CN103083710A - Corneal contact lens nursing composition containing trehalose quaternary ammonium salt - Google Patents
Corneal contact lens nursing composition containing trehalose quaternary ammonium salt Download PDFInfo
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- CN103083710A CN103083710A CN2013100238439A CN201310023843A CN103083710A CN 103083710 A CN103083710 A CN 103083710A CN 2013100238439 A CN2013100238439 A CN 2013100238439A CN 201310023843 A CN201310023843 A CN 201310023843A CN 103083710 A CN103083710 A CN 103083710A
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- ammonium salt
- contact lens
- quaternary ammonium
- chloride
- corneal contact
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
A corneal contact lens nursing composition containing trehalose quaternary ammonium salt is provided; the corneal contact lens nursing composition is characterized by consisting of the following components in percentage by weight: 0.001-2% of trehalose quaternary ammonium salt, 0.01-2% of isotonic regulator, 0.05-2% of surfactant, 0.01-1% of complexing agent, 0.01-3% of buffer, 0.00001-1% of anti-microorganism compound and 89-99.91899% of water. The composition provided by the invention has corneal contact lens storing, sterilizing, cleaning, lubricating, hydrating and anti-drying functions and is very effective for relieving dryness and stiffness of eyes; by adopting the composition, the death rate of corneal epithelial cells under a dry condition is reduced and the repairing of corneal epithelial cells and endothelial cells is prompted. The kill rate of each composition to escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is greater than 99.9% and the kill rate to candida albica and solanaceae fusarium is greater than 90.0%.
Description
Technical field
The present invention relates to a kind of compositions of corneal contact lens nursing.Specifically, said composition is a kind of corneal contact lens nursing composition that comprises trehalose quaternary ammonium salt.
Background technology
Corneal contact lens can be divided into rigid, semi-hard and soft three kinds, and hard corneal contact lens is by basically not making through the polymethyl methacrylate (PMMA) of oxygen and siloxanes and the acrylate copolymer of oxygen permeable; Semi-hard corneal contact lens is to be made by oxygen permeable and the silicone rubber that can keep the anterior corneal surface eupnea, needs keep moistening with the Wetting Solution of special use, to satisfy comfortableness and physiological requirement; Soft corneal contact lens, the most frequently used is the eyeglass of being made by poly hydroxy ethyl acrylate (HEMA).The HEMA molecule is network structure, makes eyeglass have the function of absorption and release low molecular weight liquid, and the eyeglass network structure is more loose large, and water content is higher, and the soft corneal contact lens of tens kinds of specifications has been arranged now.
Existing soft corneal contact lens, has higher hydrophilic, because corneal contact lens is worn into eyes, it hides before cornea, hindered cornea and caused the cornea anoxia with contacting of air, tear except moistening cornea, conjunctiva, is also wanted moistening eyeglass in addition, cause adacrya, cause that eyeglass wearer's eye is dry and astringent, acid is swollen.
Trehalose (α-D-glucopyranosyl-α-D-glucopyra-noside), be a kind of stable irreducibility disaccharidase, linked by two pyranoid ring glucose molecules and 1,1-glycosidic bond.Because trehalose is nonreducing sugar by special disaccharidase molecular composition; character is highly stable; can form special protecting film at cell surface under the abominable condition such as high temperature, high and cold, dry dehydration; effectively the protection biomolecular structure is not destroyed, thus the life process of the body that sustains life and biological characteristic.Because trehalose has protection biological cell and active substance active unique biological property that is not damaged under the poor environments such as drying; the foreign study personnel are just in the derivant of active research trehalose, and use it for the feasibility of corneal contact lens nursing composition.
Summary of the invention
The purpose of this invention is to provide a kind of corneal contact lens nursing composition, said composition is the aqueous solution that oozes adjusting agent, buffer agent, chelating agent, trehalose quaternary ammonium salt, surfactant, antimicrobial such as to include, and is used for the rewetting of the storage, sterilization, cleaning of corneal contact lens eyeglass, lubricated, moisturizing and eyeglass.Be kept at corneal contact lens in compositions during use or drip above-mentioned composition or directly splash into ophthalmic on corneal contact lens.
