CN103097390B - β‑官能化二羟基‑二氢卟酚用于PDT的应用 - Google Patents

β‑官能化二羟基‑二氢卟酚用于PDT的应用 Download PDF

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CN103097390B
CN103097390B CN201180039522.7A CN201180039522A CN103097390B CN 103097390 B CN103097390 B CN 103097390B CN 201180039522 A CN201180039522 A CN 201180039522A CN 103097390 B CN103097390 B CN 103097390B
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substituent
group
carbon atom
chlorin
cooh
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CN103097390A (zh
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D·艾澈
A·维厄
C·B·W·斯达克
V·阿波切特
S·格瑞夫
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Fairfield Industries Inc
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Biolitec Investment Ii Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180039522.7A 2010-07-22 2011-08-12 β‑官能化二羟基‑二氢卟酚用于PDT的应用 Active CN103097390B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36670710P 2010-07-22 2010-07-22
PCT/US2011/047576 WO2012012809A2 (en) 2010-07-22 2011-08-12 APPLICATION OF β-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT

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CN103097390A CN103097390A (zh) 2013-05-08
CN103097390B true CN103097390B (zh) 2017-03-08

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EP (1) EP2870159B1 (https=)
JP (1) JP2013532664A (https=)
CN (1) CN103097390B (https=)
BR (1) BR112013001576A2 (https=)
IL (1) IL224381B (https=)
MX (1) MX353394B (https=)
PL (1) PL2870159T3 (https=)
WO (1) WO2012012809A2 (https=)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
EP2616065B1 (en) * 2010-07-22 2017-11-01 biolitec Unternehmensbeteiligungs II AG Glyco-substituted dihydroxy-chlorins and b-functionalized chlorins for anti-microbial photodynamic therapy
WO2013015774A1 (en) 2011-07-22 2013-01-31 Biolitec Pharma Marketing Ltd Glyco-substituted dihydroxy-chlorins and b-functionalized chlorins for anti-microbial photodynamic therapy
CN103995045A (zh) * 2014-05-29 2014-08-20 武汉矽感科技有限公司 离子迁移谱仪用于检测乐果和马拉硫磷残留的用途及方法
CA2985187C (en) * 2015-05-07 2024-01-02 Luzitin, S.A. Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof
US9722103B2 (en) 2015-06-26 2017-08-01 Sunpower Corporation Thermal compression bonding approaches for foil-based metallization of solar cells
CN104940950B (zh) * 2015-07-09 2017-11-28 武汉大学 一种肿瘤靶向多肽光敏剂键合物
CN111196819B (zh) * 2018-11-16 2023-03-28 中国科学院上海药物研究所 一类d-a-d型苯并吡嗪类化合物及制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043143C (zh) * 1994-10-26 1999-04-28 不列颠哥伦比亚省大学 β,β-二羟基中位取代的二氢卟酚、异细菌二氢卟酚、细菌二氢卟酚,和从β,β-未取代的四吡咯大环制备所述化合物的方法
WO2010033678A2 (en) * 2008-09-18 2010-03-25 Ceramoptec Industries, Inc. Novel method and application of unsymmetrically meso-substituted porphyrins and chlorins for pdt

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
JP6041360B2 (ja) * 2011-07-22 2016-12-07 バイオリテック ウンターネーメンスベタイリグンクス ツヴァイ アクツィエンゲゼルシャフト 抗菌性光線力学療法のための、糖−置換ジヒドロキシ−クロリン及びβ−官能化クロリン

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043143C (zh) * 1994-10-26 1999-04-28 不列颠哥伦比亚省大学 β,β-二羟基中位取代的二氢卟酚、异细菌二氢卟酚、细菌二氢卟酚,和从β,β-未取代的四吡咯大环制备所述化合物的方法
WO2010033678A2 (en) * 2008-09-18 2010-03-25 Ceramoptec Industries, Inc. Novel method and application of unsymmetrically meso-substituted porphyrins and chlorins for pdt

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Compound I and II Analogs of a Chlorin.;K. Jayaraj et al.;《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》;19950901;第117卷(第35期);9079 *

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WO2012012809A3 (en) 2012-05-18
JP2013532664A (ja) 2013-08-19
PL2870159T3 (pl) 2018-01-31
BR112013001576A2 (pt) 2016-07-19
WO2012012809A2 (en) 2012-01-26
EP2870159A2 (en) 2015-05-13
CN103097390A (zh) 2013-05-08
EP2870159A4 (en) 2015-08-12
IL224381B (en) 2018-03-29
EP2870159B1 (en) 2017-06-28
MX2013000877A (es) 2013-07-03
MX353394B (es) 2018-01-11

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