were improved.

Case 3: A 37-year-old man who drinks well but is easily sick recently and often loses his memory after drinking too much. In addition, they have difficulty falling asleep and are not easily tired.

The results before and 3 months after administration are shown in Table 2 below.
As a result, the total number of answers decreased by 15 points from 36 points to 21 points
A little, evaluated as effective. Mainly by alcohol
Memory disorders, sleep disorders and daily living functions improved. Table 2 Improvement effects of subjective symptomsCase 1 Case 2 Case 3 Question No. Before the test 3 months later Before the test 3 months later Before the test 3 months later   1) 0 0 0 0 0 0 2) 1 1 1 1 2 1 3) 0 0 1 1 2 1 4) 1 1 0 0 0 0 5) 2 2 0 0 0 0 6) 1 1 2 2 0 0 7) 0 0 0 0 0 0 8) 0 0 1 1 0 0 9) 0 0 0 0 0 0 10) 1 1 0 0 0 0 11) 1 1 3 1 2 1 12) 1 1 3 1 3 1 13) 2 2 2 2 2 2 14) 2 2 3 2 3 2 15) 3 2 1 1 0 0 16) 2 2 2 2 0 0 17) 3 2 3 2 1 1 18) 2 2 2 2 1 1 19) 2 2 3 3 0 0 20) 3 2 3 2 2 1 21) 2 2 1 1 0 0 22) 2 1 1 1 1 1 23) 2 1 1 1 1 1 24) 3 2 3 2 2 1 25) 3 3 2 2 2 1 26) 2 2 3 2 2 1 27) 3 3 2 2 1 1 28) 0 0 0 0 0 0 29) 3 2 1 1 3 2 30) 2 2 1 1 3 131) 3 2 1 1 3 1 Total 52 44 46 37 36 21

[0030]

EFFECT OF THE INVENTION The agent for improving and preventing cerebral function according to the present invention has almost no concern about side effects and the like, and has sufficient safety and broader comprehensiveness especially in application to self-medication. Effect is exhibited.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 31/44 A61K 31/44 31/455 31/455 31/51 31/51 31/525 31/525 31/68 31/68 31/685 31/685 35/28 35/28 35/54 35/54

Claims (2)

[Claims] 1. An agent for improving and preventing brain function comprising saffron powder or extract, ginkgo biloba extract, egg yolk lecithin, and vitamin B group as active ingredients. 2. The agent for improving and preventing brain function according to claim 1, further comprising at least one of docosahexaenoic acid, grape seed extract, bone marrow extract and vitamin E.