Technical scheme of the present invention is achieved in the following ways: contain the corneal contact lens nursing composition of trehalose quaternary ammonium salt, by weight percentage, composed of the following components:
Trehalose quaternary ammonium salt is 0.001-2%, waits that to ooze adjusting agent be 0.01-2%, and surfactant is 0.05-2%, and chelating agent is 0.01-1%, and buffer agent is 0.01-3%, and Antimicrobe compound is 0.00001-1%, water 89-99.91899%.
Above-mentioned grade is oozed at least a in monosaccharide that adjusting agent is sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glucose, propylene glycol, glycerol, sorbitol, mannitol.
Above-mentioned surfactant can be at least a in poloxamer (Poloxamer), pool Luo Shamin (Poloxamines), tyloxapol (Tyloxapol), Polysorbate, sodium lauroyl glutamate, dodecanamide propyl hydroxy sulfo lycine.
Above-mentioned chelating agent is at least a in ethylenediaminetetraacetic acid, 2-amino-2-methyl-1-propanol (AMP-95), N-dodecyl ethylenediamine triacetic acid.
Above-mentioned buffer agent is at least a in boric acid, Borax, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, trometamol (TRIS AMINO).
Above-mentioned antimicrobial is polyquaternary ammonium salt-1(Polyquaternium-1), poly hexamethylene biguanide (polyhexamethylene biguanide, PHMB), at least a in poly-aminopropyl biguanide (polyaminopropyl biguanide, PAPB), alexidine (Alexidine), benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, sorbic acid.
The method for preparing conditioning liquid compositions of the present invention is: by weight percentage said components is put into water successively and dissolve, adjust pH at 6.5-7.8 with sodium hydroxide and hydrochloric acid, osmotic pressure is at 260-340 mosm/KgH
2O, solution gets final product through the membrane filter aseptic filtration in 0.22 μ m aperture.
The present invention, have the storage, sterilization, cleaning of corneal contact lens eyeglass, lubricated, moisturizing, resist drying function, dry and astringent and sour swollen very effective to easing eyes reduces the mortality rate of corneal epithelial cell in dry environment, promotes the reparation of corneal epithelium and intradermal cell.Each compositions to the killing rate of escherichia coli, bacillus pyocyaneus, staphylococcus aureus greater than 99.9%, to the killing rate of Candida albicans, Solanaceae sickle mycete greater than 90.0%.
The specific embodiment
The corneal contact lens nursing composition that contains trehalose quaternary ammonium salt, by weight percentage, composed of the following components:
Trehalose quaternary ammonium salt content is 0.001-2%, be 0.01-2% Deng oozing adjusting agent content, surface-active contents is 0.05-2%, and chelating agent content is 0.01-1%, buffer content is 0.01-3%, and antimicrobial compound levels is 0.00001-1%, water 89-99.91899%.
Embodiment 1:
Trehalose quaternary ammonium salt 2%, Deng oozing adjusting agent: sodium chloride 0.36%, potassium chloride 0.04%, surfactant: poloxamer 0.2%, chelating agent: disodiumedetate 0.1%, buffer agent: boric acid 0.64%, Borax 0.09%, antimicrobial: poly hexamethylene biguanide (PHMB) 0.000018%, water 96.569992%.
Embodiment 2:
Trehalose quaternary ammonium salt 1% waits and oozes adjusting agent: sodium chloride 0.5%, surfactant: poloxamer 0.2%, chelating agent: disodiumedetate 0.1%, buffer agent: boric acid 0.64%, Borax 0.09%, antimicrobial: poly hexamethylene biguanide 0.000018%, water 97.46009%.
Embodiment 3:
Trehalose quaternary ammonium salt 0.5%, Deng oozing adjusting agent: sodium chloride 0.6%, surfactant: sodium lauroyl glutamate 0. 15%, chelating agent: disodiumedetate 0.1%, buffer agent: sodium hydrogen phosphate 0.17%, sodium dihydrogen phosphate 0.03%, antimicrobial: poly hexamethylene biguanide 0.00001%, alexidine (Alexidine) 0.00004%, water 98.45%.
Embodiment 4:
Trehalose quaternary ammonium salt 0.5%, etc. ooze adjusting agent: sodium chloride 0.6%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: sodium hydrogen phosphate 0.17%, sodium dihydrogen phosphate 0.03%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.0002%, water 98.3%.
Embodiment 5:
Trehalose quaternary ammonium salt 0.8%, Deng oozing adjusting agent: sodium chloride 0.6%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: sodium hydrogen phosphate 0.17%, sodium dihydrogen phosphate 0.03%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.0002%, water 98.0%.
Embodiment 6:
Trehalose quaternary ammonium salt 0.8%, Deng oozing adjusting agent: sodium chloride 0.2%, chelating agent: disodiumedetate 0.1%, surfactant: poloxamer 0.2%, buffer agent: boric acid 1.6%, Borax 0.09%, sodium citrate 0.4%, trometamol 0.6%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.0002%, water 96.01%.
Embodiment 7:
Trehalose quaternary ammonium salt 0.3%, Deng oozing adjusting agent: sodium chloride 0.3%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: trometamol 0.3%, sodium dihydrogen phosphate 0.5%, antimicrobial: poly hexamethylene biguanide 0.000012%, polyquaternary ammonium salt (Polyquaternium-1) 0.001%, pure water 98.2%.
Embodiment 8:
Trehalose quaternary ammonium salt 0.8%, Deng oozing adjusting agent: sodium chloride 0.2%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: trometamol 0.3%, boric acid 1.2%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.0002%, pure water 97.1%.
Embodiment 9:
Trehalose quaternary ammonium salt 0.5%, Deng oozing adjusting agent: sodium chloride 0.2%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: trometamol 0.3%, boric acid 1.2%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.00002%, pure water 97.4%.
Embodiment 10:
Trehalose quaternary ammonium salt 0.5%, Deng oozing adjusting agent: sodium chloride 0.6%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: disodiumedetate 0.1%, buffer agent: boric acid 0.64%, Borax 0.09%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.00003%, pure water 97.77%.
Embodiment 11:
Trehalose quaternary ammonium salt 0.8%, Deng oozing adjusting agent: sodium chloride 0.4%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: N-dodecyl ethylenediamine triacetic acid 0.2%, buffer agent: trometamol 0.2%, sodium dihydrogen phosphate 0.4%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.00003%, pure water 97.7%.
Embodiment 12:
Trehalose quaternary ammonium salt 0.3%, Deng oozing adjusting agent: sodium chloride 0.4%, surfactant: dodecanamide propyl hydroxy sulfo lycine 0.3%, chelating agent: N-dodecyl ethylenediamine triacetic acid 0.2%, buffer agent: trometamol 0.2%, sodium dihydrogen phosphate 0.4%, antimicrobial: poly hexamethylene biguanide 0.000015%, cetylpyridinium chloride 0.0002%, pure water 98.2%.
The method for preparing conditioning liquid compositions of the present invention is followed successively by: above-mentioned composition is put into pure water dissolve, adjust pH at 6.5-7.8 with sodium hydroxide and hydrochloric acid, osmotic pressure is at 260-340 mosm/KgH
2O, solution is through the membrane filter aseptic filtration in 0.22 μ m aperture.Be immersed in corneal contact lens in compositions during use or drip above-mentioned composition or directly splash into ophthalmic on corneal contact lens.
The compositions of different schemes is through on probation, show the compositions of using the different content trehalose quaternary ammonium salt, the lubricated resist drying effect that reaches of moisturizing is directly proportional to use amount, the trehalose quaternary ammonium salt amount is more, moisturizing is lubricated and the resist drying effect is stronger, and in the present composition, the trehalose quaternary ammonium salt preferred amounts is 0.001-8%(W/W).
According to different preferred embodiments, the contact lens that the present composition is applicable to soak carries out disinfection, so also comprises at least a antimicrobial in this preferred composition.Because the contact lens of said composition nursing is directly put into eyes, so this antimicrobial should be to have good biocompatibility with eyes.In the contact lens immersion and antiseptic solution of routine, antimicrobial exists with the amount of effective disinfect contact lense, and preferred sterilization amount is to reduce the load of microorganisms amount at certain hour with certain logarithm level.Different components by the implementation method preparation, the test germicidal efficiency, each implements the germicidal efficiency test to escherichia coli, bacillus pyocyaneus, staphylococcus aureus and Candida albicans, Solanaceae sickle mycete, its result, each compositions to the killing rate of escherichia coli, bacillus pyocyaneus, staphylococcus aureus greater than 99.9%, to the killing rate of Candida albicans, Solanaceae sickle mycete greater than 90.0%.
The pH value of compositions of the present invention needs compatible with eyes, and the pH value that is fit to is about 6.5-7.8, preferably at 6.8-7.5.
According to different preferred embodiments, the present composition is applicable to corneal contact lens cleaning, sterilization, lubricated, moisturizing, storage, alleviate eye dry and astringent, sour swollen, effectively reduce the mortality rate of eye cell in dry environment on cornea, promote the reparation of corneal epithelium and intradermal cell.
For keeping the stability of said composition, added chelating agent in compositions of the present invention, chelating agent is combined with heavy metal ion.
Compositions of the present invention need be a solution that oozes with eye liquid etc., and the osmotic pressure of preferred said composition is about 260-340mosm/KgH
2O, preferred osmotic pressure are 280-320 mosm/KgH
2O。
Compositions of the present invention comprises the resist drying wetting agent, and the resist drying wetting agent is trehalose quaternary ammonium salt, and is dry and astringent, sour swollen to guarantee alleviating in use eye.The trehalose quaternary ammonium salt chemical property is very stable, at aspects such as eye liquid formulation, dry eye treatment, preservation of cornea, larger progress is arranged.
Compositions of the present invention comprises surfactant, this component can be cationic surfactant, anion surfactant, non-ionic surface active agent, amphoteric surfactant, this surfactant needs not stimulate with eyes, have good and the eyes compatibility, this material is mainly removed the pollutant on contact lens.
The present invention shows through animal experiment, and compositions good biocompatibility of the present invention is without general toxic reaction with to the zest of animal conjunctiva and iris and cornea tissue.
Claims (2)
1. the corneal contact lens nursing composition that contains trehalose quaternary ammonium salt, by weight percentage, it is characterized in that: composed of the following components: trehalose quaternary ammonium salt is 0.001-2%, be 0.01-2% Deng oozing adjusting agent, surfactant is 0.05-2%, chelating agent is 0.01-1%, and buffer agent is 0.01-3%, and Antimicrobe compound is 0.00001-1%, water 89-99.91899%;
Above-mentioned grade is oozed at least a in monosaccharide that adjusting agent is sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glucose, propylene glycol, glycerol, sorbitol, mannitol; Surfactant can be at least a in poloxamer (Poloxamer), pool Luo Shamin (Poloxamines), tyloxapol (Tyloxapol), Polysorbate, sodium lauroyl glutamate, dodecanamide propyl hydroxy sulfo lycine;
Above-mentioned chelating agent is at least a in ethylenediaminetetraacetic acid, 2-amino-2-methyl-1-propanol (AMP-95), N-dodecyl ethylenediamine triacetic acid;
Above-mentioned buffer agent is at least a in boric acid, Borax, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, trometamol (TRIS AMINO);
Above-mentioned antimicrobial is polyquaternary ammonium salt-1(Polyquaternium-1), poly hexamethylene biguanide (polyhexamethylene biguanide, PHMB), at least a in poly-aminopropyl biguanide (polyaminopropyl biguanide, PAPB), alexidine (Alexidine), benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, sorbic acid.
2. method for preparing corneal contact lens nursing composition claimed in claim 1: it is characterized in that: be 0.001-2% with trehalose quaternary ammonium salt by weight percentage, be 0.01-2% Deng oozing adjusting agent, surfactant is 0.05-2%, chelating agent is 0.01-1%, buffer agent is 0.01-3%, and Antimicrobe compound is 0.00001-1%, water 89-99.91899%; Put into successively water and dissolve, adjust pH at 6.5-7.8 with sodium hydroxide and hydrochloric acid, osmotic pressure is at 260-340 mosm/KgH
2O, solution gets final product through the membrane filter aseptic filtration in 0.22 μ m aperture.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100238439A CN103083710A (en) | 2013-01-23 | 2013-01-23 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
| PCT/CN2013/086855 WO2014114124A1 (en) | 2013-01-23 | 2013-11-11 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013100238439A CN103083710A (en) | 2013-01-23 | 2013-01-23 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
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| CN103083710A true CN103083710A (en) | 2013-05-08 |
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| CN2013100238439A Pending CN103083710A (en) | 2013-01-23 | 2013-01-23 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
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| WO (1) | WO2014114124A1 (en) |
Cited By (6)
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| WO2014114124A1 (en) * | 2013-01-23 | 2014-07-31 | 江苏海伦隐形眼镜有限公司 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
| CN105031705A (en) * | 2015-06-24 | 2015-11-11 | 黄红林 | Contact lens disinfecting and moisturizing medicinal solution |
| CN108350589A (en) * | 2015-11-06 | 2018-07-31 | 株式会社杰希优 | Nickel plating additive and satin nickel plating bath containing it |
| CN109722347A (en) * | 2019-01-03 | 2019-05-07 | 山东省药学科学院 | A kind of moisturizing lubricating composition containing xanthan gum and its application |
| CN113144207A (en) * | 2021-02-07 | 2021-07-23 | 山西利普达医药科技有限公司 | Composition containing polyquaternium-1 and application thereof |
| IT202100017396A1 (en) * | 2021-07-01 | 2023-01-01 | Azienda Unita Sanitaria Locale Della Romagna | Conservation method at room temperature of tissues and organs intended for clinical use |
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| WO2023229667A1 (en) * | 2022-05-24 | 2023-11-30 | The Cleveland Clinic Foundation | Topical angiotensin ii receptor blockers (arbs) for treating eye conditions |
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| CN101691479B (en) * | 2009-09-25 | 2013-01-16 | 海昌隐形眼镜有限公司 | Corneal contact lens preserving liquid composition and preparation method thereof |
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- 2013-11-11 WO PCT/CN2013/086855 patent/WO2014114124A1/en active Application Filing
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| WO2009113161A1 (en) * | 2008-03-12 | 2009-09-17 | 株式会社メニコン | Solution composition for contact lenses |
| CN101343293A (en) * | 2008-08-22 | 2009-01-14 | 烟台海岸带可持续发展研究所 | Moisture absorption humectant employing trehalose quaternary ammonium salt and preparation thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014114124A1 (en) * | 2013-01-23 | 2014-07-31 | 江苏海伦隐形眼镜有限公司 | Corneal contact lens nursing composition containing trehalose quaternary ammonium salt |
| CN105031705A (en) * | 2015-06-24 | 2015-11-11 | 黄红林 | Contact lens disinfecting and moisturizing medicinal solution |
| CN108350589A (en) * | 2015-11-06 | 2018-07-31 | 株式会社杰希优 | Nickel plating additive and satin nickel plating bath containing it |
| CN109722347A (en) * | 2019-01-03 | 2019-05-07 | 山东省药学科学院 | A kind of moisturizing lubricating composition containing xanthan gum and its application |
| CN113144207A (en) * | 2021-02-07 | 2021-07-23 | 山西利普达医药科技有限公司 | Composition containing polyquaternium-1 and application thereof |
| IT202100017396A1 (en) * | 2021-07-01 | 2023-01-01 | Azienda Unita Sanitaria Locale Della Romagna | Conservation method at room temperature of tissues and organs intended for clinical use |
| WO2023275819A1 (en) * | 2021-07-01 | 2023-01-05 | Azienda Unita' Sanitaria Locale Della Romagna | Room temperature method of preservation of tissues for clinical use |
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| Publication number | Publication date |
|---|---|
| WO2014114124A1 (en) | 2014-07-31 |
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Application publication date: 20130508 |